{"id":"https://openalex.org/W2143752913","doi":null,"title":"Small RNA-mediated Gene Regulation in Caenorhabditis elegans","display_name":"Small RNA-mediated Gene Regulation in Caenorhabditis elegans","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2143752913","mag":"2143752913"},"language":"en","primary_location":{"id":"pmh:oai:erepo.uef.fi:123456789/9588","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:ISBN:978-951-27-1117-8","pdf_url":"https://erepo.uef.fi/bitstreams/47b098c1-80f7-4c8d-ac6c-4d79d48c6e66/download","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://erepo.uef.fi/bitstreams/47b098c1-80f7-4c8d-ac6c-4d79d48c6e66/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012480325","display_name":"Suvi Asikainen","orcid":"https://orcid.org/0000-0002-2558-3711","observed_orcids":["https://orcid.org/0000-0002-2558-3711"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Suvi Asikainen","raw_affiliation_strings":["University of Eastern Finland"],"raw_orcid":"https://orcid.org/0000-0002-2558-3711","affiliations":[{"raw_affiliation_string":"University of Eastern Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012480325"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.8589000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-rna","display_name":"small RNA","score":0.8970000147819519},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.8379999995231628},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9259999990463257},{"id":"https://openalex.org/keywords/sirna","display_name":"siRNA","score":0.6859999895095825},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6959999799728394},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.5440000295639038},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9570000171661377},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.6990000009536743},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.8600000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8290022611618042},{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.7395886778831482},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.738357424736023},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.7218994498252869},{"id":"https://openalex.org/C2779341050","wikidata":"https://www.wikidata.org/wiki/Q24287527","display_name":"Small RNA","level":4,"score":0.6765996217727661},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6594045162200928},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.5903622508049011},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.5704804062843323},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5591892004013062},{"id":"https://openalex.org/C2191507","wikidata":"https://www.wikidata.org/wiki/Q7277185","display_name":"RNA silencing","level":5,"score":0.5219035744667053},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5208624005317688},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5006198883056641},{"id":"https://openalex.org/C147724379","wikidata":"https://www.wikidata.org/wiki/Q2367421","display_name":"Piwi-interacting RNA","level":5,"score":0.47093716263771057},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4409283399581909},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41088417172431946}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:erepo.uef.fi:123456789/9588","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:ISBN:978-951-27-1117-8","pdf_url":"https://erepo.uef.fi/bitstreams/47b098c1-80f7-4c8d-ac6c-4d79d48c6e66/download","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2143752913","doi":null,"is_oa":false,"landing_page_url":"https://epublications.uef.fi/pub/urn_isbn_978-951-27-1117-8/urn_isbn_978-951-27-1117-8.