{"id":"https://openalex.org/W2142634854","doi":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","title":"Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis","display_name":"Leishmania salvage and remodelling of host sphingolipids in amastigote survival and acidocalcisome biogenesis","publication_year":2005,"publication_date":"2005-02-04","ids":{"openalex":"https://openalex.org/W2142634854","doi":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","mag":"2142634854","pmid":"https://pubmed.ncbi.nlm.nih.gov/15720561","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3803142"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2958.2005.04493.x","doi":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2005.04493.x","source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2005.04493.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100323985","display_name":"Kai Zhang","orcid":"https://orcid.org/0000-0002-6616-1806","observed_orcids":["https://orcid.org/0000-0002-6616-1806"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Zhang","raw_affiliation_strings":["Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038207517","display_name":"Fong\u2010Fu Hsu","orcid":"https://orcid.org/0000-0001-5368-0183","observed_orcids":["https://orcid.org/0000-0001-5368-0183"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fong\u2010Fu Hsu","raw_affiliation_strings":["Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008199007","display_name":"David A. Scott","orcid":"https://orcid.org/0000-0002-8668-2449","observed_orcids":["https://orcid.org/0000-0002-8668-2449"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Scott","raw_affiliation_strings":["Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA","Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000842323","display_name":"Roberto Docampo","orcid":"https://orcid.org/0000-0003-4229-8784","observed_orcids":["https://orcid.org/0000-0003-4229-8784"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Docampo","raw_affiliation_strings":["Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015602933","display_name":"JOHN W. TURK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Turk","raw_affiliation_strings":["Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007063454","display_name":"Stephen M. Beverley","orcid":"https://orcid.org/0000-0001-5319-0811","observed_orcids":["https://orcid.org/0000-0001-5319-0811"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen M. Beverley","raw_affiliation_strings":["Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, Box 8230, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007063454"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":7.9309,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.97722069,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"55","issue":"5","first_page":"1566","last_page":"1578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.005799999926239252,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania-major","display_name":"Leishmania major","score":0.996999979019165},{"id":"https://openalex.org/keywords/sphingolipids","display_name":"sphingolipids","score":0.9610000252723694},{"id":"https://openalex.org/keywords/inositol-phosphorylceramide","display_name":"inositol phosphorylceramide","score":0.8349999785423279},{"id":"https://openalex.org/keywords/acidocalcisomes","display_name":"acidocalcisomes","score":0.6830000281333923},{"id":"https://openalex.org/keywords/amastigotes","display_name":"amastigotes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/promastigotes","display_name":"promastigotes","score":0.7590000033378601},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.5849999785423279},{"id":"https://openalex.org/keywords/macrophage-survival","display_name":"macrophage survival","score":0.7250000238418579},{"id":"https://openalex.org/keywords/lysosome-related-organelles","display_name":"lysosome-related organelles","score":0.847000002861023},{"id":"https://openalex.org/keywords/multivesicular-bodies","display_name":"multivesicular bodies","score":0.7699999809265137},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.5600000023841858}],"concepts":[{"id":"https://openalex.org/C98319499","wikidata":"https://www.wikidata.org/wiki/Q455445","display_name":"Amastigote","level":4,"score":0.9307655096054077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8994417190551758},{"id":"https://openalex.org/C2779546828","wikidata":"https://www.wikidata.org/wiki/Q6556736","display_name":"Lipophosphoglycan","level":5,"score":0.8005788922309875},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.7592308521270752},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6987591981887817},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.6739842295646667},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.6361030340194702},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.5755451321601868},{"id":"https://openalex.org/C155432671","wikidata":"https://www.wikidata.org/wiki/Q17073362","display_name":"Organelle