{"id":"https://openalex.org/W2143003193","doi":"https://doi.org/10.1111/j.1365-2265.2006.02704.x","title":"Treatment of hereditary angioneurotic oedema (HANE) with tibolone","display_name":"Treatment of hereditary angioneurotic oedema (HANE) with tibolone","publication_year":2006,"publication_date":"2006-11-07","ids":{"openalex":"https://openalex.org/W2143003193","doi":"https://doi.org/10.1111/j.1365-2265.2006.02704.x","mag":"2143003193","pmid":"https://pubmed.ncbi.nlm.nih.gov/17223985"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2265.2006.02704.x","doi":"https://doi.org/10.1111/j.1365-2265.2006.02704.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.2006.02704.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110827224","display_name":"Helmut Werner Ott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"H. W. Ott","raw_affiliation_strings":["Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria. helmut.ott@uibk.ac.at","Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria. helmut.ott@uibk.ac.at","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]},{"raw_affiliation_string":"Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113085293","display_name":"Verena Mattle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"V. Mattle","raw_affiliation_strings":["Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026777542","display_name":"Dijana Had\u017eiomerovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"D. Hadziomerovic","raw_affiliation_strings":["Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Licht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]},{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"P. Licht","raw_affiliation_strings":["Department of Internal Medicine III, University of Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine III, University of Erlangen, Germany","institution_ids":["https://openalex.org/I181369854","https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084448230","display_name":"K D\u00f6inghaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. D\u00f6inghaus","raw_affiliation_strings":["Division of Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Erlangen-Nu\u0308rnberg, Germany,","Division of Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Erlangen-N\u00fcrnberg, Germany,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Erlangen-Nu\u0308rnberg, Germany,","institution_ids":["https://openalex.org/I181369854"]},{"raw_affiliation_string":"Division of Endocrinology and Reproductive Medicine, Department of Obstetrics and Gynaecology, University of Erlangen-N\u00fcrnberg, Germany,","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015549021","display_name":"ANDREA RUBBERT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"A. Rubbert","raw_affiliation_strings":["Department of Internal Medicine, University of Cologne, Germany","Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002520863","display_name":"Karin Manger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"K. Manger","raw_affiliation_strings":["Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059789259","display_name":"Bernhard Manger","orcid":"https://orcid.org/0000-0003-2375-0069","observed_orcids":["https://orcid.org/0000-0003-2375-0069"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Manger","raw_affiliation_strings":["Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109954828","display_name":"Joachim R. Kalden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J. Kalden","raw_affiliation_strings":["Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of Tu\u0308bingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Division of Endocrinology, Department of Obstetrics and Gynaecology, University of T\u00fcbingen, Germany, and","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005560493","display_name":"L. Wildt","orcid":"https://orcid.org/0000-0003-1933-2593","observed_orcids":["https://orcid.org/0000-0003-1933-2593"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"L. Wildt","raw_affiliation_strings":["Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Division of Gynaecological Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5110827224"],"corresponding_institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.4057,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.64768336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"66","issue":"2","first_page":"180","last_page":"184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tibolone","display_name":"tibolone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/danazol","display_name":"danazol","score":0.8899999856948853},{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.8450000286102295},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.7369999885559082},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C2777416354","wikidata":"https://www.wikidata.org/wiki/Q419652","display_name":"Danazol","level":3,"score":0.9894118309020996},{"id":"https://openalex.org/C2777457466","wikidata":"https://www.wikidata.org/wiki/Q413805","display_name":"Tibolone","level":3,"score":0.9765192866325378},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7340081930160522},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6965786814689636},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6264321804046631},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.5529305934906006},{"id":"https://openalex.org/C2777788586","wikidata":"https://www.wikidata.org/wiki/Q2096745","display_name":"Hereditary