{"id":"https://openalex.org/W2141908220","doi":"https://doi.org/10.2174/156652307782151461","title":"Immune Responses to Gene Product of Inducible Promoters","display_name":"Immune Responses to Gene Product of Inducible Promoters","publication_year":2007,"publication_date":"2007-10-01","ids":{"openalex":"https://openalex.org/W2141908220","doi":"https://doi.org/10.2174/156652307782151461","mag":"2141908220","pmid":"https://pubmed.ncbi.nlm.nih.gov/17979680"},"language":"en","primary_location":{"id":"doi:10.2174/156652307782151461","doi":"https://doi.org/10.2174/156652307782151461","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156652307782151461","pdf_url":null,"source":{"id":"https://openalex.org/S31345238","display_name":"Current Gene Therapy","issn_l":"1566-5232","issn":["1566-5232","1875-5631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Gene Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084630333","display_name":"Caroline Le Guiner","orcid":"https://orcid.org/0000-0002-6904-2300","observed_orcids":["https://orcid.org/0000-0002-6904-2300"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Caroline Guiner","raw_affiliation_strings":["INSERM U649, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, CHU-H\u00f4tel Dieu, B\u00e2t J Monnet, 30 Boulevard J Monnet, 44035, Nantes Cedex 01, France. caroline.le-guiner@univ-nantes.fr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U649, Universit\u00e9 de Nantes, Facult\u00e9 de M\u00e9decine, CHU-H\u00f4tel Dieu, B\u00e2t J Monnet, 30 Boulevard J Monnet, 44035, Nantes Cedex 01, France. caroline.le-guiner@univ-nantes.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078612323","display_name":"Knut Stieger","orcid":"https://orcid.org/0000-0002-8298-5629","observed_orcids":["https://orcid.org/0000-0002-8298-5629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Knut Stieger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016875954","display_name":"Richard O. Snyder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Snyder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089785088","display_name":"Fabienne Rolling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fabienne Rolling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5006456461","display_name":"Philippe Moullier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I3019204325","display_name":"Centre Hospitalier Universitaire de Nantes","ror":"https://ror.org/05c1qsg97","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019204325"]},{"id":"https://openalex.org/I4405260337","display_name":"Universit\u00e9 de Nantes","ror":"https://ror.org/03kjmz544","country_code":"FR","type":"education","lineage":["https://openalex.org/I4405260337","https://openalex.org/I97188460"]},{"id":"https://openalex.org/I97188460","display_name":"Nantes Universit\u00e9","ror":"https://ror.org/03gnr7b55","country_code":"FR","type":"education","lineage":["https://openalex.org/I97188460"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philippe Moullier","raw_affiliation_strings":["INSERM U649, Universite de Nantes, Faculte de Medecine, CHU-Hotel Dieu, Bat. J. Monnet, 30 Boulevard J. Monnet, 44035 Nantes Cedex 01, France.,France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U649, Universite de Nantes, Faculte de Medecine, CHU-Hotel Dieu, Bat. J. Monnet, 30 Boulevard J. Monnet, 44035 Nantes Cedex 01, France.,France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I3019204325","https://openalex.org/I4405260337","https://openalex.org/I97188460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5531,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.83666588,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"7","issue":"5","first_page":"334","last_page":"346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.030899999663233757,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inducible-promoters","display_name":"inducible promoters","score":0.8299999833106995},{"id":"https://openalex.org/keywords/immune-response","display_name":"immune response","score":0.5870000123977661},{"id":"https://openalex.org/keywords/transcriptional-activator","display_name":"transcriptional activator","score":0.7360000014305115},{"id":"https://openalex.org/keywords/transgene-expression-regulation","display_name":"transgene expression regulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/nonhuman-primates","display_name":"non-human primates","score":0.906000018119812},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.8410000205039978},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/gene-delivery-vectors","display_name":"gene delivery vectors","score":0.6269999742507935},{"id":"https://openalex.org/keywords/long-term-transgene-expression","display_name":"long-term transgene