{"id":"https://openalex.org/W2142947451","doi":"https://doi.org/10.1152/ajplung.00359.2010","title":"Alternaria alternataserine proteases induce lung inflammation and airway epithelial cell activation via PAR2","display_name":"Alternaria alternataserine proteases induce lung inflammation and airway epithelial cell activation via PAR2","publication_year":2011,"publication_date":"2011-02-05","ids":{"openalex":"https://openalex.org/W2142947451","doi":"https://doi.org/10.1152/ajplung.00359.2010","mag":"2142947451","pmid":"https://pubmed.ncbi.nlm.nih.gov/21296894","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3075100"},"language":"en","primary_location":{"id":"doi:10.1152/ajplung.00359.2010","doi":"https://doi.org/10.1152/ajplung.00359.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00359.2010","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3075100","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012818050","display_name":"Scott A. Boitano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Scott Boitano","raw_affiliation_strings":["Departments of 1Physiology,","Dept. of Physiology, Arizona Respiratory Center, Arizona Health Sciences Center, 1501 N. Campbell Ave., Tucson, AZ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Physiology,","institution_ids":[]},{"raw_affiliation_string":"Dept. of Physiology, Arizona Respiratory Center, Arizona Health Sciences Center, 1501 N. Campbell Ave., Tucson, AZ, USA","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109274734","display_name":"Andrea N. Flynn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea N. Flynn","raw_affiliation_strings":["Departments of 1Physiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Physiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004882128","display_name":"Cara L. Sherwood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cara L. Sherwood","raw_affiliation_strings":["Cell Biology and Anatomy, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology and Anatomy, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stephanie M. Schulz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie M. Schulz","raw_affiliation_strings":["Departments of 1Physiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Physiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057252095","display_name":"Justin Hoffman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Justin Hoffman","raw_affiliation_strings":["Departments of 1Physiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1Physiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084309335","display_name":"Irina Gruzinova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irina Gruzinova","raw_affiliation_strings":["Pediatrics, Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006730507","display_name":"Michael Daines","orcid":"https://orcid.org/0000-0003-2464-9034","observed_orcids":["https://orcid.org/0000-0003-2464-9034"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael O. Daines","raw_affiliation_strings":["Pediatrics, Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatrics, Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona","institution_ids":["https://openalex.org/I138006243"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012818050"],"corresponding_institution_ids":["https://openalex.org/I138006243"],"apc_list":null,"apc_paid":null,"fwci":8.0074,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.97893905,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"300","issue":"4","first_page":"L605","last_page":"L614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alternaria-alternata","display_name":"Alternaria alternata","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fungal-allergens","display_name":"fungal allergens","score":0.8009999990463257},{"id":"https://openalex.org/keywords/serine-protease","display_name":"serine protease","score":0.9810000061988831},{"id":"https://openalex.org/keywords/protease-activated-receptor-2","display_name":"protease-activated receptor 2","score":0.9229999780654907},{"id":"https://openalex.org/keywords/par2","display_name":"PAR2","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/airway-epithelial-cells","display_name":"airway epithelial cells","score":0.953000009059906},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.8550000190734863},{"id":"https://openalex.org/keywords/allergic-asthma","display_name":"allergic asthma","score":0.9129999876022339},{"id":"https://openalex.org/keywords/par1","display_name":"PAR1","score":0.44999998807907104},{"id":"https://openalex.org/keywords/par3","display_name":"Par3","score":0.703000009059906},{"id":"https://openalex.org/keywords/protease-activated-receptor-4","display_name":"PAR4","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bronchial-epithelial-cells","display_name":"bronchial epithelial cells","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.8494828939437866},{"id":"https://openalex.org/C2780720873","wikidata":"https://www.wikidata.org/wiki/Q2704244","display_name":"Alternaria alternata","level":2,"score":0.7482519149780273},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.6417034864425659},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5708851218223572},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5329602360725403},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.513405442237854},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5030271410942078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4816371500492096},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37369436025619507},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37027278542518616},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32467854022979736},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3103903532028198},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2016865313053131},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09810134768486023},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000528","descriptor_name":"Alternaria","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D044464","descriptor_name":"Receptor, PAR-2","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057057","descriptor_name":"Serine Proteases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1152/ajplung.00359.2010","doi":"https://doi.org/10.1152/ajplung.00359.2010","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajplung.00359.2010","pdf_url":null,"source":{"id":"https://openalex.org/S47245711","display_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","issn_l":"1040-0605","issn":["1040-0605","1522-1504"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3075100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3075100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Lung Cell Mol Physiol","raw_type":"Text"},{"id":"pmid:21296894","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21296894","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Lung cellular and molecular physiology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.845.8981","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.845.8981","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ajplung.physiology.org/content/ajplung/300/4/L605.