{"id":"https://openalex.org/W2141892423","doi":"https://doi.org/10.1016/j.bbapap.2010.05.007","title":"Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors","display_name":"Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors","publication_year":2010,"publication_date":"2010-05-25","ids":{"openalex":"https://openalex.org/W2141892423","doi":"https://doi.org/10.1016/j.bbapap.2010.05.007","mag":"2141892423","pmid":"https://pubmed.ncbi.nlm.nih.gov/20580860"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbapap.2010.05.007","doi":"https://doi.org/10.1016/j.bbapap.2010.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2010.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Zhigang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhigang Wang","raw_affiliation_strings":["Oligonucleotide Therapeutics Unit, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA. zhigang.wang@pfizer.com","Oligonucleotide Therapeutics Unit, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oligonucleotide Therapeutics Unit, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA. zhigang.wang@pfizer.com","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Oligonucleotide Therapeutics Unit, Pfizer, Inc., 620 Memorial Drive, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110054571","display_name":"William Watt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Watt","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 301 Henrietta Street, Kalamazoo, MI 49007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 301 Henrietta Street, Kalamazoo, MI 49007, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062649281","display_name":"Nathan A. Brooks","orcid":"https://orcid.org/0009-0007-6028-2096","observed_orcids":["https://orcid.org/0009-0007-6028-2096","https://orcid.org/0000-0002-5111-6914"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan A. Brooks","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 301 Henrietta Street, Kalamazoo, MI 49007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 301 Henrietta Street, Kalamazoo, MI 49007, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010793382","display_name":"Melissa S. Harris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa S. Harris","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 216 Eastern Pointe Rd, Groton, CT 06840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 216 Eastern Pointe Rd, Groton, CT 06840, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jan Urban","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Urban","raw_affiliation_strings":["8841 Helen James Avenue, San Diego, CA 92126, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"8841 Helen James Avenue, San Diego, CA 92126, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037017590","display_name":"Doug Boatman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126734","display_name":"Arena Pharmaceuticals (United States)","ror":"https://ror.org/02w3y1050","country_code":"US","type":"company","lineage":["https://openalex.org/I4210126734"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas Boatman","raw_affiliation_strings":["Arena Pharmaceuticals, 6166 Nancy Ridge Dr., San Diego, CA 92121, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arena Pharmaceuticals, 6166 Nancy Ridge Dr., San Diego, CA 92121, USA","institution_ids":["https://openalex.org/I4210126734"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009139171","display_name":"Michael McMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael McMillan","raw_affiliation_strings":["Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003425745","display_name":"Michael R. Kahn","orcid":"https://orcid.org/0000-0003-4992-3191","observed_orcids":["https://orcid.org/0000-0003-4992-3191"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Kahn","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA","Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA","Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, University of Southern California, 1501 San Pablo St., Los Angeles, CA 90033, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016822525","display_name":"Robert L. Heinrikson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109725","display_name":"Proteos (United States)","ror":"https://ror.org/01wrvt331","country_code":"US","type":"company","lineage":["https://openalex.org/I4210109725"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Heinrikson","raw_affiliation_strings":["Proteos, Inc., 4717 Campus Drive, Kalamazoo, MI 49008, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteos, Inc., 4717 Campus Drive, Kalamazoo, MI 49008, USA","institution_ids":["https://openalex.org/I4210109725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065771099","display_name":"Barry\u00a0C. Finzel","orcid":"https://orcid.org/0000-0001-8761-3384","observed_orcids":["https://orcid.org/0000-0001-8761-3384"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barry C. Finzel","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 301 Henrietta Street, Kalamazoo, MI 49007, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 301 Henrietta Street, Kalamazoo, MI 49007, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024130203","display_name":"Arthur J. Wittwer","orcid":"https://orcid.org/0000-0003-3995-2626","observed_orcids":["https://orcid.org/0000-0003-3995-2626"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arthur J. Wittwer","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036741368","display_name":"James R. Blinn","orcid":"https://orcid.org/0000-0001-7210-9011","observed_orcids":["https://orcid.org/0000-0001-7210-9011"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Blinn","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036584579","display_name":"Satwik Kamtekar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satwik Kamtekar","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072275265","display_name":"Alfredo G. Tomasselli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alfredo G. Tomasselli","raw_affiliation_strings":["Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Research