{"id":"https://openalex.org/W2142013301","doi":null,"title":"Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells.","display_name":"Influence of coenzyme A-independent transacylase and cyclooxygenase inhibitors on the proliferation of breast cancer cells.","publication_year":1999,"publication_date":"1999-12-15","ids":{"openalex":"https://openalex.org/W2142013301","mag":"2142013301","pmid":"https://pubmed.ncbi.nlm.nih.gov/10626809"},"language":"en","primary_location":{"id":"pmid:10626809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10626809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113868292","display_name":"A.J. Trimboli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405269449","display_name":"Wake Forest University Health Sciences","ror":"https://ror.org/046r1r105","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]},{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A J Trimboli","raw_affiliation_strings":["Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA","institution_ids":["https://openalex.org/I4405269449","https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045592581","display_name":"B. Moseley Waite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B M Waite","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110438556","display_name":"Gen\u2010ichi Atsumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Atsumi","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042733401","display_name":"Alfred Nji Fonteh","orcid":"https://orcid.org/0000-0003-4860-5749","observed_orcids":["https://orcid.org/0000-0003-4860-5749"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A N Fonteh","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052336784","display_name":"Andrew M. Namen","orcid":"https://orcid.org/0000-0001-5003-0900","observed_orcids":["https://orcid.org/0000-0001-5003-0900"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A M Namen","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052098064","display_name":"Carl E. Clay","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C E Clay","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058221234","display_name":"Tim Kute","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T E Kute","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035175377","display_name":"Kevin P. High","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K P High","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085840629","display_name":"Mark C. Willingham","orcid":"https://orcid.org/0000-0002-6576-8809","observed_orcids":["https://orcid.org/0000-0002-6576-8809"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M C Willingham","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036628305","display_name":"Floyd H. Chilton","orcid":"https://orcid.org/0000-0002-3686-0198","observed_orcids":["https://orcid.org/0000-0002-3686-0198"]},"institutions":[{"id":"https://openalex.org/I47251452","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724","country_code":"US","type":"education","lineage":["https://openalex.org/I47251452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"F H Chilton","raw_affiliation_strings":["Wake Forest University, Winston-Salem, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wake Forest University, Winston-Salem, United States","institution_ids":["https://openalex.org/I47251452"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1327,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76803874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"59","issue":"24","first_page":"6171","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.7990000247955322},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6209999918937683},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibitors","display_name":"cyclooxygenase inhibitors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.578000009059906},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.7760000228881836},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.7910000085830688},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolites","display_name":"arachidonic acid metabolites","score":0.7739999890327454},{"id":"https://openalex.org/keywords/estrogen-receptor-negative-breast-cancer","display_name":"estrogen receptor-negative breast cancer","score":0.6079999804496765},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.9390000104904175}],"concepts":[{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.6216331124305725},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5503031611442566},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5276597738265991},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48082244396209717},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.44658640027046204},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.44508856534957886},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.4150729775428772},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3869168162345886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3422221541404724},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32417023181915283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3228813707828522},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30940771102905273},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29124972224235535},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1856485903263092},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005230","descriptor_name":"Fatty Acids, Nonesterified","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016861","descriptor_name":"Cyclooxygenase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:10626809","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10626809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006730071","doi":null,"is_oa":false,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2014979","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Research","raw_type":"journal