{"id":"https://openalex.org/W2141896665","doi":null,"title":"IMPORTANCE OF EPIGENETIC CHANGES IN THE THYROID CANCER INCIDENCE AND THEIR THERAPEUTIC APPLICATIONS (REVIEW ARTICLE)","display_name":"IMPORTANCE OF EPIGENETIC CHANGES IN THE THYROID CANCER INCIDENCE AND THEIR THERAPEUTIC APPLICATIONS (REVIEW ARTICLE)","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2141896665","mag":"2141896665"},"language":"en","primary_location":{"id":"mag:2141896665","doi":null,"is_oa":false,"landing_page_url":"https://www.sid.ir/fa/VEWSSID/J_pdf/67713930301.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003559502","display_name":"Maryam Zarkesh","orcid":"https://orcid.org/0000-0002-8519-4865","observed_orcids":["https://orcid.org/0000-0002-8519-4865"]},"institutions":[{"id":"https://openalex.org/I4210106249","display_name":"Research Institute for Endocrine Sciences","ror":"https://ror.org/01kpm1136","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210106249"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Maryam Zarkesh","raw_affiliation_strings":["Cellular and Molecular Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-8519-4865","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I4210106249","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064799287","display_name":"Mahdi Taghadosi","orcid":"https://orcid.org/0000-0002-3516-0130","observed_orcids":["https://orcid.org/0000-0002-3516-0130"]},"institutions":[{"id":"https://openalex.org/I39642139","display_name":"Kermanshah University of Medical Sciences","ror":"https://ror.org/05vspf741","country_code":"IR","type":"education","lineage":["https://openalex.org/I39642139"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahdi Taghaddosi","raw_affiliation_strings":["Department of Immunology, Faculty of Medicine, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Faculty of Medicine, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran","institution_ids":["https://openalex.org/I39642139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080500381","display_name":"Fereidoun Azizi","orcid":"https://orcid.org/0000-0002-6470-2517","observed_orcids":["https://orcid.org/0000-0002-6470-2517","https://orcid.org/0000-0002-7335-3873","https://orcid.org/0000-0002-7515-5651"]},"institutions":[{"id":"https://openalex.org/I4210106249","display_name":"Research Institute for Endocrine Sciences","ror":"https://ror.org/01kpm1136","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210106249"]},{"id":"https://openalex.org/I48379061","display_name":"Shahid Beheshti University","ror":"https://ror.org/0091vmj44","country_code":"IR","type":"education","lineage":["https://openalex.org/I48379061"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Fereidoun Azizi","raw_affiliation_strings":["Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Science Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0002-6470-2517","affiliations":[{"raw_affiliation_string":"Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Science Tehran Iran","institution_ids":["https://openalex.org/I4210106249","https://openalex.org/I48379061","https://openalex.org/I58048189"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017879739","display_name":"Azita Zadeh\u2013Vakili","orcid":"https://orcid.org/0000-0001-6775-5537","observed_orcids":["https://orcid.org/0000-0001-6775-5537"]},"institutions":[{"id":"https://openalex.org/I4210106249","display_name":"Research Institute for Endocrine Sciences","ror":"https://ror.org/01kpm1136","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210106249"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Azita Zadeh\u2013Vakili","raw_affiliation_strings":["Cellular and Molecular Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":"https://orcid.org/0000-0001-6775-5537","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I4210106249","https://openalex.org/I58048189"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057534597","display_name":"Mehdi Hedayati","orcid":"https://orcid.org/0000-0001-5816-775X","observed_orcids":["https://orcid.org/0000-0001-5816-775X","https://orcid.org/0000-0001-6775-8148"]},"institutions":[{"id":"https://openalex.org/I4210106249","display_name":"Research Institute for Endocrine Sciences","ror":"https://ror.org/01kpm1136","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4210106249"]},{"id":"https://openalex.org/I58048189","display_name":"Shahid Beheshti University of Medical Sciences","ror":"https://ror.org/034m2b326","country_code":"IR","type":"education","lineage":["https://openalex.org/I58048189"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehdi Hedayati","raw_affiliation_strings":["Cellular and