{"id":"https://openalex.org/W2143969780","doi":"https://doi.org/10.1042/bj20021806","title":"Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity","display_name":"Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity","publication_year":2003,"publication_date":"2003-03-12","ids":{"openalex":"https://openalex.org/W2143969780","doi":"https://doi.org/10.1042/bj20021806","mag":"2143969780","pmid":"https://pubmed.ncbi.nlm.nih.gov/12529172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1223246"},"language":"en","primary_location":{"id":"doi:10.1042/bj20021806","doi":"https://doi.org/10.1042/bj20021806","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20021806","pdf_url":"https://portlandpress.com/biochemj/article-pdf/370/3/1077/711144/bj3701077.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/370/3/1077/711144/bj3701077.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002169409","display_name":"A. Jane Bardwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Jane BARDWELL","raw_affiliation_strings":["Department of Developmental and Cell Biology, 5207 McGaugh Hall, University of California, Irvine, CA 92697-2300, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, 5207 McGaugh Hall, University of California, Irvine, CA 92697-2300, U.S.A","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034904990","display_name":"Mahsa Abdollahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahsa ABDOLLAHI","raw_affiliation_strings":["Department of Developmental and Cell Biology, 5207 McGaugh Hall, University of California, Irvine, CA 92697-2300, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, 5207 McGaugh Hall, University of California, Irvine, CA 92697-2300, U.S.A","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079448426","display_name":"Lee Bardwell","orcid":"https://orcid.org/0000-0002-2393-8363","observed_orcids":["https://orcid.org/0000-0002-2393-8363"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lee BARDWELL","raw_affiliation_strings":["Department of Developmental and Cell Biology, 5207 McGaugh Hall, University of California, Irvine, CA 92697-2300, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Developmental and Cell Biology, 5207 McGaugh Hall, University of California, Irvine, CA 92697-2300, U.S.A","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":3.017,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":{"value":0.92695717,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"370","issue":"3","first_page":"1077","last_page":"1085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.20399999618530273,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.06040000170469284,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.6779999732971191},{"id":"https://openalex.org/keywords/mek2","display_name":"MEK2","score":1.0},{"id":"https://openalex.org/keywords/erk2","display_name":"ERK2","score":0.8379999995231628},{"id":"https://openalex.org/keywords/mkp-1","display_name":"MKP-1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ste7","display_name":"Ste7","score":0.8180000185966492},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/kinase-activation","display_name":"kinase activation","score":0.3840000033378601},{"id":"https://openalex.org/keywords/phosphatase-dephosphorylation","display_name":"phosphatase dephosphorylation","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.764192521572113},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6867451667785645},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6723405122756958},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.5976890325546265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5580485463142395},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5442276000976562},{"id":"https://openalex.org/C132149769","wikidata":"https://www.wikidata.org/wiki/Q899651","display_name":"Mitogen-activated protein kinase","level":3,"score":0.5067444443702698},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.45969879627227783},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4432518482208252},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.43886882066726685},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4012489914894104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39303576946258545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37844204902648926},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3215067982673645},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.03946864604949951}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017027","descriptor_name":"Protein Tyrosine Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048370","descriptor_name":"MAP Kinase Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054638","descriptor_name":"Dual Specificity Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054645","descriptor_name":"Protein Phosphatase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20021806","doi":"https://doi.org/10.1042/bj20021806","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20021806","pdf_url":"https://portlandpress.com/biochemj/article-pdf/370/3/1077/711144/bj3701077.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1223246","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1223246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:12529172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12529172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"mag:2742095153","doi":null,"is_oa":false,"landing_page_url":"https://www.researchgate.net/profile/Lee_Bardwell/publication/228512241_Docking_Sites_on_MEKs_MAP_Kinase_Phosphatases_and_the_Elk-1_Transcription_Factor_Compete_for_Binding_to_ERK2_and_are_Crucial_for_Enzymatic_Activity/links/0046351a7779e3e771000000.