{"id":"https://openalex.org/W2141891741","doi":"https://doi.org/10.1128/jb.180.20.5421-5425.1998","title":"Fumarate Regulation of Gene Expression in Escherichia coli by the DcuSR ( dcuSR Genes) Two-Component Regulatory System","display_name":"Fumarate Regulation of Gene Expression in Escherichia coli by the DcuSR ( dcuSR Genes) Two-Component Regulatory System","publication_year":1998,"publication_date":"1998-10-15","ids":{"openalex":"https://openalex.org/W2141891741","doi":"https://doi.org/10.1128/jb.180.20.5421-5425.1998","mag":"2141891741","pmid":"https://pubmed.ncbi.nlm.nih.gov/9765574","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/107591"},"language":"en","primary_location":{"id":"doi:10.1128/jb.180.20.5421-5425.1998","doi":"https://doi.org/10.1128/jb.180.20.5421-5425.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.180.20.5421-5425.1998","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC107591","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016304419","display_name":"Evelyn Zientz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Evelyn Zientz","raw_affiliation_strings":["<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056422039","display_name":"Johannes Bongaerts","orcid":"https://orcid.org/0009-0007-8656-1472","observed_orcids":["https://orcid.org/0009-0007-8656-1472"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Bongaerts","raw_affiliation_strings":["<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000968335","display_name":"Gottfried Unden","orcid":"https://orcid.org/0000-0003-4906-1835","observed_orcids":["https://orcid.org/0000-0003-4906-1835"]},"institutions":[{"id":"https://openalex.org/I197323543","display_name":"Johannes Gutenberg University Mainz","ror":"https://ror.org/023b0x485","country_code":"DE","type":"education","lineage":["https://openalex.org/I197323543"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gottfried Unden","raw_affiliation_strings":["<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]},{"raw_affiliation_string":"Institut fu\u0308r Mikrobiologie und Weinforschung, Johannes Gutenberg- Universita\u0308t Mainz, 55099 Mainz, Germany","institution_ids":["https://openalex.org/I197323543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I197323543"],"apc_list":null,"apc_paid":null,"fwci":1.7218,"has_fulltext":false,"cited_by_count":126,"citation_normalized_percentile":{"value":0.83746021,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"180","issue":"20","first_page":"5421","last_page":"5425"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fumarate-reductase","display_name":"fumarate reductase","score":0.8840000033378601},{"id":"https://openalex.org/keywords/succinate-dehydrogenase","display_name":"succinate dehydrogenase","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C121612415","wikidata":"https://www.wikidata.org/wiki/Q5508536","display_name":"Fumarate reductase","level":4,"score":0.8915013074874878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7966033816337585},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.7873024940490723},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.628080427646637},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6143540143966675},{"id":"https://openalex.org/C138223613","wikidata":"https://www.wikidata.org/wiki/Q232956","display_name":"Two-component regulatory system","level":4,"score":0.6062546372413635},{"id":"https://openalex.org/C201663137","wikidata":"https://www.wikidata.org/wiki/Q21198990","display_name":"Periplasmic space","level":4,"score":0.5935469269752502},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.5806286334991455},{"id":"https://openalex.org/C2781196521","wikidata":"https://www.wikidata.org/wiki/Q24965710","display_name":"Response regulator","level":4,"score":0.5773922801017761},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.42107030749320984},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3729899525642395},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.08227652311325073}],"mesh":[{"descriptor_ui":"D000071677","descriptor_name":"Histidine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003998","descriptor_name":"Dicarboxylic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005650","descriptor_name":"Fumarates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013385","descriptor_name":"Succinate Dehydrogenase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016254","descriptor_name":"Mutagenesis, Insertional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017920","descriptor_name":"Antiporters","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029382","descriptor_name":"Dicarboxylic Acid Transporters","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1128/jb.180.20.5421-5425.1998","doi":"https://doi.org/10.1128/jb.180.20.5421-5425.