{"id":"https://openalex.org/W2141594040","doi":"https://doi.org/10.1562/2005-08-08-ra-641","title":"Topical Bioadhesive Patch Systems Enhance Selectivity of Protoporphyrin IX Accumulation","display_name":"Topical Bioadhesive Patch Systems Enhance Selectivity of Protoporphyrin IX Accumulation","publication_year":2006,"publication_date":"2006-02-13","ids":{"openalex":"https://openalex.org/W2141594040","doi":"https://doi.org/10.1562/2005-08-08-ra-641","mag":"2141594040","pmid":"https://pubmed.ncbi.nlm.nih.gov/16475870"},"language":"en","primary_location":{"id":"doi:10.1562/2005-08-08-ra-641","doi":"https://doi.org/10.1562/2005-08-08-ra-641","is_oa":false,"landing_page_url":"https://doi.org/10.1562/2005-08-08-ra-641","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035668087","display_name":"Ryan F. Donnelly","orcid":"https://orcid.org/0000-0002-0766-4147","observed_orcids":["https://orcid.org/0000-0002-0766-4147"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ryan F. Donnelly","raw_affiliation_strings":["School of Pharmacy, Queen's University Belfast, Medical Biology Centre, UK. r.donnelly@qub.ac.uk","Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, UK. r.donnelly@qub.ac.uk","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","institution_ids":[]},{"raw_affiliation_string":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610612","display_name":"Liwei Ma","orcid":"https://orcid.org/0000-0002-7867-8060","observed_orcids":["https://orcid.org/0000-0002-7867-8060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li\u2010Wei Ma","raw_affiliation_strings":["Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089578099","display_name":"Petras Juzenas","orcid":"https://orcid.org/0000-0002-0114-903X","observed_orcids":["https://orcid.org/0000-0002-0114-903X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petras Juzenas","raw_affiliation_strings":["Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","Institute for Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","institution_ids":[]},{"raw_affiliation_string":"Institute for Cancer Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085281978","display_name":"Vladimir Lani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vladimir Lani","raw_affiliation_strings":["Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090257452","display_name":"Paul A. McCarron","orcid":"https://orcid.org/0000-0002-2292-9887","observed_orcids":["https://orcid.org/0000-0002-2292-9887"]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul A. McCarron","raw_affiliation_strings":["School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK","Queen\u2019s University Belfast#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Queen\u2019s University Belfast#TAB#","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108085320","display_name":"A. David Woolfson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126231945","display_name":"Queen's University Belfast","ror":"https://ror.org/00hswnk62","country_code":"GB","type":"education","lineage":["https://openalex.org/I126231945"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. David Woolfson","raw_affiliation_strings":["School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK","Queen\u2019s University Belfast#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK","institution_ids":["https://openalex.org/I126231945"]},{"raw_affiliation_string":"Queen\u2019s University Belfast#TAB#","institution_ids":["https://openalex.org/I126231945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110489519","display_name":"Johan E. Moan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan Moan","raw_affiliation_strings":["Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","Institute for Cancer Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Montebello, Oslo, Norway","institution_ids":[]},{"raw_affiliation_string":"Institute for Cancer Research","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035668087"],"corresponding_institution_ids":["https://openalex.org/I126231945"],"apc_list":{"value":4330,"currency":"USD","value_usd":4330},"apc_paid":null,"fwci":1.27,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.78253548,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"82","issue":"3","first_page":"670","last_page":"675"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protoporphyrin-ix-accumulation","display_name":"protoporphyrin IX accumulation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/5-aminolevulinic-acid","display_name":"5-aminolevulinic acid","score":0.9789999723434448},{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/skin-tumors","display_name":"skin tumors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-selectivity","display_name":"tumor selectivity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/stratum-corneum","display_name":"stratum corneum","score":0.8259999752044678},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.5730000138282776},{"id":"https://openalex.org/keywords/transplantable-tumors","display_name":"transplantable tumors","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.9718976616859436},{"id":"https://openalex.org/C2776634624","wikidata":"https://www.wikidata.org/wiki/Q4914690","display_name":"Bioadhesive","level":3,"score":0.9495500326156616},{"id":"https://openalex.org/C2779671804","wikidata":"https://www.wikidata.org/wiki/Q619815","display_name":"Protoporphyrin