{"id":"https://openalex.org/W2141920376","doi":null,"title":"Regional sex differences in progestin receptor induction in the rat hypothalamus: effects of various doses of estradiol benzoate.","display_name":"Regional sex differences in progestin receptor induction in the rat hypothalamus: effects of various doses of estradiol benzoate.","publication_year":1987,"publication_date":"1987-08-01","ids":{"openalex":"https://openalex.org/W2141920376","mag":"2141920376","pmid":"https://pubmed.ncbi.nlm.nih.gov/3612252","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6568974"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:5768816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6568974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6568974","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081952675","display_name":"Theodore J. Brown","orcid":"https://orcid.org/0000-0002-3074-4516","observed_orcids":["https://orcid.org/0000-0002-3074-4516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T J Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026102466","display_name":"Ann S. Clark","orcid":"https://orcid.org/0000-0002-4274-9816","observed_orcids":["https://orcid.org/0000-0002-4274-9816"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A S Clark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059343766","display_name":"Neil James MacLusky","orcid":"https://orcid.org/0000-0002-9202-0564","observed_orcids":["https://orcid.org/0000-0002-9202-0564"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N J MacLusky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3167,"has_fulltext":false,"cited_by_count":84,"citation_normalized_percentile":{"value":0.90148912,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"8","first_page":"2529","last_page":"36"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.5131999850273132,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.38989999890327454,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8650000095367432},{"id":"https://openalex.org/keywords/estradiol-benzoate","display_name":"estradiol benzoate","score":0.8650000095367432},{"id":"https://openalex.org/keywords/ventromedial-hypothalamic-nucleus","display_name":"ventromedial hypothalamus","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/estrogen-dose-response","display_name":"estrogen dose-response","score":0.5960000157356262},{"id":"https://openalex.org/keywords/preoptic-area","display_name":"preoptic area","score":0.6620000004768372},{"id":"https://openalex.org/keywords/gonadectomy","display_name":"gonadectomy","score":0.7400000095367432},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.9240000247955322}],"concepts":[{"id":"https://openalex.org/C2776607906","wikidata":"https://www.wikidata.org/wiki/Q50383885","display_name":"Progestin","level":3,"score":0.8973910808563232},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8225672245025635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8224685192108154},{"id":"https://openalex.org/C2778506572","wikidata":"https://www.wikidata.org/wiki/Q11450699","display_name":"Estradiol benzoate","level":4,"score":0.7118213176727295},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6160011887550354},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5232763886451721},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5192144513130188},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.49955248832702637},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4309409260749817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41540664434432983},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38591063022613525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24584612250328064},{"id":"https://openalex.org/C8264082","wikidata":"https://www.wikidata.org/wiki/Q7113259","display_name":"Ovariectomized rat","level":3,"score":0.10758626461029053},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05396422743797302},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011397","descriptor_name":"Promegestone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011980","descriptor_name":"Receptors, Progesterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:5768816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6568974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6568974","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6568974","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neurosci","raw_type":"Text"},{"id":"pmid:3612252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3612252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of