{"id":"https://openalex.org/W2142406885","doi":"https://doi.org/10.1161/01.str.0000196987.68770.b3","title":"Genome-Wide Scan for White Matter Hyperintensity","display_name":"Genome-Wide Scan for White Matter Hyperintensity","publication_year":2005,"publication_date":"2005-12-02","ids":{"openalex":"https://openalex.org/W2142406885","doi":"https://doi.org/10.1161/01.str.0000196987.68770.b3","mag":"2142406885","pmid":"https://pubmed.ncbi.nlm.nih.gov/16322484"},"language":"en","primary_location":{"id":"doi:10.1161/01.str.0000196987.68770.b3","doi":"https://doi.org/10.1161/01.str.0000196987.68770.b3","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.0000196987.68770.b3","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003219679","display_name":"Anita L. DeStefano","orcid":"https://orcid.org/0000-0002-9335-2819","observed_orcids":["https://orcid.org/0000-0002-9335-2819"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita L. DeStefano","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Anita L. DeStefano From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Anita L. DeStefano From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025242738","display_name":"Larry D. Atwood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry D. Atwood","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Larry D. Atwood From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Larry D. Atwood From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008596377","display_name":"Joseph M. Massaro","orcid":"https://orcid.org/0000-0002-2682-4812","observed_orcids":["https://orcid.org/0000-0002-2682-4812"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Massaro","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Joseph M. Massaro From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Joseph M. Massaro From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057944271","display_name":"Nancy L. Heard\u2010Costa","orcid":"https://orcid.org/0000-0001-9730-0306","observed_orcids":["https://orcid.org/0000-0001-9730-0306"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy Heard-Costa","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Nancy Heard-Costa From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Nancy Heard-Costa From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063754448","display_name":"Alexa Beiser","orcid":"https://orcid.org/0000-0001-8551-7778","observed_orcids":["https://orcid.org/0000-0001-8551-7778"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa Beiser","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017168859","display_name":"Rhoda Au","orcid":"https://orcid.org/0000-0001-7742-4491","observed_orcids":["https://orcid.org/0000-0001-7742-4491"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhoda Au","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Rhoda Au From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Rhoda Au From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036370752","display_name":"Philip A. Wolf","orcid":"https://orcid.org/0000-0002-7752-3526","observed_orcids":["https://orcid.org/0000-0002-7752-3526"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip A. Wolf","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Philip A. Wolf From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"Philip A. Wolf From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071825455","display_name":"Charles S DeCarli","orcid":"https://orcid.org/0000-0003-1914-2693","observed_orcids":["https://orcid.org/0000-0003-1914-2693"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles DeCarli","raw_affiliation_strings":["From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","Charles DeCarli From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass; the Department of Neurology (A.L.D., L.D.A., N.H.-C., R.A., P.A.W.), Boston University School of Medicine, Boston, Mass; the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass; Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I111088046","https://openalex.org/I84218800"]},{"raw_affiliation_string":"Charles DeCarli From the Department of Biostatistics (A.L.D., L.D.A., J.M.M., A.B.), Boston University School of Public Health, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]},{"raw_affiliation_string":"Department of Neurology and Center for Neuroscience (C.D.), University of California at Davis, Sacramento, Calif","institution_ids":["https://openalex.org/I84218800"]},{"raw_affiliation_string":"the Department of Mathematics and Statistics (J.M.M.), Boston University, Boston, Mass","institution_ids":["https://openalex.org/I111088046"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.2792,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.94339193,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"37","issue":"1","first_page":"77","last_page":"81"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter-hyperintensities","display_name":"white matter hyperintensities","score":0.9850000143051147},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.6830000281333923},{"id":"https://openalex.org/keywords/chromosome-4","display_name":"chromosome 4","score":0.8999999761581421},{"id":"https://openalex.org/keywords/chromosome-17","display_name":"chromosome 17","score":0.781000018119812},{"id":"https://openalex.org/keywords/heritability","display_name":"heritability","score":0.7179999947547913},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6650000214576721},{"id":"https://openalex.org/keywords/cerebrovascular-disease","display_name":"cerebrovascular disease","score":0.9869999885559082},{"id":"https://openalex.org/keywords/framingham-heart-study","display_name":"Framingham Heart Study","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.8278263807296753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7562007904052734},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.61616450548172},{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.6036956906318665},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.4989013671875},{"id":"https://openalex.org/C142870003","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Genetic linkage","level":3,"score":0.49311158061027527},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.47274813055992126},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.45899397134780884},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45821091532707214},{"id":"https://openalex.org/C31266012","wikidata":"https://www.wikidata.org/wiki/Q6554340","display_name":"Linkage (software)","level":3,"score":0.44066858291625977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3839365541934967},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3792787194252014},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.36348581314086914},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3539361357688904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2726132273674011},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.22037425637245178},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.21674680709838867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11952468752861023},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.11729663610458374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1097639799118042},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002894","descriptor_name":"Chromosomes, Human, Pair 4","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008040","descriptor_name":"Genetic Linkage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019655","descriptor_name":"Quantitative Trait, Heritable","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1161/01.str.0000196987.68770.b3","doi":"https://doi.org/10.1161/01.str.0000196987.68770.b3","is_oa":false,"landing_page_url":"https://doi.org/10.1161/01.str.0000196987.68770.b3","pdf_url":null,"source":{"id":"https://openalex.org/S62532593","display_name":"Stroke","issn_l":"0039-2499","issn":["0039-2499","1524-4628"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"journal-article"},{"id":"pmid:16322484","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16322484","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stroke","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G250621538","display_name":null,"funder_award_id":"N01\u2010HC25195","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6382590792","display_name":"MRI, Genetics & Cognitive Precursors of AD and Dementia","funder_award_id":"R01AG016495","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G641917991","display_name":"The Framingham Heart Study","funder_award_id":"n01hc25195-41-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7618461031","display_name":"Boston University Alzheimer's Disease Center","funder_award_id":"P30AG013846","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8779974883","display_name":"Epidemiology of Dementia in the Framingham Study","funder_award_id":"R01AG008122","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000906853","display_name":"Precursors of Stroke Incidence and Prognosis","funder_award_id":"R01NS017950","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1588644690","https://openalex.org/W1932103862","https://openalex.org/W1971548649","https://openalex.org/W1972085661","https://openalex.org/W1976741643","https://openalex.org/W1980763739","https://openalex.org/W1982685626","https://openalex.org/W1983090660","https://openalex.org/W1994137501","https://openalex.org/W1997344968","https://openalex.org/W1998594057","https://openalex.org/W2005980822","https://openalex.org/W2018007042","https://openalex.org/W2021556801","https://openalex.org/W2040845149","https://openalex.org/W2044092843","https://openalex.org/W2056293291","https://openalex.org/W2060665323","https://openalex.org/W2063426414","https://openalex.org/W2069752278","https://openalex.org/W2077856677","https://openalex.org/W2080099880","https://openalex.org/W2083384274","https://openalex.org/W2086034688","https://openalex.org/W2086220616","https://openalex.org/W2090819718","https://openalex.org/W2091163929","https://openalex.org/W2100809123","https://openalex.org/W2105660961","https://openalex.org/W2107871825","https://openalex.org/W2109334713","https://openalex.org/W2113007696","https://openalex.org/W2121642311","https://openalex.org/W2124686490","https://openalex.org/W2131176843","https://openalex.org/W2135876850","https://openalex.org/W2143060791","https://openalex.org/W2147088002","https://openalex.org/W2147758955","https://openalex.org/W2152488179","https://openalex.org/W2154730509","https://openalex.org/W2161197885","https://openalex.org/W2163718643","https://openalex.org/W2164265846","https://openalex.org/W2166776142","https://openalex.org/W2171251197","https://openalex.org/W2211287272","https://openalex.org/W4245099342"],"related_works":["https://openalex.org/W2124686490","https://openalex.org/W4306321086","https://openalex.org/W7073642998","https://openalex.org/W1982947392","https://openalex.org/W3112772595","https://openalex.org/W7100439985","https://openalex.org/W1999288550","https://openalex.org/W7096574062","https://openalex.org/W2166838767","https://openalex.org/W7160429586"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"White":[3],"matter":[4],"hyperintensity":[5],"(WMH)":[6],"volume":[7,72,224],"is":[8,225],"associated":[9],"with":[10,122,147,165,204],"aging":[11],"and":[12,15,67,69,82,128,152],"cerebrovascular":[13],"disease":[14],"has":[16],"been":[17],"demonstrated":[18],"to":[19,41,109,161,170],"have":[20,216],"a":[21,37,52,166,220],"high":[22],"heritability":[23],"in":[24,32,51,155,172],"the":[25,56,101,105,173,183,231],"Framingham":[26,57],"Heart":[27,58],"Study":[28],"as":[29,31,76],"well":[30],"other":[33,125],"studies.":[34],"We":[35,215],"performed":[36],"genome-wide":[38],"linkage":[39,89,139,174],"analysis":[40,90,140,175],"identify":[42],"chromosomal":[43],"regions":[44],"that":[45,219],"may":[46],"harbor":[47],"genes":[48],"influencing":[49,222],"WMH":[50,68,108,160,223],"family-based":[53],"sample":[54],"of":[55,104,107,135,168,182,191,230],"Study.":[59],"METHODS:":[60],"Brain":[61],"magnetic":[62,149],"resonance":[63,150],"scans":[64],"were":[65,74,133],"performed,":[66],"total":[70],"cranial":[71],"(TCV)":[73],"quantified":[75],"previously":[77],"described":[78],"on":[79,115,198,211,227],"2259":[80],"cohort":[81],"offspring":[83],"participants.":[84],"The":[85],"outcome":[86],"used":[87],"for":[88,100],"was":[91,113,163,193,206],"an":[92],"age":[93,97],"specific":[94],"(within":[95],"10-year":[96],"groups)":[98],"z-score":[99,112],"natural":[102],"logarithm":[103,181],"ratio":[106],"TCV.":[110],"This":[111],"based":[114],"2230":[116],"individuals":[117,130,143],"after":[118],"excluding":[119],"26":[120],"participants":[121],"neurological":[123],"conditions":[124],"than":[126],"stroke":[127],"3":[129],"whose":[131],"ages":[132],"out":[134],"range.":[136],"Variance":[137],"component":[138],"included":[141],"747":[142],"(mean":[144],"age=62.16+/-12.43":[145],"years)":[146],"both":[148],"measure":[151],"genotype":[153],"information":[154],"237":[156],"families.":[157],"Mean":[158],"percent":[159],"TCV":[162],"0.098+/-0.175":[164],"range":[167],"0.00025%":[169],"1.37%":[171],"subjects.":[176],"RESULTS:":[177],"A":[178,201],"maximum":[179],"multipoint":[180],"odds":[184],"(LOD)":[185],"score=3.69,":[186],"which":[187],"indicates":[188],"significant":[189,217],"evidence":[190,218],"linkage,":[192],"observed":[194,207],"at":[195,208],"4":[196,229],"cM":[197,210],"chromosome":[199,212,228],"4.":[200],"suggestive":[202],"peak":[203],"LOD=1.78":[205],"95":[209],"17.":[213],"CONCLUSIONS:":[214],"gene":[221],"located":[226],"human":[232],"genome.":[233]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}