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1042/bj20021806","doi":"https://doi.org/10.1042/bj20021806","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20021806","pdf_url":"https://portlandpress.com/biochemj/article-pdf/370/3/1077/711144/bj3701077.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6554039465","display_name":"MAP kinase cascade signal transmission and specificity","funder_award_id":"R01GM060366","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143969780.pdf","grobid_xml":"https://content.openalex.org/works/W2143969780.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1528882361","https://openalex.org/W1566737177","https://openalex.org/W1766090917","https://openalex.org/W1913244564","https://openalex.org/W1964048941","https://openalex.org/W1967218150","https://openalex.org/W1968189883","https://openalex.org/W1970554113","https://openalex.org/W1973473002","https://openalex.org/W1980514336","https://openalex.org/W1985065252","https://openalex.org/W1990065094","https://openalex.org/W1999813498","https://openalex.org/W2001959826","https://openalex.org/W2004793363","https://openalex.org/W2007275795","https://openalex.org/W2007559737","https://openalex.org/W2008297774","https://openalex.org/W2009930457","https://openalex.org/W2017012572","https://openalex.org/W2018221682","https://openalex.org/W2020184457","https://openalex.org/W2027649846","https://openalex.org/W2028333426","https://openalex.org/W2038982119","https://openalex.org/W2041798139","https://openalex.org/W2059624730","https://openalex.org/W2059986458","https://openalex.org/W2061699263","https://openalex.org/W2068583506","https://openalex.org/W2083076387","https://openalex.org/W2083117403","https://openalex.org/W2084766033","https://openalex.org/W2087609448","https://openalex.org/W2094074884","https://openalex.org/W2095510483","https://openalex.org/W2097569409","https://openalex.org/W2097783992","https://openalex.org/W2099221935","https://openalex.org/W2100774604","https://openalex.org/W2103157474","https://openalex.org/W2105298978","https://openalex.org/W2110911902","https://openalex.org/W2111222398","https://openalex.org/W2111252945","https://openalex.org/W2112568143","https://openalex.org/W2119670701","https://openalex.org/W2120781124","https://openalex.org/W2152589434","https://openalex.org/W2155158959","https://openalex.org/W2168259122","https://openalex.org/W2170723584","https://openalex.org/W2312303591","https://openalex.org/W3217178944","https://openalex.org/W4239714346","https://openalex.org/W4243108152","https://openalex.org/W4249688612"],"related_works":["https://openalex.org/W2742095153","https://openalex.org/W2083117403","https://openalex.org/W2103157474","https://openalex.org/W2075968748","https://openalex.org/W1982596292","https://openalex.org/W2011659866","https://openalex.org/W1985672893","https://openalex.org/W2006005106","https://openalex.org/W3177273881","https://openalex.org/W1992023215"],"abstract_inverted_index":{"Mitogen-activated":[0],"protein":[1],"kinase":[2],"(MAPK)":[3],"cascades":[4],"control":[5],"gene":[6],"expression":[7],"patterns":[8],"in":[9,26],"response":[10],"to":[11,68,172],"extracellular":[12],"stimuli.":[13],"MAPK/ERK":[14],"(extracellular-signal-regulated":[15],"kinase)":[16],"kinases":[17],"(MEKs)":[18],"activate":[19],"MAPKs":[20,49],"by":[21,35],"phosphorylating":[22],"them;":[23],"activated":[24],"MAPKs,":[25],"turn,":[27],"phosphorylate":[28],"target":[29,135],"transcription":[30,167],"factors,":[31],"and":[32,43,53,77,91,113,148,164],"are":[33,182],"deactivated":[34],"phosphatases.":[36],"One":[37],"mechanism":[38],"for":[39,101,170,184],"maintaining":[40],"signal":[41],"specificity":[42],"efficiency":[44],"is":[45],"the":[46,60,69,103,138,152,165,173],"interaction":[47],"of":[48,72,85,89,94,126,133,145,151,176],"with":[50,143],"their":[51],"substrates":[52],"regulators":[54],"through":[55],"high-affinity":[56],"docking":[57],"sites.":[58],"In":[59,115],"present":[61],"study,":[62],"we":[63],"show":[64],"that":[65,161,181],"peptides":[66,119,142],"corresponding":[67],"MAPK-docking":[70,124,153],"sites":[71],"MEK1,":[73],"MEK2,":[74,109],"Ste7,":[75],"Elk-1":[76,166],"MAPK":[78],"phosphatase":[79],"(MKP)-2":[80],"potently":[81,129],"inhibit":[82],"MEK2":[83,104],"phosphorylation":[84,88,132],"ERK2,":[86],"ERK2":[87,112,177],"Elk-1,":[90],"MKP-1":[92],"dephosphorylation":[93],"ERK2.":[95],"Each":[96],"peptide":[97,105],"inhibited":[98,106,120],"multiple":[99],"reactions;":[100],"example,":[102],"not":[107],"only":[108],"but":[110],"also":[111,128],"MKP-1.":[114],"addition,":[116],"these":[117],"docking-site":[118],"MEK2-ERK2":[121],"binding.":[122],"The":[123],"site":[125,136,154],"MEK1":[127],"stimulated":[130],"ERK2-mediated":[131],"a":[134],"on":[137],"same":[139,174],"peptide.":[140],"Control":[141],"mutations":[144],"conserved":[146],"basic":[147],"hydrophobic":[149],"residues":[150],"consensus":[155],"lacked":[156],"biological":[157],"activity.":[158,186],"We":[159],"conclude":[160],"MEKs,":[162],"MKPs":[163],"factor":[168],"compete":[169],"binding":[171],"region":[175],"via":[178],"protein-protein":[179],"interactions":[180],"crucial":[183],"kinase/phosphatase":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}