{"id":"https://openalex.org/W2142880945","doi":"https://doi.org/10.1158/1078-0432.ccr-11-0687","title":"Specific PET Imaging of xC\u2212 Transporter Activity Using a 18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism","display_name":"Specific PET Imaging of xC\u2212 Transporter Activity Using a 18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism","publication_year":2011,"publication_date":"2011-07-13","ids":{"openalex":"https://openalex.org/W2142880945","doi":"https://doi.org/10.1158/1078-0432.ccr-11-0687","mag":"2142880945","pmid":"https://pubmed.ncbi.nlm.nih.gov/21750203"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-11-0687","doi":"https://doi.org/10.1158/1078-0432.ccr-11-0687","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-11-0687","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001182989","display_name":"Norman Koglin","orcid":"https://orcid.org/0000-0001-7583-8201","observed_orcids":["https://orcid.org/0000-0001-7583-8201"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Norman Koglin","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073336819","display_name":"Andr\u00e9 Mueller","orcid":"https://orcid.org/0000-0001-7271-9303","observed_orcids":["https://orcid.org/0000-0001-7271-9303"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andre Mueller","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059197712","display_name":"Mathias Berndt","orcid":"https://orcid.org/0000-0002-5846-0398","observed_orcids":["https://orcid.org/0000-0002-5846-0398"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Berndt","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080143107","display_name":"Heribert Schmitt\u2010Willich","orcid":"https://orcid.org/0000-0002-3895-1093","observed_orcids":["https://orcid.org/0000-0002-3895-1093"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heribert Schmitt-Willich","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052007068","display_name":"Luisella Toschi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Luisella Toschi","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021075936","display_name":"Andrew Wills Stephens","orcid":"https://orcid.org/0000-0001-5052-6586","observed_orcids":["https://orcid.org/0000-0001-5052-6586","https://orcid.org/0000-0002-4434-2307"]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrew W. Stephens","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028931164","display_name":"Volker Gekeler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Gekeler","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038556008","display_name":"Matthias Friebe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Friebe","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112685194","display_name":"Ludger M. Dinkelborg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67348948","display_name":"Bayer (Germany)","ror":"https://ror.org/04hmn8g73","country_code":"DE","type":"company","lineage":["https://openalex.org/I67348948"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ludger M. Dinkelborg","raw_affiliation_strings":["Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliation: Global Drug Discovery, Bayer HealthCare, Berlin, Germany","institution_ids":["https://openalex.org/I67348948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I67348948"],"apc_list":null,"apc_paid":null,"fwci":5.3609,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.95990174,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"17","issue":"18","first_page":"6000","last_page":"6011"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9110999703407288,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.03359999880194664,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.023600000888109207,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/system-xc","display_name":"system xc-","score":0.6769999861717224},{"id":"https://openalex.org/keywords/cystine-glutamate-exchanger","display_name":"cystine/glutamate exchanger","score":0.9210000038146973},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.7960000038146973},{"id":"https://openalex.org/keywords/radiosynthesis","display_name":"radiotracer synthesis","score":0.6650000214576721},{"id":"https://openalex.org/keywords/tumor-specific-imaging","display_name":"tumor-specific imaging","score":0.5260000228881836},{"id":"https://openalex.org/keywords/tumor-to-background-ratio","display_name":"tumor-to-background ratio","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2776970183","wikidata":"https://www.wikidata.org/wiki/Q20155580","display_name":"Radiosynthesis","level":3,"score":0.7178387641906738},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6860508918762207},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5600515007972717},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5519647598266602},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5289759039878845},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.46079617738723755},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4417649507522583},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42134928703308105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37271568179130554},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33637258410453796},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3258489668369293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27110862731933594},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2297462522983551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1836112141609192},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011923","descriptor_name":"Rats, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027182","descriptor_name":"Amino Acid Transport System