{"id":"https://openalex.org/W2141546801","doi":null,"title":"Clinical and hematological phenotype of homozygous hemoglobin E: revisit of a benign condition with hidden reproductive risk.","display_name":"Clinical and hematological phenotype of homozygous hemoglobin E: revisit of a benign condition with hidden reproductive risk.","publication_year":2009,"publication_date":"2009-03-01","ids":{"openalex":"https://openalex.org/W2141546801","mag":"2141546801","pmid":"https://pubmed.ncbi.nlm.nih.gov/19323016"},"language":"en","primary_location":{"id":"pmid:19323016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19323016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Southeast Asian journal of tropical medicine and public health","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006834859","display_name":"Kalaya Tachavanich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kalaya Tachavanich","raw_affiliation_strings":["Hematology/Oncology Division, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology/Oncology Division, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080150203","display_name":"Vip Viprakasit","orcid":"https://orcid.org/0000-0003-3162-1849","observed_orcids":["https://orcid.org/0000-0003-3162-1849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vip Viprakasit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084801881","display_name":"Worawut Chinchang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Worawut Chinchang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001686972","display_name":"Waraporn Glomglao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waraporn Glomglao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109838467","display_name":"Parichat Pung\u2010Amritt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Parichat Pung-Amritt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110326972","display_name":"Voravarn S. Tanphaichitr","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Voravarn S Tanphaichitr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.921,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.73860182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"40","issue":"2","first_page":"306","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11660","display_name":"Blood groups and transfusion","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemoglobin-e","display_name":"hemoglobin E","score":0.8560000061988831},{"id":"https://openalex.org/keywords/beta-globin-variant","display_name":"beta-globin variant","score":0.8090000152587891},{"id":"https://openalex.org/keywords/iron-deficiency","display_name":"iron deficiency","score":0.7139999866485596},{"id":"https://openalex.org/keywords/iron-supplementation","display_name":"iron supplementation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fetal-hemoglobin","display_name":"fetal hemoglobin","score":0.878000020980835},{"id":"https://openalex.org/keywords/alpha-thalassemia","display_name":"alpha-thalassemia","score":0.8220000267028809},{"id":"https://openalex.org/keywords/g6pd-deficiency","display_name":"glucose-6-phosphate dehydrogenase deficiency","score":0.9670000076293945},{"id":"https://openalex.org/keywords/reproductive-risk","display_name":"reproductive risk","score":0.6499999761581421},{"id":"https://openalex.org/keywords/misdiagnosis","display_name":"misdiagnosis","score":0.6539999842643738},{"id":"https://openalex.org/keywords/dna-analysis","display_name":"DNA analysis","score":0.41499999165534973},{"id":"https://openalex.org/keywords/hematological-phenotype","display_name":"hematological phenotype","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2779440204","wikidata":"https://www.wikidata.org/wiki/Q1260186","display_name":"Hepatosplenomegaly","level":3,"score":0.7774664163589478},{"id":"https://openalex.org/C2781217586","wikidata":"https://www.wikidata.org/wiki/Q17022356","display_name":"Hemoglobin E","level":3,"score":0.7676033973693848},{"id":"https://openalex.org/C2777799968","wikidata":"https://www.wikidata.org/wiki/Q185137","display_name":"Thalassemia","level":2,"score":0.7364607453346252},{"id":"https://openalex.org/C2779668550","wikidata":"https://www.wikidata.org/wiki/Q1642147","display_name":"Hemoglobinopathy","level":3,"score":0.6355077028274536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.586749255657196},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.5004634857177734},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.49076446890830994},{"id":"https://openalex.org/C2777417653","wikidata":"https://www.wikidata.org/wiki/Q1313081","display_name":"Iron deficiency","level":3,"score":0.47821947932243347},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4713520407676697},{"id":"https://openalex.org/C2776175824","wikidata":"https://www.wikidata.org/wiki/Q1145668","display_name":"Hemolytic