{"id":"https://openalex.org/W2143055286","doi":"https://doi.org/10.1158/1055-9965.epi-09-0959","title":"UGT2B10 Genotype Influences Nicotine Glucuronidation, Oxidation, and Consumption","display_name":"UGT2B10 Genotype Influences Nicotine Glucuronidation, Oxidation, and Consumption","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W2143055286","doi":"https://doi.org/10.1158/1055-9965.epi-09-0959","mag":"2143055286","pmid":"https://pubmed.ncbi.nlm.nih.gov/20501767","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2882998"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.epi-09-0959","doi":"https://doi.org/10.1158/1055-9965.epi-09-0959","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-09-0959","pdf_url":"https://aacrjournals.org/cebp/article-pdf/19/6/1423/2272354/1423.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://aacrjournals.org/cebp/article-pdf/19/6/1423/2272354/1423.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060364617","display_name":"Jeannette Zinggeler Berg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeannette Zinggeler Berg","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044141752","display_name":"Linda B. von Weymarn","orcid":"https://orcid.org/0000-0002-4516-4602","observed_orcids":["https://orcid.org/0000-0002-4516-4602"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda B. von Weymarn","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","Carcinogenesis and Chemoprevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Carcinogenesis and Chemoprevention","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066665569","display_name":"Elizabeth A. Thompson","orcid":"https://orcid.org/0000-0002-3346-0367","observed_orcids":["https://orcid.org/0000-0002-3346-0367"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth A. Thompson","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088323085","display_name":"Katherine M. Wickham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine M. Wickham","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009888712","display_name":"Natalie A. Weisensel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalie A. Weisensel","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054433219","display_name":"Dorothy K. Hatsukami","orcid":"https://orcid.org/0000-0002-1108-2609","observed_orcids":["https://orcid.org/0000-0002-1108-2609"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorothy K. Hatsukami","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","Psychiatry & Behavioral Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]},{"raw_affiliation_string":"Psychiatry & Behavioral Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022126431","display_name":"Sharon E. Murphy","orcid":"https://orcid.org/0000-0001-5391-8104","observed_orcids":["https://orcid.org/0000-0001-5391-8104"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sharon E. Murphy","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Biochemistry Molecular Biology and Biophysics, and 2Psychiatry, Masonic Cancer Center, University of Minnesota, Minneapolis Minnesota","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022126431"],"corresponding_institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"],"apc_list":null,"apc_paid":null,"fwci":1.4765,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.7804878,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"6","first_page":"1423","last_page":"1431"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ugt2b10","display_name":"UGT2B10","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nicotine-metabolism","display_name":"nicotine metabolism","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cotinine","display_name":"cotinine","score":0.7009999752044678},{"id":"https://openalex.org/keywords/trans-3-hydroxycotinine","display_name":"trans-3'-hydroxycotinine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/nicotine-n-oxide","display_name":"nicotine N-oxide","score":0.7789999842643738},{"id":"https://openalex.org/keywords/smoking-behavior","display_name":"smoking behavior","score":0.7379999756813049},{"id":"https://openalex.org/keywords/udp-glucuronosyltransferase","display_name":"UDP-glucuronosyltransferase","score":0.875},{"id":"https://openalex.org/keywords/smokers","display_name":"smokers","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2776319443","wikidata":"https://www.wikidata.org/wiki/Q421177","display_name":"Cotinine","level":3,"score":0.9270957708358765},{"id":"https://openalex.org/C2779547902","wikidata":"https://www.wikidata.org/wiki/Q28086552","display_name":"Nicotine","level":2,"score":0.9088703393936157},{"id":"https://openalex.org/C2779907587","wikidata":"https://www.wikidata.org/wiki/Q14901439","display_name":"Glucuronidation","level":4,"score":0.9022496938705444},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5504209399223328},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.537699282169342},{"id":"https://openalex.org/C2779186261","wikidata":"https://www.wikidata.org/wiki/Q137786","display_name":"Glucuronide","level":3,"score":0.467315137386322},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4010666012763977},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38049858808517456},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3718906044960022},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28065815567970276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20898008346557617},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009538","descriptor_name":"Nicotine","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014453","descriptor_name":"Glucuronosyltransferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020719","descriptor_name":"Glucuronides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020719","descriptor_name":"Glucuronides","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1055-9965.epi-09-0959","doi":"https://doi.org/10.1158/1055-9965.epi-09-0959","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-09-0959","pdf_url":"https://aacrjournals.org/cebp/article-pdf/19/6/1423/2272354/1423.