Molecular Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran","institution_ids":["https://openalex.org/I4210106249","https://openalex.org/I58048189"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2179,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56018883,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"17","issue":"3","first_page":"1","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.7919999957084656},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.8410000205039978},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/deacetylase-inhibitors","display_name":"deacetylase inhibitors","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.953000009059906},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6340000033378601},{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.8220000267028809},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/medullary-thyroid-carcinoma","display_name":"medullary thyroid carcinoma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.7863198518753052},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6998108625411987},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6683477759361267},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.6261440515518188},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.597262442111969},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5914082527160645},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49303457140922546},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47199156880378723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3860098421573639},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.34673571586608887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29752597212791443},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13066595792770386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0784115195274353}],"mesh":[],"locations_count":3,"locations":[{"id":"mag:2141896665","doi":null,"is_oa":false,"landing_page_url":"https://www.sid.ir/fa/VEWSSID/J_pdf/67713930301.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2262487559","doi":null,"is_oa":false,"landing_page_url":"https://www.sid.ir/En/Journal/ViewPaper.aspx?ID=420023","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"mag:2574213964","doi":null,"is_oa":false,"landing_page_url":"http://mjms.modares.ac.ir/article-30-10579-fa.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306536599","display_name":"\u067e\u0698\u0648\u0647\u0634\u200c\u0647\u0627\u06cc \u0622\u0633\u06cc\u0628\u200c\u0634\u0646\u0627\u0633\u06cc \u0632\u06cc\u0633\u062a\u06cc","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u067e\u0698\u0648\u0647\u0634\u200c\u0647\u0627\u06cc \u0622\u0633\u06cc\u0628\u200c\u0634\u0646\u0627\u0633\u06cc \u0632\u06cc\u0633\u062a\u06cc","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W35840313","https://openalex.org/W1214372385","https://openalex.org/W1486257535","https://openalex.org/W1531290807","https://openalex.org/W1567665577","https://openalex.org/W1580488470","https://openalex.org/W1580935979","https://openalex.org/W1656693504","https://openalex.org/W1670226482","https://openalex.org/W1784857457","https://openalex.org/W1894542317","https://openalex.org/W1949662878","https://openalex.org/W1960984881","https://openalex.org/W1965193916","https://openalex.org/W1965750166","https://openalex.org/W1967018540","https://openalex.org/W1971621147","https://openalex.org/W1972755526","https://openalex.org/W1972846893","https://openalex.org/W1973470991","https://openalex.org/W1975193550","https://openalex.org/W1975986176","https://openalex.org/W1977166318","https://openalex.org/W1979921882","https://openalex.org/W1984025642","https://openalex.org/W1985402095","https://openalex.org/W1985569070","https://openalex.org/W1987239589","https://openalex.org/W1988101947","https://openalex.org/W1988688032","https://openalex.org/W1990171304","https://openalex.org/W1991991004","https://openalex.org/W1994605750","https://openalex.org/W1998990473","https://openalex.org/W2005027487","https://openalex.org/W2006562902","https://openalex.org/W2007951368","https://openalex.org/W2009325024","https://openalex.org/W2010338407","https://openalex.org/W2010437021","https://openalex.org/W2011043467","https://openalex.org/W2012422571","https://openalex.org/W2013177151","https://openalex.org/W2015735594","https://openalex.org/W2015966437","https://openalex.org/W2017182704","https://openalex.org/W2018669273","https://openalex.org/W2019620407","https://openalex.org/W2020617263","https://openalex.org/W2022285476","https://openalex.org/W2022631710","https://openalex.org/W2025776416","https://openalex.org/W2027659511","https://openalex.org/W2027855079","https://openalex.org/W2028383173","https://openalex.org/W2029868343","https://openalex.org/W2030536418","https://openalex.org/W2031351595","https://openalex.org/W2031541159","https://openalex.org/W2033833696","https://openalex.org/W2033882181","https://openalex.org/W2035216589","https://openalex.org/W2035974695","https://openalex.org/W2036986058","https://openalex.org/W2040257851","https://openalex.org/W2040935714","https://openalex.org/W2043033879","https://