y+","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027182","descriptor_name":"Amino Acid Transport System y+","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064847","descriptor_name":"Multimodal Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-11-0687","doi":"https://doi.org/10.1158/1078-0432.ccr-11-0687","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-11-0687","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:21750203","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21750203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320303","display_name":"Bayer HealthCare","ror":"https://ror.org/04hmn8g73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W69095940","https://openalex.org/W564657590","https://openalex.org/W1484146962","https://openalex.org/W1515337665","https://openalex.org/W1531373906","https://openalex.org/W1596236557","https://openalex.org/W1599662080","https://openalex.org/W1774382181","https://openalex.org/W1844290099","https://openalex.org/W1965339680","https://openalex.org/W1971210299","https://openalex.org/W1978978516","https://openalex.org/W1980058210","https://openalex.org/W1981502499","https://openalex.org/W1989369955","https://openalex.org/W1996365670","https://openalex.org/W1999447004","https://openalex.org/W2003237182","https://openalex.org/W2011465631","https://openalex.org/W2014058353","https://openalex.org/W2014397667","https://openalex.org/W2015207840","https://openalex.org/W2028897202","https://openalex.org/W2038611992","https://openalex.org/W2041399911","https://openalex.org/W2044565982","https://openalex.org/W2044992110","https://openalex.org/W2047360716","https://openalex.org/W2056843519","https://openalex.org/W2058650387","https://openalex.org/W2060592426","https://openalex.org/W2068888011","https://openalex.org/W2079162384","https://openalex.org/W2082748378","https://openalex.org/W2090880672","https://openalex.org/W2101463846","https://openalex.org/W2108934854","https://openalex.org/W2137749199","https://openalex.org/W2138249892","https://openalex.org/W2139301359","https://openalex.org/W2151523321","https://openalex.org/W2153178365","https://openalex.org/W2162420845","https://openalex.org/W2169447002","https://openalex.org/W2332263328","https://openalex.org/W2952652342","https://openalex.org/W2998152615","https://openalex.org/W4285719527","https://openalex.org/W6615805031","https://openalex.org/W6638023825","https://openalex.org/W6638865642"],"related_works":["https://openalex.org/W1876494746","https://openalex.org/W2327893179","https://openalex.org/W2082970604","https://openalex.org/W2095452241","https://openalex.org/W2147896673","https://openalex.org/W2948816975","https://openalex.org/W2543912773","https://openalex.org/W2063345355","https://openalex.org/W2332263328","https://openalex.org/W2346639870"],"abstract_inverted_index":{"PURPOSE:":[0],"(18)F-labeled":[1],"small":[2],"molecules":[3],"targeting":[4],"adaptations":[5],"of":[6,46,52,62,67,100,146,152,229],"tumor":[7,14,106,171,177,181,189,230],"metabolism":[8],"possess":[9],"the":[10,50,77,86,113,156],"potential":[11],"for":[12,59,85,137,241],"early":[13],"detection":[15],"with":[16,175],"high":[17,180],"sensitivity":[18],"and":[19,103,144,170,179,235],"specificity":[20,109],"by":[21],"positron":[22],"emission":[23],"tomography":[24],"(PET)":[25],"imaging.":[26],"Compounds":[27],"tracing":[28],"deranged":[29],"pathways":[30],"other":[31],"than":[32],"glycolysis":[33],"may":[34],"have":[35],"advantages":[36],"in":[37,71,97,101,104,112,118,129,167,187,198,201,223,239],"situations":[38],"where":[39],"2-[\u00b9\u2078F]fluoro-2-deoxy-d-glucose":[40],"(FDG)":[41],"has":[42],"limitations.":[43],"The":[44,90,133],"aim":[45],"this":[47],"study":[48],"was":[49,83,95,110,135,185],"generation":[51],"a":[53,98,209,226],"metabolically":[54],"stable":[55],"\u00b9\u2078F-labeled":[56,92],"glutamate":[57,124],"analogue":[58],"PET":[60,93,173,212],"imaging":[61,174],"tumors.":[63],"EXPERIMENTAL":[64],"DESIGN:":[65],"Derivatives":[66],"l-glutamate":[68],"were":[69,165],"investigated":[70,111],"cell":[72,130],"competition":[73],"assays":[74],"to":[75,182,203,218],"characterize":[76],"responsible":[78],"transporter.":[79],"An":[80],"automated":[81],"radiosynthesis":[82,134],"established":[84,136],"most":[87],"promising":[88],"candidate.":[89],"resulting":[91],"tracer":[94,213],"characterized":[96],"panel":[99],"vitro":[102],"vivo":[105,224],"models.":[107,190],"Tumor":[108],"turpentine":[114],"oil-induced":[115],"inflammation":[116],"model":[117],"rats.":[119],"RESULTS:":[120],"A":[121],"fluoropropyl":[122],"substituted":[123],"derivative":[125],"showed":[126,149],"strong":[127],"inhibition":[128],"uptake":[131,142],"assays.":[132],"(4S)-4-(3-[\u00b9\u2078F]fluoropropyl)-l-glutamate":[138],"(BAY":[139],"94-9392).":[140],"Tracer":[141],"studies":[143,237],"analysis":[145],"knockdown":[147],"cells":[148],"specific":[150],"transport":[151],"BAY":[153,193,206],"94-9392":[154,194,207],"via":[155],"cystine/glutamate":[157],"exchanger":[158],"designated":[159],"as":[160,225],"system":[161,220],"x(C)(-).":[162],"No":[163],"metabolites":[164],"observed":[166],"mouse":[168],"blood":[169],"cells.":[172],"excellent":[176],"visualization":[178],"background":[183],"ratios":[184],"achieved":[186],"preclinical":[188,234],"In":[191],"addition,":[192],"did":[195],"not":[196],"accumulate":[197],"inflammatory":[199],"lesions":[200],"contrast":[202],"FDG.":[204],"CONCLUSIONS:":[205],"is":[208],"new":[210],"tumor-specific":[211],"which":[214],"could":[215],"be":[216],"useful":[217],"examine":[219],"x(C)(-)":[221],"activity":[222],"possible":[227],"hallmark":[228],"oxidative":[231],"stress.":[232],"Both":[233],"clinical":[236],"are":[238],"progress":[240],"further":[242],"characterization.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}