{"id":"https://openalex.org/W2141264092","doi":"https://doi.org/10.3851/imp2492","title":"Antiretroviral-Based HIV-1 Prevention: Antiretroviral Treatment and Pre-Exposure Prophylaxis","display_name":"Antiretroviral-Based HIV-1 Prevention: Antiretroviral Treatment and Pre-Exposure Prophylaxis","publication_year":2012,"publication_date":"2012-11-01","ids":{"openalex":"https://openalex.org/W2141264092","doi":"https://doi.org/10.3851/imp2492","mag":"2141264092","pmid":"https://pubmed.ncbi.nlm.nih.gov/23221365","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3531985"},"language":"en","primary_location":{"id":"doi:10.3851/imp2492","doi":"https://doi.org/10.3851/imp2492","is_oa":false,"landing_page_url":"https://doi.org/10.3851/imp2492","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3531985","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090773831","display_name":"Connie Celum","orcid":"https://orcid.org/0000-0002-8813-3419","observed_orcids":["https://orcid.org/0000-0002-8813-3419"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Connie Celum","raw_affiliation_strings":["Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064486492","display_name":"Jared M. Baeten","orcid":"https://orcid.org/0000-0001-8242-8438","observed_orcids":["https://orcid.org/0000-0001-8242-8438"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jared M Baeten","raw_affiliation_strings":["Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Global Health, Medicine and Epidemiology, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090773831"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":0.8329,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.61694616,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"8","first_page":"1483","last_page":"1493"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-prevention","display_name":"HIV-1 prevention","score":0.9810000061988831},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/pre-exposure-prophylaxis","display_name":"pre-exposure prophylaxis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tenofovir-gel","display_name":"tenofovir gel","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tenofovir-disoproxil-fumarate","display_name":"tenofovir disoproxil fumarate","score":0.9940000176429749},{"id":"https://openalex.org/keywords/emtricitabine-tenofovir","display_name":"tenofovir/emtricitabine","score":0.9169999957084656},{"id":"https://openalex.org/keywords/hiv-transmission-reduction","display_name":"HIV transmission reduction","score":0.6299999952316284},{"id":"https://openalex.org/keywords/serodiscordant-couples","display_name":"serodiscordant couples","score":0.9070000052452087},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.7889999747276306},{"id":"https://openalex.org/keywords/early-art-initiation","display_name":"early ART initiation","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2779778239","wikidata":"https://www.wikidata.org/wiki/Q422604","display_name":"Emtricitabine","level":5,"score":0.9351345300674438},{"id":"https://openalex.org/C2780500702","wikidata":"https://www.wikidata.org/wiki/Q7455026","display_name":"Serodiscordant","level":5,"score":0.9027688503265381},{"id":"https://openalex.org/C2779496540","wikidata":"https://www.wikidata.org/wiki/Q7239230","display_name":"Pre-exposure prophylaxis","level":5,"score":0.8667430281639099},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7892492413520813},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6161026954650879},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5032548308372498},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.4843946099281311},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4615402817726135},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.45287618041038513},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4166327714920044},{"id":"https://openalex.org/C2779344132","wikidata":"https://www.wikidata.org/wiki/Q155954","display_name":"Tenofovir","level":3,"score":0.4160413444042206},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.41559773683547974},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4146210551261902},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.4109245538711548},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.3742442727088928},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32864537835121155},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.2980971336364746},{"id":"https://openalex.org/C2776939746","wikidata":"https://www.wikidata.org/wiki/Q853451","display_name":"Men who have sex with men","level":4,"score":0.2656283378601074},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.11241686344146729},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10829728841781616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.064779132604599},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C2776983459","wikidata":"https://www.wikidata.org/wiki/Q41083","display_name":"Syphilis","level":3,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011292","descriptor_name":"Premedication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011634","descriptor_name":"Public Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3851/imp2492","doi":"https://doi.org/10.3851/imp2492","is_oa":false,"landing_page_url":"https://doi.org/10.3851/imp2492","pdf_url":null,"source":{"id":"https://openalex.org/S137629795","display_name":"Antiviral Therapy","issn_l":"1359-6535","issn":["1359-6535","2040-2058"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral Therapy","raw_type":"journal-article"},{"id":"pmid:23221365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23221365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antiviral