{"id":"https://openalex.org/W2141296569","doi":"https://doi.org/10.1373/clinchem.2008.111245","title":"Seasonal and Sex Variation of High-Sensitivity C-Reactive Protein in Healthy Adults: A Longitudinal Study","display_name":"Seasonal and Sex Variation of High-Sensitivity C-Reactive Protein in Healthy Adults: A Longitudinal Study","publication_year":2009,"publication_date":"2009-01-28","ids":{"openalex":"https://openalex.org/W2141296569","doi":"https://doi.org/10.1373/clinchem.2008.111245","mag":"2141296569","pmid":"https://pubmed.ncbi.nlm.nih.gov/19179270","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2706542"},"language":"en","primary_location":{"id":"doi:10.1373/clinchem.2008.111245","doi":"https://doi.org/10.1373/clinchem.2008.111245","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.111245","pdf_url":"https://academic.oup.com/clinchem/article-pdf/55/2/313/32673939/clinchem0313.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/clinchem/article-pdf/55/2/313/32673939/clinchem0313.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055893152","display_name":"David E. Chiriboga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David E Chiriboga","raw_affiliation_strings":["Division of Preventive and Behavioral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive and Behavioral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018762211","display_name":"Yunsheng Ma","orcid":"https://orcid.org/0000-0003-2317-3716","observed_orcids":["https://orcid.org/0000-0003-2317-3716"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yunsheng Ma","raw_affiliation_strings":["Division of Preventive and Behavioral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive and Behavioral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446244","display_name":"Wenjun Li","orcid":"https://orcid.org/0000-0001-5335-7386","observed_orcids":["https://orcid.org/0000-0001-5335-7386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenjun Li","raw_affiliation_strings":["Division of Preventive and Behavioral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive and Behavioral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110100597","display_name":"Edward J. Stanek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J Stanek","raw_affiliation_strings":["University of Massachusetts School of Public Health and Health Sciences, Amherst, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Massachusetts School of Public Health and Health Sciences, Amherst, MA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038298202","display_name":"James R. H\u00e9bert","orcid":"https://orcid.org/0000-0002-0677-2672","observed_orcids":["https://orcid.org/0000-0002-0677-2672"]},"institutions":[{"id":"https://openalex.org/I155781252","display_name":"University of South Carolina","ror":"https://ror.org/02b6qw903","country_code":"US","type":"education","lineage":["https://openalex.org/I155781252"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R He\u0301bert","raw_affiliation_strings":["Arnold School of Public Health, University of South Carolina, Columbia, SC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Arnold School of Public Health, University of South Carolina, Columbia, SC","institution_ids":["https://openalex.org/I155781252"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113618396","display_name":"Philip A. Merriam","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip A Merriam","raw_affiliation_strings":["Division of Preventive and Behavioral Medicine and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Preventive and Behavioral Medicine and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022721640","display_name":"Eric S. Rawson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190816365","display_name":"Bloomsburg University","ror":"https://ror.org/007dga614","country_code":"US","type":"education","lineage":["https://openalex.org/I190816365"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric S Rawson","raw_affiliation_strings":["Department of Exercise Science and Athletics, Bloomsburg University of Pennsylvania, Bloomsburg, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science and Athletics, Bloomsburg University of Pennsylvania, Bloomsburg, PA","institution_ids":["https://openalex.org/I190816365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080466261","display_name":"Ira S. Ockene","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ira S