{"id":"https://openalex.org/W2143085371","doi":"https://doi.org/10.1093/jac/dkt515","title":"A single nucleotide in the promoter region modulates the expression of the -lactamase OXA-61 in Campylobacter jejuni","display_name":"A single nucleotide in the promoter region modulates the expression of the -lactamase OXA-61 in Campylobacter jejuni","publication_year":2014,"publication_date":"2014-01-09","ids":{"openalex":"https://openalex.org/W2143085371","doi":"https://doi.org/10.1093/jac/dkt515","mag":"2143085371","pmid":"https://pubmed.ncbi.nlm.nih.gov/24408987"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkt515","doi":"https://doi.org/10.1093/jac/dkt515","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkt515","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060239112","display_name":"Ximin Zeng","orcid":"https://orcid.org/0000-0003-2795-6988","observed_orcids":["https://orcid.org/0000-0003-2795-6988"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"X. Zeng","raw_affiliation_strings":["Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019407143","display_name":"Steven D. Brown","orcid":"https://orcid.org/0000-0002-9281-3898","observed_orcids":["https://orcid.org/0000-0002-9281-3898"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Brown","raw_affiliation_strings":["Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083792846","display_name":"Barbara Erin Gillespie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Gillespie","raw_affiliation_strings":["Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082435542","display_name":"Jun Lin","orcid":"https://orcid.org/0000-0003-0377-1030","observed_orcids":["https://orcid.org/0000-0003-0377-1030"]},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Lin","raw_affiliation_strings":["Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Science, The University of Tennessee, 2506 River Drive, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082435542"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.6744,"has_fulltext":false,"cited_by_count":83,"citation_normalized_percentile":{"value":0.81047577,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"69","issue":"5","first_page":"1215","last_page":"1223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.8032000064849854,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10486","display_name":"Salmonella and Campylobacter epidemiology","score":0.18860000371932983,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/campylobacter-jejuni","display_name":"Campylobacter jejuni","score":0.996999979019165},{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"beta-lactamase","score":0.8140000104904175},{"id":"https://openalex.org/keywords/beta-lactam-resistance","display_name":"beta-lactam resistance","score":0.9570000171661377},{"id":"https://openalex.org/keywords/promoter-mutations","display_name":"promoter mutations","score":0.8029999732971191},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7379999756813049},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.7749999761581421},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ampicillin-resistance","display_name":"ampicillin resistance","score":0.8339999914169312},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7009999752044678},{"id":"https://openalex.org/keywords/natural-transformation","display_name":"natural transformation","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2776957140","wikidata":"https://www.wikidata.org/wiki/Q265488","display_name":"Campylobacter jejuni","level":3,"score":0.877013087272644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7728449106216431},{"id":"https://openalex.org/C64872895","wikidata":"https://www.wikidata.org/wiki/Q1361360","display_name":"Transversion","level":4,"score":0.7266857624053955},{"id":"https://openalex.org/C2779910956","wikidata":"https://www.wikidata.org/wiki/Q131488","display_name":"Campylobacter","level":3,"score":0.5522543787956238},{"id":"https://openalex.org/C183641309","wikidata":"https://www.wikidata.org/wiki/Q306264","display_name":"Amp resistance","level":4,"score":0.5023701190948486},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.49671703577041626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.48338738083839417},{"id":"https://openalex.org/C188082640","wikidata":"https://www.wikidata.org/wiki/Q1780899","display_name":"Complementation","level":4,"score":0.45413148403167725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45034027099609375},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4071303606033325},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.2800416946411133},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.1838890016078949},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.14385798573493958}],"mesh":[{"descriptor_ui":"D000668","descriptor_name":"Ampicillin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016123","descriptor_name":"Campylobacter jejuni","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016123","descriptor_name":"Campylobacter jejuni","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016123","descriptor_name":"Campylobacter