{"id":"https://openalex.org/W2140901337","doi":"https://doi.org/10.1128/jb.180.2.290-295.1998","title":"The Adhesion-Associated sca Operon in Streptococcus gordonii Encodes an Inducible High-Affinity ABC Transporter for Mn 2+ Uptake","display_name":"The Adhesion-Associated sca Operon in Streptococcus gordonii Encodes an Inducible High-Affinity ABC Transporter for Mn 2+ Uptake","publication_year":1998,"publication_date":"1998-01-15","ids":{"openalex":"https://openalex.org/W2140901337","doi":"https://doi.org/10.1128/jb.180.2.290-295.1998","mag":"2140901337","pmid":"https://pubmed.ncbi.nlm.nih.gov/9440518","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/106884"},"language":"en","primary_location":{"id":"doi:10.1128/jb.180.2.290-295.1998","doi":"https://doi.org/10.1128/jb.180.2.290-295.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.180.2.290-295.1998","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC106884","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108573576","display_name":"Paul E. Kolenbrander","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul E. Kolenbrander","raw_affiliation_strings":["<!--label omitted: 1-->Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and","Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108523586","display_name":"Roxanna N. Andersen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roxanna N. Andersen","raw_affiliation_strings":["<!--label omitted: 1-->Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and","Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 1-->Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]},{"raw_affiliation_string":"Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892,1 and","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103562709","display_name":"Rachel A. Baker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Rachel A. Baker","raw_affiliation_strings":["<!--label omitted: 2-->Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2","Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2","institution_ids":["https://openalex.org/I80281795"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036602050","display_name":"Howard F. Jenkinson","orcid":"https://orcid.org/0000-0002-9195-7945","observed_orcids":["https://orcid.org/0000-0002-9195-7945"]},"institutions":[{"id":"https://openalex.org/I80281795","display_name":"University of Otago","ror":"https://ror.org/01jmxt844","country_code":"NZ","type":"education","lineage":["https://openalex.org/I80281795"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"Howard F. Jenkinson","raw_affiliation_strings":["<!--label omitted: 2-->Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2","Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"<!--label omitted: 2-->Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2","institution_ids":["https://openalex.org/I80281795"]},{"raw_affiliation_string":"Molecular Oral Biology Laboratory, Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand2","institution_ids":["https://openalex.org/I80281795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.7049,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.96638781,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"180","issue":"2","first_page":"290","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9437999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.01850000023841858,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-gordonii","display_name":"Streptococcus gordonii","score":0.9940000176429749},{"id":"https://openalex.org/keywords/abc-transporters","display_name":"ABC transporters","score":0.9570000171661377},{"id":"https://openalex.org/keywords/manganese-uptake","display_name":"manganese uptake","score":0.9309999942779541},{"id":"https://openalex.org/keywords/zinc-inhibition","display_name":"zinc inhibition","score":0.6389999985694885},{"id":"https://openalex.org/keywords/dna-mediated-gene-transfer","display_name":"DNA-mediated gene transfer","score":0.6600000262260437},{"id":"https://openalex.org/keywords/adhesion","display_name":"adhesion","score":0.7200000286102295},{"id":"https://openalex.org/keywords/proton-motive-force","display_name":"proton motive force","score":0.859000027179718},{"id":"https://openalex.org/keywords/manganese-limitation","display_name":"manganese limitation","score":0.40799999237060547},{"id":"https://openalex.org/keywords/gene-inactivation","display_name":"gene inactivation","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2780368718","wikidata":"https://www.wikidata.org/wiki/Q7623352","display_name":"Streptococcus gordonii","level":4,"score":0.9305301904678345},{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.9219970107078552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8553826212882996},{"id":"https://openalex.org/C44312359","wikidata":"https://www.wikidata.org/wiki/Q286958","display_name":"ATP-binding