{"id":"https://openalex.org/W2140930481","doi":"https://doi.org/10.1158/0008-5472.can-13-2397","title":"A Preclinical Assay for Chemosensitivity in Multiple Myeloma","display_name":"A Preclinical Assay for Chemosensitivity in Multiple Myeloma","publication_year":2013,"publication_date":"2013-12-06","ids":{"openalex":"https://openalex.org/W2140930481","doi":"https://doi.org/10.1158/0008-5472.can-13-2397","mag":"2140930481","pmid":"https://pubmed.ncbi.nlm.nih.gov/24310398","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3915502"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-13-2397","doi":"https://doi.org/10.1158/0008-5472.can-13-2397","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-13-2397","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3915502","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071385993","display_name":"Zayar P. Khin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zayar P. Khin","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Maria L.C. Ribeiro","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria L.C. Ribeiro","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063365288","display_name":"Timothy Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Jacobson","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054463097","display_name":"Lori Hazlehurst","orcid":"https://orcid.org/0000-0001-7040-4084","observed_orcids":["https://orcid.org/0000-0001-7040-4084"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Hazlehurst","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108298475","display_name":"Lia Elena Perez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lia Perez","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077110117","display_name":"Rachid Baz","orcid":"https://orcid.org/0000-0003-4538-4733","observed_orcids":["https://orcid.org/0000-0003-4538-4733"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachid Baz","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053572690","display_name":"Kenneth H. Shain","orcid":"https://orcid.org/0000-0003-4178-8888","observed_orcids":["https://orcid.org/0000-0003-4178-8888"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Shain","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086011649","display_name":"Ariosto Siqueira Silva","orcid":"https://orcid.org/0000-0003-3237-9986","observed_orcids":["https://orcid.org/0000-0003-3237-9986"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ariosto S. Silva","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Imaging and Metabolism, 2Molecular Oncology, 3Bone Marrow Transplantation, and 4Department of Hematologic Malignancies, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086011649"],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":2.8677,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.91093151,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"74","issue":"1","first_page":"56","last_page":"67"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/chemosensitivity","display_name":"chemosensitivity","score":0.8790000081062317},{"id":"https://openalex.org/keywords/preclinical-drug-testing","display_name":"preclinical drug testing","score":0.7300000190734863},{"id":"https://openalex.org/keywords/microfluidic-cell-culture","display_name":"microfluidic cell culture","score":0.625},{"id":"https://openalex.org/keywords/three-dimensional-extracellular-matrix","display_name":"three-dimensional extracellular matrix","score":0.8339999914169312},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9210000038146973},{"id":"https://openalex.org/keywords/mesenchymal-cells","display_name":"mesenchymal cells","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":0.9020000100135803},{"id":"https://openalex.org/keywords/melphalan","display_name":"melphalan","score":1.0},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7229999899864197},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cell-viability-quantification","display_name":"cell viability quantification","score":0.7760000228881836},{"id":"https://openalex.org/keywords/precision-oncology","display_name":"precision oncology","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7920006513595581},{"id":"https://openalex.org/C2777478702","wikidata":"https://www.wikidata.org/wiki/Q419319","display_name":"Bortezomib","level":3,"score":0.6031584739685059},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5796831846237183},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5719242095947266},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5573832392692566},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5358574986457825},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5301374197006226},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3850228190422058},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.24501937627792358},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.211527019739151},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.18291804194450378}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046210","descriptor_name":"Microfluidic