openalex.org/W2043807895","https://openalex.org/W2047029503","https://openalex.org/W2050425302","https://openalex.org/W2054823635","https://openalex.org/W2057285945","https://openalex.org/W2061578142","https://openalex.org/W2061888322","https://openalex.org/W2062093164","https://openalex.org/W2066145073","https://openalex.org/W2069392223","https://openalex.org/W2072445168","https://openalex.org/W2075435981","https://openalex.org/W2090368545","https://openalex.org/W2095469194","https://openalex.org/W2096501714","https://openalex.org/W2098249941","https://openalex.org/W2098267495","https://openalex.org/W2099803844","https://openalex.org/W2101376833","https://openalex.org/W2102650381","https://openalex.org/W2104875539","https://openalex.org/W2108668400","https://openalex.org/W2109845080","https://openalex.org/W2112537790","https://openalex.org/W2116929318","https://openalex.org/W2117691193","https://openalex.org/W2117852091","https://openalex.org/W2118986295","https://openalex.org/W2123180659","https://openalex.org/W2126939839","https://openalex.org/W2128805986","https://openalex.org/W2131068030","https://openalex.org/W2131451077","https://openalex.org/W2131874016","https://openalex.org/W2132880072","https://openalex.org/W2133376873","https://openalex.org/W2135619784","https://openalex.org/W2135830745","https://openalex.org/W2135883248","https://openalex.org/W2136494061","https://openalex.org/W2136854379","https://openalex.org/W2137456310","https://openalex.org/W2139526606","https://openalex.org/W2139977915","https://openalex.org/W2141410747","https://openalex.org/W2141768860","https://openalex.org/W2142845200","https://openalex.org/W2153734475","https://openalex.org/W2154221980","https://openalex.org/W2155725346","https://openalex.org/W2158396304","https://openalex.org/W2162117160","https://openalex.org/W2162224376","https://openalex.org/W2167256217","https://openalex.org/W2169388604","https://openalex.org/W2171362256","https://openalex.org/W2280718773","https://openalex.org/W2614344301","https://openalex.org/W3023435549","https://openalex.org/W3190412754","https://openalex.org/W4244623190"],"related_works":["https://openalex.org/W2117852091","https://openalex.org/W2108628225","https://openalex.org/W2758931657","https://openalex.org/W2007951368","https://openalex.org/W4410521569","https://openalex.org/W2620265051","https://openalex.org/W2171522900","https://openalex.org/W4362699190","https://openalex.org/W2969361423","https://openalex.org/W2580561556"],"abstract_inverted_index":{"cancer,":[0,137,176],"the":[1,49,63,66,116,155,166],"most":[2,167],"common":[3],"endocrine":[4],"malignancy":[5],"worldwide,":[6],"originates":[7],"from":[8],"follicular":[9],"epithelial":[10],"cells.":[11],"It":[12],"is":[13,132,139],"classified":[14],"as":[15],"a":[16],"well-differentiated":[17],"thyroid":[18,29,33,43,80,97,103,136,148,175],"carcinoma":[19,34,44],"(WDTC)":[20],"-follicular":[21],"(FTC)":[22],"and":[23,36,109,121,183,186,195],"papillary":[24],"types":[25,173],"(PTC)-,":[26],"poorly":[27],"differentiated":[28],"carcinomas":[30,81,149],"(PDTC),":[31],"anaplastic":[32],"(ATC),":[35],"parafollicular":[37],"calcitonin-":[38],"producing":[39],"cells":[40],"include":[41],"medullary":[42],"(MTC).":[45],"Epigenetic":[90],"refers":[47],"to":[48,88,115,141],"study":[50],"of":[51,65,92,118,124,157,174],"heritable":[52],"changes":[53,75,106],"in":[54,62,79,102,107,171],"gene":[55],"expression":[56],"that":[57,73,191],"occur":[58],"without":[59],"any":[60],"alteration":[61],"pattern":[64],"primary":[67],"DNA":[68],"sequence.":[69],"Growing":[70],"evidence":[71],"shows":[72],"epigenetic":[74,169,177],"play":[76],"important":[77],"roles":[78],"and,":[82],"together":[83],"with":[84],"genetic":[85],"changes,":[86],"lead":[87],"tumorigenesis.":[89,125],"silencing":[91],"various":[93],"genes":[94,112],"specific":[95],"for":[96,134,146,179],"differentiation":[98],"have":[99,150],"been":[100,151],"detected":[101],"tumors.":[104],"These":[105],"tumor-promoting":[108],"tumor-":[110],"suppressor":[111],"also":[113],"contribute":[114],"dysregulation":[117],"thyrocyte":[119],"growth":[120],"other":[122],"aspects":[123],"However,":[126],"at":[127],"present,":[128],"no":[129],"promising":[130],"treatment":[131],"available":[133],"advanced":[135,147],"which":[138],"unresponsive":[140],"radioiodine.":[142],"Biologically":[143],"targeted":[144],"therapies":[145],"proposed":[152],"based":[153],"on":[154],"recognition":[156],"main":[158],"oncogenic":[159],"mutations.":[160],"In":[161],"this":[162,181],"review":[163],"we":[164],"discuss":[165],"frequent":[168],"variations":[170],"different":[172],"strategies":[178],"treating":[180],"carcinoma,":[182],"experimental":[184],"data":[185],"clinical":[187],"trials,":[188],"particularly":[189],"those":[190],"use":[192],"deacetylase":[193],"inhibitors":[194],"demethylating":[196],"agents.":[197]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}