biogenesis","level":4,"score":0.5360015034675598},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.33042964339256287},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29063865542411804},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.2850465178489685},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1488286852836609},{"id":"https://openalex.org/C2781333301","wikidata":"https://www.wikidata.org/wiki/Q1950752","display_name":"Leishmania donovani","level":4,"score":0.14756393432617188},{"id":"https://openalex.org/C2776555147","wikidata":"https://www.wikidata.org/wiki/Q331283","display_name":"Leishmaniasis","level":2,"score":0.11053293943405151},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06525251269340515},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C2778689377","wikidata":"https://www.wikidata.org/wiki/Q2046113","display_name":"Visceral leishmaniasis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1365-2958.2005.04493.x","doi":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2005.04493.x","source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},{"id":"pmid:15720561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15720561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2792873","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3803142","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3803142","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3803142","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2958.2005.04493.x","doi":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2958.2005.04493.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2958.2005.04493.x","source":{"id":"https://openalex.org/S102549058","display_name":"Molecular Microbiology","issn_l":"0950-382X","issn":["0950-382X","1365-2958"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.428600013256073}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1565341982","display_name":null,"funder_award_id":"P41-RR000954","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1607414689","display_name":null,"funder_award_id":"P41 RR-00954","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1622861684","display_name":null,"funder_award_id":"P60-DK20579","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1705444535","display_name":null,"funder_award_id":"AI23259","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1964889935","display_name":"Diabetes Research & Training Center","funder_award_id":"5p60dk020579-35","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3061316713","display_name":null,"funder_award_id":"AI 21903","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G453359876","display_name":"A Resource for Biomedical Mass Spectrometry","funder_award_id":"5p41rr000954-34","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5042754251","display_name":"Acidocalcisomes in Trypanosoma cruzi","funder_award_id":"R21AI023259","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6931879977","display_name":"DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA","funder_award_id":"R01AI021903","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G77255095","display_name":"ACIDOCALCISOMES IN TRYPANOSOMA CRUZI","funder_award_id":"R01AI023259","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G87705910","display_name":null,"funder_award_id":"P60-DK-020579","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868406","display_name":"Washington University Nutrition Obesity Research Center","funder_award_id":"P30DK056341","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G910066946","display_name":"DRUG RESISTANCE AND GENE AMPLIFICATION IN LEISHMANIA","funder_award_id":"R37AI021903","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2142634854.pdf","grobid_xml":"https://content.openalex.org/works/W2142634854.