{"id":"https://openalex.org/W2143708909","doi":"https://doi.org/10.1021/bi8005434","title":"Hydrogen Location in Stages of an Enzyme-Catalyzed Reaction: Time-of-Flight Neutron Structure of d -Xylose Isomerase with Bound d -Xylulose","display_name":"Hydrogen Location in Stages of an Enzyme-Catalyzed Reaction: Time-of-Flight Neutron Structure of d -Xylose Isomerase with Bound d -Xylulose","publication_year":2008,"publication_date":"2008-06-26","ids":{"openalex":"https://openalex.org/W2143708909","doi":"https://doi.org/10.1021/bi8005434","mag":"2143708909","pmid":"https://pubmed.ncbi.nlm.nih.gov/18578508","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2488401"},"language":"en","primary_location":{"id":"doi:10.1021/bi8005434","doi":"https://doi.org/10.1021/bi8005434","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi8005434","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2488401","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089578194","display_name":"Andrey Y. Kovalevsky","orcid":"https://orcid.org/0000-0003-4459-9142","observed_orcids":["https://orcid.org/0000-0003-4459-9142"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrey Y. Kovalevsky","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109568269","display_name":"Amy K. Katz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy K. Katz","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091487383","display_name":"H. L. Carrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. L. Carrell","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Leif Hanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leif Hanson","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073038108","display_name":"Marat Mustyakimov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marat Mustyakimov","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007140681","display_name":"S. Zo\u00eb Fisher","orcid":"https://orcid.org/0000-0001-8287-0269","observed_orcids":["https://orcid.org/0000-0001-8287-0269"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Zoe Fisher","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015921759","display_name":"Leighton Coates","orcid":"https://orcid.org/0000-0003-2342-049X","observed_orcids":["https://orcid.org/0000-0003-2342-049X"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leighton Coates","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020693564","display_name":"BENNO P. SCHOENBORN","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benno P. Schoenborn","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059547677","display_name":"Gerard J. Bunick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard J. Bunick","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109131922","display_name":"JENNY PICKWORTH GLUSKER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenny P. Glusker","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054131711","display_name":"Paul A. Langan","orcid":"https://orcid.org/0000-0002-0247-3122","observed_orcids":["https://orcid.org/0000-0002-0247-3122"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]},{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]},{"id":"https://openalex.org/I90871651","display_name":"University of Toledo","ror":"https://ror.org/01pbdzh19","country_code":"US","type":"education","lineage":["https://openalex.org/I90871651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Paul Langan","raw_affiliation_strings":["M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"M888, Bioscience Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111-2497, Chemistry Department, University of Toledo, Toledo, Ohio 43606, and Chemistry Department, University of Tennessee, Knoxville, Tennessee 37996","institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5054131711"],"corresponding_institution_ids":["https://openalex.org/I1289437631","https://openalex.org/I1343871089","https://openalex.org/I75027704","https://openalex.org/I90871651"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1814,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.92886212,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"47","issue":"29","first_page":"7595","last_page":"7597"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d-xylose-isomerase","display_name":"D-xylose isomerase","score":0.9340000152587891},{"id":"https://openalex.org/keywords/d-xylulose","display_name":"D-xylulose","score":0.9399999976158142},{"id":"https://openalex.org/keywords/hydrogen-positions","display_name":"hydrogen atom positions","score":0.703000009059906},{"id":"https://openalex.org/keywords/enzyme-mechanism","display_name":"enzyme mechanism","score":0.621999979019165},{"id":"https://openalex.org/keywords/catalytic-water","display_name":"catalytic water","score":0.6769999861717224},{"id":"https://openalex.org/keywords/hydroxyl-anion","display_name":"hydroxyl anion","score":0.8420000076293945},{"id":"https://openalex.org/keywords/protonation-states","display_name":"protonation states","score":0.6600000262260437},{"id":"https://openalex.org/keywords/hydrogen-bonding","display_name":"hydrogen bonding","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.8866143226623535},{"id":"https://openalex.org/C2781264208","wikidata":"https://www.wikidata.org/wiki/Q118026","display_name":"Isomerase","level":3,"score":0.8308953046798706},{"id":"https://openalex.org/C2779277513","wikidata":"https://www.wikidata.org/wiki/Q8045529","display_name":"Xylose