and Development, Pfizer, Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5072275265"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":null,"fwci":1.0401,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.74601504,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"1804","issue":"9","first_page":"1817","last_page":"1831"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":1.0},{"id":"https://openalex.org/keywords/irreversible-inhibitors","display_name":"irreversible inhibitors","score":0.7940000295639038},{"id":"https://openalex.org/keywords/peptidomimetics","display_name":"peptidomimetics","score":0.8849999904632568},{"id":"https://openalex.org/keywords/z-vad-fmk","display_name":"z-VAD-fmk","score":0.9120000004768372},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.5519999861717224},{"id":"https://openalex.org/keywords/structure-based-drug-design","display_name":"structure-based drug design","score":0.6679999828338623},{"id":"https://openalex.org/keywords/allosteric-site","display_name":"allosteric site","score":0.7630000114440918},{"id":"https://openalex.org/keywords/executioner-caspases","display_name":"executioner caspases","score":0.6340000033378601},{"id":"https://openalex.org/keywords/initiator-caspases","display_name":"initiator caspases","score":0.9480000138282776},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.6850000023841858}],"concepts":[{"id":"https://openalex.org/C124790011","wikidata":"https://www.wikidata.org/wiki/Q2069797","display_name":"Peptidomimetic","level":3,"score":0.8813585042953491},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.7809790968894958},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.6870706677436829},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.6162930727005005},{"id":"https://openalex.org/C2775998712","wikidata":"https://www.wikidata.org/wiki/Q14907714","display_name":"Caspase-9","level":5,"score":0.5543071627616882},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5281945466995239},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.5005764961242676},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.47495102882385254},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4264587461948395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40625593066215515},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.3976331949234009},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.35430872440338135},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.34361422061920166},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.3426542282104492}],"mesh":[{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003460","descriptor_name":"Crystallization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbapap.2010.05.007","doi":"https://doi.org/10.1016/j.bbapap.2010.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbapap.2010.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S4210222880","display_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","issn_l":"1570-9639","issn":["1570-9639","1878-1454"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","raw_type":"journal-article"},{"id":"pmid:20580860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20580860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337189","display_name":"Institute of Microbiology, Chinese Academy of Sciences","ror":"https://ror.org/047yhep71"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1531683153","https://openalex.org/W1539796472","https://openalex.org/W1540436551","https://openalex.org/W1542039550","https://openalex.org/W1571529930","https://openalex.org/W1607777232","https://openalex.org/W1745634660","https://openalex.org/W1797495572","https://openalex.org/W1864051101","https://openalex.org/W1875906722","https://openalex.org/W1908051699","https://openalex.org/W1967436988","https://openalex.org/W1972263342","https://openalex.org/W1976570855","https://openalex.org/W1983476428","https://openalex.org/W1986191025","https://openalex.org/W1988518686","https://openalex.org/W1991455654","https://openalex.org/W1993229800","https://openalex.org/W1993720954","https://openalex.org/W1996874641","https://openalex.org/W1999576623","https://openalex.org/W2001641653","https://openalex.org/W2008757142","https://openalex.org/W2009007740","https://openalex.org/W2010034007","https://openalex.org/W2016090036","https://openalex.org/W2024105041","https://openalex.org/W2029901584","https://openalex.org/W2030232070","https://openalex.org/W2030805785","https://openalex.org/W2033735656","https://openalex.org/W2038840577","https://openalex.org/W2039356047","https://openalex.org/W2044445066","https://openalex.org/W2046369289","https://openalex.org/W2051155342","https://openalex.org/W2056155809","https://openalex.org/W2057819166","https://openalex.org/W2061497413","https://openalex.org/W2062014088","https://openalex.org/W2069159000","https://openalex.org/W2072944243","https://openalex.org/W2080476827","https://openalex.org/W2087092800","https://openalex.org/W2088363148","https://openalex.org/W2094265468","https://openalex.org/W2103345627","https://openalex.org/W2107237397","https://openalex.org/W2111507533","https://openalex.org/W2115596527","https://openalex.org/W2124965465","https://openalex.org/W2137834530","https://openalex.org/W2138144052","https://openalex.org/W2141604026","https://openalex.org/W2144081223","https://openalex.org/W2150130743","https://openalex.org/W2154571107","https://openalex.org/W2155022710","https://openalex.org/W2156179144","https://openalex.org/W2157042020","https://openalex.org/W2162168106","https://openalex.org/W2180476533","https://openalex.org/W2952757297","https://openalex.org/W4253658821","https://openalex.org/W7018033056"],"related_works":["https://openalex.org/W3148280502","https://openalex.org/W2950386715","https://openalex.org/W2050991439","https://openalex.org/W2116162926","https://openalex.org/W2044362105","https://openalex.org/W1573115815","https://openalex.org/W4309436471","https://openalex.org/W2111507533","https://openalex.org/W2087578110","https://openalex.org/W2014578146"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