therapy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2838902","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3531985","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3531985","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3531985","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Antivir Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2838902","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3531985","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1084389469","display_name":"Delivery of integrated PrEP and ART for HIV prevention for couples in Kenya","funder_award_id":"R01MH095507","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320308573","display_name":"Gilead Sciences","ror":"https://ror.org/056546b03"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1480425134","https://openalex.org/W1973540642","https://openalex.org/W2001602693","https://openalex.org/W2009386518","https://openalex.org/W2011362666","https://openalex.org/W2016002216","https://openalex.org/W2018045144","https://openalex.org/W2023680960","https://openalex.org/W2029558670","https://openalex.org/W2033997636","https://openalex.org/W2036967775","https://openalex.org/W2043472980","https://openalex.org/W2043824209","https://openalex.org/W2049134317","https://openalex.org/W2050494263","https://openalex.org/W2063995574","https://openalex.org/W2074195738","https://openalex.org/W2079766092","https://openalex.org/W2080732718","https://openalex.org/W2097057569","https://openalex.org/W2099048494","https://openalex.org/W2100430786","https://openalex.org/W2101072866","https://openalex.org/W2103920597","https://openalex.org/W2106363895","https://openalex.org/W2116165373","https://openalex.org/W2116605213","https://openalex.org/W2117057469","https://openalex.org/W2121288293","https://openalex.org/W2121296127","https://openalex.org/W2122231602","https://openalex.org/W2124995497","https://openalex.org/W2126184004","https://openalex.org/W2127756962","https://openalex.org/W2127832030","https://openalex.org/W2133053181","https://openalex.org/W2135466424","https://openalex.org/W2144000274","https://openalex.org/W2146634980","https://openalex.org/W2147022351","https://openalex.org/W2149759731","https://openalex.org/W2150793371","https://openalex.org/W2152505869","https://openalex.org/W2156151523","https://openalex.org/W2156896622","https://openalex.org/W2158513952","https://openalex.org/W2161496228","https://openalex.org/W2162226934","https://openalex.org/W2164817588","https://openalex.org/W2164903312","https://openalex.org/W2168251450","https://openalex.org/W2314461521","https://openalex.org/W2316970929","https://openalex.org/W3150504294","https://openalex.org/W4233110931"],"related_works":["https://openalex.org/W2332535573","https://openalex.org/W2132439494","https://openalex.org/W2518394424","https://openalex.org/W2324968015","https://openalex.org/W1996174738","https://openalex.org/W2030228493","https://openalex.org/W2325487946","https://openalex.org/W2066045140","https://openalex.org/W2773154339","https://openalex.org/W2806405379"],"abstract_inverted_index":{"Antiretroviral-based":[0],"HIV-1":[1,16,29,40,45,56,98,115,140,157,186,201,232],"prevention":[2,116,202],"strategies":[3],"-":[4,31],"including":[5],"antiretroviral":[6],"treatment":[7],"(ART)":[8],"to":[9,27,146,181,205,210,226,248],"reduce":[10,227],"the":[11,33,84,110,164,179],"infectiousness":[12],"of":[13,59,70,86,102,112,168,183,199,221],"individuals":[14,26,217],"with":[15,52,159],"and":[17,19,61,80,89,104,125,132,161,191,208,233,241],"oral":[18,127],"topical":[20],"pre-exposure":[21],"prophylaxis":[22],"(PrEP)":[23],"for":[24,38,114,166,185,196,230],"uninfected":[25],"prevent":[28],"acquisition":[30],"are":[32,173],"most":[34],"promising":[35],"new":[36],"approaches":[37],"decreasing":[39],"spread.":[41],"Observational":[42],"studies":[43,137],"among":[44],"serodiscordant":[46],"couples":[47],"have":[48,108,138,154],"associated":[49],"ART":[50,71,190,207,225],"initiation":[51,69],"a":[53,62,94],"reduction":[54,96],"in":[55,83,93,97,151,170],"transmission":[57],"risk":[58,229],"80-92%,":[60],"recent":[63],"randomized":[64],"trial":[65],"demonstrated":[66,139],"that":[67],"earlier":[68,219],"(that":[72],"is,":[73],"at":[74,218],"CD4(+)":[75],"T-cell":[76],"counts":[77],"between":[78],"350":[79],"550":[81],"cells/mm(3)),":[82],"context":[85],"virological":[87],"monitoring":[88],"adherence":[90,244],"support,":[91],"resulted":[92],"96%":[95],"transmission.":[99],"A":[100],"number":[101],"ongoing":[103],"recently-completed":[105],"clinical":[106],"trials":[107,150,172],"assessed":[109],"efficacy":[111,169,182],"PrEP":[113,209],"as":[117,189],"pericoitally":[118],"administered":[119],"or":[120],"daily-administered":[121],"1%":[122],"tenofovir":[123,128],"gel":[124],"daily":[126],"disoproxil":[129],"fumarate":[130],"(TDF)":[131],"combination":[133],"emtricitabine":[134],"(FTC)/TDF.":[135],"Completed":[136],"protection":[141,158],"efficacies":[142],"ranging":[143],"from":[144],"39%":[145],"75%.":[147],"However,":[148],"two":[149],"African":[152],"women":[153],"shown":[155],"no":[156],"TDF":[160],"FTC/TDF":[162],"PrEP;":[163],"reasons":[165],"lack":[167],"those":[171],"being":[174],"investigated.":[175],"Adherence":[176],"is":[177],"likely":[178],"key":[180],"antiretrovirals":[184],"prevention,":[187],"both":[188],"PrEP.":[192],"Critical":[193],"unanswered":[194],"questions":[195],"successful":[197],"delivery":[198],"antiretroviral-based":[200],"include":[203],"how":[204],"target":[206],"realize":[211],"maximum":[212],"population":[213],"benefits,":[214],"whether":[215,234,242],"HIV-1-infected":[216],"stages":[220],"infection":[222],"would":[223,238],"accept":[224],"their":[228],"transmitting":[231],"highest-risk":[235],"HIV-1-negative":[236],"persons":[237],"use":[239],"PrEP,":[240],"high":[243,250],"could":[245],"be":[246],"sustained":[247],"achieve":[249],"effectiveness.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}