{"id":"https://openalex.org/W2141815299","doi":"https://doi.org/10.1016/s0021-9258(18)88892-5","title":"Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.","display_name":"Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.","publication_year":1985,"publication_date":"1985-06-01","ids":{"openalex":"https://openalex.org/W2141815299","doi":"https://doi.org/10.1016/s0021-9258(18)88892-5","mag":"2141815299","pmid":"https://pubmed.ncbi.nlm.nih.gov/2987243"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)88892-5","doi":"https://doi.org/10.1016/s0021-9258(18)88892-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)88892-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)88892-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035941891","display_name":"Jeffrey Benovic","orcid":"https://orcid.org/0000-0001-5705-7129","observed_orcids":["https://orcid.org/0000-0001-5705-7129"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Benovic","raw_affiliation_strings":["Duke Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Medical Center","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070180381","display_name":"LINDA JOY PIKE","orcid":"https://orcid.org/0000-0002-6708-5008","observed_orcids":["https://orcid.org/0000-0002-6708-5008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L J Pike","raw_affiliation_strings":["Biochemistry and Molecular Biophysics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biophysics","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079119381","display_name":"Richard A. Cerione","orcid":"https://orcid.org/0000-0003-4512-5897","observed_orcids":["https://orcid.org/0000-0003-4512-5897"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Cerione","raw_affiliation_strings":["Duke Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Duke Medical Center","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054272162","display_name":"Claudia Staniszewski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Staniszewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111008388","display_name":"T Yoshimasa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Yoshimasa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110109771","display_name":"Juan Codina","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Codina","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007698609","display_name":"Marc G. Caron","orcid":"https://orcid.org/0000-0003-0172-2710","observed_orcids":["https://orcid.org/0000-0003-0172-2710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M G Caron","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080672788","display_name":"Robert J. Lefkowitz","orcid":"https://orcid.org/0000-0003-1472-7545","observed_orcids":["https://orcid.org/0000-0003-1472-7545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R J Lefkowitz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":8.0892,"has_fulltext":false,"cited_by_count":320,"citation_normalized_percentile":{"value":0.98475163,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"260","issue":"11","first_page":"7094","last_page":"7101"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/receptor-phosphorylation","display_name":"receptor phosphorylation","score":0.9110000133514404},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9649999737739563},{"id":"https://openalex.org/keywords/receptor-dephosphorylation","display_name":"receptor dephosphorylation","score":0.843999981880188},{"id":"https://openalex.org/keywords/isoproterenol","display_name":"isoproterenol","score":0.796999990940094},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":0.8029999732971191},{"id":"https://openalex.org/keywords/alprenolol","display_name":"alprenolol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/beta-adrenergic-receptor-desensitization","display_name":"beta-adrenergic receptor desensitization","score":0.8109999895095825},{"id":"https://openalex.org/keywords/g-protein-coupling","display_name":"G protein coupling","score":0.6150000095367432},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hamster-lung","display_name":"hamster lung","score":0.8270000219345093},{"id":"https://openalex.org/keywords/receptor-g-protein-interaction","display_name":"receptor-G protein interaction","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6658859848976135},{"id":"https://openalex.org/C181912034","wikidata":"https://www.wikidata.org/wiki/Q1101143","display_name":"Dephosphorylation","level":4,"score":0.5807105898857117},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5784500241279602},{"id":"https://openalex.org/C56165258","wikidata":"https://www.wikidata.org/wiki/Q6046910","display_name":"Interleukin-13 receptor","level":5,"score":0.49309417605400085},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.466789573431015},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4571599066257477},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39005738496780396},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38556283712387085},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3776746988296509},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29540079832077026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2765825390815735},{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.12827107310295105},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.06815651059150696},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007545","descriptor_name":"Isoproterenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011943","descriptor_name":"Receptors, Adrenergic, beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)88892-5","doi":"https://doi.org/10.1016/s0021-9258(18)88892-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)88892-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:2987243","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2987243","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)88892-5","doi":"https://doi.org/10.1016/s0021-9258(18)88892-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)88892-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1280406276","display_name":null,"funder_award_id":"HL 