{"id":"https://openalex.org/W2143330341","doi":"https://doi.org/10.1152/ajplung.00378.2001","title":"Activity of pulmonary edema fluid interleukin-8 bound to \u03b12-macroglobulin in patients with acute lung injury","display_name":"Activity of pulmonary edema fluid interleukin-8 bound to \u03b12-macroglobulin in patients with acute lung injury","publication_year":2002,"publication_date":"2002-05-01","ids":{"openalex":"https://openalex.org/W2143330341","doi":"https://doi.org/10.1152/ajplung.00378.2001","mag":"2143330341","pmid":"https://pubmed.ncbi.nlm.nih.gov/11943675"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00378.2001","doi":"https://doi.org/10.1152/ajplung.00378.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00378.2001","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030666328","display_name":"Anna Kurdowska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90436673","display_name":"The University of Texas Health Science Center at Tyler","ror":"https://ror.org/01sps7q28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I90436673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna K. Kurdowska","raw_affiliation_strings":["Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and","institution_ids":["https://openalex.org/I90436673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108613084","display_name":"Thomas Geiser","orcid":"https://orcid.org/0000-0002-9038-0101","observed_orcids":["https://orcid.org/0000-0002-9038-0101"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas K. Geiser","raw_affiliation_strings":["School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042809774","display_name":"Susanne M. Alden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90436673","display_name":"The University of Texas Health Science Center at Tyler","ror":"https://ror.org/01sps7q28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I90436673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susanne M. Alden","raw_affiliation_strings":["Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and","institution_ids":["https://openalex.org/I90436673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010072762","display_name":"Bozena R. Dziadek","orcid":"https://orcid.org/0000-0002-4942-7385","observed_orcids":["https://orcid.org/0000-0002-4942-7385"]},"institutions":[{"id":"https://openalex.org/I90436673","display_name":"The University of Texas Health Science Center at Tyler","ror":"https://ror.org/01sps7q28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I90436673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bozena R. Dziadek","raw_affiliation_strings":["Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and","institution_ids":["https://openalex.org/I90436673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002700915","display_name":"James McC. Noble","orcid":"https://orcid.org/0000-0003-0648-6702","observed_orcids":["https://orcid.org/0000-0003-0648-6702"]},"institutions":[{"id":"https://openalex.org/I90436673","display_name":"The University of Texas Health Science Center at Tyler","ror":"https://ror.org/01sps7q28","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I90436673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Noble","raw_affiliation_strings":["Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708; and","institution_ids":["https://openalex.org/I90436673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015180104","display_name":"Thomas J. Nuckton","orcid":"https://orcid.org/0000-0001-7324-2332","observed_orcids":["https://orcid.org/0000-0001-7324-2332"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Nuckton","raw_affiliation_strings":["School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052576862","display_name":"Michael A. Matthay","orcid":"https://orcid.org/0000-0003-3039-8155","observed_orcids":["https://orcid.org/0000-0003-3039-8155"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Matthay","raw_affiliation_strings":["School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143-0130","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1639,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.88023384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"282","issue":"5","first_page":"L1092","last_page":"L1098"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.7074999809265137,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.11599999666213989,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.039900001138448715,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.9769999980926514},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9900000095367432},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":1.0},{"id":"https://openalex.org/keywords/hydrostatic-pulmonary-edema","display_name":"hydrostatic pulmonary edema","score":0.9580000042915344},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.4699999988079071},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/cytokine-activity","display_name":"cytokine activity","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.8970111608505249},{"id":"https://openalex.org/C2776468924","wikidata":"https://www.wikidata.org/wiki/Q857667","display_name":"Pulmonary