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.180.20.5421-5425.1998","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:185258","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC107591","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:107591","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/107591","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:9765574","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9765574","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.606.2259","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.606.2259","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jb.asm.org/content/180/20/5421.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:185258","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC107591","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W21947383","https://openalex.org/W1512374553","https://openalex.org/W1519479476","https://openalex.org/W1544263417","https://openalex.org/W1639038258","https://openalex.org/W1657802603","https://openalex.org/W1660421813","https://openalex.org/W1775222556","https://openalex.org/W1795675295","https://openalex.org/W1959663215","https://openalex.org/W1961428397","https://openalex.org/W1977874184","https://openalex.org/W2020775251","https://openalex.org/W2022554333","https://openalex.org/W2025879472","https://openalex.org/W2028699235","https://openalex.org/W2034137330","https://openalex.org/W2070932843","https://openalex.org/W2072339497","https://openalex.org/W2085176594","https://openalex.org/W2085655308","https://openalex.org/W2099926472","https://openalex.org/W2108141139","https://openalex.org/W2129634655","https://openalex.org/W2134153749","https://openalex.org/W2141653906","https://openalex.org/W2144233663","https://openalex.org/W3145802305","https://openalex.org/W4298020519"],"related_works":["https://openalex.org/W7100788830","https://openalex.org/W2168503607","https://openalex.org/W2072669678","https://openalex.org/W6926223660","https://openalex.org/W2773559456","https://openalex.org/W6888985433","https://openalex.org/W6945304758","https://openalex.org/W2145637825","https://openalex.org/W2094064667","https://openalex.org/W2039393870"],"abstract_inverted_index":{"In":[0],"Escherichia":[1],"coli":[2,56],"the":[3,6,44,53,60,66,78,95,108,111,127,132,140,149,161,184],"genes":[4,46,64],"encoding":[5,144],"anaerobic":[7,79],"fumarate":[8,72],"respiratory":[9],"system":[10],"are":[11,41,154],"transcriptionally":[12],"regulated":[13,159],"by":[14,20,43,102,126,160],"C4-dicarboxylates.":[15],"The":[16,164],"regulation":[17,180],"is":[18,86,122,170],"effected":[19],"a":[21,28,34,90],"two-component":[22,166],"regulatory":[23,167],"system,":[24,168],"DcuSR,":[25,174],"consisting":[26],"of":[27,59,68,71,77,110,139,181,183],"sensory":[29],"histidine":[30],"kinase":[31],"(DcuS)":[32],"and":[33,39,62,76,104,118,148],"response":[35],"regulator":[36],"(DcuR).":[37],"DcuS":[38,85,105],"DcuR":[40,103],"encoded":[42],"dcuSR":[45],"(previously":[47],"yjdHG)":[48],"at":[49],"93.7":[50],"min":[51],"on":[52,178],"calculated":[54],"E.":[55],"map.":[57],"Inactivation":[58],"dcuR":[61],"dcuS":[63],"caused":[65],"loss":[67],"C4-dicarboxylate-stimulated":[69],"synthesis":[70],"reductase":[73],"(frdABCD":[74],"genes)":[75],"fumarate-succinate":[80],"antiporter":[81],"DcuB":[82],"(dcuB":[83],"gene).":[84],"predicted":[87],"to":[88,107,173],"contain":[89],"large":[91],"periplasmic":[92],"domain":[93],"as":[94],"supposed":[96],"site":[97],"for":[98],"C4-dicarboxylate":[99,142,179],"sensing.":[100],"Regulation":[101],"responded":[106],"presence":[109],"C4-dicarboxylates":[112],"fumarate,":[113],"succinate,":[114],"malate,":[115],"aspartate,":[116],"tartrate,":[117],"maleate.":[119],"Since":[120],"maleate":[121],"not":[123],"taken":[124],"up":[125],"bacteria":[128],"under":[129],"these":[130],"conditions,":[131],"carboxylates":[133],"presumably":[134],"act":[135],"from":[136],"without.":[137],"Genes":[138],"aerobic":[141,150],"pathway":[143],"succinate":[145,151],"dehydrogenase":[146],"(sdhCDAB)":[147],"carrier":[152],"(dctA)":[153],"only":[155],"marginally":[156],"or":[157],"negatively":[158],"DcuSR":[162],"system.":[163],"CitAB":[165],"which":[169],"highly":[171],"similar":[172],"had":[175],"no":[176],"effect":[177],"any":[182],"genes.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