jejuni","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016680","descriptor_name":"Genome, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jac/dkt515","doi":"https://doi.org/10.1093/jac/dkt515","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkt515","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:24408987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24408987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkt515v1","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkt515v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309931","display_name":"AgResearch","ror":"https://ror.org/0124gwh94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1484060262","https://openalex.org/W1543102554","https://openalex.org/W1975771250","https://openalex.org/W1991330646","https://openalex.org/W1996764065","https://openalex.org/W2004494938","https://openalex.org/W2011591718","https://openalex.org/W2013030981","https://openalex.org/W2014791123","https://openalex.org/W2014998308","https://openalex.org/W2018883772","https://openalex.org/W2048622484","https://openalex.org/W2054223760","https://openalex.org/W2079081483","https://openalex.org/W2092731763","https://openalex.org/W2096375646","https://openalex.org/W2099303284","https://openalex.org/W2103706295","https://openalex.org/W2106534163","https://openalex.org/W2107508284","https://openalex.org/W2108368634","https://openalex.org/W2117398483","https://openalex.org/W2120904752","https://openalex.org/W2134809564","https://openalex.org/W2135352715","https://openalex.org/W2138621884","https://openalex.org/W2143236729","https://openalex.org/W2143874510","https://openalex.org/W2144855770","https://openalex.org/W2157612734","https://openalex.org/W2159813365","https://openalex.org/W2160319576","https://openalex.org/W2163069781","https://openalex.org/W2165920198","https://openalex.org/W2166576226","https://openalex.org/W2170798409","https://openalex.org/W2323233140","https://openalex.org/W2331738366","https://openalex.org/W4240236037"],"related_works":["https://openalex.org/W2165920198","https://openalex.org/W7225964","https://openalex.org/W2135352715","https://openalex.org/W2994815499","https://openalex.org/W2188843535","https://openalex.org/W4388636807","https://openalex.org/W4388340317","https://openalex.org/W2128377962","https://openalex.org/W2055135288","https://openalex.org/W2386542546"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Despite":[1],"prevalent":[2],"\u03b2-lactam":[3,18,156,183,236],"resistance":[4,19,157,184,237],"in":[5,64,138,154,175,185,204,220,223,238],"Campylobacter":[6],"jejuni,":[7],"an":[8],"important":[9],"zoonotic":[10],"enteric":[11],"pathogen,":[12],"the":[13,59,94,139,148,160,176,195,201,205,231],"molecular":[14,87,168],"basis":[15],"of":[16,53,62,71,98,116,134,142,147,162,208,217,235],"\u03b2-lactamase-mediated":[17],"is":[20,47],"still":[21,37],"largely":[22],"unknown.":[23],"In":[24],"particular,":[25],"some":[26],"C.":[27,65,72,186,221],"jejuni":[28,73,187,222],"strains":[29],"that":[30,194],"carry":[31],"\u03b2-lactamase":[32,43,63,218],"gene":[33],"blaOXA-61":[34,46,135,163,177],"(Cj0299)":[35],"are":[36],"susceptible":[38],"to":[39,49,57,78,92,181],"\u03b2-lactams":[40],"with":[41],"undetected":[42],"activity,":[44],"suggesting":[45],"subjected":[48,77],"regulation.":[50],"The":[51,145,170],"objective":[52],"this":[54,224],"study":[55],"was":[56,76,136,164,179],"determine":[58],"regulatory":[60,96],"mechanism":[61,97,216],"jejuni.":[66],"METHODS:":[67],"An":[68],"ampicillin-resistant":[69,140],"derivative":[70,141],"NCTC":[74,143],"11168":[75],"whole":[79],"genome":[80],"sequencing":[81],"and":[82,119,233],"comparative":[83],"genomics":[84],"analysis.":[85],"Complementary":[86],"experiments":[88],"were":[89],"further":[90],"performed":[91],"examine":[93],"identified":[95,137],"blaOXA-61,":[99],"which":[100,226],"included":[101],"complementation,":[102],"promoter":[103,178],"fusion":[104],"assay,":[105],"real-time":[106],"RT-PCR,":[107],"natural":[108],"transformation":[109],"using":[110],"a":[111,213],"defined":[112],"PCR":[113],"fragment,":[114],"survey":[115],"clinical":[117],"isolates":[118],"transcription":[120],"start":[121,190],"site":[122,191],"mapping.":[123],"RESULTS:":[124],"A":[125],"single":[126],"nucleotide":[127],"mutation":[128,153],"(G":[129],"\u2192":[130,150,172,197],"T":[131,151,173,198],"transversion)":[132],"upstream":[133],"11168.":[144],"role":[146],"G":[149,171,196],"point":[152],"acquired":[155],"through":[158],"up-regulating":[159],"expression":[161],"confirmed":[165],"by":[166],"multiple":[167],"approaches.":[169],"transversion":[174,199],"linked":[180],"high-level":[182],"isolates.":[188],"Transcription":[189],"mapping":[192],"indicated":[193],"restored":[200],"TATA":[202],"box":[203],"-10":[206],"region":[207],"blaOXA-61.":[209],"CONCLUSIONS:":[210],"We":[211],"demonstrated":[212],"novel":[214],"genetic":[215],"regulation":[219,232],"study,":[225],"will":[227],"provide":[228],"insights":[229],"into":[230],"evolution":[234],"Campylobacter.":[239]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
