{"id":"https://openalex.org/W2143085129","doi":"https://doi.org/10.1093/nar/19.10.2655","title":"The amdR product and a CCAAT-binding factor bind to adjacent, possibly overlapping DNA sequences in the promoter region of the Aspergillus nidulans amdS gene","display_name":"The amdR product and a CCAAT-binding factor bind to adjacent, possibly overlapping DNA sequences in the promoter region of the Aspergillus nidulans amdS gene","publication_year":1991,"publication_date":"1991-05-25","ids":{"openalex":"https://openalex.org/W2143085129","doi":"https://doi.org/10.1093/nar/19.10.2655","mag":"2143085129","pmid":"https://pubmed.ncbi.nlm.nih.gov/2041742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/328183"},"language":"en","primary_location":{"id":"doi:10.1093/nar/19.10.2655","doi":"https://doi.org/10.1093/nar/19.10.2655","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/19.10.2655","pdf_url":"https://academic.oup.com/nar/article-pdf/19/10/2655/6180376/19-10-2655.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/nar/article-pdf/19/10/2655/6180376/19-10-2655.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113594904","display_name":"R. van Heeswijck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"R. van Heeswijck","raw_affiliation_strings":["Department of Genetics, University of Melbourne, Parkville, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Melbourne, Parkville, Victoria, Australia","institution_ids":["https://openalex.org/I165779595"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026285748","display_name":"Michael J. Hynes","orcid":"https://orcid.org/0000-0001-9160-1693","observed_orcids":["https://orcid.org/0000-0001-9160-1693"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"M. J. Hynes","raw_affiliation_strings":["Department of Genetics, University of Melbourne Parkville, Victoria 3052, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, University of Melbourne Parkville, Victoria 3052, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026285748"],"corresponding_institution_ids":["https://openalex.org/I165779595"],"apc_list":{"value":3992,"currency":"USD","value_usd":3992},"apc_paid":null,"fwci":1.4464,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.80387785,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"19","issue":"10","first_page":"2655","last_page":"2660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspergillus-nidulans","display_name":"Aspergillus nidulans","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ccaat-binding-factor","display_name":"CCAAT-binding factor","score":0.8489999771118164},{"id":"https://openalex.org/keywords/ccaat-box","display_name":"CCAAT box","score":0.9259999990463257},{"id":"https://openalex.org/keywords/zinc-finger-dna-binding-protein","display_name":"zinc finger DNA-binding protein","score":0.7639999985694885},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/promoter","display_name":"promoter","score":0.5989999771118164},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.6190000176429749},{"id":"https://openalex.org/keywords/filamentous-fungi","display_name":"filamentous fungi","score":0.5580000281333923},{"id":"https://openalex.org/keywords/basal-transcription","display_name":"basal transcription","score":0.4970000088214874}],"concepts":[{"id":"https://openalex.org/C2776923806","wikidata":"https://www.wikidata.org/wiki/Q683881","display_name":"Aspergillus nidulans","level":4,"score":0.8621233105659485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8523942232131958},{"id":"https://openalex.org/C179716448","wikidata":"https://www.wikidata.org/wiki/Q2508056","display_name":"CAAT box","level":5,"score":0.8477585315704346},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6542583703994751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6008351445198059},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5404144525527954},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5265070796012878},{"id":"https://openalex.org/C24284526","wikidata":"https://www.wikidata.org/wiki/Q204785","display_name":"Zinc finger","level":4,"score":0.4499666094779968},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4409447908401489},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4301777482032776},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.4127178490161896},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3141600489616394},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.14429420232772827},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001233","descriptor_name":"Aspergillus nidulans","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001233","descriptor_name":"Aspergillus nidulans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004271","descriptor_name":"DNA, Fungal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015345","descriptor_name":"Oligonucleotide Probes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022762","descriptor_name":"CCAAT-Enhancer-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/nar/19.10.2655","doi":"https://doi.org/10.1093/nar/19.10.2655","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/19.10.2655","pdf_url":"https://academic.oup.com/nar/article-pdf/19/10/2655/6180376/19-10-2655.