{"id":"https://openalex.org/W2142993751","doi":"https://doi.org/10.1095/biolreprod.102.009167","title":"Copper-Deficient Rat Embryos Are Characterized by Low Superoxide Dismutase Activity and Elevated Superoxide Anions1","display_name":"Copper-Deficient Rat Embryos Are Characterized by Low Superoxide Dismutase Activity and Elevated Superoxide Anions1","publication_year":2003,"publication_date":"2003-03-01","ids":{"openalex":"https://openalex.org/W2142993751","doi":"https://doi.org/10.1095/biolreprod.102.009167","mag":"2142993751","pmid":"https://pubmed.ncbi.nlm.nih.gov/12604640"},"language":"en","primary_location":{"id":"doi:10.1095/biolreprod.102.009167","doi":"https://doi.org/10.1095/biolreprod.102.009167","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod.102.009167","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113539050","display_name":"Susan Nicole Hawk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan N. Hawk","raw_affiliation_strings":["Department of Nutrition, University of California at Davis, Davis, California 95616-8869, USA","Departments of Nutrition, University of California at Davis, Davis, California 95616-8869"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nutrition, University of California at Davis, Davis, California 95616-8869, USA","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Departments of Nutrition, University of California at Davis, Davis, California 95616-8869","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030171634","display_name":"Louise Lanoue","orcid":"https://orcid.org/0000-0003-2779-0391","observed_orcids":["https://orcid.org/0000-0003-2779-0391"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louise Lanoue","raw_affiliation_strings":["Departments of Nutrition, University of California at Davis, Davis, California 95616-8869"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, University of California at Davis, Davis, California 95616-8869","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043985150","display_name":"Carl L. Keen","orcid":"https://orcid.org/0000-0001-6602-4417","observed_orcids":["https://orcid.org/0000-0001-6602-4417"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl L. Keen","raw_affiliation_strings":["Departments of Nutrition, University of California at Davis, Davis, California 95616-8869","Internal Medicine, University of California at Davis, Davis, California 95616-8869"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, University of California at Davis, Davis, California 95616-8869","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Internal Medicine, University of California at Davis, Davis, California 95616-8869","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067204793","display_name":"Catherine L. Kwik-Uribe","orcid":"https://orcid.org/0000-0001-5684-039X","observed_orcids":["https://orcid.org/0000-0001-5684-039X"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine L. Kwik-Uribe","raw_affiliation_strings":["Departments of Nutrition, University of California at Davis, Davis, California 95616-8869"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, University of California at Davis, Davis, California 95616-8869","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015043500","display_name":"Robert B. Rucker","orcid":"https://orcid.org/0000-0002-7804-0278","observed_orcids":["https://orcid.org/0000-0002-7804-0278"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Rucker","raw_affiliation_strings":["Departments of Nutrition, University of California at Davis, Davis, California 95616-8869"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, University of California at Davis, Davis, California 95616-8869","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110436647","display_name":"Janet Y. Uriu\u2010Adams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Janet Y. Uriu-Adams","raw_affiliation_strings":["Departments of Nutrition, University of California at Davis, Davis, California 95616-8869"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Nutrition, University of California at Davis, Davis, California 95616-8869","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110436647"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":{"value":4605,"currency":"USD","value_usd":4605},"apc_paid":null,"fwci":2.4568,"has_fulltext":false,"cited_by_count":70,"citation_normalized_percentile":{"value":0.8847179,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"68","issue":"3","first_page":"896","last_page":"903"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/copper-deficiency","display_name":"copper deficiency","score":0.996999979019165},{"id":"https://openalex.org/keywords/embryonic-development","display_name":"embryonic development","score":0.6389999985694885},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9110000133514404},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.878000020980835},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.949999988079071},{"id":"https://openalex.org/keywords/teratogenicity","display_name":"teratogenicity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.871999979019165},{"id":"https://openalex.org/keywords/glutathione-reductase","display_name":"glutathione reductase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/copper-zinc-superoxide-dismutase","display_name":"copper-zinc superoxide dismutase","score":0.703000009059906},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7260000109672546},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/oxidative-dna-damage","display_name":"oxidative DNA damage","score":0.8399999737739563},{"id":"https://openalex.org/keywords/developmental-malformations","display_name":"developmental malformations","score":0.8090000152587891},{"id":"https://openalex.org/keywords/rat-embryo","display_name":"rat