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:erepo.uef.fi:123456789/9588","doi":null,"is_oa":true,"landing_page_url":"http://urn.fi/URN:ISBN:978-951-27-1117-8","pdf_url":"https://erepo.uef.fi/bitstreams/47b098c1-80f7-4c8d-ac6c-4d79d48c6e66/download","source":{"id":"https://openalex.org/S4306402418","display_name":"UEF eRepo (University of Eastern Finland)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I175532246","host_organization_name":"University of Eastern Finland","host_organization_lineage":["https://openalex.org/I175532246"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322885","display_name":"NordForsk","ror":"https://ror.org/05bqzfg94"},{"id":"https://openalex.org/F4320329810","display_name":"Saastamoisen s\u00e4\u00e4ti\u00f6","ror":"https://ror.org/03f0nw643"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143752913.pdf","grobid_xml":"https://content.openalex.org/works/W2143752913.grobid-xml"},"referenced_works_count":134,"referenced_works":["https://openalex.org/W45534775","https://openalex.org/W76198007","https://openalex.org/W1505732106","https://openalex.org/W1514080071","https://openalex.org/W1550876205","https://openalex.org/W1647075334","https://openalex.org/W1659052949","https://openalex.org/W1856401128","https://openalex.org/W1877873625","https://openalex.org/W1911220294","https://openalex.org/W1920303762","https://openalex.org/W1921244251","https://openalex.org/W1969719291","https://openalex.org/W1969816188","https://openalex.org/W1973510303","https://openalex.org/W1973699456","https://openalex.org/W1976679748","https://openalex.org/W1978337436","https://openalex.org/W1978381665","https://openalex.org/W1978717279","https://openalex.org/W1979565277","https://openalex.org/W1980147942","https://openalex.org/W1980269624","https://openalex.org/W1981506621","https://openalex.org/W1983906182","https://openalex.org/W1987908533","https://openalex.org/W1988467918","https://openalex.org/W1992170226","https://openalex.org/W2004271888","https://openalex.org/W2015735754","https://openalex.org/W2018295108","https://openalex.org/W2019028138","https://openalex.org/W2020456835","https://openalex.org/W2020458511","https://openalex.org/W2023018514","https://openalex.org/W2024000520","https://openalex.org/W2027891004","https://openalex.org/W2028466333","https://openalex.org/W2031110588","https://openalex.org/W2032080066","https://openalex.org/W2034206562","https://openalex.org/W2034831897","https://openalex.org/W2037541952","https://openalex.org/W2044604140","https://openalex.org/W2046318418","https://openalex.org/W2051252016","https://openalex.org/W2051864496","https://openalex.org/W2054268736","https://openalex.org/W2056030683","https://openalex.org/W2057558367","https://openalex.org/W2062040901","https://openalex.org/W2062573998","https://openalex.org/W2062916004","https://openalex.org/W2069271564","https://openalex.org/W2069799979","https://openalex.org/W2070571588","https://openalex.org/W2072155079","https://openalex.org/W2077293902","https://openalex.org/W2079902244","https://openalex.org/W2082187624","https://openalex.org/W2082270407","https://openalex.org/W2087453865","https://openalex.org/W2096196036","https://openalex.org/W2096246936","https://openalex.org/W2101276421","https://openalex.org/W2104933707","https://openalex.org/W2108010346","https://openalex.org/W2108266886","https://openalex.org/W2111646903","https://openalex.org/W2112264994","https://openalex.org/W2114570899","https://openalex.org/W2115225629","https://openalex.org/W2116524992","https://openalex.org/W2117991391","https://openalex.org/W2120020297","https://openalex.org/W2120141187","https://openalex.org/W2120726784","https://openalex.org/W2122683221","https://openalex.org/W2122716364","https://openalex.org/W2123431154","https://openalex.org/W2123631503","https://openalex.org/W2124774982","https://openalex.org/W2127497651","https://openalex.org/W2128114769","https://openalex.org/W2128709215","https://openalex.org/W2130979840","https://openalex.org/W2131293603","https://openalex.org/W2132957118","https://openalex.org/W2134712940","https://openalex.org/W2136148915","https://openalex.org/W2136495792","https://openalex.org/W2136991248","https://openalex.org/W2138664009","https://openalex.org/W2138835651","https://openalex.org/W2138910750","https://openalex.org/W2138954682","https://openalex.org/W2139122866","https://openalex.org/W2141429139","https://openalex.org/W2142305917","https://openalex.org/W2143826011","https://openalex.org/W2145825942","https://openalex.org/W2146138309","https://openalex.org/W2149788324","https://openalex.org/W2151722180","https://openalex.org/