{"id":"https://openalex.org/W2140959430","doi":null,"title":"Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases.","display_name":"Suppression of adrenal function by low-dose prednisone: assessment with 24-hour urinary steroid hormone profiles--a review of five cases.","publication_year":2006,"publication_date":"2006-03-01","ids":{"openalex":"https://openalex.org/W2140959430","mag":"2140959430","pmid":"https://pubmed.ncbi.nlm.nih.gov/16597193"},"language":"en","primary_location":{"id":"pmid:16597193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16597193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative medicine review : a journal of clinical therapeutic","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109255017","display_name":"Patrick N. Friel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick N Friel","raw_affiliation_strings":["Washington State Toxicology Laboratory, 2203 Airport Way South, Seattle, WA 98134, USA. Pat.Friel@wsp.wa.gov"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington State Toxicology Laboratory, 2203 Airport Way South, Seattle, WA 98134, USA. Pat.Friel@wsp.wa.gov","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002650405","display_name":"Thomas S. Alexander","orcid":"https://orcid.org/0000-0002-7285-6241","observed_orcids":["https://orcid.org/0000-0002-7285-6241"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Alexander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055236917","display_name":"Jonathan V. Wright","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan V Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3624,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.6818199,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"11","issue":"1","first_page":"40","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prednisone","display_name":"prednisone","score":0.984000027179718},{"id":"https://openalex.org/keywords/glucocorticoid-suppression","display_name":"glucocorticoid suppression","score":0.6629999876022339},{"id":"https://openalex.org/keywords/adrenal-function","display_name":"adrenal function","score":0.8629999756813049},{"id":"https://openalex.org/keywords/dehydroepiandrosterone","display_name":"dehydroepiandrosterone","score":0.5740000009536743},{"id":"https://openalex.org/keywords/androsterone","display_name":"androsterone","score":0.7229999899864197},{"id":"https://openalex.org/keywords/etiocholanolone","display_name":"etiocholanolone","score":0.9769999980926514},{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.7940000295639038},{"id":"https://openalex.org/keywords/tetrahydrocorticosterone","display_name":"tetrahydrocorticosterone","score":0.9620000123977661},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.8759999871253967},{"id":"https://openalex.org/keywords/lupus","display_name":"lupus","score":0.7649999856948853},{"id":"https://openalex.org/keywords/glucocorticoid-receptor","display_name":"glucocorticoid receptor","score":0.8149999976158142}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8214222192764282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7965468168258667},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.7032681107521057},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.6255676746368408},{"id":"https://openalex.org/C2780546910","wikidata":"https://www.wikidata.org/wiki/Q185690","display_name":"Adrenocorticotropic hormone","level":3,"score":0.5686439275741577},{"id":"https://openalex.org/C2780484280","wikidata":"https://www.wikidata.org/wiki/Q423185","display_name":"Cortisone","level":2,"score":0.5396963953971863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5156668424606323},{"id":"https://openalex.org/C2776992908","wikidata":"https://www.wikidata.org/wiki/Q408376","display_name":"Dehydroepiandrosterone","level":4,"score":0.4984583854675293},{"id":"https://openalex.org/C2780657110","wikidata":"https://www.wikidata.org/wiki/Q2505402","display_name":"Dehydroepiandrosterone sulfate","level":4,"score":0.48859792947769165},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4787551760673523},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.4660452604293823},{"id":"https://openalex.org/C2777911890","wikidata":"https://www.wikidata.org/wiki/Q62614","display_name":"Androgen","level":3,"score":0.4610314667224884},{"id":"https://openalex.org/C2778129406","wikidata":"https://www.wikidata.org/wiki/Q2507454","display_name":"Adrenal insufficiency","level":2,"score":0.4526812434196472},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.331649512052536}],"mesh":[{"descriptor_ui":"D000309","descriptor_name":"Adrenal Insufficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D000309","descriptor_name":"Adrenal