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W51578940","https://openalex.org/W212361883","https://openalex.org/W318054603","https://openalex.org/W1535433473","https://openalex.org/W1539102283","https://openalex.org/W1570068227","https://openalex.org/W1639192928","https://openalex.org/W1855405486","https://openalex.org/W1964395067","https://openalex.org/W1967545598","https://openalex.org/W1967872268","https://openalex.org/W1976608130","https://openalex.org/W1979353967","https://openalex.org/W1987013095","https://openalex.org/W1989859478","https://openalex.org/W1994879603","https://openalex.org/W2002204067","https://openalex.org/W2002315028","https://openalex.org/W2005097296","https://openalex.org/W2005978096","https://openalex.org/W2008002968","https://openalex.org/W2013771465","https://openalex.org/W2018138443","https://openalex.org/W2021505229","https://openalex.org/W2024211563","https://openalex.org/W2028663640","https://openalex.org/W2039070421","https://openalex.org/W2046208000","https://openalex.org/W2047149101","https://openalex.org/W2051731160","https://openalex.org/W2052745477","https://openalex.org/W2070396907","https://openalex.org/W2075907568","https://openalex.org/W2081380820","https://openalex.org/W2087100451","https://openalex.org/W2087677809","https://openalex.org/W2099989610","https://openalex.org/W2100312575","https://openalex.org/W2103951463","https://openalex.org/W2113351822","https://openalex.org/W2123540590","https://openalex.org/W2134708266","https://openalex.org/W2136311909","https://openalex.org/W2136662212","https://openalex.org/W2146046478","https://openalex.org/W2156915710","https://openalex.org/W2167986691","https://openalex.org/W2169931949","https://openalex.org/W2299319945","https://openalex.org/W2300399382","https://openalex.org/W2341415803","https://openalex.org/W2402676464","https://openalex.org/W2461551233","https://openalex.org/W3129911986","https://openalex.org/W4211044652","https://openalex.org/W4247632830"],"related_works":["https://openalex.org/W4296817116","https://openalex.org/W1987013095","https://openalex.org/W2050403312","https://openalex.org/W7100673336","https://openalex.org/W2012027695","https://openalex.org/W2146046478","https://openalex.org/W3186643232","https://openalex.org/W7099847337","https://openalex.org/W2139138716","https://openalex.org/W7149880405"],"abstract_inverted_index":{"Sphingolipids":[0],"(SLs)":[1],"play":[2,205],"essential":[3],"roles":[4,207],"in":[5,9,26,46,53,93,187,208,214],"most":[6,88],"eukaryotes,":[7],"but":[8,35],"the":[10,66,76,120,133,143,162,173,179,215],"trypanosomatid":[11],"protozoan":[12],"Leishmania":[13],"major":[14],"their":[15],"functions":[16],"differ":[17],"significantly.":[18],"Previously":[19],"we":[20,71,156],"showed":[21,72,138],"that":[22,139,149],"null":[23],"mutants":[24],"defective":[25],"de":[27],"novo":[28],"sphingoid":[29],"base":[30],"synthesis":[31],"(spt2-)":[32],"lacked":[33],"SLs":[34,198],"grew":[36],"well":[37],"and":[38,61,82,103,111,192,199,211],"retained":[39,75],"lipid":[40],"rafts":[41],"while":[42],"replicating":[43],"as":[44,86],"promastigotes":[45,164],"vitro.":[47],"However,":[48,92,185],"they":[49],"experienced":[50],"catastrophic":[51],"defects":[52],"membrane":[54],"trafficking":[55],"on":[56],"entry":[57],"into":[58],"stationary":[59],"phase,":[60],"failed":[62],"to":[63,65,78,109,172],"differentiate":[64],"infective":[67],"metacyclic":[68],"form.":[69],"Here":[70],"this":[73,176],"mutant":[74],"ability":[77],"enter":[79],"macrophages":[80,110],"silently":[81],"inhibit":[83],"activation,":[84],"although":[85],"expected":[87],"parasites":[89,150],"were":[90,106],"destroyed.":[91],"mouse":[94],"infections,":[95],"after":[96],"a":[97,158],"delay":[98],"rapidly":[99],"progressive":[100],"lesions":[101],"appeared,":[102],"purified":[104],"amastigotes":[105,189,204],"fully":[107],"virulent":[108],"mice.":[112],"Mass":[113],"spectrometry":[114],"of":[115,122,125,145,161,175,197],"spt2-":[116,163,188],"amastigote":[117],"lipids":[118],"revealed":[119],"presence":[121],"high":[123],"levels":[124],"parasite-specific":[126],"inositol":[127],"phosphorylceramides":[128],"(IPCs)":[129],"not":[130],"synthesized":[131],"by":[132,202],"mammalian":[134],"hosts.":[135],"Inhibitor":[136],"studies":[137],"salvage":[140,196],"occurs":[141],"at":[142],"level":[144],"complex":[146],"SLs,":[147],"suggesting":[148],"carry":[151],"out":[152],"'headgroup'":[153],"remodelling.":[154],"Additionally,":[155],"describe":[157],"new":[159],"defect":[160],"involving":[165],"'empty'":[166],"acidocalcisomes":[167],"(ACs),":[168],"which":[169],"may":[170],"point":[171],"origin":[174],"organelle":[177],"from":[178],"lysosome-related":[180],"organelle/multivesicular":[181],"body":[182],"biogenesis":[183,210],"pathway.":[184],"ACs":[186],"appeared":[190],"quantitatively":[191],"morphologically":[193],"normal.":[194],"Thus":[195],"other":[200],"molecules":[201],"intracellular":[203],"key":[206],"AC":[209],"parasite":[212],"survival":[213],"host.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}