{"id":"https://openalex.org/W2143441972","doi":"https://doi.org/10.1080/07357900600981398","title":"Current Update of Cytokines in Pancreatic Cancer: Pathogenic Mechanisms, Clinical Indication, and Therapeutic Values","display_name":"Current Update of Cytokines in Pancreatic Cancer: Pathogenic Mechanisms, Clinical Indication, and Therapeutic Values","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W2143441972","doi":"https://doi.org/10.1080/07357900600981398","mag":"2143441972","pmid":"https://pubmed.ncbi.nlm.nih.gov/17118780"},"language":"en","primary_location":{"id":"doi:10.1080/07357900600981398","doi":"https://doi.org/10.1080/07357900600981398","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07357900600981398","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039564839","display_name":"Louis W. Feurino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis W. Feurino","raw_affiliation_strings":["Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA","Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103393690","display_name":"William E. Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William E. Fisher","raw_affiliation_strings":["Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002100576","display_name":"Uddalak Bharadwaj","orcid":"https://orcid.org/0000-0002-8676-7258","observed_orcids":["https://orcid.org/0000-0002-8676-7258"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uddalak Bharadwaj","raw_affiliation_strings":["Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","Infectious Diseases, Infection Control, and Employee Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Infectious Diseases, Infection Control, and Employee Health","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038846608","display_name":"Qizhi Cathy Yao","orcid":"https://orcid.org/0000-0002-2267-0588","observed_orcids":["https://orcid.org/0000-0002-2267-0588"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qizhi Yao","raw_affiliation_strings":["Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108098298","display_name":"Changyi Chen","orcid":"https://orcid.org/0009-0006-1718-4717","observed_orcids":["https://orcid.org/0009-0006-1718-4717"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changyi Chen","raw_affiliation_strings":["Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106387597","display_name":"Min Li","orcid":"https://orcid.org/0000-0002-1310-2503","observed_orcids":["https://orcid.org/0000-0002-1310-2503"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Li","raw_affiliation_strings":["Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":0.1617,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.19047619,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"24","issue":"7","first_page":"696","last_page":"703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":1.0},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.996999979019165},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.6340000033378601},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/cytokine-targeted-therapy","display_name":"cytokine-targeted therapy","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6809999942779541},{"id":"https://openalex.org/keywords/pathogenesis","display_name":"pathogenesis","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8063660264015198},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6758295297622681},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6753523945808411},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6721165180206299},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.607520341873169},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5922986268997192},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5378711819648743},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5119565725326538},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5077853798866272},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4281647503376007},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.41681310534477234},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4149108827114105},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.24818789958953857},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22312453389167786}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1080/07357900600981398","doi":"https://doi.org/10.1080/07357900600981398","is_oa":false,"landing_page_url":"https://doi.org/10.1080/07357900600981398","pdf_url":null,"source":{"id":"https://openalex.org/S121125331","display_name":"Cancer