Insufficiency","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000738","descriptor_name":"Androsterone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D003687","descriptor_name":"Dehydroepiandrosterone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005043","descriptor_name":"Etiocholanolone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011241","descriptor_name":"Prednisone","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true}],"locations_count":3,"locations":[{"id":"pmid:16597193","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16597193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alternative medicine review : a journal of clinical therapeutic","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.474.9060","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.474.9060","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://69.164.208.4/files/Suppression of Adrenal Function by Low-dose Prednisone: Assessment with 24-hour Urinary Steroid Hormone Profiles .pdf","raw_type":"text"},{"id":"mag:2140959430","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16597193","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1527507383","https://openalex.org/W1600828810","https://openalex.org/W1875064638","https://openalex.org/W1987069610","https://openalex.org/W2019733623","https://openalex.org/W2022548509","https://openalex.org/W2030061122","https://openalex.org/W2055258931","https://openalex.org/W2079279434","https://openalex.org/W2082296579","https://openalex.org/W2137843808","https://openalex.org/W2145759481","https://openalex.org/W2150421446","https://openalex.org/W2166041080","https://openalex.org/W2324268873"],"related_works":["https://openalex.org/W7099357949","https://openalex.org/W7100133802","https://openalex.org/W2415111711","https://openalex.org/W1996148605","https://openalex.org/W49434772","https://openalex.org/W2055258931","https://openalex.org/W2072352119","https://openalex.org/W2156662406","https://openalex.org/W2426874008","https://openalex.org/W3009313971"],"abstract_inverted_index":{"The":[0],"impact":[1],"of":[2,139,160,191,206,217,219],"the":[3,31,84,134,155],"synthetic":[4],"glucocorticoid":[5,39,146,156],"prednisone":[6,105,151,212],"on":[7],"adrenal":[8,38],"steroid":[9,17],"hormone":[10,18,115,173,193],"production":[11,100],"was":[12,34,49,79,118],"examined":[13],"using":[14],"24-hour":[15],"urinary":[16,43],"profiling.":[19],"Five":[20],"women,":[21],"who":[22],"were":[23,28,65,91],"chronically":[24],"taking":[25,211],"low-dose":[26],"prednisone,":[27],"tested,":[29],"and":[30,46,60,89,98,142,176,178,198,202],"relevant":[32],"literature":[33],"reviewed.":[35],"As":[36],"expected,":[37],"production,":[40,194],"measured":[41],"by":[42,133,166],"terminal":[44,73],"cortisol":[45,59],"cortisone":[47],"metabolites,":[48],"markedly":[50],"suppressed":[51,81,92,119],"compared":[52],"to":[53,67,93,113,120],"reference":[54],"range":[55],"values":[56],"(p=0.03).":[57],"Urinary":[58,75],"cortisone,":[61],"reflecting":[62],"circulating":[63],"glucocorticoids,":[64,140],"decreased":[66],"a":[68,94,121,128],"lesser":[69,95],"extent":[70],"than":[71],"their":[72],"metabolites.":[74,144],"dehydroepiandrosterone":[76],"(DHEA)":[77],"excretion":[78],"dramatically":[80],"(p=0.03),":[82],"while":[83],"downstream":[85],"androgen":[86],"metabolites":[87],"androsterone":[88],"etiocholanolone":[90],"extent.":[96,123],"Aldosterone":[97],"tetrahydrocorticosterone":[99],"demonstrated":[101],"modest":[102],"suppression":[103,159],"after":[104],"administration,":[106],"but":[107,158],"allo-tetrahydrocorticosterone,":[108],"which":[109],"is":[110,148,152,163,169],"highly":[111],"sensitive":[112],"adrenocorticotropic":[114],"(ACTH)":[116],"secretion,":[117],"greater":[122],"Prednisone":[124],"administration":[125],"results":[126],"in":[127,130,189,209],"decrease":[129],"ACTH":[131],"secretion":[132],"anterior":[135],"pituitary,":[136],"suppressing":[137],"synthesis":[138,147,162],"DHEA,":[141],"DHEA":[143,161,168,182,207],"Decreased":[145],"adaptive,":[149],"because":[150],"active":[153],"at":[154],"receptor,":[157],"not":[164],"mitigated":[165],"prednisone.":[167],"an":[170],"important":[171],"sex":[172,192],"precursor,":[174],"neurosteroid,":[175],"endocrine":[177,197],"immune":[179,199],"modulator;":[180],"therefore,":[181],"depletion":[183],"may":[184],"have":[185],"significant":[186],"adverse":[187,221],"consequences":[188],"terms":[190],"bone":[195],"health,":[196],"system":[200],"function,":[201],"neuropsychiatric":[203],"status.":[204],"Studies":[205],"replacement":[208],"patients":[210],"for":[213],"lupus":[214],"demonstrate":[215],"amelioration":[216],"some":[218],"these":[220],"effects.":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}