16037","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3010207925","display_name":"Organization and Function of Cellular Structure","funder_award_id":"T32GM007184","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1487452375","https://openalex.org/W1487878207","https://openalex.org/W1490808252","https://openalex.org/W1495650500","https://openalex.org/W1509019649","https://openalex.org/W1509663711","https://openalex.org/W1515731319","https://openalex.org/W1533788848","https://openalex.org/W1533887373","https://openalex.org/W1535470439","https://openalex.org/W1556012018","https://openalex.org/W1562393866","https://openalex.org/W1564466121","https://openalex.org/W1566050966","https://openalex.org/W1566146794","https://openalex.org/W1589012184","https://openalex.org/W1592735689","https://openalex.org/W1598316265","https://openalex.org/W1658992953","https://openalex.org/W1676716323","https://openalex.org/W1977676788","https://openalex.org/W1990243260","https://openalex.org/W1990538114","https://openalex.org/W1997577845","https://openalex.org/W2010607758","https://openalex.org/W2016758816","https://openalex.org/W2031965971","https://openalex.org/W2046753575","https://openalex.org/W2049296045","https://openalex.org/W2089775890","https://openalex.org/W2092096020","https://openalex.org/W2094959748","https://openalex.org/W2100837269","https://openalex.org/W2119153517","https://openalex.org/W2129388093","https://openalex.org/W2132702380","https://openalex.org/W2146907325","https://openalex.org/W2172509713","https://openalex.org/W2223822401","https://openalex.org/W2251920431","https://openalex.org/W2338243600","https://openalex.org/W2345438193"],"related_works":["https://openalex.org/W2047896617","https://openalex.org/W1530935792","https://openalex.org/W1940252732","https://openalex.org/W2406023984","https://openalex.org/W2023627293","https://openalex.org/W6979767679","https://openalex.org/W1488128956","https://openalex.org/W1535470439","https://openalex.org/W313835219","https://openalex.org/W1727796232"],"abstract_inverted_index":{"In":[0],"some":[1],"systems,":[2],"such":[3],"as":[4,208],"the":[5,11,21,39,42,48,53,84,110,119,181,188,194,197,202,263,266],"turkey":[6,247],"erythrocyte,":[7],"agonist-promoted":[8],"phosphorylation":[9,40,114,134,171,234],"of":[10,20,41,52,72,87,95,112,151,169,183,196,232,260,262,265],"beta-adrenergic":[12,45,59,268],"receptor":[13,46,77,113,137,152,170,189,198,233,269],"appears":[14],"to":[15,65,187,199,241],"be":[16,28,79,139],"associated":[17],"with":[18,201,251],"desensitization":[19],"adenylate":[22],"cyclase":[23],"system.":[24],"This":[25],"process":[26],"can":[27,78,138],"partially":[29],"mimicked":[30],"by":[31,47,83,118,142,157,164,192,210,270],"cyclic":[32,54,88,252,271],"AMP":[33],"analogs.":[34],"Accordingly,":[35],"we":[36],"have":[37],"investigated":[38],"pure":[43,49],"mammalian":[44],"catalytic":[50,85],"subunit":[51,86],"AMP-dependent":[55,89,272],"protein":[56,90,273],"kinase.":[57,274],"The":[58,76,149,166,229],"receptor,":[60],"purified":[61],"from":[62],"hamster":[63],"lung":[64],"apparent":[66],"homogeneity,":[67],"contains":[68],"a":[69,103,106,143,257],"single":[70],"polypeptide":[71],"Mr":[73],"approximately":[74],"64,000.":[75],"phosphorylated":[80],"in":[81,109],"vitro":[82],"kinase":[91],"(approximately":[92],"2":[93],"mol":[94],"phosphate":[96],"(on":[97],"serine":[98],"residues)":[99],"per":[100],"mol).":[101],"Isoproterenol,":[102],"beta-agonist,":[104],"promoted":[105],"2-3-fold":[107,156],"increase":[108],"rate":[111,150],"which":[115],"was":[116,172,190,214],"blocked":[117,163],"beta-antagonists":[120],"propranolol":[121],"and":[122,159,177,185,235],"alprenolol.":[123,165],"High":[124],"performance":[125],"liquid":[126],"chromatographic":[127],"tryptic":[128],"peptide":[129],"mapping":[130],"reveals":[131],"two":[132],"major":[133],"sites.":[135],"Phosphorylated":[136],"completely":[140],"dephosphorylated":[141],"high":[144],"molecular":[145],"weight":[146],"phosphoprotein":[147],"phosphatase.":[148],"dephosphorylation":[153],"is":[154,162],"enhanced":[155],"isoproterenol":[158,184],"this":[160],"effect":[161],"functional":[167,236],"significance":[168],"examined":[173],"using":[174],"ligand":[175],"binding":[176,182],"reconstitution":[178],"techniques.":[179],"While":[180],"alprenolol":[186],"unaffected":[191],"phosphorylation,":[193],"ability":[195],"interact":[200],"stimulatory":[203],"guanine":[204],"nucleotide":[205],"regulatory":[206],"protein,":[207],"assessed":[209],"isoproterenol-promoted":[211],"GTPase":[212],"activity,":[213],"decreased":[215],"24":[216],"+/-":[217,220],"1%":[218],"(mean":[219],"S.E.,":[221],"p":[222],"less":[223],"than":[224],"0.001,":[225],"n":[226],"=":[227],"17).":[228],"quantitative":[230],"extent":[231],"impairment":[237],"are":[238],"virtually":[239],"identical":[240],"those":[242],"previously":[243],"observed":[244],"when":[245],"intact":[246],"erythrocytes":[248],"were":[249],"incubated":[250],"AMP.":[253],"These":[254],"data":[255],"provide":[256],"direct":[258],"demonstration":[259],"regulation":[261],"function":[264],"isolated":[267]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}