{"id":"https://openalex.org/W2143163","doi":null,"title":"[Multiple system atrophy with a-/hypo-ceruloplasminemia: distribution of iron in brains of 2 autopsy cases].","display_name":"[Multiple system atrophy with a-/hypo-ceruloplasminemia: distribution of iron in brains of 2 autopsy cases].","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2143163","mag":"2143163","pmid":"https://pubmed.ncbi.nlm.nih.gov/12561083"},"language":"ja","primary_location":{"id":"pmid:12561083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12561083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rinsho shinkeigaku = Clinical neurology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023015524","display_name":"Hiroshi Kurisaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156366","display_name":"Tokyo National Hospital","ror":"https://ror.org/05asn5035","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137409","https://openalex.org/I4210156366"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kurisaki","raw_affiliation_strings":["Department of Neurology, National Tokyo Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, National Tokyo Hospital","institution_ids":["https://openalex.org/I4210156366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061235872","display_name":"Harumi Yomono","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harumi Yomono","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024641774","display_name":"Shigeo Murayama","orcid":"https://orcid.org/0000-0001-9709-5242","observed_orcids":["https://orcid.org/0000-0001-9709-5242"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shigeo Murayama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020678496","display_name":"Akira Hebisawa","orcid":"https://orcid.org/0009-0008-9410-6418","observed_orcids":["https://orcid.org/0009-0008-9410-6418"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akira Hebisawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.00034043,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"42","issue":"4","first_page":"293","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.7139000296592712,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","score":0.2741999924182892,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.9959999918937683},{"id":"https://openalex.org/keywords/serum-ceruloplasmin","display_name":"serum ceruloplasmin","score":0.8920000195503235},{"id":"https://openalex.org/keywords/brain-iron-accumulation","display_name":"brain iron accumulation","score":0.8629999756813049},{"id":"https://openalex.org/keywords/iron-staining","display_name":"iron staining","score":0.4959999918937683},{"id":"https://openalex.org/keywords/substantia-nigra","display_name":"substantia nigra","score":0.8370000123977661},{"id":"https://openalex.org/keywords/putamen","display_name":"putamen","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dentate-nucleus","display_name":"dentate nucleus","score":0.8989999890327454},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.8500000238418579},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"neurodegeneration","score":0.5149999856948853},{"id":"https://openalex.org/keywords/autopsy-findings","display_name":"autopsy findings","score":0.3970000147819519},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.6489999890327454},{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.609000027179718},{"id":"https://openalex.org/keywords/neuronal-cytoplasmic-inclusions","display_name":"neuronal cytoplasmic inclusions","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.7573816776275635},{"id":"https://openalex.org/C2780938664","wikidata":"https://www.wikidata.org/wiki/Q753278","display_name":"Substantia nigra","level":4,"score":0.7301352024078369},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6995687484741211},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.6750775575637817},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6400452256202698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5330620408058167},{"id":"https://openalex.org/C2779504383","wikidata":"https://www.wikidata.org/wiki/Q41482","display_name":"Autopsy","level":2,"score":0.5230630040168762},{"id":"https://openalex.org/C2781294515","wikidata":"https://www.wikidata.org/wiki/Q2733470","display_name":"Stain","level":3,"score":0.47109588980674744},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.38025426864624023},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.37478646636009216},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35042595863342285},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.26518821716308594},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.11524659395217896}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002570","descriptor_name":"Ceruloplasmin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011699","descriptor_name":"Putamen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013378","descriptor_name":"Substantia Nigra","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019578","descriptor_name":"Multiple System Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12561083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12561083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rinsho shinkeigaku = Clinical neurology","raw_type":"Case