Ockene","raw_affiliation_strings":["Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA","institution_ids":["https://openalex.org/I166722992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5018762211"],"corresponding_institution_ids":[],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":2.1155,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.87791837,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"55","issue":"2","first_page":"313","last_page":"321"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.7689999938011169,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.15610000491142273,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.9929999709129333},{"id":"https://openalex.org/keywords/seasonal-variation","display_name":"seasonal variation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9950000047683716},{"id":"https://openalex.org/keywords/healthy-adults","display_name":"healthy adults","score":0.7570000290870667},{"id":"https://openalex.org/keywords/plasma-volume","display_name":"plasma volume","score":0.5759999752044678},{"id":"https://openalex.org/keywords/waist-and-hip-circumference","display_name":"waist and hip circumference","score":0.8849999904632568},{"id":"https://openalex.org/keywords/diastolic-blood-pressure","display_name":"diastolic blood pressure","score":0.9679999947547913},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.39899998903274536}],"concepts":[{"id":"https://openalex.org/C125403950","wikidata":"https://www.wikidata.org/wiki/Q2111082","display_name":"Seasonality","level":2,"score":0.6385097503662109},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6362937092781067},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.6037296652793884},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.570837676525116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4895494878292084},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.47045981884002686},{"id":"https://openalex.org/C2776193436","wikidata":"https://www.wikidata.org/wiki/Q236232","display_name":"Waist","level":3,"score":0.43116194009780884},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.3509671092033386},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.32925018668174744},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15611308813095093},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08643516898155212},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002097","descriptor_name":"C-Reactive Protein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008137","descriptor_name":"Longitudinal Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1373/clinchem.2008.111245","doi":"https://doi.org/10.1373/clinchem.2008.111245","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.111245","pdf_url":"https://academic.oup.com/clinchem/article-pdf/55/2/313/32673939/clinchem0313.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:19179270","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19179270","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2706542","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2706542","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Chem","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1015.7087","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1015.7087","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://works.bepress.com/edward_stanek/7/download/","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.605.3775","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.605.3775","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.clinchem.org/content/55/2/313.full.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.umassmed.edu:prevbeh_pp-1061","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.umassmed.edu/prevbeh_pp/62","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Preventive and Behavioral Medicine Publications","raw_type":"text"},{"id":"pmh:oai:works.bepress.com:edward_stanek-1013","doi":null,"is_oa":false,"landing_page_url":"https://works.bepress.com/edward_stanek/7","pdf_url":null,"source":{"id":"https://openalex.org/S4306402240","display_name":"ScholarWorks@UMassAmherst (University of Massachusetts Amherst)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I24603500","host_organization_name":"University of Massachusetts Amherst","host_organization_lineage":["https://openalex.org/I24603500"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Edward J. Stanek","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1373/clinchem.2008.111245","doi":"https://doi.org/10.1373/clinchem.2008.111245","is_oa":true,"landing_page_url":"https://doi.org/10.1373/clinchem.2008.111245","pdf_url":"https://academic.oup.com/clinchem/article-pdf/55/2/313/32673939/clinchem0313.pdf","source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G6727852325","display_name":null,"funder_award_id":"1R01 HL073194-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G863959910","display_name":"Determinants of C-Reactive Protein","funder_award_id":"R21HL076796","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2141296569.pdf","grobid_xml":"https://content.openalex.org/works/W2141296569.