IX","level":3,"score":0.8918444514274597},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.7669063806533813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6032009124755859},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.41196656227111816},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36243969202041626},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3396325409412384},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1699628233909607},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.157981276512146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14778363704681396},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06888735294342041},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.05647239089012146},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011524","descriptor_name":"Protoporphyrins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D012869","descriptor_name":"Skin Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1562/2005-08-08-ra-641","doi":"https://doi.org/10.1562/2005-08-08-ra-641","is_oa":false,"landing_page_url":"https://doi.org/10.1562/2005-08-08-ra-641","pdf_url":null,"source":{"id":"https://openalex.org/S61245073","display_name":"Photochemistry and Photobiology","issn_l":"0031-8655","issn":["0031-8655","1751-1097"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and Photobiology","raw_type":"journal-article"},{"id":"pmid:16475870","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16475870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Photochemistry and photobiology","raw_type":"Journal Article"},{"id":"pmh:10.1562/2005-08-08-RA-641","doi":null,"is_oa":false,"landing_page_url":"http://www.bioone.org/doi/10.1562/2005-08-08-RA-641","pdf_url":null,"source":{"id":"https://openalex.org/S4306402358","display_name":"BioOne Complete (BioOne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210111627","host_organization_name":"BioOne","host_organization_lineage":["https://openalex.org/I4210111627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"text"},{"id":"pmh:oai:pure.qub.ac.uk/portal:publications/5b3c8d51-ed71-46db-bfc2-cf99ae5ce67a","doi":null,"is_oa":false,"landing_page_url":"https://pure.qub.ac.uk/en/publications/5b3c8d51-ed71-46db-bfc2-cf99ae5ce67a","pdf_url":null,"source":{"id":"https://openalex.org/S4306402319","display_name":"Research Portal (Queen's University Belfast)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126231945","host_organization_name":"Queen's University Belfast","host_organization_lineage":["https://openalex.org/I126231945"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Donnelly, R, Ma, L W, Juzenas, P, Iani, V, McCarron, P, Woolfson, D & Moan, J 2006, 'Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation.', Photochemistry and Photobiology, vol. 82(3), no. 3, pp. 670-675. https://doi.org/10.1562/2005-08-08-RA-641","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1506108633","https://openalex.org/W1987479252","https://openalex.org/W1990140985","https://openalex.org/W1997785029","https://openalex.org/W2000022287","https://openalex.org/W2000565274","https://openalex.org/W2004850865","https://openalex.org/W2013275649","https://openalex.org/W2018351351","https://openalex.org/W2025011011","https://openalex.org/W2032080098","https://openalex.org/W2035691044","https://openalex.org/W2044096564","https://openalex.org/W2044686030","https://openalex.org/W2048646869","https://openalex.org/W2052452459","https://openalex.org/W2052821687","https://openalex.org/W2058057535","https://openalex.org/W2073585288","https://openalex.org/W2076894165","https://openalex.org/W2080795148","https://openalex.org/W2101115940","https://openalex.org/W2118361204","https://openalex.org/W2128171069","https://openalex.org/W2166471370","https://openalex.org/W2174377998","https://openalex.org/W2468474796","https://openalex.org/W2602944490"],"related_works":["https://openalex.org/W1968420604","https://openalex.org/W1986861467","https://openalex.org/W1971690392","https://openalex.org/W2028012228","https://openalex.org/W7131810454","https://openalex.org/W2401269765","https://openalex.org/W2001749797","https://openalex.org/W4247730499","https://openalex.org/W2169039770","https://openalex.org/W1989806930"],"abstract_inverted_index":{"In":[0],"clinical":[1],"5-aminolevulinic":[2],"acid":[3],"(ALA)-based":[4],"photodynamic":[5],"therapy":[6],"(PDT)":[7],"of":[8,21,35,59,95,97,104,111],"skin":[9,64,88],"tumors":[10,37,66],"it":[11,29],"is":[12],"desirable":[13],"to":[14,38,52,68,84],"develop":[15],"vehicles":[16],"that":[17,103,114],"minimize":[18],"the":[19,31,36,72,78,98,105],"penetration":[20],"ALA":[22],"through":[23,30],"normal":[24,87],"stratum":[25,33,118],"corneum":[26,34,119],"and":[27,89,120],"maximize":[28],"compromised":[32,116],"improve":[39],"tumor":[40,117],"selectivity.":[41],"We":[42],"have":[43],"designed":[44],"a":[45,122],"bioadhesive":[46],"patch,":[47,99],"which":[48],"may":[49],"be":[50],"able":[51],"achieve":[53],"this":[54],"aim.":[55],"It":[56],"induces":[57,81],"levels":[58],"protoporphyrin":[60],"IX":[61],"(PpIX)":[62],"in":[63,86,121],"overlying":[65],"similar":[67],"those":[69],"induced":[70],"by":[71,109],"proprietary":[73],"cream":[74],"(Porphin)":[75],"but":[76],"at":[77,90],"same":[79],"time":[80],"less":[82],"PpIX":[83],"form":[85],"distant":[91],"sites.":[92],"The":[93],"mechanisms":[94],"action":[96],"as":[100],"compared":[101],"with":[102,125],"cream,":[106],"were":[107],"studied":[108],"means":[110],"Cuprophan":[112],"barriers":[113],"mimic":[115],"mouse":[123],"model":[124],"transplanted":[126],"tumors.":[127]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