Reports"},{"id":"mag:2143163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12561083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1999731487","https://openalex.org/W2148736507","https://openalex.org/W2150691484","https://openalex.org/W2041212846","https://openalex.org/W2077390122","https://openalex.org/W1989825490","https://openalex.org/W2136008370","https://openalex.org/W2056505927","https://openalex.org/W2019427862","https://openalex.org/W1555145120","https://openalex.org/W2166206018","https://openalex.org/W2065742866","https://openalex.org/W2036614693","https://openalex.org/W187222491","https://openalex.org/W2063985696","https://openalex.org/W2046826725","https://openalex.org/W2039729151","https://openalex.org/W2052531416","https://openalex.org/W2038394364","https://openalex.org/W2028317903","https://openalex.org/W2018151716","https://openalex.org/W1970266617","https://openalex.org/W1576597982","https://openalex.org/W1513255349","https://openalex.org/W1577820728","https://openalex.org/W2057977645","https://openalex.org/W2088612477","https://openalex.org/W1988787228","https://openalex.org/W2148673977","https://openalex.org/W1965652744","https://openalex.org/W1981057134","https://openalex.org/W1595948784","https://openalex.org/W1997664026","https://openalex.org/W2124923401","https://openalex.org/W2080038265","https://openalex.org/W1973251012","https://openalex.org/W2028413349","https://openalex.org/W2050650077","https://openalex.org/W1984764741","https://openalex.org/W2022735531","https://openalex.org/W2129368032","https://openalex.org/W4232755864","https://openalex.org/W2051202415","https://openalex.org/W1984453334","https://openalex.org/W2049601903","https://openalex.org/W2499801008","https://openalex.org/W2090153088","https://openalex.org/W1990493491","https://openalex.org/W2067037742","https://openalex.org/W2089543118","https://openalex.org/W2046143144","https://openalex.org/W2118093120","https://openalex.org/W2027199315","https://openalex.org/W2155330992","https://openalex.org/W2006842412","https://openalex.org/W2124090088"],"related_works":["https://openalex.org/W2297732521","https://openalex.org/W4396978920","https://openalex.org/W4386476155","https://openalex.org/W1964888497","https://openalex.org/W3199882579","https://openalex.org/W7095197738","https://openalex.org/W4412072188","https://openalex.org/W4389404749","https://openalex.org/W2915471593","https://openalex.org/W4386441428"],"abstract_inverted_index":{"OBJECTIVE:":[0],"We":[1],"presented":[2],"first":[3],"two":[4,59],"cases":[5,50,60,113,224,271,296],"of":[6,21,26,41,58,67,83,87,101,110,116,149,170,176,199,210,214,225,231,268,292,299,308,320,338,344,346],"multiple":[7],"system":[8],"atrophy":[9],"(MSA)":[10],"with":[11,114,227,277],"a-/hypo-ceruloplasminemia":[12],"(hypo-Cp).":[13],"To":[14],"know":[15],"whether":[16],"hypo-Cp":[17,347,358],"was":[18,135,152,165,182,204],"a":[19,318,335,355],"cause":[20,319,337],"MSA,":[22,119,301],"we":[23,45,80,98,220,324],"investigated":[24],"distribution":[25,82,86,169],"iron":[27,88,102,237,280,315,331],"in":[28,103,241,251,263,284,327,351],"brains.":[29],"METHODS:":[30],"Investigating":[31],"history,":[32],"neurological":[33],"sings":[34],"and":[35,38,85,107,129,142,154,178,194,244,266,287,348,359],"symptoms,":[36],"neuroimagings,":[37],"neuropathological":[39],"findings":[40,291],"the":[42,73,77,111,232,293,294,328],"2":[43,49,74,78,112,120,124,181,222,233,295,329],"cases,":[44,79,330],"demonstrate":[46],"that":[47,236],"these":[48],"were":[51,61,239,247,260,282,297,303,333],"typical":[52,166,205,300],"MSA.":[53,206,360],"Serum":[54],"ceruloplasmin":[55],"(Cp)":[56],"values":[57,213],"investigated,":[62],"as":[63,65,172,174,272,275,306,317],"well":[64,173],"those":[66,115,298,307],"14":[68,217],"MSA":[69,167,218,226,270,276,339,349],"patients":[70],"diagnosed":[71,216],"after":[72,147,157,195],"cases.":[75],"In":[76],"compared":[81,99],"lesions":[84],"depositions":[89,100,238,259,281,316,332],"revealed":[90,235],"by":[91],"Berlin":[92],"blue":[93],"stain":[94,230],"(iron":[95],"stain).":[96],"Further,":[97],"substantia":[104,242,264],"nigra,":[105],"putamen,":[106,245],"dentate":[108],"nucleus":[109],"4":[117],"control":[118,269],"Parkinson's":[121],"disease":[122,145],"(PD),":[123],"amyotrophic":[125],"lateral":[126],"sclerosis":[127],"(ALS),":[128],"3":[130],"controls.":[131,288],"RESULTS:":[132],"Case":[133,180],"1":[134],"68-year-old":[136],"man":[137,184],"who":[138,185],"developed":[139,186],"gait":[140],"disturbance,":[141],"had":[143,192],"anti-Parkinson":[144],"drugs":[146],"diagnosis":[148],"PD.":[150],"Parkinsonism":[151],"progressed,":[153],"became":[155],"bed-ridden":[156],"6":[158],"years":[159,197],"when":[160],"he":[161,191],"died.":[162],"Neuropathological":[163,202],"finding":[164,203],"from":[168],"lesions,":[171,322],"existence":[175],"GCIs":[177],"NCIs.":[179],"61-year-old":[183],"parkinsonism.":[187],"After":[188],"9":[189],"years,":[190],"tracheostomy,":[193],"11":[196],"died":[198],"renal":[200],"failure.":[201],"With":[207],"an":[208],"investigation":[209],"serum":[211],"Cp":[212],"clinically":[215],"patients,":[219],"found":[221,240,249],"other":[223],"hypo-Cp.":[228,311],"Iron":[229,258],"brains":[234],"nigra":[243,265],"but":[246,279,302],"not":[248,304,334],"neither":[250],"pontine":[252],"base,":[253],"cerebellum,":[254],"nor":[255],"inferior":[256],"olive.":[257],"also":[261],"seen":[262],"putamen":[267],"same":[273,305],"degree":[274],"hypo-Cp,":[278],"fewer":[283],"PD,":[285],"ALS":[286],"CONCLUSION:":[289],"Clinico-pathological":[290],"previously":[309],"reported":[310],"Previous":[312],"reports":[313],"suggested":[314],"brain":[321],"but,":[323],"concluded":[325],"that,":[326],"direct":[336],"lesions.":[340],"However,":[341],"high":[342],"incidence":[343],"association":[345],"shown":[350],"our":[352],"study":[353],"suggests":[354],"relation":[356],"between":[357]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