Analytical Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.can-13-2397","doi":"https://doi.org/10.1158/0008-5472.can-13-2397","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-13-2397","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:24310398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24310398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3915502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3915502","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3915502","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3915502","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3922124991","display_name":"A Translational Model of Evolution of Myeloma Adhesion-Mediated Drug Resistance","funder_award_id":"R21CA164322","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6762418406","display_name":"Explosive Evolution Under Stress:  The Driving Forces of Cancer Dynamics (Main)","funder_award_id":"U54CA143803","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000876523","display_name":"Moffitt Cancer Center Support Grant","funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320311073","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1582504095","https://openalex.org/W1820859680","https://openalex.org/W1891860149","https://openalex.org/W1931964440","https://openalex.org/W1965570423","https://openalex.org/W1966657674","https://openalex.org/W1991660588","https://openalex.org/W1996451804","https://openalex.org/W2009058293","https://openalex.org/W2016776350","https://openalex.org/W2045175259","https://openalex.org/W2045522345","https://openalex.org/W2058201897","https://openalex.org/W2066616821","https://openalex.org/W2071122929","https://openalex.org/W2081831571","https://openalex.org/W2082343402","https://openalex.org/W2088580309","https://openalex.org/W2103562758","https://openalex.org/W2113716960","https://openalex.org/W2131938193","https://openalex.org/W2137878070","https://openalex.org/W2140582160","https://openalex.org/W2143108036","https://openalex.org/W2143455585","https://openalex.org/W2145980885","https://openalex.org/W2166278790","https://openalex.org/W2166517289","https://openalex.org/W2166618727","https://openalex.org/W2169987170","https://openalex.org/W2256456292","https://openalex.org/W2320302422","https://openalex.org/W2412146140"],"related_works":["https://openalex.org/W1988910254","https://openalex.org/W904214523","https://openalex.org/W3160555839","https://openalex.org/W2096553204","https://openalex.org/W2605974076","https://openalex.org/W2914511474","https://openalex.org/W3157326797","https://openalex.org/W2609004154","https://openalex.org/W2970028187","https://openalex.org/W3044063134"],"abstract_inverted_index":{"Accurate":[0],"preclinical":[1,30,191],"predictions":[2,18],"of":[3,7,25,50,78,91,195,206],"the":[4,26,48,79,89,105],"clinical":[5,151,207],"efficacy":[6],"experimental":[8,131],"cancer":[9,77],"drugs":[10],"are":[11,55],"highly":[12],"desired":[13],"but":[14],"often":[15],"haphazard.":[16],"Such":[17],"might":[19],"be":[20,176,201],"improved":[21,40],"by":[22,32],"incorporating":[23,96],"elements":[24],"tumor":[27,59,106],"microenvironment":[28],"in":[29,72,122,155,203],"models":[31,126,205],"providing":[33],"a":[34,113,213],"more":[35],"physiological":[36],"setting.":[37],"In":[38],"generating":[39,196],"xenograft":[41],"models,":[42],"it":[43],"is":[44,193],"generally":[45],"accepted":[46],"that":[47,186,199],"use":[49],"primary":[51,164],"tumors":[52],"from":[53,104],"patients":[54],"preferable":[56],"to":[57,68,87,119,129,146,178,215,217],"clonal":[58],"cell":[60,123,159,167],"lines.":[61],"Here":[62],"we":[63,143],"describe":[64],"an":[65,75],"interdisciplinary":[66,190],"platform":[67,83],"study":[69],"drug":[70,181,184],"response":[71],"multiple":[73,152,157,165],"myeloma,":[74],"incurable":[76],"bone":[80],"marrow.":[81],"This":[82,189],"uses":[84],"microfluidic":[85],"technology":[86],"minimize":[88],"number":[90],"cells":[92,102],"per":[93],"experiment,":[94],"while":[95],"three-dimensional":[97],"extracellular":[98],"matrix":[99],"and":[100,112,148,161,183],"mesenchymal":[101],"derived":[103],"microenvironment.":[107],"We":[108,169],"used":[109,128,177,202],"sequential":[110],"imaging":[111,116],"novel":[114],"digital":[115],"analysis":[117],"algorithm":[118],"quantify":[120],"changes":[121],"viability.":[124],"Computational":[125],"were":[127],"convert":[130],"data":[132,198],"into":[133],"dose-exposure-response":[134],"\"surfaces,\"":[135],"which":[136],"offered":[137],"predictive":[138],"utility.":[139],"Using":[140],"this":[141,173],"platform,":[142],"predicted":[144],"chemosensitivity":[145],"bortezomib":[147],"melphalan,":[149],"two":[150],"myeloma":[153,158,166],"treatments,":[154],"three":[156],"lines":[160],"seven":[162],"patient-derived":[163],"populations.":[168],"also":[170],"demonstrated":[171],"how":[172],"system":[174],"could":[175],"investigate":[179],"environment-mediated":[180],"resistance":[182],"combinations":[185],"target":[187],"it.":[188],"assay":[192],"capable":[194],"quantitative":[197],"can":[200],"computational":[204],"response,":[208],"demonstrating":[209],"its":[210],"utility":[211],"as":[212],"tool":[214],"contribute":[216],"personalized":[218],"oncology.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