W2152041515","https://openalex.org/W2154166273","https://openalex.org/W2154841861","https://openalex.org/W2155396586","https://openalex.org/W2157334713","https://openalex.org/W2158627784","https://openalex.org/W2159638567","https://openalex.org/W2159746639","https://openalex.org/W2160226189","https://openalex.org/W2162278418","https://openalex.org/W2163078167","https://openalex.org/W2165804743","https://openalex.org/W2166819889","https://openalex.org/W2167999293","https://openalex.org/W2168230240","https://openalex.org/W2169296937","https://openalex.org/W2169441235","https://openalex.org/W2182775511","https://openalex.org/W2182927876","https://openalex.org/W2183989098","https://openalex.org/W2184064907","https://openalex.org/W2184442881","https://openalex.org/W2184470929","https://openalex.org/W2184752712","https://openalex.org/W2292621739","https://openalex.org/W2317539043","https://openalex.org/W2550621372","https://openalex.org/W2555457476","https://openalex.org/W7033783247","https://openalex.org/W7100139990"],"related_works":["https://openalex.org/W1994676607","https://openalex.org/W2099931758","https://openalex.org/W2391711927","https://openalex.org/W2163998989","https://openalex.org/W2124774982","https://openalex.org/W2116708466","https://openalex.org/W2474205242","https://openalex.org/W2075106432","https://openalex.org/W3133813486","https://openalex.org/W2995754389"],"abstract_inverted_index":{"Small":[0],"RNA-mediated":[1],"gene":[2,13],"silencing":[3],"is":[4,17],"an":[5,68,111],"ancient,":[6],"evolutionarily":[7],"conserved":[8],"and":[9,33,48,61,95,125,142,156,176,195,199],"only":[10],"recently":[11],"discovered":[12],"regulatory":[14],"mechanism.This":[15],"thesis":[16],"aimed":[18],"towards":[19],"understanding":[20,212],"the":[21,28,103,193,217],"function":[22],"of":[23,117,164,171,197,213,219,225],"small":[24,45,82,119,201,226],"RNA":[25,46,58],"pathways":[26,47],"in":[27,39,53,62,105,133,137,166,187,205,223],"model":[29],"organism":[30],"Caenorhabditis":[31],"elegans,":[32],"furthermore":[34],"to":[35,43,79,89,101,130,158,207],"understand":[36],"their":[37,49,77,126,214],"role":[38],"neurodegenerative":[40,230],"diseases.In":[41],"order":[42,206],"study":[44],"potential":[50],"therapeutic":[51],"applications":[52],"neurological":[54],"diseases,":[55],"molecular":[56],"genetic,":[57],"interference,":[59],"microarray,":[60],"silico":[63],"techniques":[64],"were":[65,74,123,128,152,174,182,203],"used":[66],"as":[67,184],"experimental":[69],"approach.Firstly,":[70],"different":[71,92],"neuron":[72,93],"types":[73,94],"examined":[75],"for":[76,229],"sensitivity":[78,86],"exogenously":[80],"delivered":[81],"interfering":[83,120],"RNAs":[84,121,202],"(exo-siRNAs).The":[85],"was":[87,99],"found":[88,129,157],"vary":[90],"between":[91],"dysfunctional":[96],"RRF-3":[97],"protein":[98,138],"shown":[100],"increase":[102],"effectiveness":[104,194],"all":[106],"measured":[107,175],"cell":[108],"types.Secondly,":[109],"using":[110,220],"rrf-3":[112],"mutant":[113],"animal,":[114],"candidate":[115],"targets":[116],"endogenous":[118,145,200],"(endo-siRNAs)":[122],"identified":[124,148,183],"functions":[127,196],"be":[131],"enriched":[132],"regulating":[134],"genes":[135],"involved":[136,186],"phosphorylation,":[139],"embryonic":[140],"development,":[141],"sperm":[143],"motility.Thirdly,":[144],"siRNAs":[146],"previously":[147],"by":[149,154],"high-throughput":[150],"sequencing":[151],"distributed":[153],"size":[155],"have":[159],"size-specific":[160],"functions.Finally,":[161],"expression":[162],"levels":[163],"microRNAs":[165],"several":[167],"C.":[168],"elegans":[169],"models":[170],"Parkinson's":[172,188],"disease":[173],"two":[177],"differentially":[178],"regulated":[179],"microRNA":[180],"families":[181],"potentially":[185],"disease-associated":[189],"pathogenic":[190],"mechanisms.In":[191],"conclusion,":[192],"exogenous":[198],"studied":[204],"provide":[208],"a":[209],"more":[210],"thorough":[211],"biology":[215],"with":[216],"prospect":[218],"this":[221],"information":[222],"development":[224],"RNA-based":[227],"therapies":[228],"diseases.":[231]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}