neuroscience : the official journal of the Society for Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.321.5435","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.5435","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.jneurosci.org/content/7/8/2529.full.pdf","raw_type":"text"},{"id":"mag:2141920376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3612252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5768816","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6568974","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1498891976","https://openalex.org/W1678736636","https://openalex.org/W1973395583","https://openalex.org/W1983808977","https://openalex.org/W1987666584","https://openalex.org/W1989386819","https://openalex.org/W1993167968","https://openalex.org/W1993501520","https://openalex.org/W1999959617","https://openalex.org/W2006144973","https://openalex.org/W2008898910","https://openalex.org/W2010973976","https://openalex.org/W2025956305","https://openalex.org/W2044816110","https://openalex.org/W2045888428","https://openalex.org/W2048202584","https://openalex.org/W2062859014","https://openalex.org/W2065295152","https://openalex.org/W2066775412","https://openalex.org/W2075394288","https://openalex.org/W2081395560","https://openalex.org/W2097130278","https://openalex.org/W2098704636","https://openalex.org/W2104055907","https://openalex.org/W2119840434","https://openalex.org/W2123380538","https://openalex.org/W2123498378","https://openalex.org/W2128635872","https://openalex.org/W2129115045","https://openalex.org/W2130809570","https://openalex.org/W2329442555"],"related_works":["https://openalex.org/W2032004890","https://openalex.org/W2098704636","https://openalex.org/W2039232106","https://openalex.org/W2003345618","https://openalex.org/W2001750265","https://openalex.org/W2043321656","https://openalex.org/W2094807377","https://openalex.org/W2082690685","https://openalex.org/W2117368265","https://openalex.org/W1973308410"],"abstract_inverted_index":{"In":[0],"the":[1,23,54,113,139,152,173,198,221,230,236,239,254,261],"rat,":[2],"sex":[3,15,34,55,79,144,191,214,251],"differences":[4,80,215,240,252],"in":[5,17,22,36,57,63,83,87,112,138,146,151,162,172,193,197,216,220,241,248,253,260],"behavioral":[6,242],"responsiveness":[7],"to":[8,244],"progesterone":[9,245],"have":[10,52],"been":[11,30],"correlated":[12],"with":[13,46,67,96],"a":[14,106,129,149,160,190],"difference":[16,35,56,145,150,161,192],"estrogen-induced":[18],"progestin":[19,37,60,85,110,136,155,169,195,218,258],"receptor":[20,38,61,170],"induction":[21,39,62,171,256],"ventromedial":[24],"nucleus":[25,176],"(VMN).":[26],"It":[27],"has":[28],"recently":[29],"suggested":[31],"that":[32,142,238],"this":[33,97,143],"may":[40,246],"only":[41],"be":[42],"present":[43],"after":[44],"treatment":[45],"large":[47],"doses":[48,69,203],"of":[49,70,93,109,115,118,135,154,168,184,229,257],"estrogen.":[50],"We":[51],"evaluated":[53],"hypothalamic":[58],"cytosol":[59,84,194,217],"gonadectomized/adrenalectomized":[64],"rats":[65,188],"treated":[66,95],"moderate":[68],"estradiol":[71],"benzoate":[72],"(EB;":[73],"20":[74],"micrograms/kg":[75,210],"body":[76,211],"weight).":[77,212],"No":[78,213],"were":[81,103,126,225],"detected":[82],"binding":[86,111,133,137,147,156,163,196,219],"mediobasal":[88],"hypothalamus":[89],"or":[90,208,223],"preoptic":[91,175],"area":[92],"animals":[94],"dose":[98],"48":[99],"hr":[100],"before":[101],"they":[102],"killed.":[104],"However,":[105],"higher":[107],"level":[108],"VMN":[114,140,183,199],"females":[116],"than":[117],"males":[119],"was":[120],"found":[121],"when":[122],"these":[123],"brain":[124],"regions":[125],"examined":[127],"using":[128],"microdissection":[130],"technique.":[131],"Saturation":[132],"analysis":[134],"indicated":[141,189],"reflects":[148],"number":[153],"sites,":[157],"and":[158,182,186],"not":[159],"affinity.":[164],"A":[165],"dose-response":[166],"study":[167],"medial":[174],"(mPON),":[177],"arcuate-median":[178],"eminence":[179],"region":[180],"(ARC-ME),":[181],"male":[185],"female":[187],"at":[200,227],"all":[201],"EB":[202],"tested":[204,231],"(2,":[205],"8,":[206],"40,":[207],"200":[209],"mPON":[222],"ARC-ME":[224],"observed":[226],"any":[228],"doses.":[232],"These":[233],"results":[234],"support":[235],"idea":[237],"sensitivity":[243],"result":[247],"part":[249],"from":[250],"estrogen":[255],"receptors":[259],"VMN.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
