{"id":"https://openalex.org/W2141895871","doi":"https://doi.org/10.1111/j.1600-0447.1992.tb01453.x","title":"Carbamazepine versus lithium in the prophylaxis of bipolar affective disorder","display_name":"Carbamazepine versus lithium in the prophylaxis of bipolar affective disorder","publication_year":1992,"publication_date":"1992-02-01","ids":{"openalex":"https://openalex.org/W2141895871","doi":"https://doi.org/10.1111/j.1600-0447.1992.tb01453.x","mag":"2141895871","pmid":"https://pubmed.ncbi.nlm.nih.gov/1543034"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0447.1992.tb01453.x","doi":"https://doi.org/10.1111/j.1600-0447.1992.tb01453.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0447.1992.tb01453.x","pdf_url":null,"source":{"id":"https://openalex.org/S199498439","display_name":"Acta Psychiatrica Scandinavica","issn_l":"0001-690X","issn":["0001-690X","1600-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Psychiatrica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036271142","display_name":"N. Coxhead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"N. Coxhead","raw_affiliation_strings":["Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007825498","display_name":"Trevor Silverstone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"T. Silverstone","raw_affiliation_strings":["Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's and the Royal London Hospitals, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's and the Royal London Hospitals, London, United Kingdom","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079","https://openalex.org/I2801259928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037167848","display_name":"John Cookson","orcid":"https://orcid.org/0000-0002-1057-8338","observed_orcids":["https://orcid.org/0000-0002-1057-8338"]},"institutions":[{"id":"https://openalex.org/I1307195382","display_name":"St Bartholomew's Hospital","ror":"https://ror.org/00nh9x179","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1307195382","https://openalex.org/I225661044"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I2801259928","display_name":"Royal London Hospital","ror":"https://ror.org/019my5047","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I225661044","https://openalex.org/I2801259928"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Cookson","raw_affiliation_strings":["Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's and the Royal London Hospitals, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Unit of Human Psychopharmacology, Medical Colleges of St. Bartholomew's and the Royal London Hospitals, London, United Kingdom","institution_ids":["https://openalex.org/I1307195382","https://openalex.org/I166337079","https://openalex.org/I2801259928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036271142"],"corresponding_institution_ids":["https://openalex.org/I166337079"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":4.6649,"has_fulltext":false,"cited_by_count":133,"citation_normalized_percentile":{"value":0.9517876,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"85","issue":"2","first_page":"114","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/lithium","display_name":"lithium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":0.9710000157356262},{"id":"https://openalex.org/keywords/prophylaxis","display_name":"prophylaxis","score":0.8050000071525574},{"id":"https://openalex.org/keywords/relapse-rate","display_name":"relapse rate","score":0.7889999747276306},{"id":"https://openalex.org/keywords/lithium-withdrawal","display_name":"lithium withdrawal","score":0.9589999914169312},{"id":"https://openalex.org/keywords/drug-switching","display_name":"drug switching","score":0.43799999356269836},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6340000033378601},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.6349999904632568},{"id":"https://openalex.org/keywords/skin-rash","display_name":"rash","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.9914910793304443},{"id":"https://openalex.org/C2778541603","wikidata":"https://www.wikidata.org/wiki/Q152763","display_name":"Lithium (medication)","level":2,"score":0.8410029411315918},{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.653408408164978},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.5498695969581604},{"id":"https://openalex.org/C2780550438","wikidata":"https://www.wikidata.org/wiki/Q2622367","display_name":"Mood stabilizer","level":4,"score":0.5146218538284302},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42815423011779785},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42666706442832947},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3869132101535797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30920517444610596},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.28705883026123047},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.1593710482120514}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002220","descriptor_name":"Carbamazepine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016651","descriptor_name":"Lithium Carbonate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016651","descriptor_name":"Lithium Carbonate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016651","descriptor_name":"Lithium Carbonate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0447.1992.tb01453.x","doi":"https://doi.org/10.1111/j.1600-0447.1992.tb01453.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0447.1992.tb01453.x","pdf_url":null,"source":{"id":"https://openalex.org/S199498439","display_name":"Acta Psychiatrica Scandinavica","issn_l":"0001-690X","issn":["0001-690X","1600-0447"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Psychiatrica Scandinavica","raw_type":"journal-article"},{"id":"pmid:1543034","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1543034","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta psychiatrica Scandinavica","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W657523627","https://openalex.org/W1975781199","https://openalex.org/W1980693157","https://openalex.org/W1994161727","https://openalex.org/W2005974480","https://openalex.org/W2007188863","https://openalex.org/W2011644493","https://openalex.org/W2018472636","https://openalex.org/W2022976035","https://openalex.org/W2035928849","https://openalex.org/W2041989812","https://openalex.org/W2069959657","https://openalex.org/W2091281461","https://openalex.org/W2093946052","https://openalex.org/W2114613490","https://openalex.org/W2156597700","https://openalex.org/W2160070901","https://openalex.org/W2413489950","https://openalex.org/W2418223479","https://openalex.org/W2470249851"],"related_works":["https://openalex.org/W2013360878","https://openalex.org/W2093828549","https://openalex.org/W2022746100","https://openalex.org/W2071403897","https://openalex.org/W2048459953","https://openalex.org/W2011128825","https://openalex.org/W2165990107","https://openalex.org/W2036891893","https://openalex.org/W1975295411","https://openalex.org/W2404117576"],"abstract_inverted_index":{"A":[0],"12-month":[1],"double-blind":[2],"trial":[3],"of":[4,15,123],"carbamazepine":[5,36,64,78,107,114,131],"vs":[6],"lithium,":[7],"given":[8],"as":[9,116,118],"sole":[10],"treatment":[11],"for":[12],"the":[13,43,50,61,67,91,121],"prophylaxis":[14,122],"bipolar":[16,124],"affective":[17,125],"disorder,":[18],"was":[19,47],"carried":[20],"out":[21],"in":[22,49,63,66,120],"31":[23],"patients.":[24],"All":[25],"were":[26,32,83,88],"previously":[27],"stable":[28],"on":[29,40,54,57,77,94,97],"lithium;":[30],"15":[31],"switched":[33],"over":[34],"to":[35,100,130],"and":[37,82],"16":[38],"remained":[39],"lithium.":[41],"Although":[42],"overall":[44],"relapse":[45],"rate":[46],"similar":[48],"2":[51],"groups":[52],"(6":[53],"carbamazepine,":[55],"8":[56],"lithium),":[58],"nearly":[59],"all":[60],"relapses":[62],"occurred":[65],"first":[68],"month,":[69],"probably":[70],"precipitated":[71],"by":[72],"lithium":[73,98,119,129],"withdrawal.":[74],"Two":[75],"patients":[76],"developed":[79],"a":[80],"rash":[81],"withdrawn.":[84],"More":[85],"side":[86],"effects":[87],"noted":[89],"during":[90],"early":[92],"stages":[93],"carbamazepine.":[95],"Patients":[96],"tended":[99],"gain":[101],"weight":[102],"(+4":[103],"kg)":[104],"compared":[105],"with":[106],"(-3.1":[108],"kg).":[109],"It":[110],"is":[111,115],"concluded":[112],"that":[113],"effective":[117],"disorder;":[126],"changeover":[127],"from":[128],"should":[132],"be":[133],"done":[134],"slowly.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}