{"id":"https://openalex.org/W2140990138","doi":"https://doi.org/10.1128/ec.00270-10","title":"eIF2\u03b1 Kinases Control Chalone Production in Dictyostelium discoideum","display_name":"eIF2\u03b1 Kinases Control Chalone Production in Dictyostelium discoideum","publication_year":2011,"publication_date":"2011-01-29","ids":{"openalex":"https://openalex.org/W2140990138","doi":"https://doi.org/10.1128/ec.00270-10","mag":"2140990138","pmid":"https://pubmed.ncbi.nlm.nih.gov/21278229","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3127634"},"language":"en","primary_location":{"id":"doi:10.1128/ec.00270-10","doi":"https://doi.org/10.1128/ec.00270-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00270-10","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/ec.00270-10","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043291968","display_name":"Robert L. Bowman","orcid":"https://orcid.org/0000-0002-8294-8748","observed_orcids":["https://orcid.org/0000-0002-8294-8748"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Bowman","raw_affiliation_strings":["Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032125566","display_name":"Yanhua Xiong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanhua Xiong","raw_affiliation_strings":["Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113564892","display_name":"Janet H. Kirsten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet H. Kirsten","raw_affiliation_strings":["Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042711640","display_name":"Charles K. Singleton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles K. Singleton","raw_affiliation_strings":["Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, Tennessee 37235-1634","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":null,"apc_paid":null,"fwci":0.7615,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.68177394,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"10","issue":"4","first_page":"494","last_page":"501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.3774000108242035,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.3774000108242035,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.12210000306367874,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0835999995470047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eif2alpha-kinase","display_name":"eIF2\u03b1 kinase","score":0.8930000066757202},{"id":"https://openalex.org/keywords/gcn2","display_name":"GCN2","score":0.7409999966621399},{"id":"https://openalex.org/keywords/chalone","display_name":"chalone","score":0.7820000052452087},{"id":"https://openalex.org/keywords/apra","display_name":"APRA","score":1.0},{"id":"https://openalex.org/keywords/dictyostelium-discoideum","display_name":"Dictyostelium discoideum","score":0.968999981880188},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.9490000009536743},{"id":"https://openalex.org/keywords/translational-control","display_name":"translational regulation","score":0.7350000143051147},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.9649999737739563},{"id":"https://openalex.org/keywords/culmination","display_name":"culmination","score":0.3499999940395355},{"id":"https://openalex.org/keywords/developmental-regulation","display_name":"developmental regulation","score":0.4059999883174896},{"id":"https://openalex.org/keywords/secreted-proteins","display_name":"secreted proteins","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2775969001","wikidata":"https://www.wikidata.org/wiki/Q134351","display_name":"Dictyostelium discoideum","level":3,"score":0.7956218123435974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6872580647468567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6835783123970032},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.6241027116775513},{"id":"https://openalex.org/C2775889303","wikidata":"https://www.wikidata.org/wiki/Q17146891","display_name":"Dictyostelium","level":3,"score":0.61376953125},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5680596828460693},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.44662317633628845},{"id":"https://openalex.org/C4718897","wikidata":"https://www.wikidata.org/wiki/Q5408698","display_name":"Eukaryotic translation","level":5,"score":0.4140078127384186},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.3797399699687958},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25246483087539673},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.11221253871917725},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08346819877624512}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004023","descriptor_name":"Dictyostelium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015852","descriptor_name":"Eukaryotic Initiation Factor-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050150","descriptor_name":"Chalones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/ec.00270-10","doi":"https://doi.org/10.1128/ec.00270-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00270-10","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3127634","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3127634","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryot