{"id":"https://openalex.org/W2142803386","doi":null,"title":"ROLE OF LATENT EBV GENES IN THE INDUCTION OF GENOMIC INSTABILITY IN BURKITT'S LYMPHOMA","display_name":"ROLE OF LATENT EBV GENES IN THE INDUCTION OF GENOMIC INSTABILITY IN BURKITT'S LYMPHOMA","publication_year":2009,"publication_date":"2009-05-21","ids":{"openalex":"https://openalex.org/W2142803386","mag":"2142803386"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26901700","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Role_of_latent_EBV_genes_in_the_induction_of_genomic_instability_in_Burkitt_s_lymphoma/26901700","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/39017","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055343588","display_name":"Bettina Gruhne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bettina Gruhne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055343588"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epstein-barr-virus","display_name":"Epstein-Barr virus","score":0.9589999914169312},{"id":"https://openalex.org/keywords/burkitt-lymphoma","display_name":"Burkitt lymphoma","score":0.9419999718666077},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.9330000281333923},{"id":"https://openalex.org/keywords/ebna1","display_name":"EBNA1","score":0.7960000038146973},{"id":"https://openalex.org/keywords/dicentric-chromosomes","display_name":"dicentric chromosomes","score":0.7129999995231628},{"id":"https://openalex.org/keywords/telomere-dysfunction","display_name":"telomere dysfunction","score":0.7770000100135803},{"id":"https://openalex.org/keywords/h2ax-phosphorylation","display_name":"H2AX phosphorylation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9810000061988831},{"id":"https://openalex.org/keywords/nadph-oxidase-2","display_name":"NADPH oxidase 2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/nox2","display_name":"NOX2","score":0.4480000138282776},{"id":"https://openalex.org/keywords/viral-transcriptional-regulation","display_name":"viral transcription regulation","score":0.47200000286102295}],"concepts":[{"id":"https://openalex.org/C178169997","wikidata":"https://www.wikidata.org/wiki/Q2892636","display_name":"Genome instability","level":4,"score":0.7227323055267334},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5049899220466614},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4994771480560303},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.48022323846817017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4386095404624939},{"id":"https://openalex.org/C207821765","wikidata":"https://www.wikidata.org/wiki/Q405372","display_name":"Instability","level":2,"score":0.4243486225605011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40793120861053467},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38102656602859497},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33839690685272217},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33204638957977295},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.293899804353714},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10343089699745178},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.08223196864128113},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.0572609007358551},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26901700","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Role_of_latent_EBV_genes_in_the_induction_of_genomic_instability_in_Burkitt_s_lymphoma/26901700","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/39017","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39017","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2142803386","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/39017/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/39017","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/39017","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":211,"referenced_works":["https://openalex.org/W8047324","https://openalex.org/W37844384","https://openalex.org/W41630896","https://openalex.org/W43558850","https://openalex.org/W50462763","https://openalex.org/W86122477","https://openalex.org/W147000388","https://openalex.org/W184238969","https://openalex.org/W241669560","https://openalex.org/W1480741751","https://openalex.org/W1486724739","https://openalex.org/W1488614375","https://openalex.org/W1489123075","https://openalex.org/W1490220034","https://openalex.org/W1506669504","https://openalex.org/W1520599149","https://openalex.org/W1533555842","https://openalex.org/W1541806623","https://openalex.org/W1543