{"id":"https://openalex.org/W2140935524","doi":"https://doi.org/10.1210/jc.2014-3277","title":"11\u03b2-Hydroxysteroid Dehydrogenase Activity in the Brain Does Not Contribute to Systemic Interconversion of Cortisol and Cortisone in Healthy Men","display_name":"11\u03b2-Hydroxysteroid Dehydrogenase Activity in the Brain Does Not Contribute to Systemic Interconversion of Cortisol and Cortisone in Healthy Men","publication_year":2014,"publication_date":"2014-11-13","ids":{"openalex":"https://openalex.org/W2140935524","doi":"https://doi.org/10.1210/jc.2014-3277","mag":"2140935524","pmid":"https://pubmed.ncbi.nlm.nih.gov/25393644","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318893"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2014-3277","doi":"https://doi.org/10.1210/jc.2014-3277","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2014-3277","pdf_url":"https://academic.oup.com/jcem/article-pdf/100/2/483/20287700/jcem0483.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jcem/article-pdf/100/2/483/20287700/jcem0483.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089468954","display_name":"Alixe H. M. Kilgour","orcid":"https://orcid.org/0000-0003-1270-821X","observed_orcids":["https://orcid.org/0000-0003-1270-821X"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alixe H.M. Kilgour","raw_affiliation_strings":["MRC Centre for Cognitive Aging and Cognitive Epidemiology (A.H.M.K.), Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Centre for Cognitive Aging and Cognitive Epidemiology (A.H.M.K.), Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Scott Semple","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Scott Semple","raw_affiliation_strings":["BHF Centre for Cardiovascular Science (S.S., R.A., B.R.W.), Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom","Clinical Research Imaging Centre (S.S.), Edinburgh, United Kingdom","Geriatric Medicine Unit, and Centre for Clinical Brain Sciences (S.S., I.M., P.A.), University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BHF Centre for Cardiovascular Science (S.S., R.A., B.R.W.), Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Clinical Research Imaging Centre (S.S.), Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Geriatric Medicine Unit, and Centre for Clinical Brain Sciences (S.S., I.M., P.A.), University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103229239","display_name":"Ian Marshall","orcid":"https://orcid.org/0000-0003-4445-1551","observed_orcids":["https://orcid.org/0000-0003-4445-1551"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian Marshall","raw_affiliation_strings":["Geriatric Medicine Unit, and Centre for Clinical Brain Sciences (S.S., I.M., P.A.), University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Geriatric Medicine Unit, and Centre for Clinical Brain Sciences (S.S., I.M., P.A.), University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Andrews","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1324252669","display_name":"NHS Lothian","ror":"https://ror.org/03q82t418","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669"]},{"id":"https://openalex.org/I2800150677","display_name":"Western General Hospital","ror":"https://ror.org/009kr6r15","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Peter Andrews","raw_affiliation_strings":["Critical Care (P.A.), Western General Hospital, NHS Lothian University Hospitals Division, Edinburgh EH4 2XU, United Kingdom","Geriatric Medicine Unit, and Centre for Clinical Brain Sciences (S.S., I.M., P.A.), University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Critical Care (P.A.), Western General Hospital, NHS Lothian University Hospitals Division, Edinburgh EH4 2XU, United Kingdom","institution_ids":["https://openalex.org/I1324252669","https://openalex.org/I2800150677"]},{"raw_affiliation_string":"Geriatric Medicine Unit, and Centre for Clinical Brain Sciences (S.S., I.M., P.A.), University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018893535","display_name":"Ruth Andrew","orcid":"https://orcid.org/0000-0002-6916-2994","observed_orcids":["https://orcid.org/0000-0002-6916-2994"]},"institutions":[{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ruth Andrew","raw_affiliation_strings":["BHF Centre for Cardiovascular Science (S.S., R.A., B.R.W.), Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BHF Centre for Cardiovascular Science (S.S., R.A., B.R.W.), Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017724906","display_name":"Brian Robert Walker","orcid":"https://orcid.org/0000-0002-2416-1648","observed_orcids":["https://orcid.org/0000-0002-2416-1648","https://orcid.org/0000-0001-7345-2110"]},"institutions":[{"id":"https://openalex.org/I4210164624","display_name":"The Queen's Medical Research Institute","ror":"https://ror.org/059zxg644","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brian R. Walker","raw_affiliation_strings":["BHF Centre for Cardiovascular Science (S.S., R.A., B.R.W.), Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BHF Centre for Cardiovascular Science (S.S., R.A., B.R.W.), Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom","institution_ids":["https://openalex.org/I4210164624","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5089468954"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":{"value":3750,"currency":"USD","value_usd":3750},"fwci":2.4008,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.89329967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"100","issue":"2","first_page":"483","last_page":"489"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.48100000619888306,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.48100000619888306,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.3278999924659729,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.15489999949932098,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/11beta-hydroxysteroid-dehydrogenase-type-1","display_name":"11\u03b2-hydroxysteroid dehydrogenase type 1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/brain-steroid-metabolism","display_name":"brain steroid metabolism","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.7570000290870667},{"id":"https://openalex.org/keywords/cortisone","display_name":"cortisone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.6359999775886536},{"id":"https://openalex.org/keywords/phase-contrast-mri","display_name":"phase-contrast MRI","score":0.7260000109672546},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2780484280","wikidata":"https://www.wikidata.org/wiki/Q423185","display_name":"Cortisone","level":2,"score":0.9388381242752075},{"id":"https://openalex.org/C166075782","wikidata":"https://www.wikidata.org/wiki/Q171604","display_name":"11\u03b2-hydroxysteroid dehydrogenase type 1","level":4,"score":0.7501164674758911},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7420792579650879},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7177045345306396},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.52122962474823},{"id":"https://openalex.org/C2777956836","wikidata":"https://www.wikidata.org/wiki/Q749592","display_name":"Jugular vein","level":2,"score":0.517583966255188},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5080227851867676},{"id":"https://openalex.org/C2780841215","wikidata":"https://www.wikidata.org/wiki/Q422549","display_name":"Glucocorticoid","level":2,"score":0.4582478404045105},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24092772603034973},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1803906261920929},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.15228107571601868},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09358716011047363},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043205","descriptor_name":"11-beta-Hydroxysteroid Dehydrogenase Type 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1210/jc.2014-3277","doi":"https://doi.org/10.1210/jc.2014-3277","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2014-3277","pdf_url":"https://academic.oup.com/jcem/article-pdf/100/2/483/20287700/jcem0483.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3303180","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318893","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4318893","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4318893","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Endocrinol Metab","raw_type":"Text"},{"id":"pmid:25393644","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25393644","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pure.ed.ac.uk:openaire/cbc5ffe3-c5ed-499d-be22-b6e23f37e8eb","doi":null,"is_oa":true,"landing_page_url":"https://www.research.ed.ac.uk/files/18628601/11_Hydroxysteroid_Dehydrogenase_Activity_in_the_Brain_Does_Not_Contribute_to_Systemic_Interconversion_of_Cortisol_and_Cortisone_in_Healthy_Men.pdf","pdf_url":"https://www.research.ed.ac.uk/files/18628601/11_Hydroxysteroid_Dehydrogenase_Activity_in_the_Brain_Does_Not_Contribute_to_Systemic_Interconversion_of_Cortisol_and_Cortisone_in_Healthy_Men.pdf","source":{"id":"https://openalex.org/S4306400321","display_name":"Edinburgh Research Explorer (University of Edinburgh)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I98677209","host_organization_name":"University of Edinburgh","host_organization_lineage":["https://openalex.org/I98677209"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kilgour, A H M, Semple, S, Marshall, I, Andrews, P, Andrew, R & Walker, B R 2015, '11\u03b2-Hydroxysteroid Dehydrogenase Activity in the Brain Does Not Contribute to Systemic Interconversion of Cortisol and Cortisone in Healthy Men', The Journal of Clinical Endocrinology & Metabolism (JCEM), vol. 100, no. 2, pp. 483-489. https://doi.org/10.1210/jc.2014-3277, https://doi.org/10.1210/jc.2014-3277","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.25405/ncl.34343571","doi":"https://doi.org/10.25405/ncl.34343571","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34343571","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.25405/ncl.34343571.v1","doi":"https://doi.org/10.25405/ncl.34343571.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34343571.