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3075100","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3075100","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Physiol Lung Cell Mol Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2921493865","display_name":null,"funder_award_id":"AI083403","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4559631247","display_name":"Alternaria proteases and protease defenses in asthma","funder_award_id":"R01AI083403","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000856510","display_name":"Training in Environmental Toxicology of Human Disease","funder_award_id":"T32ES007091","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000864416","display_name":"Interdisciplinary Training in Cardiovascular Research","funder_award_id":"T32HL007249","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000867487","display_name":"Southwest Environmental Health Sciences Center","funder_award_id":"P30ES006694","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332603","display_name":"University of California, San Diego","ror":"https://ror.org/0168r3w48"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1481542987","https://openalex.org/W1494978858","https://openalex.org/W1504820480","https://openalex.org/W1642728877","https://openalex.org/W1811719059","https://openalex.org/W1823764983","https://openalex.org/W1889671843","https://openalex.org/W1963938486","https://openalex.org/W1965072920","https://openalex.org/W1966870605","https://openalex.org/W1967781832","https://openalex.org/W1977056120","https://openalex.org/W1992045794","https://openalex.org/W1995810932","https://openalex.org/W1997495128","https://openalex.org/W2004868312","https://openalex.org/W2017724962","https://openalex.org/W2021494707","https://openalex.org/W2036614649","https://openalex.org/W2037583192","https://openalex.org/W2052945303","https://openalex.org/W2055492964","https://openalex.org/W2059400964","https://openalex.org/W2063975118","https://openalex.org/W2065429063","https://openalex.org/W2075057594","https://openalex.org/W2085000613","https://openalex.org/W2085423167","https://openalex.org/W2086357056","https://openalex.org/W2101520378","https://openalex.org/W2103849013","https://openalex.org/W2104831363","https://openalex.org/W2112612062","https://openalex.org/W2135599949","https://openalex.org/W2136483009","https://openalex.org/W2141260882","https://openalex.org/W2151441249","https://openalex.org/W2167358960","https://openalex.org/W2219086625"],"related_works":["https://openalex.org/W2074244209","https://openalex.org/W167157212","https://openalex.org/W4200016702","https://openalex.org/W2897502407","https://openalex.org/W4389024427","https://openalex.org/W614253112","https://openalex.org/W204094356","https://openalex.org/W2334494548","https://openalex.org/W7097459749","https://openalex.org/W2776735800"],"abstract_inverted_index":{"Allergens":[0,11],"are":[1,213],"diverse":[2],"proteins":[3],"from":[4,49],"mammals,":[5],"birds,":[6],"arthropods,":[7],"plants,":[8],"and":[9,28,57,119,154,206],"fungi.":[10],"associated":[12],"with":[13,100,140,156],"asthma":[14],"(asthmagens)":[15],"share":[16],"a":[17,37,77],"common":[18],"protease":[19,113],"activity":[20],"that":[21,188],"may":[22],"directly":[23],"impact":[24,46],"respiratory":[25],"epithelial":[26,89,202],"biology":[27],"lead":[29],"to":[30,69,86,170,195],"symptoms":[31],"of":[32,47,115,135,151,221],"asthma.":[33,223],"Alternaria":[34],"alternata":[35,51,66,83,117,172,190],"is":[36],"strong":[38],"asthmagen":[39],"in":[40,55,63,72,94,137,179,199,204,209,218],"semiarid":[41],"regions.":[42],"We":[43],"examined":[44],"the":[45,70,130,167,219],"proteases":[48,191],"A.":[50,65,82,116,145,162,171,189],"on":[52,58,161,176],"lung":[53,79],"inflammation":[54],"vivo":[56],"cleaving":[59],"protease-activated":[60],"receptor-2":[61],"(PAR(2))":[62],"vitro.":[64],"filtrate":[67,84],"applied":[68,85],"airway":[71,201],"nonsensitized":[73],"Balb/c":[74],"mice":[75],"induced":[76,92],"protease-dependent":[78],"inflammation.":[80],"Moreover,":[81],"human":[87,200],"bronchial":[88],"cells":[90,139],"(16HBE14o-)":[91],"changes":[93,148],"intracellular":[95],"Ca(2+)":[96,164,168],"concentration":[97],"([Ca(2+)](i)),":[98],"consistent":[99],"PAR(2)":[101,122,136,177,194],"activation.":[102],"These":[103,185,211],"effects":[104],"were":[105],"blocked":[106],"by":[107,111,121],"heat":[108],"inactivation":[109],"or":[110,126,142],"serine":[112],"inhibition":[114],"filtrates,":[118],"mimicked":[120],"specific":[123],"ligands":[124],"SLIGRL-NH(2)":[125],"2-furoyl-LIGRLO-NH(2),":[127],"but":[128],"not":[129],"PAR(1)-specific":[131],"ligand":[132],"TFLLR-NH(2).":[133],"Desensitization":[134],"16HBE14o-":[138],"2-furoyl-LIGRLO-NH(2)":[141],"trypsin":[143],"prevented":[144],"alternata-induced":[146,163],"[Ca(2+)](i)":[147,203],"while":[149],"desensitization":[150],"PAR(1),":[152],"PAR(3),":[153],"PAR(4)":[155],"thrombin":[157],"had":[158],"no":[159],"effect":[160],"responses.":[165],"Furthermore,":[166],"response":[169],"filtrates":[173],"was":[174],"dependent":[175],"expression":[178],"stably":[180],"transfected":[181],"HeLa":[182],"cell":[183,207],"models.":[184],"data":[186],"demonstrate":[187],"act":[192],"through":[193],"induce":[196],"rapid":[197],"increases":[198],"vitro":[205],"recruitment":[208],"vivo.":[210],"responses":[212],"likely":[214],"critical":[215],"early":[216],"steps":[217],"development":[220],"allergic":[222]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
