{"id":"https://openalex.org/W2141809112","doi":null,"title":"Clustering and periodicity of neurofibrillary tangles in the upper and lower cortical laminae in Alzheimer's disease.","display_name":"Clustering and periodicity of neurofibrillary tangles in the upper and lower cortical laminae in Alzheimer's disease.","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2141809112","mag":"2141809112","pmid":"https://pubmed.ncbi.nlm.nih.gov/18368624"},"language":"en","primary_location":{"id":"pmid:18368624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18368624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://publications.aston.ac.uk/id/eprint/4392/1/FN_Art_10046_1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040571169","display_name":"Richard A. Armstrong","orcid":"https://orcid.org/0000-0002-5046-3199","observed_orcids":["https://orcid.org/0000-0002-5046-3199"]},"institutions":[{"id":"https://openalex.org/I169199633","display_name":"Aston University","ror":"https://ror.org/05j0ve876","country_code":"GB","type":"education","lineage":["https://openalex.org/I169199633"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Richard A Armstrong","raw_affiliation_strings":["Vision Sciences, Aston University, Birmingham B4 7ET, UK. R.A.Armstrong@aston.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vision Sciences, Aston University, Birmingham B4 7ET, UK. R.A.Armstrong@aston.ac.uk","institution_ids":["https://openalex.org/I169199633"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040571169"],"corresponding_institution_ids":["https://openalex.org/I169199633"],"apc_list":null,"apc_paid":null,"fwci":0.5,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59898534,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"46","issue":"1","first_page":"26","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9639999866485596},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cortical-layers","display_name":"cortical layers","score":0.9549999833106995},{"id":"https://openalex.org/keywords/periodicity","display_name":"periodicity","score":0.6420000195503235},{"id":"https://openalex.org/keywords/cortico-cortical-pathways","display_name":"cortico-cortical pathways","score":0.8859999775886536},{"id":"https://openalex.org/keywords/feedback-projections","display_name":"feedback projections","score":0.984000027179718},{"id":"https://openalex.org/keywords/pia-mater","display_name":"pia mater","score":0.5360000133514404},{"id":"https://openalex.org/keywords/sporadic-alzheimer-s-disease","display_name":"sporadic Alzheimer's disease","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.650183379650116},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.4879879355430603},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.4655986726284027},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.46554407477378845},{"id":"https://openalex.org/C2777876421","wikidata":"https://www.wikidata.org/wiki/Q1637174","display_name":"Lobe","level":2,"score":0.42892590165138245},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3859833776950836},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3416065275669098},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010507","descriptor_name":"Periodicity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016874","descriptor_name":"Neurofibrillary Tangles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:18368624","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18368624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Folia neuropathologica","raw_type":"Journal Article"},{"id":"pmh:oai:publications.aston.ac.uk:4392","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/view/author/b688ed7dac988bb59e703b38c19badee.html>","pdf_url":"https://publications.aston.ac.uk/id/eprint/4392/1/FN_Art_10046_1.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:2141809112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18368624","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:publications.aston.ac.uk:4392","doi":null,"is_oa":true,"landing_page_url":"https://publications.aston.ac.uk/view/author/b688ed7dac988bb59e703b38c19badee.html>","pdf_url":"https://publications.aston.ac.uk/id/eprint/4392/1/FN_Art_10046_1.pdf","source":{"id":"https://openalex.org/S4306400483","display_name":"Aston Publications Explorer (Aston University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169199633","host_organization_name":"Aston University","host_organization_lineage":["https://openalex.org/I169199633"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2141809112.pdf","grobid_xml":"https://content.openalex.org/works/W2141809112.