edema","level":3,"score":0.7139415740966797},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5960644483566284},{"id":"https://openalex.org/C2780886150","wikidata":"https://www.wikidata.org/wiki/Q152234","display_name":"Edema","level":2,"score":0.5899397134780884},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5112531185150146},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.47834059596061707},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4376983940601349},{"id":"https://openalex.org/C2781054842","wikidata":"https://www.wikidata.org/wiki/Q6725283","display_name":"Macroglobulin","level":2,"score":0.43483883142471313},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.41860780119895935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4118127226829529},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4042421579360962},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.35743457078933716},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33954888582229614},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.20961087942123413},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.14909106492996216},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011654","descriptor_name":"Pulmonary Edema","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012128","descriptor_name":"Respiratory Distress Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015633","descriptor_name":"Extravascular Lung Water","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015633","descriptor_name":"Extravascular Lung Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016209","descriptor_name":"Interleukin-8","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajplung.00378.2001","doi":"https://doi.org/10.1152/ajplung.00378.2001","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00378.2001","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmid:11943675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11943675","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3429402575","display_name":null,"funder_award_id":"HL-51856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3586229703","display_name":"IL 8 BINDING PROTEINS--IMPACT ON THE LUNG","funder_award_id":"R29HL056768","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W87082738","https://openalex.org/W1461662986","https://openalex.org/W1487493292","https://openalex.org/W1504842322","https://openalex.org/W1518271910","https://openalex.org/W1535477876","https://openalex.org/W1796081530","https://openalex.org/W1927646875","https://openalex.org/W1936000095","https://openalex.org/W1967429254","https://openalex.org/W1983405778","https://openalex.org/W1992701457","https://openalex.org/W2008305761","https://openalex.org/W2019524205","https://openalex.org/W2026648244","https://openalex.org/W2028759964","https://openalex.org/W2033785962","https://openalex.org/W2041665122","https://openalex.org/W2045810087","https://openalex.org/W2048083566","https://openalex.org/W2048519644","https://openalex.org/W2051750476","https://openalex.org/W2066633143","https://openalex.org/W2068037889","https://openalex.org/W2084527905","https://openalex.org/W2093852073","https://openalex.org/W2144304154","https://openalex.org/W2153354364","https://openalex.org/W2176220887","https://openalex.org/W2183958885","https://openalex.org/W2395499922","https://openalex.org/W2468119228","https://openalex.org/W4255637152","https://openalex.org/W4285719527","https://openalex.org/W4294658238"],"related_works":["https://openalex.org/W1936000095","https://openalex.org/W2083155371","https://openalex.org/W2157969134","https://openalex.org/W1990495638","https://openalex.org/W1025520176","https://openalex.org/W2105929645","https://openalex.org/W1964964816","https://openalex.org/W1991780446","https://openalex.org/W1870613823","https://openalex.org/W3164245593"],"abstract_inverted_index":{"The":[0],"formation":[1,134],"of":[2,12,18,26,67,84,92,100,109,125],"alpha(2)-macroglobulin":[3],"(alpha(2)-M)/interleukin-8":[4],"(IL-8)":[5],"complexes":[6,31,76],"may":[7,95,135],"influence":[8],"the":[9,15,98,105,137,142],"biological":[10,120],"activity":[11],"IL-8":[13,19,28,30,85,94,103,114,126],"and":[14,29,51,122],"quantitative":[16],"assessment":[17],"activity.":[20],"Therefore,":[21],"in":[22,36,104,141],"this":[23,123],"study,":[24],"concentrations":[25,66],"free":[27,93],"with":[32,43,53,56,61,111],"alpha(2)-M":[33,68,117],"were":[34],"measured":[35],"pulmonary":[37,58],"edema":[38],"fluid":[39],"samples":[40],"from":[41,129],"patients":[42,55,110],"acute":[44,138],"lung":[45],"injury/acute":[46],"respiratory":[47],"distress":[48],"syndrome":[49],"(ALI/ARDS)":[50],"compared":[52],"control":[54],"hydrostatic":[57],"edema.":[59],"Patients":[60],"ALI/ARDS":[62],"had":[63],"significantly":[64,96],"higher":[65],"(P":[69,77],"<":[70,78],"0.01)":[71],"as":[72,74],"well":[73],"alpha(2)-M/IL-8":[75],"0.05).":[79],"Because":[80],"a":[81],"substantial":[82],"amount":[83],"is":[86],"complexed":[87],"to":[88,116],"alpha(2)-M,":[89],"standard":[90],"assays":[91],"underestimate":[97],"concentration":[99],"biologically":[101],"active":[102],"distal":[106],"air":[107],"spaces":[108],"ALI/ARDS.":[112],"Furthermore,":[113],"bound":[115],"retained":[118],"its":[119],"activity,":[121],"fraction":[124],"was":[127],"protected":[128],"proteolytic":[130],"degradation.":[131],"Thus":[132],"complex":[133],"modulate":[136],"inflammatory":[139],"process":[140],"lung.":[143]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
