{"id":"https://openalex.org/W2141786751","doi":"https://doi.org/10.1146/annurev.med.48.1.157","title":"PARANEOPLASTIC SYNDROMES AFFECTING THE CENTRAL NERVOUS SYSTEM","display_name":"PARANEOPLASTIC SYNDROMES AFFECTING THE CENTRAL NERVOUS SYSTEM","publication_year":1997,"publication_date":"1997-02-01","ids":{"openalex":"https://openalex.org/W2141786751","doi":"https://doi.org/10.1146/annurev.med.48.1.157","mag":"2141786751","pmid":"https://pubmed.ncbi.nlm.nih.gov/9046952"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.med.48.1.157","doi":"https://doi.org/10.1146/annurev.med.48.1.157","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.med.48.1.157","pdf_url":null,"source":{"id":"https://openalex.org/S16909082","display_name":"Annual Review of Medicine","issn_l":"0066-4219","issn":["0066-4219","1545-326X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111371793","display_name":"Jerome B. Posner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerome B. Posner, MD","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021;","Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. Posner@Neuro.mskcc.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021;","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. Posner@Neuro.mskcc.org","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060587778","display_name":"Josep O. Dalmau","orcid":"https://orcid.org/0000-0001-5856-2813","observed_orcids":["https://orcid.org/0000-0001-5856-2813"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Josep O. Dalmau, MD, PhD","raw_affiliation_strings":["Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021;","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":null,"apc_paid":null,"fwci":0.4569,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.43333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"48","issue":"1","first_page":"157","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11271","display_name":"Myasthenia Gravis and Thymoma","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paraneoplastic-syndrome","display_name":"paraneoplastic syndrome","score":0.9800000190734863},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.8769999742507935},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7630000114440918},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.5849999785423279},{"id":"https://openalex.org/keywords/lambert-eaton-myasthenic-syndrome","display_name":"Lambert-Eaton myasthenic syndrome","score":0.890999972820282},{"id":"https://openalex.org/keywords/paraneoplastic-cerebellar-degeneration","display_name":"paraneoplastic cerebellar degeneration","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cancer-associated-neurological-disorders","display_name":"cancer-associated neurological disorders","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2778005360","wikidata":"https://www.wikidata.org/wiki/Q3508804","display_name":"Paraneoplastic cerebellar degeneration","level":4,"score":0.7959308624267578},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.7419193387031555},{"id":"https://openalex.org/C2777764698","wikidata":"https://www.wikidata.org/wiki/Q1756898","display_name":"Lambert-Eaton myasthenic syndrome","level":3,"score":0.7251294255256653},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7175213098526001},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.6488023400306702},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6211659908294678},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6189223527908325},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4922303259372711},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4473848342895508},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.44672006368637085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41369181871414185},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.38434603810310364},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.371318519115448},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19550666213035583},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1831146478652954},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1138157844543457},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002493","descriptor_name":"Central Nervous System Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009460","descriptor_name":"Neurologic Examination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010257","descriptor_name":"Paraneoplastic Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D010257","descriptor_name":"Paraneoplastic Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010257","descriptor_name":"Paraneoplastic Syndromes","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015624","descriptor_name":"Lambert-Eaton Myasthenic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D015624","descriptor_name":"Lambert-Eaton Myasthenic Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015624","descriptor_name":"Lambert-Eaton Myasthenic Syndrome","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.med.48.1.157","doi":"https://doi.org/10.1146/annurev.med.48.1.157","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.med.48.1.157","pdf_url":null,"source":{"id":"https://openalex.org/S16909082","display_name":"Annual Review of Medicine","issn_l":"0066-4219","issn":["0066-4219","1545-326X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Medicine","raw_type":"journal-article"},{"id":"pmid:9046952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9046952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W173401580","https://openalex.org/W571357027","https://openalex.org/W1497442951","https://openalex.org/W1641292543","https://openalex.org/W1968215248","https://openalex.org/W1970019903","https://openalex.org/W1974883827","https://openalex.org/W1978092831","https://openalex.org/W1979369853","https://openalex.org/W1982203224","https://openalex.org/W1986284623","https://openalex.org/W1988126651","https://openalex.org/W1988312770","https://openalex.org/W1994162672","https://openalex.org/W1994487332","https://openalex.org/W2001032667","https://openalex.org/W2003003447","https://openalex.org/W2007472281","https://openalex.org/W2012403244","https://openalex.org/W2019119125","https://openalex.org/W2030434347","https://openalex.org/W2030543234","https://openalex.org/W2041050315","https://openalex.org/W2060387369","https://openalex.org/W2067623537","https://openalex.org/W2068608237","https://openalex.org/W2079684466","https://openalex.org/W2090348477","https://openalex.org/W2092226919","https://openalex.org/W2121119743","https://openalex.org/W2121200845","https://openalex.org/W2123633466","https://openalex.org/W2134093662","https://openalex.org/W2137518940","https://openalex.org/W2208965105","https://openalex.org/W4299651026"],"related_works":["https://openalex.org/W2083069025","https://openalex.org/W2114280442","https://openalex.org/W2399518526","https://openalex.org/W3022365257","https://openalex.org/W2410543920","https://openalex.org/W3022061096","https://openalex.org/W39330139","https://openalex.org/W2090901352","https://openalex.org/W3132204388","https://openalex.org/W3165532069"],"abstract_inverted_index":{"Paraneoplastic":[0],"syndromes":[1,9],"affecting":[2],"the":[3,21,46,49,56,69,88,93],"nervous":[4,22,50],"system":[5,23],"are":[6,60],"rare":[7],"neurologic":[8],"caused":[10],"by":[11,45,63],"cancer":[12,47,94],"but":[13],"not":[14],"ascribable":[15],"to":[16,37],"metastases.":[17],"Any":[18],"portion":[19],"of":[20,33,65,87,92],"may":[24],"be":[25,38],"involved":[26],"in":[27],"a":[28],"paraneoplastic":[29,78,82],"syndrome.":[30],"The":[31],"pathogenesis":[32],"these":[34],"disorders":[35],"appears":[36],"an":[39],"immune":[40],"reaction":[41],"against":[42,68],"antigens":[43],"shared":[44],"and":[48],"system.":[51],"Some":[52],"disorders,":[53,75],"such":[54,76],"as":[55,77],"Lambert-Eaton":[57],"myasthenic":[58],"syndrome,":[59],"effectively":[61],"treated":[62],"removal":[64,86],"autoantibodies":[66],"directed":[67],"presynaptic":[70],"cholinergic":[71],"synapse.":[72],"In":[73],"other":[74],"cerebellar":[79],"degeneration":[80],"or":[81],"sensory":[83],"neuronopathy,":[84],"neither":[85],"autoantibody":[89],"nor":[90],"treatment":[91],"is":[95],"effective.":[96]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