358981","https://openalex.org/W1559439026","https://openalex.org/W1563899879","https://openalex.org/W1578954095","https://openalex.org/W1579336178","https://openalex.org/W1581524975","https://openalex.org/W1597842281","https://openalex.org/W1598586133","https://openalex.org/W1823206601","https://openalex.org/W1835750525","https://openalex.org/W1844848296","https://openalex.org/W1894612901","https://openalex.org/W1964632614","https://openalex.org/W1965041408","https://openalex.org/W1966082666","https://openalex.org/W1966831463","https://openalex.org/W1967630964","https://openalex.org/W1967776511","https://openalex.org/W1968221261","https://openalex.org/W1968857299","https://openalex.org/W1972992388","https://openalex.org/W1975544278","https://openalex.org/W1975562645","https://openalex.org/W1976558883","https://openalex.org/W1976859150","https://openalex.org/W1977372263","https://openalex.org/W1979492815","https://openalex.org/W1980017984","https://openalex.org/W1980972136","https://openalex.org/W1984841196","https://openalex.org/W1985804036","https://openalex.org/W1987562395","https://openalex.org/W1992319818","https://openalex.org/W1992708996","https://openalex.org/W1993546845","https://openalex.org/W1994723579","https://openalex.org/W1995405908","https://openalex.org/W1995786068","https://openalex.org/W1997937385","https://openalex.org/W1998129814","https://openalex.org/W2000206408","https://openalex.org/W2000603439","https://openalex.org/W2000971601","https://openalex.org/W2001514368","https://openalex.org/W2003493907","https://openalex.org/W2008693647","https://openalex.org/W2008697983","https://openalex.org/W2010202988","https://openalex.org/W2010852984","https://openalex.org/W2011463832","https://openalex.org/W2011870420","https://openalex.org/W2013059054","https://openalex.org/W2013073993","https://openalex.org/W2013857015","https://openalex.org/W2014089858","https://openalex.org/W2015221134","https://openalex.org/W2015809080","https://openalex.org/W2019366492","https://openalex.org/W2020811267","https://openalex.org/W2021073898","https://openalex.org/W2021949742","https://openalex.org/W2022416825","https://openalex.org/W2022811243","https://openalex.org/W2023530705","https://openalex.org/W2026608413","https://openalex.org/W2026677489","https://openalex.org/W2027782774","https://openalex.org/W2029304297","https://openalex.org/W2031081061","https://openalex.org/W2035607655","https://openalex.org/W2035967445","https://openalex.org/W2036013347","https://openalex.org/W2041230744","https://openalex.org/W2043843485","https://openalex.org/W2043895957","https://openalex.org/W2044377496","https://openalex.org/W2046950493","https://openalex.org/W2047197428","https://openalex.org/W2048737737","https://openalex.org/W2048905748","https://openalex.org/W2049598883","https://openalex.org/W2050064956","https://openalex.org/W2051566601","https://openalex.org/W2054823635","https://openalex.org/W2055476151","https://openalex.org/W2056351871","https://openalex.org/W2057154903","https://openalex.org/W2057749060","https://openalex.org/W2058815198","https://openalex.org/W2060001883","https://openalex.org/W2061319065","https://openalex.org/W2062348957","https://openalex.org/W2063148408","https://openalex.org/W2063258533","https://openalex.org/W2066158249","https://openalex.org/W2067880946","https://openalex.org/W2068118422","https://openalex.org/W2072327741","https://openalex.org/W2072742143","https://openalex.org/W2072744580","https://openalex.org/W2074779681","https://openalex.org/W2075130635","https://openalex.org/W2075724873","https://openalex.org/W2075965000","https://openalex.org/W2076198853","https://openalex.org/W2076226859","https://openalex.org/W2076314401","https://openalex.org/W2079053367","https://openalex.org/W2079199354","https://openalex.org/W2079520166","https://openalex.org/W2079680569","https://openalex.org/W2082678443","https://openalex.org/W2083287556","https://openalex.org/W2084089807","https://openalex.org/W2084695608","https://openalex.org/W2084745121","https://openalex.org/W2085128107","https://openalex.org/W2086632920","https://openalex.org/W2088555353","https://openalex.org/W2090026828","https://openalex.org/W2093647324","https://openalex.org/W2093913386","https://openalex.org/W2094364202","https://openalex.org/W2095572685","https://openalex.org/W2097055664","https://openalex.org/W2097432692","https://openalex.org/W2105613536","https://openalex.org/W2107699904","https://openalex.org/W2108385487","https://openalex.org/W2110223248","https://openalex.org/W2111772438","https://