Cell","raw_type":"Text"},{"id":"pmid:21278229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21278229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/ec.00270-10","doi":"https://doi.org/10.1128/ec.00270-10","is_oa":true,"landing_page_url":"https://doi.org/10.1128/ec.00270-10","pdf_url":null,"source":{"id":"https://openalex.org/S177547185","display_name":"Eukaryotic Cell","issn_l":"1535-9778","issn":["1535-9778","1535-9786"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eukaryotic Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G834606717","display_name":"Function of Initiation Factor Kinases in Regulating Dictyostelium Development","funder_award_id":"0639836","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320337399","display_name":"Division of Integrative Organismal Systems","ror":"https://ror.org/01rvays47"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1506664443","https://openalex.org/W1542350928","https://openalex.org/W1549605620","https://openalex.org/W1644631653","https://openalex.org/W1914069668","https://openalex.org/W1968727721","https://openalex.org/W1978949887","https://openalex.org/W1990126094","https://openalex.org/W2009536847","https://openalex.org/W2011994162","https://openalex.org/W2014194720","https://openalex.org/W2014423141","https://openalex.org/W2050050314","https://openalex.org/W2052831047","https://openalex.org/W2062145837","https://openalex.org/W2066254237","https://openalex.org/W2071653602","https://openalex.org/W2080126760","https://openalex.org/W2080920431","https://openalex.org/W2084007133","https://openalex.org/W2086939601","https://openalex.org/W2092961490","https://openalex.org/W2094670093","https://openalex.org/W2096470485","https://openalex.org/W2097741715","https://openalex.org/W2100502528","https://openalex.org/W2103127692","https://openalex.org/W2112727647","https://openalex.org/W2126629767","https://openalex.org/W2127848114","https://openalex.org/W2135306929","https://openalex.org/W2139665070","https://openalex.org/W2147336345","https://openalex.org/W2160414774","https://openalex.org/W2161223493","https://openalex.org/W2166063624","https://openalex.org/W2166260863","https://openalex.org/W2186323258","https://openalex.org/W2189783757","https://openalex.org/W2740652466","https://openalex.org/W4244614471"],"related_works":["https://openalex.org/W2161223493","https://openalex.org/W2007212687","https://openalex.org/W7099290798","https://openalex.org/W2160414774","https://openalex.org/W2425447197","https://openalex.org/W2092961490","https://openalex.org/W2048556388","https://openalex.org/W2135306929","https://openalex.org/W2224048099","https://openalex.org/W2080126760"],"abstract_inverted_index":{"Growing":[0],"Dictyostelium":[1,52,84],"cells":[2,53,150,171,178],"secrete":[3],"CfaD":[4,139,173,191],"and":[5,33,73,140,192,209],"AprA,":[6],"two":[7,46],"proteins":[8,47,65,201],"that":[9,21,37,66,100,179,186,218],"have":[10,86],"been":[11,87],"characterized":[12],"as":[13],"chalones.":[14],"They":[15],"exist":[16],"within":[17],"a":[18,34,75,121,134,181,216,220],"high-molecular-weight":[19],"complex":[20],"reversibly":[22],"inhibits":[23,109],"cell":[24,30,110],"proliferation,":[25],"but":[26,143],"not":[27,118,144,161],"growth,":[28],"via":[29],"surface":[31],"receptors":[32],"signaling":[35],"pathway":[36],"includes":[38],"G":[39],"proteins.":[40],"How":[41],"the":[42,68,152,164,189,205],"production":[43,132,187,212],"of":[44,102,124,133,158,188,207],"these":[45],"is":[48,50,117,128,160,168,194,213],"regulated":[49,196],"unknown.":[51],"possess":[54,74],"three":[55],"GCN2-type":[56],"eukaryotic":[57],"initiation":[58,70],"factor":[59,71],"2":[60],"\u03b1":[61],"subunit":[62],"(eIF2\u03b1)":[63],"kinases,":[64],"phosphorylate":[67],"translational":[69],"eIF2\u03b1":[72,198],"tRNA":[76],"binding":[77],"domain":[78,107,167],"involved":[79],"in":[80,93,149,170,177,215],"their":[81,145],"regulation.":[82],"The":[83,112,156],"kinases":[85],"shown":[88],"to":[89,120,130],"function":[90],"during":[91],"development":[92],"regulating":[94],"several":[95],"processes.":[96],"We":[97,184],"show":[98],"here":[99],"expression":[101],"an":[103],"unregulated,":[104],"activated":[105,153,165],"kinase":[106,154,166],"greatly":[108],"proliferation.":[111],"inhibitory":[113],"effect":[114],"on":[115],"proliferation":[116,159],"due":[119,129],"general":[122],"inhibition":[123,157],"translation.":[125],"Instead,":[126],"it":[127],"enhanced":[131,211],"secreted":[135],"factor(s).":[136],"Indeed,":[137],"extracellular":[138],"AprA":[141,175,193],"proteins,":[142],"mRNAs,":[146],"are":[147,202],"overproduced":[148],"expressing":[151],"domain.":[155],"seen":[162],"when":[163],"expressed":[169],"lacking":[172,214],"or":[174,176],"contain":[180],"nonphosphorylatable":[182,221],"eIF2\u03b1.":[183,222],"conclude":[185],"chalones":[190],"translationally":[195],"by":[197],"phosphorylation.":[199],"Both":[200],"upregulated":[203],"at":[204],"culmination":[206],"development,":[208],"this":[210],"strain":[217],"possesses":[219]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