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:282086","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC328183","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:2041742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2041742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic acids research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:328183","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC328183/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/nar/19.10.2655","doi":"https://doi.org/10.1093/nar/19.10.2655","is_oa":true,"landing_page_url":"https://doi.org/10.1093/nar/19.10.2655","pdf_url":"https://academic.oup.com/nar/article-pdf/19/10/2655/6180376/19-10-2655.pdf","source":{"id":"https://openalex.org/S134668137","display_name":"Nucleic Acids Research","issn_l":"0305-1048","issn":["0305-1048","1362-4954","1362-4962"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nucleic Acids Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143085129.pdf","grobid_xml":"https://content.openalex.org/works/W2143085129.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W26691815","https://openalex.org/W244971111","https://openalex.org/W1497046524","https://openalex.org/W1513717105","https://openalex.org/W1619835139","https://openalex.org/W1816796174","https://openalex.org/W1820126214","https://openalex.org/W1962269101","https://openalex.org/W1964831845","https://openalex.org/W1975329612","https://openalex.org/W1975538361","https://openalex.org/W1983512144","https://openalex.org/W1992260178","https://openalex.org/W1993243592","https://openalex.org/W1998108444","https://openalex.org/W1999954355","https://openalex.org/W2011630904","https://openalex.org/W2012490729","https://openalex.org/W2013249357","https://openalex.org/W2024071214","https://openalex.org/W2037824747","https://openalex.org/W2049571290","https://openalex.org/W2056315045","https://openalex.org/W2056680589","https://openalex.org/W2061057323","https://openalex.org/W2063785333","https://openalex.org/W2120033918","https://openalex.org/W2128635872","https://openalex.org/W2147722148","https://openalex.org/W2165035684","https://openalex.org/W2183190091","https://openalex.org/W2615752336","https://openalex.org/W6739662753"],"related_works":["https://openalex.org/W2082362275","https://openalex.org/W2081330606","https://openalex.org/W2165035684","https://openalex.org/W2150899770","https://openalex.org/W2065036439","https://openalex.org/W2064030624","https://openalex.org/W2152856226","https://openalex.org/W2049833176","https://openalex.org/W1754963706","https://openalex.org/W2081597640"],"abstract_inverted_index":{"The":[0,135],"amdS":[1,57,99,150],"gene":[2],"of":[3,11,36,38,51,55,86,97,105,111,120,147,149,174],"Aspergillus":[4],"nidulans":[5,130],"is":[6,161],"regulated":[7],"by":[8],"a":[9,71,75,106,162],"number":[10],"positively":[12],"acting":[13],"regulatory":[14,40],"genes":[15,178],"which":[16,123],"act":[17],"additively":[18],"and":[19,153,165],"independently.":[20],"Using":[21],"gel":[22],"mobility":[23],"shift":[24],"assays":[25],"with":[26,115],"crude":[27],"nuclear":[28],"extracts":[29],"we":[30,82,124],"show":[31],"here":[32],"that":[33,68,159,166],"the":[34,42,52,56,61,84,98,103,112,118,144,167,172],"product":[35],"one":[37],"these":[39,184],"genes,":[41],"amdR":[43,69],"gene,":[44],"binds":[45],"to":[46,91,139],"DNA":[47,65],"fragments":[48],"containing":[49,74],"part":[50],"promoter":[53],"region":[54,96],"gene.":[58],"This":[59,157],"confirms":[60],"earlier":[62],"prediction":[63],"from":[64],"sequence":[66,101,114,137],"data":[67],"encodes":[70],"DNA-binding":[72],"protein":[73,90,122],"cysteine-rich":[76],"'zinc":[77],"finger'":[78],"motif.":[79],"In":[80],"addition":[81],"detected":[83],"binding":[85,119,132,181],"another":[87],"previously":[88],"unidentified":[89],"an":[92,128],"adjacent,":[93],"possibly":[94],"overlapping":[95],"5'":[100],"at":[102],"site":[104],"consensus":[107],"'CCAAT-box'":[108,131,136,168],"sequence.":[109],"Replacement":[110],"CCAAT":[113],"CCTTT":[116],"abolished":[117],"this":[121],"have":[125],"designated":[126],"as":[127,180,186],"A.":[129],"factor":[133],"(AnCF).":[134],"appears":[138],"be":[140],"involved":[141],"in":[142,171,187],"determining":[143],"basal":[145],"level":[146],"transcription":[148,163],"(T.G.":[151],"Littlejohn":[152],"M.J.H.,":[154],"unpublished":[155],"data).":[156],"suggests":[158],"AnCF":[160],"factor,":[164],"sequences":[169],"found":[170],"promoters":[173],"some":[175],"filamentous":[176],"fungal":[177],"function":[179],"sites":[182],"for":[183],"factors,":[185],"other":[188],"eucaryotes.":[189]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
