{"id":"https://openalex.org/W2140977301","doi":"https://doi.org/10.1002/mrm.1910130104","title":"Inhibition of lymphocyte stimulation by shift reagents","display_name":"Inhibition of lymphocyte stimulation by shift reagents","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W2140977301","doi":"https://doi.org/10.1002/mrm.1910130104","mag":"2140977301","pmid":"https://pubmed.ncbi.nlm.nih.gov/2138693"},"language":"en","primary_location":{"id":"doi:10.1002/mrm.1910130104","doi":"https://doi.org/10.1002/mrm.1910130104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1910130104","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045051542","display_name":"Daniel Y. Sze","orcid":"https://orcid.org/0000-0002-6885-0752","observed_orcids":["https://orcid.org/0000-0002-6885-0752"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Y. Sze","raw_affiliation_strings":["Stanford Magnetic Resonance Laboratory, Stanford University Medical Center, California 94305","Stanford Magnetic Resonance Laboratory, Stanford University Medical Center, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Magnetic Resonance Laboratory, Stanford University Medical Center, California 94305","institution_ids":["https://openalex.org/I4210137306"]},{"raw_affiliation_string":"Stanford Magnetic Resonance Laboratory, Stanford University Medical Center, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016690825","display_name":"Nancy L. Corbelletta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy L. Corbelletta","raw_affiliation_strings":["Division of pediatric Surgery, Stanford University Medical Center, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of pediatric Surgery, Stanford University Medical Center, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109276848","display_name":"Stephen J. Shochat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen J. Shochat","raw_affiliation_strings":["Division of pediatric Surgery, Stanford University Medical Center, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of pediatric Surgery, Stanford University Medical Center, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061199691","display_name":"Oleg Jardetzky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Oleg Jardetzky","raw_affiliation_strings":["Stanford Magnetic Resonance Laboratory, Stanford University Medical Center, Stanford, California 94305"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Magnetic Resonance Laboratory, Stanford University Medical Center, Stanford, California 94305","institution_ids":["https://openalex.org/I4210137306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210137306"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":4.7797,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.95936935,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":"1","first_page":"14","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.4657999873161316,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lanthanide-shift-reagents","display_name":"lanthanide shift reagents","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lymphocyte-stimulation","display_name":"lymphocyte stimulation","score":0.7440000176429749},{"id":"https://openalex.org/keywords/peripheral-blood-lymphocytes","display_name":"peripheral blood lymphocytes","score":0.7799999713897705},{"id":"https://openalex.org/keywords/mitogenic-stimulation","display_name":"mitogen stimulation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/biotoxicity","display_name":"biotoxicity","score":0.45899999141693115},{"id":"https://openalex.org/keywords/calcium-regulation","display_name":"calcium regulation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/membrane-biochemistry","display_name":"membrane biochemistry","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C40875361","wikidata":"https://www.wikidata.org/wiki/Q2356542","display_name":"Reagent","level":2,"score":0.9380033016204834},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.7004537582397461},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6724762320518494},{"id":"https://openalex.org/C201770740","wikidata":"https://www.wikidata.org/wiki/Q19569","display_name":"Lanthanide","level":3,"score":0.5420500040054321},{"id":"https://openalex.org/C154256306","wikidata":"https://www.wikidata.org/wiki/Q41795528","display_name":"Inert","level":2,"score":0.5259466767311096},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.39079979062080383},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.36865583062171936},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.13314497470855713},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11580398678779602},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11569499969482422},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007959","descriptor_name":"Lymphocyte Culture Test, Mixed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008214","descriptor_name":"Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008674","descriptor_name":"Metals, Rare Earth","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrm.1910130104","doi":"https://doi.org/10.1002/mrm.1910130104","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1910130104","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:2138693","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2138693","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1544717387","display_name":"BIOMEDICAL NMR RESOURCE","funder_award_id":"P41RR002300","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G3004855069","display_name":null,"funder_award_id":"RR-00711","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000930921","display_name":"NMR OF NEUROSENSORY PEPTIDES","funder_award_id":"p41rr000711:6","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1500700435","https://openalex.org/W1578698735","https://openalex.org/W1788297523","https://openalex.org/W1963984598","https://openalex.org/W1965321809","https://openalex.org/W1969758509","https://openalex.org/W1971010861","https://openalex.org/W1981508678","https://openalex.org/W1989971754","https://openalex.org/W2004479194","https://openalex.org/W2026108503","https://openalex.org/W2038643556","https://openalex.org/W2054419334","https://openalex.org/W2066972542","https://openalex.org/W2072339674","https://openalex.org/W2074040460","https://openalex.org/W2096468699","https://openalex.org/W2104162890","https://openalex.org/W2117025288","https://openalex.org/W2139929581","https://openalex.org/W2144615232","https://openalex.org/W2170517841","https://openalex.org/W2173654459","https://openalex.org/W2281322029","https://openalex.org/W2316424877","https://openalex.org/W2410003881","https://openalex.org/W2413539835","https://openalex.org/W2467166300","https://openalex.org/W4213296269"],"related_works":["https://openalex.org/W2155624697","https://openalex.org/W1976552409","https://openalex.org/W2265237947","https://openalex.org/W1988388977","https://openalex.org/W2039473766","https://openalex.org/W4248557119","https://openalex.org/W2790698098","https://openalex.org/W2995548483","https://openalex.org/W2465383304","https://openalex.org/W2071135642"],"abstract_inverted_index":{"Lanthanide":[0],"shift":[1,26,56,66,85],"reagents":[2,27,67,86],"have":[3],"opened":[4],"a":[5,62],"new":[6],"avenue":[7],"in":[8,88],"the":[9,36],"study":[10],"of":[11,41,51,59,64,75],"membrane":[12],"biochemistry,":[13],"but":[14],"their":[15],"stabilities":[16],"and":[17,32,61,71,93],"biological":[18],"reactivities":[19],"remain":[20],"questionable.":[21],"We":[22],"present":[23],"evidence":[24],"that":[25,33,83],"are":[28,91],"not":[29,79],"biologically":[30],"inert,":[31],"they":[34],"exhibit":[35],"ability":[37],"to":[38,99],"inhibit":[39],"stimulation":[40],"human":[42],"peripheral":[43],"lymphocytes":[44],"at":[45],"commonly":[46],"used":[47,87],"concentrations.":[48],"A":[49],"survey":[50,63],"various":[52,65],"mitogens":[53],"yielded":[54,68],"no":[55,69],"reagent-resistant":[57],"modes":[58],"stimulation,":[60],"effective":[70],"nontoxic":[72],"alternatives.":[73],"Involvement":[74],"calcium-regulating":[76],"mechanisms":[77],"was":[78],"apparent.":[80],"The":[81],"assumption":[82],"lanthanide":[84],"NMR":[89],"studies":[90],"nondestructive":[92],"physiologically":[94],"innocuous":[95],"is":[96],"thus":[97],"shown":[98],"be":[100],"unwarranted.":[101]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}