article"},{"id":"mag:2142013301","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10626809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3258227896","display_name":"DIETARY FATTY CONTROL OF INFLAMMATION","funder_award_id":"R01AI042022","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6466183545","display_name":"SIGNAL TRANSDUCTION MECHANISMS AND CELL FUNCTION","funder_award_id":"T32CA009422","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W75636408","https://openalex.org/W335320447","https://openalex.org/W1496912415","https://openalex.org/W1562457256","https://openalex.org/W1567654384","https://openalex.org/W1589628861","https://openalex.org/W1685016018","https://openalex.org/W1865550052","https://openalex.org/W1868796410","https://openalex.org/W1928411162","https://openalex.org/W1969301447","https://openalex.org/W1986456220","https://openalex.org/W1990030459","https://openalex.org/W1993869646","https://openalex.org/W1996188779","https://openalex.org/W2010111710","https://openalex.org/W2013988630","https://openalex.org/W2021905929","https://openalex.org/W2031313912","https://openalex.org/W2037958161","https://openalex.org/W2039606301","https://openalex.org/W2040664230","https://openalex.org/W2043707891","https://openalex.org/W2043944220","https://openalex.org/W2047863268","https://openalex.org/W2051686420","https://openalex.org/W2061816628","https://openalex.org/W2068806248","https://openalex.org/W2070380701","https://openalex.org/W2075039358","https://openalex.org/W2076092023","https://openalex.org/W2077991158","https://openalex.org/W2082577848","https://openalex.org/W2084542346","https://openalex.org/W2084697205","https://openalex.org/W2089055954","https://openalex.org/W2090333125","https://openalex.org/W2090535621","https://openalex.org/W2090805356","https://openalex.org/W2097997344","https://openalex.org/W2134634216","https://openalex.org/W2138973456","https://openalex.org/W2145168681","https://openalex.org/W2148573797","https://openalex.org/W2148907720","https://openalex.org/W2150966393","https://openalex.org/W2152311269","https://openalex.org/W2157838094","https://openalex.org/W2159973565","https://openalex.org/W2163462883","https://openalex.org/W2164926347","https://openalex.org/W2170720478","https://openalex.org/W2263192284","https://openalex.org/W2325454133","https://openalex.org/W2327667256","https://openalex.org/W2419605677"],"related_works":["https://openalex.org/W2978645762","https://openalex.org/W2074013237","https://openalex.org/W2091350945","https://openalex.org/W1994271130","https://openalex.org/W2005281513","https://openalex.org/W2016933408","https://openalex.org/W2125381755","https://openalex.org/W2503746695","https://openalex.org/W1982520980","https://openalex.org/W2127359451"],"abstract_inverted_index":{"Recent":[0],"studies":[1],"have":[2],"demonstrated":[3],"that":[4,14,44,110,140,219,227,243],"arachidonic":[5],"acid":[6,92],"(AA)":[7],"may":[8,231],"serve":[9],"as":[10],"an":[11,244],"important":[12],"signal":[13],"blocks":[15],"cell":[16,37,75,117,134,171,187,240],"proliferation":[17,38,63,172,195,241],"of":[18,31,46,54,64,86,98,170,176,196,221],"certain":[19],"neoplastic":[20],"cells.":[21,104],"The":[22,157],"current":[23],"study":[24],"was":[25,80],"conducted":[26],"to":[27,121,129,165,237,250],"determine":[28],"whether":[29],"disruption":[30,220],"AA":[32,47,87,100,178,190,222,230,246],"homeostasis":[33],"influences":[34],"breast":[35,73,185],"cancer":[36,74,186,239],"and":[39,69,93,146,155,161,173,199,242],"death.":[40],"Initial":[41],"experiments":[42,108,217],"revealed":[43,109],"inhibition":[45,79],"remodeling":[48,223],"through":[49],"membrane":[50],"phospholipids":[51],"by":[52,82],"inhibitors":[53,182],"the":[55,62,65,111,131,194,209],"enzyme,":[56],"coenzyme":[57],"A-independent":[58],"transacylase":[59],"(CoA-IT),":[60],"attenuates":[61],"estrogen":[66,70],"receptor-negative,":[67],"MDA-MB-231,":[68],"receptor-positive,":[71],"MCF-7":[72,197,206],"lines.":[76,188],"This":[77],"growth":[78],"accompanied":[81],"a":[83,96,225,233],"marked":[84],"accumulation":[85,179],"in":[88,119,133,183,205,224],"both":[89],"free":[90],"fatty":[91],"triglyceride":[94],"forms,":[95],"marker":[97],"intracellular":[99,229],"stress":[101],"within":[102],"mammalian":[103],"Cell":[105],"cycle":[106],"synchronization":[107],"CoA-IT":[112,181],"inhibitor,":[113],"SB-98625,":[114],"blocked":[115,193],"MDA-MB-231":[116],"replication":[118],"early":[120,144],"mid":[122],"G1":[123],"phase.":[124],"Time-lapse":[125],"video":[126],"microscopy,":[127],"used":[128],"observe":[130],"changes":[132],"morphology":[135],"associated":[136],"with":[137],"apoptosis,":[138],"indicated":[139],"SB-98625":[141],"treatment":[142],"induced":[143],"rounding":[145],"occasional":[147],"blebbing":[148],"but":[149],"not":[150],"late":[151],"apoptotic":[152],"events,":[153],"blistering,":[154],"lysis.":[156],"cyclooxygenase":[158],"inhibitors,":[159],"NS-398":[160],"indomethacin,":[162],"were":[163],"found":[164],"be":[166,203],"less":[167],"potent":[168],"blockers":[169],"poor":[174],"inducers":[175],"cellular":[177],"than":[180],"these":[184,216],"Finally,":[189],"provided":[191],"exogenously":[192],"cells,":[198],"this":[200,252],"effect":[201],"could":[202],"attenuated":[204],"cells":[207],"overexpressing":[208],"glutathione":[210],"peroxidase":[211],"gene,":[212],"GSHPx-1.":[213],"Taken":[214],"together,":[215],"suggest":[218],"manner":[226],"increases":[228],"represent":[232],"novel":[234],"therapeutic":[235],"strategy":[236],"reduce":[238],"oxidized":[245],"metabolite":[247],"is":[248],"likely":[249],"mediate":[251],"effect.":[253]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}