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1512719169","https://openalex.org/W1927282360","https://openalex.org/W1969047635","https://openalex.org/W1969492644","https://openalex.org/W1970642473","https://openalex.org/W1978853058","https://openalex.org/W1983483784","https://openalex.org/W1985835809","https://openalex.org/W1990506334","https://openalex.org/W2004839224","https://openalex.org/W2009005264","https://openalex.org/W2015767832","https://openalex.org/W2018026125","https://openalex.org/W2031350146","https://openalex.org/W2031993976","https://openalex.org/W2034722415","https://openalex.org/W2034943841","https://openalex.org/W2048609039","https://openalex.org/W2049234369","https://openalex.org/W2067514230","https://openalex.org/W2080208126","https://openalex.org/W2084699449","https://openalex.org/W2085846919","https://openalex.org/W2092061619","https://openalex.org/W2092975609","https://openalex.org/W2101860890","https://openalex.org/W2102259217","https://openalex.org/W2104657191","https://openalex.org/W2110833991","https://openalex.org/W2113761802","https://openalex.org/W2120366984","https://openalex.org/W2127393939","https://openalex.org/W2138903350","https://openalex.org/W2144852094","https://openalex.org/W2145359961","https://openalex.org/W2145710413","https://openalex.org/W2158859101","https://openalex.org/W2163092745","https://openalex.org/W2167826190","https://openalex.org/W2188333975","https://openalex.org/W2316376271"],"related_works":["https://openalex.org/W7099717935","https://openalex.org/W7097084680","https://openalex.org/W2105771720","https://openalex.org/W2589049042","https://openalex.org/W1970642473","https://openalex.org/W7101036067","https://openalex.org/W1873062108","https://openalex.org/W1993611737","https://openalex.org/W2154387477","https://openalex.org/W2088417416"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cross-sectional":[1],"studies":[2],"have":[3],"reported":[4],"seasonal":[5,82,150,162,214],"variation":[6,83,151,217],"in":[7,96,106,120,126,147,169,175,205,219,228,233,236],"high-sensitivity":[8],"C-reactive":[9],"protein":[10],"(hsCRP).":[11],"However,":[12],"longitudinal":[13],"data":[14,20],"are":[15],"lacking.":[16],"METHODS:":[17],"We":[18],"collected":[19],"on":[21],"diet,":[22],"physical":[23],"activity,":[24],"psychosocial":[25],"factors,":[26],"physiology,":[27],"and":[28,52,62,93,132,138,154,188,195,207,230,239,244],"anthropometric":[29],"measurements":[30],"from":[31],"534":[32],"healthy":[33],"adults":[34],"(mean":[35],"age":[36],"48":[37],"years,":[38],"48.5%":[39],"women,":[40,78],"87%":[41],"white)":[42],"at":[43],"quarterly":[44],"intervals":[45],"over":[46],"a":[47,123,166],"1-year":[48],"period":[49],"between":[50],"1994":[51],"1998.":[53],"Using":[54],"sinusoidal":[55],"regression":[56],"models,":[57],"we":[58],"estimated":[59],"peak-to-trough":[60],"amplitude":[61,84,148,215],"phase":[63],"of":[64,149,152,159,172,200,216],"the":[65,160,170,176,237],"peaks.":[66],"RESULTS:":[67],"At":[68],"baseline,":[69],"average":[70],"hsCRP":[71,118,180,201,229],"was":[72,85,94,165],"1.72":[73],"mg/L":[74,87],"(men,":[75],"1.75":[76],"mg/L;":[77],"1.68":[79],"mg/L).":[80],"Overall":[81],"0.16":[86],"(95%":[88],"CI":[89,101,111],"0.02":[90],"to":[91,103,113,210,225],"0.30)":[92],"lower":[95],"men":[97],"(0.10":[98],"mg/L,":[99,109],"95%":[100,110],"-0.11":[102],"0.31)":[104],"than":[105],"women":[107],"(0.23":[108],"0.04":[112],"0.42).":[114],"In":[115],"both":[116],"sexes,":[117],"peaked":[119],"November,":[121],"with":[122,145,192,212],"corresponding":[124],"trough":[125],"May.":[127],"Relative":[128],"plasma":[129],"volume,":[130],"waist":[131],"hip":[133],"circumference,":[134],"diastolic":[135],"blood":[136],"pressure,":[137],"depression":[139],"scores":[140],"were":[141,202],"major":[142],"factors":[143],"associated":[144],"changes":[146],"hsCRP,":[153],"taken":[155],"together":[156],"explain":[157],"most":[158],"observed":[161,218],"change.":[163],"There":[164],"20%":[167],"increase":[168],"percentage":[171],"participants":[173],"classified":[174],"high-risk":[177],"category":[178],"for":[179],"(>":[181],"or":[182],"=3":[183],"mg/L)":[184],"during":[185],"late":[186,193],"fall":[187,206],"early":[189,196],"winter":[190,208],"compared":[191,209],"spring":[194,238],"summer.":[197],"CONCLUSIONS:":[198],"Concentrations":[199],"modestly":[203],"increased":[204],"summer,":[211],"greater":[213],"women.":[220],"Conventional":[221],"classification":[222],"methods":[223],"fail":[224],"consider":[226],"seasonality":[227],"may":[231],"result":[232],"substantial":[234],"misclassifications":[235],"fall.":[240],"Future":[241],"clinical":[242],"practice":[243],"research":[245],"should":[246],"take":[247],"these":[248],"variations":[249],"into":[250],"account.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}