expression","score":0.6779999732971191}],"concepts":[{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.8593025803565979},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7585722804069519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6811603307723999},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.6291927099227905},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.5552864074707031},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.46437516808509827},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.46413204073905945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4102441668510437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.362749844789505},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34883052110671997},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3372913599014282},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2675001323223114}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007111","descriptor_name":"Immunity, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013752","descriptor_name":"Tetracycline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.2174/156652307782151461","doi":"https://doi.org/10.2174/156652307782151461","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156652307782151461","pdf_url":null,"source":{"id":"https://openalex.org/S31345238","display_name":"Current Gene Therapy","issn_l":"1566-5232","issn":["1566-5232","1875-5631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Gene Therapy","raw_type":"journal-article"},{"id":"pmid:17979680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17979680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current gene therapy","raw_type":"Journal Article"},{"id":"pmh:oai:dc.etsu.edu:etsu-works-19262","doi":null,"is_oa":false,"landing_page_url":"https://dc.etsu.edu/etsu-works/17996","pdf_url":null,"source":{"id":"https://openalex.org/S4377196424","display_name":"Digital Commons - East Tennessee State University (East Tennessee State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119443389","host_organization_name":"East Tennessee State University","host_organization_lineage":["https://openalex.org/I119443389"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ETSU Faculty Works","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1998029792","https://openalex.org/W2077186175","https://openalex.org/W1971047566","https://openalex.org/W7096920999","https://openalex.org/W1997046497","https://openalex.org/W2134233815","https://openalex.org/W2150329966","https://openalex.org/W2052813390","https://openalex.org/W1505796783","https://openalex.org/W2790991353"],"abstract_inverted_index":{"Efficient":[0],"gene":[1,34,212],"transfer":[2],"has":[3,86],"been":[4,64,76,87],"achieved":[5],"in":[6,47,89,102,114,133,147,153,178,195,207],"several":[7,56],"animal":[8,91],"models":[9,92],"using":[10,93,127],"different":[11,180],"vector":[12],"systems,":[13,96],"leading":[14,159],"to":[15,40,160],"stable":[16],"transgene":[17,85,115,166,185,205],"expression.":[18,169],"The":[19],"tight":[20],"control":[21],"of":[22,33,83,107,157,164,211],"this":[23,54,148],"expression":[24],"is":[25,38],"now":[26],"an":[27,108],"important":[28],"outcome":[29],"for":[30,43,50,184],"the":[31,68,71,84,105,128,144,161,165,174],"field":[32],"therapy.":[35],"Such":[36,120],"regulation":[37,82,116,149,167,206],"likely":[39],"be":[41,189,201],"required":[42],"therapeutic":[44],"applications":[45],"and":[46,70,138,168],"some":[48],"instances":[49],"safety":[51],"reasons.":[52],"For":[53],"purpose,":[55],"regulatable":[57,131],"systems":[58,74,182],"depending":[59],"on":[60,192],"small":[61,90],"molecules":[62],"have":[63,75],"developed.":[65],"Among":[66],"these,":[67],"tetracycline":[69,130],"rapamycin":[72],"dependent":[73],"largely":[77],"used.":[78],"However,":[79],"if":[80],"long-term":[81,204],"obtained":[88],"these":[94,179],"inducible":[95],"when":[97,126],"translational":[98],"studies":[99],"were":[100,117,151],"initiated":[101],"larger":[103],"animals,":[104],"development":[106],"immune":[109,121,141,175,198],"response":[110,122],"against":[111,143],"proteins":[112],"involved":[113,146],"often":[118],"observed.":[119],"was":[123],"especially":[124],"documented":[125,152],"TetOn":[129],"system":[132,150],"nonhuman":[134],"primates":[135],"(NHP).":[136],"Humoral":[137],"destructive":[139],"cellular":[140],"responses":[142,176,199],"transactivator":[145],"a":[154],"large":[155],"majority":[156],"NHP":[158],"complete":[162],"loss":[163],"This":[170],"review":[171],"will":[172,188],"describe":[173],"observed":[177],"model":[181],"applied":[183],"regulation.":[186],"Focus":[187],"finally":[190],"given":[191],"future":[193,208],"directions":[194],"which":[196],"such":[197],"might":[200],"surmounted,":[202],"enabling":[203],"clinical":[209],"developments":[210],"transfer.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
