{"id":"https://openalex.org/W2141900184","doi":"https://doi.org/10.1126/scisignal.1242002pe14","title":"Dancing with Multiple Partners","display_name":"Dancing with Multiple Partners","publication_year":2002,"publication_date":"2002-03-19","ids":{"openalex":"https://openalex.org/W2141900184","doi":"https://doi.org/10.1126/scisignal.1242002pe14","mag":"2141900184","pmid":"https://pubmed.ncbi.nlm.nih.gov/11904458"},"language":"en","primary_location":{"id":"doi:10.1126/scisignal.1242002pe14","doi":"https://doi.org/10.1126/scisignal.1242002pe14","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.1242002pe14","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075469665","display_name":"Darren G. Woodside","orcid":"https://orcid.org/0000-0002-8521-6593","observed_orcids":["https://orcid.org/0000-0002-8521-6593"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"D. G. Woodside","raw_affiliation_strings":["Texas Biotechnology Corporation, 7000 Fannin, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas Biotechnology Corporation, 7000 Fannin, Houston, TX 77030, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5075469665"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5423,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.61682525,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2002","issue":"124","first_page":"pe14","last_page":"pe14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/integrins","display_name":"integrins","score":0.9129999876022339},{"id":"https://openalex.org/keywords/protease-activated-receptor-1","display_name":"protease-activated receptor 1","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.9649999737739563},{"id":"https://openalex.org/keywords/syk","display_name":"Syk","score":0.7360000014305115},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.8320000171661377},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C35174551","wikidata":"https://www.wikidata.org/wiki/Q7660502","display_name":"Syk","level":4,"score":0.889863908290863},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.7619720697402954},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.6468156576156616},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6312493681907654},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5709865093231201},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5623018145561218},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43247997760772705},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.41576290130615234},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.4102552533149719},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.3499179482460022},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32736772298812866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24175778031349182}],"mesh":[{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006160","descriptor_name":"Guanosine Triphosphate","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1126/scisignal.1242002pe14","doi":"https://doi.org/10.1126/scisignal.1242002pe14","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scisignal.1242002pe14","pdf_url":null,"source":{"id":"https://openalex.org/S155937366","display_name":"Science Signaling","issn_l":"1937-9145","issn":["1937-9145","1945-0877"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Signaling","raw_type":"journal-article"},{"id":"doi:10.1126/stke.2002.124.pe14","doi":"https://doi.org/10.1126/stke.2002.124.pe14","is_oa":false,"landing_page_url":"https://doi.org/10.1126/stke.2002.124.pe14","pdf_url":null,"source":{"id":"https://openalex.org/S4210180107","display_name":"Science s STKE","issn_l":"1525-8882","issn":["1525-8882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science's STKE","raw_type":"journal-article"},{"id":"pmid:11904458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11904458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science's STKE : signal transduction knowledge environment","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W166344167","https://openalex.org/W1482828226","https://openalex.org/W1483477945","https://openalex.org/W1540271729","https://openalex.org/W1567065545","https://openalex.org/W1586171131","https://openalex.org/W1593107231","https://openalex.org/W1598532102","https://openalex.org/W1618519163","https://openalex.org/W1623022149","https://openalex.org/W1787674222","https://openalex.org/W1968260614","https://openalex.org/W1977426071","https://openalex.org/W1979035442","https://openalex.org/W1980823970","https://openalex.org/W2009665567","https://openalex.org/W2012730541","https://openalex.org/W2015176049","https://openalex.org/W2016441306","https://openalex.org/W2017309426","https://openalex.org/W2029231027","https://openalex.org/W2030625703","https://openalex.org/W2032669514","https://openalex.org/W2037583192","https://openalex.org/W2040540681","https://openalex.org/W2041726757","https://openalex.org/W2048524749","https://openalex.org/W2049396239","https://openalex.org/W2050940330","https://openalex.org/W2059188737","https://openalex.org/W2063529214","https://openalex.org/W2064540749","https://openalex.org/W2065663262","https://openalex.org/W2067884008","https://openalex.org/W2071725107","https://openalex.org/W2071852938","https://openalex.org/W2072583244","https://openalex.org/W2081971657","https://openalex.org/W2086818135","https://openalex.org/W2086992732","https://openalex.org/W2088544660","https://openalex.org/W2095472636","https://openalex.org/W2095769092","https://openalex.org/W2098314604","https://openalex.org/W2099675490","https://openalex.org/W2103721183","https://openalex.org/W2107258432","https://openalex.org/W2116949924","https://openalex.org/W2124961362","https://openalex.org/W2150888122","https://openalex.org/W2156451315","https://openalex.org/W2159242529","https://openalex.org/W2164330595","https://openalex.org/W2168918180","https://openalex.org/W2169584935","https://openalex.org/W2169889031","https://openalex.org/W2187724289","https://openalex.org/W2325795238","https://openalex.org/W4405991224"],"related_works":["https://openalex.org/W4241051110","https://openalex.org/W4414586068","https://openalex.org/W2143594596","https://openalex.org/W36557223","https://openalex.org/W2134925393","https://openalex.org/W2172659222","https://openalex.org/W4387347522","https://openalex.org/W1989046246","https://openalex.org/W2951262477","https://openalex.org/W1963522960"],"abstract_inverted_index":{"Transmembrane":[0],"proteins,":[1],"such":[2],"as":[3],"G":[4,50,59,73],"protein-coupled":[5],"receptors":[6],"(GPCRs)":[7],"and":[8,27,83,101],"integrins,":[9],"activate":[10],"intracellular":[11,102],"signaling":[12,55],"pathways":[13],"through":[14,56],"interactions":[15],"with":[16,34,97],"downstream":[17],"binding":[18,109,124,133],"partners.":[19],"Woodside":[20],"discusses":[21],"two":[22],"examples":[23],"in":[24,30,47,126],"which":[25],"GPCRs":[26],"integrins":[28],"interact":[29],"a":[31,57,144],"noncompeting":[32,132],"manner":[33],"more":[35],"than":[36],"one":[37],"partner.":[38],"The":[39,75],"specific":[40],"GPCR":[41],"described":[42,78],"is":[43,79],"the":[44,69,80,87,99,113,122,137],"thrombin":[45],"receptor,":[46],"experiments":[48],"where":[49],"protein":[51,60],"peptides":[52,119],"selectively":[53],"block":[54],"particular":[58],"that":[61],"does":[62],"not":[63,116],"appear":[64],"to":[65,71,112,136],"inhibit":[66],"coupling":[67],"of":[68,86,95,104,110,139],"receptor":[70,146],"other":[72],"proteins.":[74],"second":[76],"system":[77],"alphaIIbbeta3":[81],"integrin":[82,100,114],"its":[84],"activation":[85],"nonreceptor":[88],"tyrosine":[89],"kinase":[90],"Syk.":[91],"Syk":[92,111,123],"appeared":[93],"capable":[94],"interacting":[96],"both":[98],"domains":[103],"immune":[105,127],"response":[106,128],"receptors,":[107],"because":[108],"was":[115],"inhibited":[117],"by":[118],"based":[120],"on":[121],"site":[125],"receptors.":[129],"Thus,":[130],"multiple,":[131],"partners":[134],"add":[135],"complexity":[138],"signal":[140],"transduction":[141],"outputs":[142],"from":[143],"single":[145],"complex.":[147]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