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},{"id":"pmid:20501767","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20501767","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2110900","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2882998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2882998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2882998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Epidemiol Biomarkers Prev","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.epi-09-0959","doi":"https://doi.org/10.1158/1055-9965.epi-09-0959","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.epi-09-0959","pdf_url":"https://aacrjournals.org/cebp/article-pdf/19/6/1423/2272354/1423.pdf","source":{"id":"https://openalex.org/S8391440","display_name":"Cancer Epidemiology Biomarkers & Prevention","issn_l":"1055-9965","issn":["1055-9965","1538-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Epidemiology, Biomarkers &amp; Prevention","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1358164825","display_name":"Medical Scientist Training Program","funder_award_id":"T32GM008244","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1404478654","display_name":"Tobacco Exposure Reduction","funder_award_id":"5p50da013333-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G408852088","display_name":null,"funder_award_id":"DA13333","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G679113020","display_name":null,"funder_award_id":"P50- DA013333","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G993203148","display_name":"P450-mediated Nicotine Metabolism","funder_award_id":"F30DA020968","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2143055286.pdf","grobid_xml":"https://content.openalex.org/works/W2143055286.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1963548286","https://openalex.org/W1970748036","https://openalex.org/W1982969180","https://openalex.org/W1983906278","https://openalex.org/W1985501132","https://openalex.org/W1987502189","https://openalex.org/W1994597412","https://openalex.org/W1995402453","https://openalex.org/W1996745171","https://openalex.org/W1997828131","https://openalex.org/W2015658785","https://openalex.org/W2020466267","https://openalex.org/W2030358514","https://openalex.org/W2039748447","https://openalex.org/W2048099302","https://openalex.org/W2054843958","https://openalex.org/W2092870550","https://openalex.org/W2096659232","https://openalex.org/W2096690433","https://openalex.org/W2098436801","https://openalex.org/W2099847601","https://openalex.org/W2101876919","https://openalex.org/W2107725125","https://openalex.org/W2107817292","https://openalex.org/W2112181332","https://openalex.org/W2122179629","https://openalex.org/W2122485375","https://openalex.org/W2130528787","https://openalex.org/W2134552151","https://openalex.org/W2136827296","https://openalex.org/W2137599927","https://openalex.org/W2142259952","https://openalex.org/W2144475254","https://openalex.org/W2155963578","https://openalex.org/W2160606169","https://openalex.org/W2169463741","https://openalex.org/W2185675491","https://openalex.org/W4300624582"],"related_works":["https://openalex.org/W2133476676","https://openalex.org/W3023497215","https://openalex.org/W1983906278","https://openalex.org/W7097637689","https://openalex.org/W2096659232","https://openalex.org/W2029586372","https://openalex.org/W2115105291","https://openalex.org/W2082527986","https://openalex.org/W7099728153","https://openalex.org/W2149606343"],"abstract_inverted_index":{"BACKGROUND:":[0],"Tobacco":[1],"exposure":[2],"is":[3,29],"routinely":[4],"assessed":[5],"by":[6],"quantifying":[7],"nicotine":[8,18,27,41,56,85,97,115,131,157,172,205,217,222,232,245],"metabolites":[9],"in":[10,26,51,71,89,142,216],"plasma":[11,78],"or":[12,132],"urine.":[13],"On":[14],"average,":[15],"80%":[16],"of":[17,39,48,82,96,109,147,156,171,244],"undergoes":[19],"C-oxidation":[20,119],"to":[21,37,114,150,159],"cotinine.":[22],"However,":[23],"interindividual":[24],"variation":[25],"glucuronidation":[28,32],"substantial,":[30],"and":[31,58,66,77,98,118,161,164,234],"accounts":[33],"for":[34,104,125,200,221],"from":[35],"0%":[36],"40%":[38],"total":[40,67],"metabolism.":[42],"We":[43],"report":[44],"here":[45],"the":[46,72,94,110,126,242],"effect":[47],"a":[49,52,143,152,168],"polymorphism":[50],"UDP-glucuronsyltransferase,":[53],"UGT2B10,":[54],"on":[55,247],"metabolism":[57,233,246],"consumption.":[59],"METHODS:":[60],"Nicotine,":[61],"cotinine,":[62,151],"their":[63,135],"N-glucuronide":[64],"conjugates,":[65],"trans-3'-hydroxycotinine":[68],"were":[69,102,174],"quantified":[70,88],"urine":[73],"(n":[74,79],"=":[75,80],"327)":[76],"115)":[81],"smokers.":[83,91,209],"Urinary":[84],"N-oxide":[86],"was":[87,120],"105":[90],"Nicotine":[92,166],"equivalents,":[93,116,167],"sum":[95],"all":[99],"major":[100],"metabolites,":[101],"calculated":[103],"each":[105],"smoker.":[106],"The":[107],"relationship":[108],"UGT2B10":[111,201,229],"Asp67Tyr":[112,127,177,202],"allele":[113,128],"N-glucuronidation,":[117,218],"determined.":[121],"RESULTS:":[122],"Individuals":[123,198],"heterozygous":[124,199],"excreted":[129],"less":[130,204],"cotinine":[133,148,163],"as":[134,219],"glucuronide":[136,149,158],"conjugates":[137],"than":[138,206],"did":[139],"wild-type,":[140],"resulting":[141],"60%":[144],"lower":[145,154,175],"ratio":[146,155],"50%":[153],"nicotine,":[160],"increased":[162],"trans-3'-hydroxycotinine.":[165],"robust":[169],"biomarker":[170],"intake,":[173],"among":[176],"heterozygotes":[178],"compared":[179],"with":[180],"individuals":[181],"without":[182],"this":[183],"allele:":[184],"58.2":[185],"(95%":[186,193],"confidence":[187,194],"interval,":[188,195],"48.9-68.2)":[189],"versus":[190],"69.2":[191],"nmol/mL":[192],"64.3-74.5).":[196],"CONCLUSIONS:":[197],"consume":[203],"do":[207],"wild-type":[208],"This":[210],"striking":[211],"observation":[212],"suggests":[213],"that":[214],"variations":[215],"reported":[220],"C-oxidation,":[223],"may":[224],"influence":[225],"smoking":[226],"behavior.":[227],"IMPACT:":[228],"genotype":[230],"influences":[231],"should":[235],"be":[236],"taken":[237],"into":[238],"account":[239],"when":[240],"characterizing":[241],"role":[243],"smoking.":[248]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