embryo","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.8532766103744507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7864827513694763},{"id":"https://openalex.org/C2780795997","wikidata":"https://www.wikidata.org/wiki/Q413283","display_name":"Superoxide","level":3,"score":0.7651171684265137},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.627991795539856},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.5169146060943604},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.366859495639801},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3244161605834961},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2804090976715088},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24517306685447693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.09072849154472351},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D003300","descriptor_name":"Copper","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005314","descriptor_name":"Embryonic and Fetal Development","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005980","descriptor_name":"Glutathione Reductase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005980","descriptor_name":"Glutathione Reductase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013481","descriptor_name":"Superoxides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1095/biolreprod.102.009167","doi":"https://doi.org/10.1095/biolreprod.102.009167","is_oa":false,"landing_page_url":"https://doi.org/10.1095/biolreprod.102.009167","pdf_url":null,"source":{"id":"https://openalex.org/S130598054","display_name":"Biology of Reproduction","issn_l":"0006-3363","issn":["0006-3363","1529-7268"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of Reproduction","raw_type":"journal-article"},{"id":"pmid:12604640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12604640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of reproduction","raw_type":"Journal Article"},{"id":"pmh:10.1095/biolreprod.102.009167","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1095/biolreprod.102.009167","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W3924184","https://openalex.org/W182820266","https://openalex.org/W215825895","https://openalex.org/W1484563081","https://openalex.org/W1568733499","https://openalex.org/W1873078527","https://openalex.org/W1926913142","https://openalex.org/W1930476736","https://openalex.org/W1953402842","https://openalex.org/W1975980695","https://openalex.org/W1996833241","https://openalex.org/W2001486727","https://openalex.org/W2003337850","https://openalex.org/W2004471846","https://openalex.org/W2007567460","https://openalex.org/W2011803888","https://openalex.org/W2019571858","https://openalex.org/W2032982569","https://openalex.org/W2037017107","https://openalex.org/W2037897177","https://openalex.org/W2044556913","https://openalex.org/W2054153004","https://openalex.org/W2057855533","https://openalex.org/W2061019838","https://openalex.org/W2061288729","https://openalex.org/W2062145064","https://openalex.org/W2064450614","https://openalex.org/W2067579838","https://openalex.org/W2067588722","https://openalex.org/W2070283293","https://openalex.org/W2079759543","https://openalex.org/W2093053818","https://openalex.org/W2093319519","https://openalex.org/W2096271859","https://openalex.org/W2096964065","https://openalex.org/W2107016225","https://openalex.org/W2110566202","https://openalex.org/W2128635872","https://openalex.org/W2130781987","https://openalex.org/W2132970443","https://openalex.org/W2151624907","https://openalex.org/W2158054215","https://openalex.org/W2164420294","https://openalex.org/W2169647820","https://openalex.org/W2274848233","https://openalex.org/W2318340336","https://openalex.org/W2342991747","https://openalex.org/W2390235908","https://openalex.org/W2398950748","https://openalex.org/W4206239690","https://openalex.org/W4234181541","https://openalex.org/W4388278961","https://openalex.org/W4388279126"],"related_works":["https://openalex.org/W2037017107","https://openalex.org/W2048226531","https://openalex.org/W2088950940","https://openalex.org/W143405872","https://openalex.org/W2037946071","https://openalex.org/W158151709","https://openalex.org/W2315305441","https://openalex.org/W2433520401","https://openalex.org/W1964583970","https://openalex.org/W2200688660"],"abstract_inverted_index":{"The":[0],"teratogenicity":[1],"of":[2,79,91,157,235],"copper":[3],"(Cu)":[4],"deficiency":[5,208],"may":[6,226],"result":[7],"from":[8],"increased":[9,160],"oxidative":[10,13,181,228],"stress":[11],"and":[12,45,65,74,115,159,170,179,214,230],"damage.":[14],"Dams":[15],"were":[16,30,70,86,100,186],"fed":[17],"either":[18],"control":[19,73,129,133],"(8.0":[20],"microg":[21,26],"Cu/g)":[22,27],"or":[23,40,52,104],"Cu-deficient":[24,51,75,121,125,137,151,197,224],"(0.5":[25],"diets.":[28],"Embryos":[29],"collected":[31],"on":[32,41],"Gestational":[33,42],"Day":[34,43],"12":[35],"for":[36,47,55,162,177,196],"in":[37,50,56,72,102,120,124,132,148,165,210,222],"vivo":[38],"studies":[39],"10":[44],"cultured":[46,123,131],"48":[48],"h":[49],"Cu-adequate":[53],"media":[54],"vitro":[57,149],"studies.":[58],"Superoxide":[59,84],"dismutase":[60],"(SOD),":[61],"glutathione":[62,66],"peroxidase":[63],"(GPX),":[64],"reductase":[67],"(GR)":[68],"activities":[69,106],"measured":[71,87],"embryos":[76,122,130,138,152,198,211],"as":[77,88,144],"markers":[78],"the":[80,147,166,189,223,233],"oxidant":[81],"defense":[82],"system.":[83],"anions":[85,164],"an":[89],"index":[90],"exposure":[92],"to":[93,128,173,199,232],"reactive":[94],"oxygen":[95],"species":[96],"(ROS).":[97],"No":[98],"differences":[99],"found":[101],"GPX":[103],"GR":[105],"among":[107,188],"treatment":[108],"groups.":[109],"However,":[110],"SOD":[111,216],"activity":[112],"was":[113,194],"lower":[114],"superoxide":[116,163],"anion":[117],"concentrations":[118,185,203,221],"higher":[119,155,201],"serum":[126],"compared":[127,172],"serum.":[134],"Even":[135],"so,":[136],"had":[139,153],"similar":[140,187],"CuZnSOD":[141],"protein":[142],"levels":[143],"controls.":[145,174,205],"In":[146],"system,":[150],"a":[154,192],"frequency":[156],"malformations":[158,213],"staining":[161],"forebrain,":[167],"heart,":[168],"forelimb,":[169],"somites":[171],"When":[175],"assessed":[176],"lipid":[178],"DNA":[180],"damage,":[182],"conjugated":[183],"diene":[184],"groups,":[190],"but":[191],"tendency":[193],"observed":[195],"have":[200],"8-hydroxy-2'-deoxyguanosine":[202],"than":[204],"Thus,":[206],"Cu":[207],"resulted":[209],"with":[212],"reduced":[215],"enzyme":[217],"activity.":[218],"Increased":[219],"ROS":[220],"embryo":[225],"cause":[227],"damage":[229],"contribute":[231],"occurrence":[234],"developmental":[236],"defects.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}