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W16029853","https://openalex.org/W97067864","https://openalex.org/W128037027","https://openalex.org/W145538831","https://openalex.org/W579582464","https://openalex.org/W644314260","https://openalex.org/W1511379621","https://openalex.org/W1556008598","https://openalex.org/W1821885973","https://openalex.org/W1965401887","https://openalex.org/W1975285051","https://openalex.org/W1975442701","https://openalex.org/W1975949045","https://openalex.org/W1992265419","https://openalex.org/W2004763497","https://openalex.org/W2013729857","https://openalex.org/W2021904740","https://openalex.org/W2028935440","https://openalex.org/W2030470579","https://openalex.org/W2035339855","https://openalex.org/W2041040025","https://openalex.org/W2068349234","https://openalex.org/W2071670137","https://openalex.org/W2082665846","https://openalex.org/W2083143568","https://openalex.org/W2083946279","https://openalex.org/W2103440561","https://openalex.org/W2146729934","https://openalex.org/W2154584808","https://openalex.org/W4246229348"],"related_works":["https://openalex.org/W644314260","https://openalex.org/W1975949045","https://openalex.org/W145538831","https://openalex.org/W1579281172","https://openalex.org/W2029923284","https://openalex.org/W1821885973","https://openalex.org/W1988146765","https://openalex.org/W2154584808","https://openalex.org/W2016601024","https://openalex.org/W2955011744"],"abstract_inverted_index":{"In":[0,89,257],"Alzheimer's":[1],"disease":[2],"(AD),":[3],"neurofibrillary":[4],"tangles":[5],"(NFT)":[6],"occur":[7],"within":[8],"neurons":[9],"in":[10,53,83,103,110,115,122,132,141,145,150,154,181,198,207,218,229,233,248,266],"both":[11,104],"the":[12,24,32,36,45,51,56,62,79,84,105,117,128,142,151,167,183,187,192,199,208,219,230,241,251,267],"upper":[13,85,106,118,143,200,220,268],"and":[14,26,48,65,70,86,107,114,149,178,194,206,253,269],"lower":[15,87,108,120,152,209,231,270],"cortical":[16],"laminae.":[17,88,271],"Using":[18],"a":[19,75,159],"statistical":[20],"method":[21],"that":[22,44,72],"estimates":[23],"size":[25,47,185],"spacing":[27],"of":[28,50,55,61,81,97,127,163,173,186,189,191,202,211,216,240],"NFT":[29,52,82,100,129,164,174,217,242,260],"clusters":[30,80,165,172,261],"along":[31,166],"cortex":[33],"parallel":[34],"to":[35,250,263],"pia":[37],"mater,":[38],"two":[39],"hypotheses":[40],"were":[41,101,175,222],"tested:":[42],"1)":[43],"cluster":[46],"distribution":[49],"gyri":[54,93,113,148,205],"temporal":[57,91],"lobe":[58,92],"reflect":[59],"degeneration":[60],"feedforward":[63],"(FF)":[64],"feedback":[66],"(FB)":[67],"cortico-cortical":[68,196,255],"pathways,":[69],"2)":[71],"there":[73],"is":[74],"spatial":[76],"relationship":[77],"between":[78,176],"16":[90],"from":[94],"10":[95],"cases":[96],"sporadic":[98],"AD,":[99],"present":[102],"laminae":[109,121,144,153,201,210,221,232],"11/16":[111],"(69%)":[112],"either":[116],"or":[119],"5/16":[123,234],"(31%)":[124,235],"gyri.":[125,134,214,236],"Clustering":[126],"was":[130,139],"observed":[131,140],"all":[133],"A":[135],"significant":[136],"peak-to-peak":[137],"distance":[138],"13/15":[146],"(87%)":[147],"8/12":[155],"(67%)":[156],"gyri,":[157,259],"suggesting":[158],"regularly":[160,170],"repeating":[161],"pattern":[162],"cortex.":[168],"The":[169,237],"distributed":[171],"500":[177],"800":[179],"microm":[180],"size,":[182],"estimated":[184],"cells":[188],"origin":[190],"FF":[193,252],"FB":[195,254],"projections,":[197],"6/13":[203],"(46%)":[204],"2/8":[212],"(25%)":[213],"Clusters":[215],"spatially":[223],"correlated":[224],"(in":[225],"phase)":[226],"with":[227,245],"those":[228],"clustering":[238],"patterns":[239],"are":[243],"consistent":[244],"their":[246],"formation":[247],"relation":[249],"pathways.":[256],"most":[258],"appeared":[262],"develop":[264],"independently":[265]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}