{"id":"https://openalex.org/W2143612367","doi":"https://doi.org/10.2337/diacare.23.11.1694","title":"von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes.","display_name":"von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes.","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W2143612367","doi":"https://doi.org/10.2337/diacare.23.11.1694","mag":"2143612367","pmid":"https://pubmed.ncbi.nlm.nih.gov/11092294"},"language":"en","primary_location":{"id":"doi:10.2337/diacare.23.11.1694","doi":"https://doi.org/10.2337/diacare.23.11.1694","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.23.11.1694","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111995720","display_name":"DaLi Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Feng","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059202016","display_name":"Sven\u2013Erik Bursell","orcid":"https://orcid.org/0009-0007-4348-6425","observed_orcids":["https://orcid.org/0009-0007-4348-6425","https://orcid.org/0000-0003-4902-5455"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S E Bursell","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058107798","display_name":"AC Clermont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A C Clermont","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103544412","display_name":"Izabella Lipinska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I Lipinska","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042011351","display_name":"Lloyd Paul Aiello","orcid":"https://orcid.org/0000-0003-2012-3465","observed_orcids":["https://orcid.org/0000-0003-2012-3465"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L P Aiello","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069785394","display_name":"Lori M. Laffel","orcid":"https://orcid.org/0000-0002-9675-3001","observed_orcids":["https://orcid.org/0000-0002-9675-3001","https://orcid.org/0000-0003-2202-492X"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Laffel","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009528569","display_name":"George Liang King","orcid":"https://orcid.org/0000-0002-0335-5881","observed_orcids":["https://orcid.org/0000-0002-0335-5881"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G L King","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089858920","display_name":"Geoffrey H. Tofler","orcid":"https://orcid.org/0000-0001-5922-7259","observed_orcids":["https://orcid.org/0000-0001-5922-7259"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G H Tofler","raw_affiliation_strings":["Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Prevention of Cardiovascular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA. dfeng2@caregroup.harvard.edu","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7597,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.74575811,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"11","first_page":"1694","last_page":"1698"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12599","display_name":"Retinal and Optic Conditions","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":0.9020000100135803},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9800000190734863},{"id":"https://openalex.org/keywords/retinal-circulation","display_name":"retinal circulation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/retinal-blood-flow","display_name":"retinal blood flow","score":0.9959999918937683},{"id":"https://openalex.org/keywords/retinal-circulation-time","display_name":"retinal circulation time","score":0.9599999785423279},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8600000143051147},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.9010000228881836},{"id":"https://openalex.org/keywords/vitamin-e-therapy","display_name":"vitamin E therapy","score":0.7039999961853027},{"id":"https://openalex.org/keywords/glycemic-control","display_name":"glycemic control","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hba1c","display_name":"HbA1c","score":0.8920000195503235},{"id":"https://openalex.org/keywords/retinal-hypoxia","display_name":"retinal hypoxia","score":0.6840000152587891},{"id":"https://openalex.org/keywords/microvascular-complications","display_name":"microvascular complications","score":0.9179999828338623}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8523193597793579},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.6897686719894409},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6711910963058472},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.6441671848297119},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.6426900625228882},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5702691674232483},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.5594343543052673},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.510705292224884},{"id":"https://openalex.org/C2780248432","wikidata":"https://www.wikidata.org/wiki/Q1434206","display_name":"Fluorescein angiography","level":3,"score":0.42814117670059204},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.3381972908973694},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.19767579436302185}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003922","descriptor_name":"Diabetes Mellitus, Type 