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1210/jc.2014-3277","doi":"https://doi.org/10.1210/jc.2014-3277","is_oa":true,"landing_page_url":"https://doi.org/10.1210/jc.2014-3277","pdf_url":"https://academic.oup.com/jcem/article-pdf/100/2/483/20287700/jcem0483.pdf","source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1394528540","display_name":"Centre for Cognitive Ageing & Cognitive Epidemiology","funder_award_id":"MR/K026992/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7907314737","display_name":"RENEWAL: Tissue-specific determinants of glucocorticoid signalling in humans \u2013 new mechanisms and therapies for cardiovascular risk","funder_award_id":"RG/11/4/28734","funder_id":"https://openalex.org/F4320319992","funder_display_name":"British Heart Foundation"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320319992","display_name":"British Heart Foundation","ror":"https://ror.org/02wdwnk04"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140935524.pdf","grobid_xml":"https://content.openalex.org/works/W2140935524.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W63938293","https://openalex.org/W1964332980","https://openalex.org/W1964922902","https://openalex.org/W1984875054","https://openalex.org/W2017851269","https://openalex.org/W2025959002","https://openalex.org/W2030599445","https://openalex.org/W2054886307","https://openalex.org/W2080616233","https://openalex.org/W2081276639","https://openalex.org/W2086580814","https://openalex.org/W2098527120","https://openalex.org/W2100018795","https://openalex.org/W2109095584","https://openalex.org/W2130325529","https://openalex.org/W2138848668","https://openalex.org/W2150843481","https://openalex.org/W2153965794","https://openalex.org/W2162015134","https://openalex.org/W2164058090","https://openalex.org/W2314101063","https://openalex.org/W2965635017"],"related_works":["https://openalex.org/W2773791588","https://openalex.org/W4388537244","https://openalex.org/W2030599445","https://openalex.org/W4232811356","https://openalex.org/W4241556965","https://openalex.org/W1544104573","https://openalex.org/W1979169025","https://openalex.org/W2082091293","https://openalex.org/W2098527120","https://openalex.org/W2152760742"],"abstract_inverted_index":{"CONTEXT":[0],"AND":[1,87,154],"OBJECTIVE:":[2],"11\u03b2-hydroxysteroid":[3],"dehydrogenase":[4],"type":[5],"1":[6],"(11\u03b2HSD1)":[7],"catalyses":[8],"regeneration":[9],"of":[10,82,165,184,213,226,247],"cortisol":[11,25],"in":[12,28,49,77,173,204,208,215,228,250],"liver,":[13],"adipose":[14],"tissue,":[15],"and":[16,69,79,92,117,123,138,162],"skeletal":[17],"muscle,":[18],"making":[19],"a":[20,44,72],"substantial":[21],"contribution":[22,64,212],"to":[23,55,61,65,70,110,218,234,243],"circulating":[24],"as":[26],"demonstrated":[27],"humans":[29],"by":[30,146],"combining":[31],"stable":[32],"isotope":[33],"tracer":[34,158],"infusion":[35],"with":[36,120,170],"arteriovenous":[37],"sampling.":[38],"In":[39],"the":[40,134,191,216,229,237,251],"brain,":[41],"11\u03b2HSD1":[42,58,76,83,198,214,227,248],"is":[43,222,231],"potential":[45],"therapeutic":[46],"target":[47],"implicated":[48],"age-associated":[50],"cognitive":[51],"dysfunction.":[52],"We":[53],"aimed":[54],"quantify":[56,111,244],"brain":[57,217,230],"activity,":[59],"both":[60],"assess":[62],"its":[63],"systemic":[66,163,219],"cortisol/cortisone":[67,166,220],"turnover":[68,221],"develop":[71],"tool":[73],"for":[74,126],"measuring":[75],"dementia":[78],"following":[80],"administration":[81],"inhibitors.":[84],"DESIGN,":[85],"SETTING,":[86],"PARTICIPANTS:":[88],"With":[89],"ethical":[90],"approval":[91],"informed":[93],"consent,":[94],"8":[95],"healthy":[96,174,209],"men":[97,210],"aged":[98],"38.1":[99],"years":[100],"(sd":[101],"16.5)":[102],"underwent":[103],"an":[104,139],"ECG-gated":[105],"phase-contrast":[106],"magnetic":[107],"resonance":[108],"scan":[109],"internal":[112,135,192],"jugular":[113,136,193],"vein":[114,137],"blood":[115],"flow":[116],"were":[118,131,144,160,168],"infused":[119],"1,2":[121],"[(2)H]2-cortisone":[122],"9,11,12,12":[124],"[(2)H]4-cortisol":[125],"3":[127],"h":[128],"before":[129],"samples":[130],"obtained":[132],"from":[133],"arterialized":[140],"hand":[141],"vein.":[142,194],"Steroids":[143],"quantified":[145],"liquid":[147],"chromatography-tandem":[148],"mass":[149],"spectrometry.":[150],"MAIN":[151],"OUTCOME":[152],"MEASURES":[153],"RESULTS:":[155],"Steady":[156],"state":[157],"enrichments":[159],"achieved":[161],"indices":[164],"interconversion":[167],"consistent":[169],"previous":[171],"studies":[172],"men.":[175],"However,":[176],"there":[177],"was":[178],"no":[179],"measurable":[180],"release":[181],"or":[182,188],"production":[183],"cortisol,":[185],"9,12,12":[186],"[(2)H]3-cortisol":[187],"cortisone":[189],"into":[190],"CONCLUSIONS:":[195],"Although":[196],"cerebral":[197],"reductase":[199],"activity":[200],"may":[201],"be":[202],"greater":[203],"cognitively":[205],"impaired":[206],"patients,":[207],"any":[211],"negligible.":[223],"The":[224],"influence":[225],"likely":[232],"confined":[233],"subregions,":[235],"notably":[236],"hippocampus.":[238],"Alternative":[239],"approaches":[240],"are":[241],"required":[242],"pharmacodynamics":[245],"effects":[246],"inhibitors":[249],"human":[252],"brain.":[253]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}