{"id":"https://openalex.org/W2143183201","doi":"https://doi.org/10.1093/ajcn/87.3.688","title":"Pharmacokinetics of a single, large dose of cholecalciferol","display_name":"Pharmacokinetics of a single, large dose of cholecalciferol","publication_year":2008,"publication_date":"2008-03-01","ids":{"openalex":"https://openalex.org/W2143183201","doi":"https://doi.org/10.1093/ajcn/87.3.688","mag":"2143183201","pmid":"https://pubmed.ncbi.nlm.nih.gov/18326608"},"language":"en","primary_location":{"id":"doi:10.1093/ajcn/87.3.688","doi":"https://doi.org/10.1093/ajcn/87.3.688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ajcn/87.3.688","pdf_url":null,"source":{"id":"https://openalex.org/S71285955","display_name":"American Journal of Clinical Nutrition","issn_l":"0002-9165","issn":["0002-9165","1938-3207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Clinical Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1093/ajcn/87.3.688","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013910412","display_name":"M.A. Ilahi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marium Ilahi","raw_affiliation_strings":["Creighton University Medical Center, Omaha, NE 68131, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Creighton University Medical Center, Omaha, NE 68131, USA","institution_ids":["https://openalex.org/I2800482329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108251634","display_name":"Laura A. G. Armas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307117695","display_name":"Nebraska Medical Center","ror":"https://ror.org/03azxga02","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1307117695"]},{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Laura AG Armas","raw_affiliation_strings":["From the Creighton University Medical Center, Omaha, NE","Internal Medicine, Nebraska Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Creighton University Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I2800482329"]},{"raw_affiliation_string":"Internal Medicine, Nebraska Medicine","institution_ids":["https://openalex.org/I1307117695"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110246581","display_name":"Robert P. Heaney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]},{"id":"https://openalex.org/I2800482329","display_name":"CHI Health Creighton University Medical Center - Bergan Mercy","ror":"https://ror.org/03z1w3b90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800482329","https://openalex.org/I2802665030","https://openalex.org/I2802797007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P Heaney","raw_affiliation_strings":["From the Creighton University Medical Center, Omaha, NE","Creighton University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Creighton University Medical Center, Omaha, NE","institution_ids":["https://openalex.org/I2800482329"]},{"raw_affiliation_string":"Creighton University;","institution_ids":["https://openalex.org/I114493937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108251634"],"corresponding_institution_ids":["https://openalex.org/I1307117695","https://openalex.org/I2800482329"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":8.3697,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.98073254,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"87","issue":"3","first_page":"688","last_page":"691"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vitamin-d-supplementation","display_name":"vitamin D supplementation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/25-hydroxyvitamin-d","display_name":"25-hydroxyvitamin D","score":0.9570000171661377},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9319999814033508},{"id":"https://openalex.org/keywords/intermittent-dosing","display_name":"intermittent dosing","score":0.7730000019073486},{"id":"https://openalex.org/keywords/dosing-interval","display_name":"dosing interval","score":0.7279999852180481},{"id":"https://openalex.org/keywords/serum-vitamin-d-levels","display_name":"serum vitamin D levels","score":0.7020000219345093},{"id":"https://openalex.org/keywords/seasonal-variation-in-vitamin-d","display_name":"seasonal variation in vitamin D","score":0.7229999899864197},{"id":"https://openalex.org/keywords/vitamin-d-deficiency","display_name":"vitamin D deficiency","score":0.48399999737739563}],"concepts":[{"id":"https://openalex.org/C2780106736","wikidata":"https://www.wikidata.org/wiki/Q139347","display_name":"Cholecalciferol","level":3,"score":0.9250888824462891},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7457391619682312},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7100651264190674},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.6977181434631348},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.574454665184021},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5478578805923462},{"id":"https://openalex.org/C2776941976","wikidata":"https://www.wikidata.org/wiki/Q139307","display_name":"Calcifediol","level":4,"score":0.5069356560707092},{"id":"https://openalex.org/C2779740938","wikidata":"https://www.wikidata.org/wiki/Q4138762","display_name":"vitamin D deficiency","level":3,"score":0.4972880184650421},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.4890371263027191},{"id":"https://openalex.org/C2776079296","wikidata":"https://www.wikidata.org/wiki/Q139195","display_name":"Calcitriol","level":3,"score":0.46714162826538086},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4116251468658447},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3607203960418701}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002762","descriptor_name":"Cholecalciferol","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008892","descriptor_name":"Milk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011863","descriptor_name":"Radioimmunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012880","descriptor_name":"Skin Pigmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013472","descriptor_name":"Sunlight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014807","descriptor_name":"Vitamin D","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014808","descriptor_name":"Vitamin D Deficiency","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050071","descriptor_name":"Bone Density Conservation Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/ajcn/87.3.688","doi":"https://doi.org/10.1093/ajcn/87.3.688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ajcn/87.3.688","pdf_url":null,"source":{"id":"https://openalex.org/S71285955","display_name":"American Journal of Clinical Nutrition","issn_l":"0002-9165","issn":["0002-9165","1938-3207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Clinical Nutrition","raw_type":"journal-article"},{"id":"pmid:18326608","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18326608","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of clinical nutrition","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/ajcn/87.3.688","doi":"https://doi.org/10.1093/ajcn/87.3.688","is_oa":true,"landing_page_url":"https://doi.org/10.1093/ajcn/87.3.688","pdf_url":null,"source":{"id":"https://openalex.org/S71285955","display_name":"American Journal of Clinical Nutrition","issn_l":"0002-9165","issn":["0002-9165","1938-3207"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Clinical Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1967938696","https://openalex.org/W1971981818","https://openalex.org/W1976613899","https://openalex.org/W2009861791","https://openalex.org/W2028497769","https://openalex.org/W2037719012","https://openalex.org/W2096150705","https://openalex.org/W2099947913","https://openalex.org/W2118323808","https://openalex.org/W2138328097","https://openalex.org/W2139211193","https://openalex.org/W2149425411","https://openalex.org/W2167598523"],"related_works":["https://openalex.org/W4292370957","https://openalex.org/W2581744944","https://openalex.org/W3030449014","https://openalex.org/W2235275753","https://openalex.org/W4403153631","https://openalex.org/W3173412784","https://openalex.org/W7213413165","https://openalex.org/W2055671040","https://openalex.org/W1991804585","https://openalex.org/W2340752706"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":19}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}