angioedema","level":2,"score":0.4268777370452881},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.17498928308486938},{"id":"https://openalex.org/C2779522080","wikidata":"https://www.wikidata.org/wiki/Q205764","display_name":"Endometriosis","level":2,"score":0.16548827290534973},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.12356218695640564},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.10975593328475952}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000799","descriptor_name":"Angioedema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009652","descriptor_name":"Norpregnenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2265.2006.02704.x","doi":"https://doi.org/10.1111/j.1365-2265.2006.02704.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2265.2006.02704.x","pdf_url":null,"source":{"id":"https://openalex.org/S182143151","display_name":"Clinical Endocrinology","issn_l":"0300-0664","issn":["0300-0664","1365-2265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Endocrinology","raw_type":"journal-article"},{"id":"pmid:17223985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17223985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical endocrinology","raw_type":"Controlled Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W20176556","https://openalex.org/W177949399","https://openalex.org/W196618428","https://openalex.org/W1559340507","https://openalex.org/W1966185086","https://openalex.org/W1970621055","https://openalex.org/W1971508361","https://openalex.org/W1972964391","https://openalex.org/W1974968229","https://openalex.org/W1984955008","https://openalex.org/W1988870163","https://openalex.org/W1989846166","https://openalex.org/W1991473086","https://openalex.org/W2004362031","https://openalex.org/W2004395480","https://openalex.org/W2007659624","https://openalex.org/W2032933719","https://openalex.org/W2036977780","https://openalex.org/W2039603716","https://openalex.org/W2041540648","https://openalex.org/W2053851252","https://openalex.org/W2056171160","https://openalex.org/W2057347176","https://openalex.org/W2059092798","https://openalex.org/W2060269207","https://openalex.org/W2068999248","https://openalex.org/W2071579747","https://openalex.org/W2077430968","https://openalex.org/W2078264642","https://openalex.org/W2081125770","https://openalex.org/W2084679499","https://openalex.org/W2086331553","https://openalex.org/W2094043068","https://openalex.org/W2229797107","https://openalex.org/W2283373568","https://openalex.org/W2318584648","https://openalex.org/W2408983088","https://openalex.org/W2410807048","https://openalex.org/W2412669740","https://openalex.org/W2414153691","https://openalex.org/W2414192940","https://openalex.org/W2414383967","https://openalex.org/W2414808130","https://openalex.org/W2421378036","https://openalex.org/W2470478810","https://openalex.org/W4240709158"],"related_works":["https://openalex.org/W2434713841","https://openalex.org/W2425178353","https://openalex.org/W2416515574","https://openalex.org/W2001890838","https://openalex.org/W2430174502","https://openalex.org/W2054653943","https://openalex.org/W2314082658","https://openalex.org/W1972464670","https://openalex.org/W622729981","https://openalex.org/W2043879443"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Eight":[1],"women,":[2],"aged":[3],"25-58":[4],"years,":[5],"with":[6,13],"hereditary":[7],"angioneurotic":[8],"oedema":[9],"(HANE)":[10],"were":[11,70],"treated":[12],"tibolone,":[14],"a":[15,30],"synthetic":[16],"steroid":[17],"exhibiting":[18],"oestrogenic,":[19],"androgenic":[20,68],"and":[21,39,43],"progestational":[22],"activity.":[23],"DESIGN:":[24],"Pilot":[25],"study.":[26],"RESULTS:":[27],"Tibolone":[28,74],"at":[29],"dose":[31],"of":[32,41,46,48,58,64,85],"2.5-7.5":[33],"mg/day":[34],"significantly":[35],"reduced":[36],"the":[37,44,67,83],"number":[38,45],"severity":[40],"attacks":[42],"ampoules":[47],"C1-esterase":[49],"inhibitor":[50],"(C1-INH)":[51],"needed":[52],"for":[53,82],"symptomatic":[54],"therapy.":[55],"The":[56],"efficacy":[57],"tibolone":[59],"was":[60],"comparable":[61],"to":[62,79],"that":[63],"danazol,":[65],"while":[66],"side-effects":[69],"considerably":[71],"reduced.":[72],"CONCLUSIONS:":[73],"may":[75],"represent":[76],"an":[77],"alternative":[78],"danazol":[80],"administration":[81],"prophylaxis":[84],"HANE":[86],"in":[87],"women.":[88]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
