{"id":"https://openalex.org/W2142813879","doi":"https://doi.org/10.1373/clinchem.2008.113019","title":"A New Tool for Oligonulceotide Import into Cells","display_name":"A New Tool for Oligonulceotide Import into Cells","publication_year":2009,"publication_date":"2009-02-22","ids":{"openalex":"https://openalex.org/W2142813879","doi":"https://doi.org/10.1373/clinchem.2008.113019","mag":"2142813879","pmid":"https://pubmed.ncbi.nlm.nih.gov/19233917"},"language":"en","primary_location":{"id":"doi:10.1373/clinchem.2008.113019","doi":"https://doi.org/10.1373/clinchem.2008.113019","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.113019","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012724467","display_name":"Daniel C. Leslie","orcid":"https://orcid.org/0000-0003-0606-792X","observed_orcids":["https://orcid.org/0000-0003-0606-792X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel C Leslie","raw_affiliation_strings":["Departments of Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031563436","display_name":"James P. Landers","orcid":"https://orcid.org/0000-0002-9310-1796","observed_orcids":["https://orcid.org/0000-0002-9310-1796"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James P Landers","raw_affiliation_strings":["Departments of Chemistry","Mechanical Engineering; and","Pathology, University of Virginia, Charlottesville, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Chemistry","institution_ids":[]},{"raw_affiliation_string":"Mechanical Engineering; and","institution_ids":[]},{"raw_affiliation_string":"Pathology, University of Virginia, Charlottesville, VA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031563436"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":0.222,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.51224267,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"55","issue":"4","first_page":"609","last_page":"610"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligonucleotide-delivery","display_name":"oligonucleotide delivery","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.75},{"id":"https://openalex.org/keywords/antisense-oligonucleotides","display_name":"antisense oligonucleotides","score":0.9649999737739563},{"id":"https://openalex.org/keywords/gene-transfer-efficiency","display_name":"gene transfer efficiency","score":0.5410000085830688},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.5640000104904175},{"id":"https://openalex.org/keywords/homologous-recombination","display_name":"homologous recombination","score":0.7730000019073486},{"id":"https://openalex.org/keywords/gene-replacement","display_name":"gene replacement","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3935600519180298},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34861549735069275},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3291867971420288},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26549816131591797}],"mesh":[{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009841","descriptor_name":"Oligonucleotides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D049329","descriptor_name":"Nanostructures","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1373/clinchem.2008.113019","doi":"https://doi.org/10.1373/clinchem.2008.113019","is_oa":false,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.113019","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:19233917","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19233917","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1977569722","https://openalex.org/W1988190543","https://openalex.org/W2009993736","https://openalex.org/W2021107851","https://openalex.org/W2155095415"],"related_works":["https://openalex.org/W623520303","https://openalex.org/W2436917752","https://openalex.org/W2526258909","https://openalex.org/W4243923575","https://openalex.org/W4417318844","https://openalex.org/W4362561087","https://openalex.org/W2039022578","https://openalex.org/W4241352451","https://openalex.org/W7165317705","https://openalex.org/W2074276758"],"abstract_inverted_index":{"The":[0,19,110],"field":[1],"of":[2,12,85,90,102,132,147],"gene":[3,44,58,76,183],"therapy":[4],"potentially":[5],"offers":[6],"physicians":[7],"an":[8,177],"entirely":[9],"new":[10],"set":[11],"armaments":[13],"with":[14,158],"which":[15],"to":[16,32,71,112,117],"battle":[17],"disease.":[18],"approach,":[20],"radical":[21],"in":[22,26,49,107,129,135],"concept":[23],"but":[24],"powerful":[25],"its":[27],"potential":[28,155,174],"effect,":[29],"generically":[30],"aims":[31],"correct":[33],"defective":[34],"genes":[35,95],"responsible":[36],"for":[37,150,175],"disease":[38],"development":[39],"by":[40,53,142],"inserting":[41],"the":[42,50,56,74,83,86,103,108,115,124,130,143,167,173,187],"normal":[43],"into":[45,123,166],"a":[46,181],"nonspecific":[47],"location":[48],"genome":[51],"or":[52,81,96],"swapping":[54],"out":[55],"abnormal":[57,75],"through":[59],"homologous":[60],"recombination.":[61],"Perhaps":[62],"more":[63],"tangible,":[64],"near-term":[65],"approaches":[66],"are":[67,140],"those":[68],"that":[69,161],"look":[70],"either":[72],"repair":[73],"via":[77],"selective":[78],"reverse":[79],"mutation":[80],"\u201cknockdown\u201d":[82],"expression":[84],"mutated":[87],"gene.":[88],"Delivery":[89],"oligonucleotides,":[91],"whether":[92],"as":[93,170,172],"entire":[94],"shorter":[97],"antisense":[98],"strands,":[99],"remains":[100],"one":[101],"most":[104],"significant":[105],"challenges":[106],"field.":[109],"linchpin":[111],"success":[113],"is":[114],"ability":[116],"efficiently":[118],"and":[119,137],"selectively":[120],"insert":[121],"oligonucleotides":[122],"desired":[125],"cells.":[126],"Current":[127],"efforts":[128],"application":[131],"oligonucleotide":[133,151],"delivery":[134,184],"this":[136],"other":[138],"arenas":[139],"restricted":[141],"relatively":[144],"low":[145],"efficiency":[146],"methods":[148],"used":[149],"transfer.":[152],"In":[153],"addition,":[154],"hazards":[156],"exist":[157],"any":[159],"method":[160],"introduces":[162],"foreign":[163],"biological":[164],"material":[165],"body\u2014toxicity":[168],"issues":[169],"well":[171],"mounting":[176],"immune":[178],"response":[179],"against":[180],"specific":[182],"vehicle":[185],"complicate":[186],"challenge.":[188]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