openalex.org/W2111817213","https://openalex.org/W2115503551","https://openalex.org/W2116449651","https://openalex.org/W2117427524","https://openalex.org/W2117903701","https://openalex.org/W2118562565","https://openalex.org/W2122922362","https://openalex.org/W2123119659","https://openalex.org/W2124427501","https://openalex.org/W2125954811","https://openalex.org/W2126376871","https://openalex.org/W2127566231","https://openalex.org/W2128016135","https://openalex.org/W2128179579","https://openalex.org/W2133074755","https://openalex.org/W2134971124","https://openalex.org/W2136724377","https://openalex.org/W2136941153","https://openalex.org/W2137251094","https://openalex.org/W2138366746","https://openalex.org/W2138617654","https://openalex.org/W2139700920","https://openalex.org/W2142617008","https://openalex.org/W2144870469","https://openalex.org/W2145339783","https://openalex.org/W2145393265","https://openalex.org/W2147226937","https://openalex.org/W2147762577","https://openalex.org/W2148156213","https://openalex.org/W2149738995","https://openalex.org/W2149881769","https://openalex.org/W2151473316","https://openalex.org/W2151858819","https://openalex.org/W2152771893","https://openalex.org/W2155224240","https://openalex.org/W2158005145","https://openalex.org/W2158107632","https://openalex.org/W2158482424","https://openalex.org/W2159064436","https://openalex.org/W2159327683","https://openalex.org/W2161002061","https://openalex.org/W2161409973","https://openalex.org/W2161791847","https://openalex.org/W2162025005","https://openalex.org/W2164034599","https://openalex.org/W2164492333","https://openalex.org/W2165042359","https://openalex.org/W2168219542","https://openalex.org/W2169249442","https://openalex.org/W2172074492","https://openalex.org/W2181273207","https://openalex.org/W2253416408","https://openalex.org/W2313847155","https://openalex.org/W2322323980","https://openalex.org/W2333225812","https://openalex.org/W2357688804","https://openalex.org/W2410054902","https://openalex.org/W2415949788","https://openalex.org/W2417062513","https://openalex.org/W2419303398","https://openalex.org/W2508147121","https://openalex.org/W2613845824"],"related_works":["https://openalex.org/W2061541027","https://openalex.org/W7056215985","https://openalex.org/W2074675451","https://openalex.org/W1978032326","https://openalex.org/W2149881769","https://openalex.org/W7213868155","https://openalex.org/W2063159220","https://openalex.org/W1567431072","https://openalex.org/W2734976255","https://openalex.org/W4414511328"],"abstract_inverted_index":{"Epidemiological":[0],"and":[1,14,37,49,104,112,125,151,157,171,195,243,262,342,354,387,412,467,492,624],"molecular":[2,176],"evidence":[3],"link":[4],"Epstein-Barr":[5,575,609],"virus":[6,22,545,576,610],"(EBV)":[7],"infection":[8],"to":[9,23,325,407,429,464,518],"a":[10,34,83,138,282,391,434,477],"variety":[11],"of":[12,20,33,42,57,91,129,147,155,159,179,186,228,245,255,276,285,293,308,315,335,340,344,372,381,393,396,410,420,424,447,453,458,470,480,487,495,509,521,531,584],"lymphoid":[13],"epithelial":[15],"malignancies":[16],"but":[17],"the":[18,21,31,40,55,61,70,89,226,246,256,301,316,338,370,379,397,471,488,507,519],"contribution":[19],"tumorigenesis":[24],"is":[25,54,215],"unclear.":[26],"Genomic":[27],"instability,":[28],"defined":[29],"by":[30,39,78,253,349,377,515,617],"establishment":[32],"mutator":[35],"phenotype":[36],"characterized":[38],"occurrence":[41,227,380],"non-clonal":[43,92],"chromosomal":[44,93,382],"aberrations,":[45,94,239],"excessive":[46],"DNA":[47,52,169,241,247,257,385,441,454,619,622],"damage":[48,170,242,258,386,442],"defects":[50],"in":[51,64,86,109,120,141,163,189,198,218,231,270,329,337,369,390,462,506,527,549],"repair,":[53],"hallmark":[56],"malignant":[58,76],"transformation.":[59],"In":[60,405],"studies":[62],"described":[63],"this":[65,87,212],"thesis,":[66],"we":[67],"have":[68],"explored":[69],"possibility":[71,357],"that":[72,202,358,482,501],"EBV":[73,110,122,126,130,133,164,180,192,219,294,309,364],"may":[74,208,366],"promote":[75,430,614],"transformation":[77],"inducing":[79,618],"genomic":[80,229,277,345,373,421,431,522,547,580,615],"instability.":[81,422],"As":[82],"first":[84],"step":[85],"analysis,":[88],"presence":[90],"including":[95],"dicentric":[96,148],"chromosomes,":[97,149],"chromosome":[98],"fragments,":[99],"gaps,":[100],"rings,":[101],"satellite":[102],"associations":[103],"double":[105],"minutes,":[106],"was":[107,135,323,347,375,414,449,483],"investigated":[108,224],"positive":[111,131,165],"negative":[113],"Burkitt":[114],"s":[115],"lymphoma":[116],"(BL)":[117],"cell":[118,166,626],"lines,":[119],"vitro":[121],"converted":[123],"BLs":[124],"genome-loss":[127],"variants":[128],"tumors.":[132],"carriage":[134],"associated":[136,280,363,415,450,484],"with":[137,145,281,416,451,485],"significant":[139,283],"increase":[140,185,197,284],"abnormal":[142,187],"metaphase":[143],"plates":[144],"prevalence":[146],"fragments":[150],"gaps.":[152],"Increased":[153],"phosphorylation":[154,254],"H2AX":[156],"lengthening":[158],"telomeres":[160],"were":[161,268,279],"detected":[162,252],"lines":[167],"suggesting":[168,201],"telomere":[172],"dysfunction":[173],"as":[174,251,305,524],"possible":[175,306],"mechanisms.":[177],"Analysis":[178],"gene":[181],"expression":[182,409,446,475],"revealed":[183],"an":[184],"metaphases":[188],"cells":[190,232],"expressing":[191,233,272,331],"latency":[193,199,362,403,611],"I":[194],"further":[196],"III,":[200],"more":[203,359],"than":[204,360],"one":[205,361],"viral":[206,426,528],"protein":[207],"be":[209,326,367],"responsible":[210],"for":[211],"phenotype.":[213],"EBNA-1":[214,271,330,438],"always":[216],"expressed":[217],"carrying":[220,401],"proliferating":[221],"cells.":[222,273,332],"We":[223],"therefore":[225],"instability":[230,278,346,374,432,523,548,581,616],"stable":[234],"or":[235],"inducible":[236],"EBNA-1.":[237],"Chromosomal":[238],"increased":[240,384],"activation":[244,389],"Damage":[248],"Response":[249],"(DDR)":[250],"sensing":[259],"kinase":[260],"ATM":[261],"its":[263],"downstream":[264],"target":[265],"histone":[266],"H2AX,":[267],"observed":[269],"These":[274],"signs":[275],"endogenous":[286],"reactive":[287,585],"oxygen":[288,586],"species":[289],"(ROS).":[290],"Bioinformatic":[291],"analysis":[292],"regulated":[295],"genes":[296,299],"identified":[297],"four":[298],"within":[300],"ROS":[302,317,341],"metabolic":[303],"pathway":[304],"targets":[307],"transcriptional":[310,493],"regulation.":[311],"The":[312,333,356],"catalytic":[313],"subunit":[314],"producing":[318],"NADPH":[319],"Oxidase":[320],"2":[321],"(Nox2)":[322],"shown":[324],"selectively":[327],"upregulated":[328],"involvement":[334],"Nox2":[336],"production":[339],"induction":[343,371,520,583],"confirmed":[348],"functional":[350],"inactivation":[351,469,486],"using":[352],"chemicals":[353],"RNAi.":[355],"product":[365],"involved":[368,505],"addressed":[376],"investigating":[378],"aberrations":[383],"DDR":[388],"panel":[392],"transfected":[394],"sub-lines":[395],"B-lymphoma":[398],"line":[399],"BJAB":[400],"individual":[402],"genes.":[404],"addition":[406],"EBNA-1,":[408],"EBNA-3C":[411,474],"LMP-1":[413,448],"these":[417,425,498],"phenotypic":[418],"markers":[419],"Each":[423],"proteins":[427,612],"appears":[428],"through":[433],"different":[435],"mechanism.":[436],"Only":[437],"directly":[439],"induced":[440,476],"via":[443,456,582],"ROS,":[444],"while":[445],"inhibition":[452],"repair":[455,623],"downregulation":[457,494],"ATM,":[459],"which":[460],"resulted":[461],"failure":[463],"phosphorylate":[465],"Chk2":[466],"consequent":[468],"G2":[472],"checkpoint.":[473],"high":[478],"degree":[479],"aneuploidy":[481],"mitotic":[489],"spindle":[490],"checkpoint":[491],"BubR1.":[496],"Collectively":[497],"results":[499],"indicate":[500],"multiple":[502],"cellular":[503],"functions":[504],"maintenance":[508],"genome":[510],"integrity":[511],"are":[512],"independently":[513,613],"targeted":[514],"EBV,":[516],"pointing":[517],"critical":[525],"event":[526],"oncogenesis.":[529],"List":[530],"scientific":[532],"papers":[533],"I.":[534],"Kamranvar":[535,567],"SA,":[536,568],"Gruhne":[537,561,603],"B,":[538,562,604],"Szeles":[539],"A,":[540],"Masucci":[541,571,605],"MG":[542,572,606],"(2007).":[543],"\"Epstein-Barr":[544],"promotes":[546,579],"Burkitts":[550],"lymphoma.\"":[551],"Oncogene":[552],"26(35):":[553],"5115-23.":[554],"Epub":[555,597],"2007":[556],"Feb":[557],"26":[558],"https://pubmed.ncbi.nlm.nih.gov/17325665":[559],"II.":[560],"Sompallae":[563],"R,":[564],"Marescotti":[565],"D,":[566],"Gastaldello":[569],"S,":[570],"(2009).":[573,607],"\"The":[574],"nuclear":[577],"antigen-1":[578],"species.\"":[587],"Proc":[588],"Natl":[589],"Acad":[590],"Sci":[591],"U":[592],"S":[593],"A":[594],"106(7):":[595],"2313-8.":[596],"2009":[598],"Jan":[599],"12":[600],"https://pubmed.ncbi.nlm.nih.gov/19139406":[601],"III.":[602],"\"Three":[608],"damage,":[620],"inhibiting":[621],"inactivating":[625],"cycle":[627],"checkpoints.\"":[628],"(Submitted)":[629]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}