anemia","level":2,"score":0.4639297127723694},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4370577335357666},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3468877971172333},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.32541796565055847},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3171197175979614},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2543908357620239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16389042139053345},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005954","descriptor_name":"Glucosephosphate Dehydrogenase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006446","descriptor_name":"Hemoglobin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011250","descriptor_name":"Pregnancy Complications, Hematologic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013785","descriptor_name":"Thailand","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017085","descriptor_name":"alpha-Thalassemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018798","descriptor_name":"Anemia, Iron-Deficiency","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055544","descriptor_name":"beta-Globins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:19323016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19323016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Southeast Asian journal of tropical medicine and public health","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.579.2890","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.579.2890","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.tm.mahidol.ac.th/seameo/2009-40-2/14-4454.pdf","raw_type":"text"},{"id":"mag:2141546801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19323016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W63041568","https://openalex.org/W1598569053","https://openalex.org/W1752411179","https://openalex.org/W1972642606","https://openalex.org/W1974944433","https://openalex.org/W1981826617","https://openalex.org/W1989361310","https://openalex.org/W1989373341","https://openalex.org/W2010414280","https://openalex.org/W2061022183","https://openalex.org/W2075245305","https://openalex.org/W2075771847","https://openalex.org/W2076531738","https://openalex.org/W2083048402","https://openalex.org/W2094175721","https://openalex.org/W2167633922","https://openalex.org/W2184741559","https://openalex.org/W2402798614","https://openalex.org/W2408060979"],"related_works":["https://openalex.org/W4300919263","https://openalex.org/W3025124594","https://openalex.org/W178853356","https://openalex.org/W2186713685","https://openalex.org/W2150911844","https://openalex.org/W2076753963","https://openalex.org/W2075771847","https://openalex.org/W2407314229","https://openalex.org/W1994812847","https://openalex.org/W2305160624"],"abstract_inverted_index":{"Hemoglobin":[0,105],"E":[1],"(HbE)":[2],"is":[3,12,25,156,174],"one":[4],"of":[5,45,62,67,89,95,125,139,168,176],"the":[6,42,111],"most":[7],"prevalent":[8],"beta-globin":[9],"variant,":[10],"which":[11,127],"widely":[13],"distributed":[14],"in":[15,19,69,166],"Southeast":[16],"Asia":[17],"especially":[18],"Thailand.":[20],"Homozygosity":[21],"for":[22,57,164],"this":[23],"variant":[24],"common":[26],"and":[27,38,53,65,84,136],"may":[28],"occur":[29],"with":[30,98],"iron":[31,46,55,99,103],"deficiency.":[32,154],"In":[33],"order":[34],"to":[35,120,130,158],"study":[36],"clinical":[37,135],"hematological":[39,93,137],"phenotypes":[40,138],"without":[41],"confounding":[43],"effect":[44,61],"deficiency,":[47],"investigations":[48],"were":[49,72,77,118],"carried":[50],"out":[51],"before":[52],"after":[54,102],"supplementation":[56],"2":[58],"months.":[59],"The":[60],"G6PD":[63,153],"deficiency":[64,100],"coinheritance":[66],"alpha-thalassemia":[68,151,165,178],"homozygous":[70,141,169],"HbE":[71,75,91,109,142,170],"also":[73,149],"studied.":[74],"homozygotes":[76],"clinically":[78],"benign,":[79],"never":[80],"had":[81,85],"been":[82],"transfused":[83],"no":[86],"hepatosplenomegaly.":[87],"Out":[88],"76":[90],"homozygotes,":[92],"parameters":[94],"7":[96],"individuals":[97],"improved":[101],"supplementation.":[104],"analysis":[106,163],"revealed":[107],"that":[108],"was":[110],"main":[112],"hemoglobin":[113],"detected,":[114],"but":[115],"12":[116],"subjects":[117],"found":[119],"have":[121],"a":[122,160],"substantial":[123],"percentage":[124],"HbF,":[126],"might":[128],"lead":[129],"misdiagnosis":[131],"as":[132],"HbE/beta-thalassemia.":[133],"Both":[134],"simple":[140],"did":[143],"not":[144],"differ":[145],"from":[146],"those":[147],"who":[148],"inherited":[150],"and/or":[152],"It":[155],"necessary":[157],"perform":[159],"comprehensive":[161],"DNA":[162],"cases":[167],"when":[171],"their":[172],"partner":[173],"suspected":[175],"having":[177],"1":[179],"gene.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}