Investigation","issn_l":"0735-7907","issn":["0735-7907","1532-4192"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Investigation","raw_type":"journal-article"},{"id":"pmid:17118780","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17118780","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer investigation","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8399999737739563,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W14997083","https://openalex.org/W1496281181","https://openalex.org/W1543909608","https://openalex.org/W1630628129","https://openalex.org/W1632652087","https://openalex.org/W1979977485","https://openalex.org/W1980761731","https://openalex.org/W1981000484","https://openalex.org/W1989657978","https://openalex.org/W1990879645","https://openalex.org/W1992675168","https://openalex.org/W2001378177","https://openalex.org/W2002276823","https://openalex.org/W2004455131","https://openalex.org/W2015677372","https://openalex.org/W2016861424","https://openalex.org/W2019518153","https://openalex.org/W2028912186","https://openalex.org/W2030447774","https://openalex.org/W2033366643","https://openalex.org/W2037647872","https://openalex.org/W2039469592","https://openalex.org/W2041405668","https://openalex.org/W2042967471","https://openalex.org/W2047234875","https://openalex.org/W2050548612","https://openalex.org/W2058301168","https://openalex.org/W2061270766","https://openalex.org/W2063051084","https://openalex.org/W2064757398","https://openalex.org/W2065916181","https://openalex.org/W2066810823","https://openalex.org/W2073949850","https://openalex.org/W2074664219","https://openalex.org/W2084688240","https://openalex.org/W2087256195","https://openalex.org/W2089166784","https://openalex.org/W2140347429","https://openalex.org/W2146616032","https://openalex.org/W2166770565","https://openalex.org/W2168152872","https://openalex.org/W2314203153","https://openalex.org/W2328965374","https://openalex.org/W2331036525","https://openalex.org/W2397237133","https://openalex.org/W2407537189","https://openalex.org/W2408176581","https://openalex.org/W2415472518","https://openalex.org/W2467204365","https://openalex.org/W4205129348"],"related_works":["https://openalex.org/W3029510224","https://openalex.org/W3041085677","https://openalex.org/W2043107232","https://openalex.org/W2046547919","https://openalex.org/W2990066301","https://openalex.org/W2022873423","https://openalex.org/W2802720332","https://openalex.org/W2782772957","https://openalex.org/W2773026993","https://openalex.org/W2011174487"],"abstract_inverted_index":{"Pancreatic":[0],"cancer":[1,8,57,80,127,161],"is":[2,23,91],"the":[3,74,83,89,96,120,123],"fourth":[4],"leading":[5],"cause":[6],"of":[7,34,85,95,101,112],"death":[9],"with":[10],"a":[11,32,109,126,141],"5-year":[12],"survival":[13,147],"less":[14],"than":[15],"5":[16],"percent":[17],"despite":[18],"rigorous":[19],"interventions.":[20],"This":[21,104],"largely":[22,93],"due":[24],"to":[25,51,61,107,131,139,144,173],"its":[26],"late":[27],"presentation,":[28],"aggressive":[29],"metastasis,":[30,156],"and":[31,60,98,148,157,163],"lack":[33],"effective":[35],"adjuvant":[36],"therapies.":[37],"Cytokines":[38],"have":[39,48,62,81],"been":[40,49,170],"studied":[41],"in":[42,56,78,115,159],"many":[43],"tumor":[44,65,145],"types,":[45],"where":[46],"they":[47],"shown":[50],"be":[52],"an":[53],"important":[54],"influence":[55],"cell":[58,128,146],"behavior":[59],"potential":[63],"as":[64,70],"markers,":[66],"therapeutic":[67],"targets,":[68],"or":[69,176],"treatments":[71],"themselves.":[72],"Recently,":[73],"roles":[75],"cytokines":[76,137,152,175],"play":[77],"pancreatic":[79,160],"become":[82],"subject":[84],"intense":[86],"investigation.":[87],"However,":[88],"story":[90],"complicated,":[92],"because":[94],"pleiotropic":[97],"overlapping":[99],"nature":[100],"cytokine":[102],"functions.":[103],"article":[105],"attempts":[106],"provide":[108],"focused":[110],"review":[111],"recent":[113],"discoveries":[114],"this":[116,167],"area":[117],"by":[118],"organizing":[119],"material":[121],"along":[122],"pathophysiologic":[124],"tasks":[125],"must":[129],"accomplish":[130],"achieve":[132],"malignancy.":[133],"We":[134],"examined":[135],"how":[136,151,166],"act":[138],"create":[140],"microenvironment":[142],"conducive":[143],"growth,":[149],"discussed":[150],"affect":[153],"proliferation,":[154],"invasion,":[155],"apoptosis":[158],"cells,":[162],"we":[164],"summarized":[165],"knowledge":[168],"has":[169],"applied":[171],"either":[172],"target":[174],"use":[177],"them":[178],"therapeutically.":[179]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