isomerase","level":4,"score":0.7791682481765747},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7570608854293823},{"id":"https://openalex.org/C126661725","wikidata":"https://www.wikidata.org/wiki/Q903420","display_name":"Isomerization","level":3,"score":0.7553707957267761},{"id":"https://openalex.org/C2780294150","wikidata":"https://www.wikidata.org/wiki/Q66589603","display_name":"Xylose","level":3,"score":0.6180031299591064},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.584760308265686},{"id":"https://openalex.org/C73585123","wikidata":"https://www.wikidata.org/wiki/Q910499","display_name":"Neutron diffraction","level":3,"score":0.5309618711471558},{"id":"https://openalex.org/C512968161","wikidata":"https://www.wikidata.org/wiki/Q556","display_name":"Hydrogen","level":2,"score":0.5049389004707336},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4620598554611206},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.4398612976074219},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.42958104610443115},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.3644474744796753},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.28296026587486267},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.2766519784927368},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21288838982582092},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1250087022781372},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.12322637438774109},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.0867888331413269}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D009502","descriptor_name":"Neutrons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014996","descriptor_name":"Xylulose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014996","descriptor_name":"Xylulose","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019747","descriptor_name":"Aldose-Ketose Isomerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019747","descriptor_name":"Aldose-Ketose Isomerases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1021/bi8005434","doi":"https://doi.org/10.1021/bi8005434","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi8005434","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:18578508","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18578508","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:1488553","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2488401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2488401","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2488401","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},{"id":"mag:3167813466","doi":null,"is_oa":false,"landing_page_url":"https://www.cup.lmu.de/ac/kluefers/homepage/L/bac/xyl_2008.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1488553","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2488401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1036414272","display_name":"APPLICATION OF CRYSTALLOGRAPHIC TECHNIQUES","funder_award_id":"R01CA010925","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G164730967","display_name":null,"funder_award_id":"GM071939","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5526477257","display_name":"Computational Tools for Neutron Protein Crystallography","funder_award_id":"R01GM071939","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G738926150","display_name":null,"funder_award_id":"CA-10925","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000285491","display_name":"Comprehensive Cancer Center Program at Fox Chase","funder_award_id":"P30CA006927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G921727105","display_name":null,"funder_award_id":"CA06927","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1500330894","https://openalex.org/W1993684667","https://openalex.org/W2015492400","https://openalex.org/W2021630428","https://openalex.org/W2024095356","https://openalex.org/W2029641302","https://openalex.org/W2030458852","https://openalex.org/W2034290050","https://openalex.org/W2034949616","https://openalex.org/W2064815331","https://openalex.org/W2091826758","https://openalex.org/W2096249575","https://openalex.org/W2112554771","https://openalex.org/W2138019321","https://openalex.org/W2424392221"],"related_works":["https://openalex.org/W3167813466","https://openalex.org/W2093535643","https://openalex.org/W2030458852","https://openalex.org/W2021341365","https://openalex.org/W2528170175","https://openalex.org/W2014554413","https://openalex.org/W1994766967","https://openalex.org/W2073206318","https://openalex.org/W1977750999","https://openalex.org/W2335961874"],"abstract_inverted_index":{"The":[0,21],"time-of-flight":[1],"neutron":[2,22],"Laue":[3],"technique":[4],"has":[5,66],"been":[6],"used":[7],"to":[8,43,69],"determine":[9],"the":[10,16,60,76,82,95],"location":[11],"of":[12,24,35,78,85,87,94],"hydrogen":[13],"atoms":[14],"in":[15,52,63,75],"enzyme":[17],"d-xylose":[18],"isomerase":[19],"(XI).":[20],"structure":[23],"crystalline":[25],"XI":[26,65],"with":[27],"bound":[28],"product,":[29],"d-xylulose,":[30],"shows,":[31],"unexpectedly,":[32],"that":[33],"O5":[34],"d-xylulose":[36],"is":[37,41,50,55,74],"not":[38],"protonated":[39,45,56],"but":[40],"hydrogen-bonded":[42],"doubly":[44],"His54.":[46],"Also,":[47],"Lys289,":[48],"which":[49,73],"neutral":[51],"native":[53,64],"XI,":[54],"(positively":[57],"charged),":[58],"while":[59],"catalytic":[61],"water":[62],"become":[67],"activated":[68],"a":[70],"hydroxyl":[71],"anion":[72],"proximity":[77],"C1":[79],"and":[80],"C2,":[81],"molecular":[83],"site":[84],"isomerization":[86],"xylose.":[88],"These":[89],"findings":[90],"impact":[91],"our":[92],"understanding":[93],"reaction":[96],"mechanism.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