1","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005340","descriptor_name":"Fibrinogen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006442","descriptor_name":"Glycated Hemoglobin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012171","descriptor_name":"Retinal Vessels","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2337/diacare.23.11.1694","doi":"https://doi.org/10.2337/diacare.23.11.1694","is_oa":false,"landing_page_url":"https://doi.org/10.2337/diacare.23.11.1694","pdf_url":null,"source":{"id":"https://openalex.org/S49878492","display_name":"Diabetes Care","issn_l":"0149-5992","issn":["0149-5992","1935-5548"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes Care","raw_type":"journal-article"},{"id":"pmid:11092294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11092294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes care","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W9822936","https://openalex.org/W94424939","https://openalex.org/W120845260","https://openalex.org/W129199501","https://openalex.org/W1651383390","https://openalex.org/W1966419887","https://openalex.org/W1975396727","https://openalex.org/W1982498987","https://openalex.org/W2002994003","https://openalex.org/W2021277702","https://openalex.org/W2025407758","https://openalex.org/W2027478328","https://openalex.org/W2034902342","https://openalex.org/W2046809996","https://openalex.org/W2049476096","https://openalex.org/W2057704624","https://openalex.org/W2062801967","https://openalex.org/W2067559761","https://openalex.org/W2080733678","https://openalex.org/W2087592853","https://openalex.org/W2090038163","https://openalex.org/W2096177597","https://openalex.org/W2116529608","https://openalex.org/W2123259795","https://openalex.org/W2171480988","https://openalex.org/W2172356054","https://openalex.org/W2396694427","https://openalex.org/W2404846762","https://openalex.org/W2411439893","https://openalex.org/W2412234712","https://openalex.org/W3134431802"],"related_works":["https://openalex.org/W973992169","https://openalex.org/W2118917492","https://openalex.org/W2101960673","https://openalex.org/W3209612058","https://openalex.org/W2411439893","https://openalex.org/W2435858568","https://openalex.org/W2387098286","https://openalex.org/W4516598","https://openalex.org/W7097172878","https://openalex.org/W2370384154"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Although":[1],"retinopathy":[2,87,227],"is":[3,17,39],"a":[4,40,215],"common":[5],"microvascular":[6,258],"complication":[7,16],"of":[8,30,65,93,109,228,260],"type":[9,80,229],"1":[10,81,230],"diabetes,":[11],"the":[12,28,62,138,244,257,263],"mechanism":[13],"for":[14,42],"this":[15],"still":[18],"unknown.":[19],"Changes":[20],"in":[21,61,225,243],"retinal":[22,32,59,158,181,217,222,245,267],"circulation":[23,60,118,159,218,246],"have":[24],"been":[25],"noted":[26],"before":[27],"development":[29],"overt":[31],"pathology.":[33],"Because":[34],"von":[35],"Willebrand":[36],"factor":[37],"(vWF)":[38],"marker":[41],"endothelial":[43],"dysfunction":[44],"and":[45,58,83,105,135,205,220,247],"mediates":[46],"platelet":[47],"adhesion,":[48],"we":[49],"determined":[50],"if":[51],"there":[52],"was":[53,95,119,145,161,212],"an":[54,199],"association":[55,200],"between":[56,201],"vWF":[57,126,149,165,211,238,264],"early":[63],"stages":[64],"diabetic":[66],"retinopathy.":[67],"RESEARCH":[68],"DESIGN":[69],"AND":[70],"METHODS:":[71],"Twenty":[72],"subjects":[73],"(aged":[74],"32.4":[75],"+/-":[76,97],"7.8":[77],"years)":[78],"with":[79,148,164,179,189,214,236],"diabetes":[82,94],"minimal":[84],"or":[85,115],"no":[86],"were":[88,101,129,175,186],"studied.":[89],"The":[90],"mean":[91],"duration":[92],"4.7":[96],"2.6":[98],"years.":[99],"Data":[100],"collected":[102],"at":[103],"baseline":[104],"after":[106],"4":[107],"months":[108],"1,800":[110],"IU":[111],"vitamin":[112],"E":[113],"therapy":[114],"placebo.":[116],"Retinal":[117,142],"evaluated":[120],"by":[121,131,137],"video":[122],"fluorescein":[123],"angiography.":[124],"Plasma":[125],"antigen":[127],"levels":[128,150,166,174,185,191,239,265],"measured":[130],"enzyme-linked":[132],"immunosorbent":[133],"assay":[134],"fibrinogen":[136,184,207],"Clauss":[139],"method.":[140],"RESULTS:":[141],"blood":[143,223,233],"flow":[144,224,234],"negatively":[146],"correlated":[147,163],"(r":[151,167,192],"=":[152,155,168,171,193,196],"-0.44,":[153],"P":[154,170,195],"0.008),":[156],"whereas":[157],"time":[160,219],"positively":[162,187],"0.33,":[169],"0.048).":[172],"Fibrinogen":[173],"not":[176],"significantly":[177],"associated":[178,188,213,235],"either":[180],"index.":[182],"However,":[183],"HbA1c":[190],"0.34,":[194],"0.01),":[197],"indicating":[198],"poor":[202],"glycemic":[203],"control":[204],"higher":[206],"levels.":[208],"CONCLUSIONS:":[209],"Increased":[210],"prolonged":[216],"reduced":[221],"early-stage":[226],"diabetes.":[231,261],"Reduced":[232],"increased":[237],"may":[240],"promote":[241],"stasis":[242],"lead":[248],"to":[249,256],"local":[250],"hypoxemia.":[251],"These":[252],"changes":[253],"might":[254],"contribute":[255],"complications":[259,268],"Whether":[262],"predict":[266],"deserves":[269],"further":[270],"investigation.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}