cassette transporter","level":4,"score":0.6336575746536255},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5751851797103882},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49212950468063354},{"id":"https://openalex.org/C2778276568","wikidata":"https://www.wikidata.org/wiki/Q190161","display_name":"Streptococcus","level":3,"score":0.48132097721099854},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4572586119174957},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3890826404094696},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.38886594772338867},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.20207080245018005}],"mesh":[{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008345","descriptor_name":"Manganese","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013291","descriptor_name":"Streptococcus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014170","descriptor_name":"Transformation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/jb.180.2.290-295.1998","doi":"https://doi.org/10.1128/jb.180.2.290-295.1998","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jb.180.2.290-295.1998","pdf_url":null,"source":{"id":"https://openalex.org/S133274750","display_name":"Journal of Bacteriology","issn_l":"0021-9193","issn":["0021-9193","1067-8832","1098-5530"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bacteriology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:184627","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC106884","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:106884","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/106884","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Bacteriol","raw_type":"Text"},{"id":"pmid:9440518","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9440518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bacteriology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:184627","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC106884","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1563504393","https://openalex.org/W1604490049","https://openalex.org/W1787160128","https://openalex.org/W1792710261","https://openalex.org/W1847112971","https://openalex.org/W1889980904","https://openalex.org/W1894476426","https://openalex.org/W1901517413","https://openalex.org/W1937584702","https://openalex.org/W1984789394","https://openalex.org/W1985652377","https://openalex.org/W1990770450","https://openalex.org/W2000615700","https://openalex.org/W2007586351","https://openalex.org/W2015326313","https://openalex.org/W2048604693","https://openalex.org/W2065129970","https://openalex.org/W2070842415","https://openalex.org/W2071522686","https://openalex.org/W2089589117","https://openalex.org/W2098810090","https://openalex.org/W2105876850","https://openalex.org/W2114432965","https://openalex.org/W2114837947","https://openalex.org/W2116895579","https://openalex.org/W2127650182","https://openalex.org/W2132372354","https://openalex.org/W2134472461","https://openalex.org/W2142092938","https://openalex.org/W2148572341","https://openalex.org/W2156173817","https://openalex.org/W2160734368","https://openalex.org/W2162097287","https://openalex.org/W2167696510","https://openalex.org/W2173603236","https://openalex.org/W2182102373","https://openalex.org/W2409411187"],"related_works":["https://openalex.org/W2136126647","https://openalex.org/W7098790777","https://openalex.org/W2162430208","https://openalex.org/W1787160128","https://openalex.org/W2998790578","https://openalex.org/W2144420906","https://openalex.org/W2059020111","https://openalex.org/W2104745924","https://openalex.org/W3153562482","https://openalex.org/W2007586351"],"abstract_inverted_index":{"ScaA":[0,82],"lipoprotein":[1],"in":[2,54,67,133,166,194,204,212],"Streptococcus":[3],"gordonii":[4],"is":[5,22,222,232],"a":[6,223],"member":[7],"of":[8,12,25,36,44,58,64,81,88,98,108,124,136,159,171,184,199,229,236],"the":[9,23,26,30,34,96,134,141,176,182,195,227],"LraI":[10],"family":[11],"homologous":[13],"polypeptides":[14],"found":[15],"among":[16],"streptococci,":[17],"pneumococci,":[18],"and":[19,60,76,94,129,209,231],"enterococci.":[20],"It":[21],"product":[24],"third":[27],"gene":[28],"within":[29],"scaCBA":[31],"operon":[32],"encoding":[33],"components":[35],"an":[37,188],"ATP-binding":[38],"cassette":[39],"(ABC)":[40],"transporter":[41],"system.":[42],"Inactivation":[43],"scaC":[45,77],"(ATP-binding":[46],"protein)":[47,51],"or":[48,100,120],"scaA":[49],"(substrate-binding":[50],"genes":[52],"resulted":[53],"both":[55],"impaired":[56],"growth":[57,235],"cells":[59,132],">":[61,99,164],"70%":[62],"inhibition":[63],"54Mn2+":[65,109,125],"uptake":[66,107,123,148],"media":[68],"containing":[69],"<":[70],"0.5":[71,92],"microM":[72,103],"Mn2+.":[73],"In":[74],"wild-type":[75,131],"mutant":[78,185],"cells,":[79,186],"production":[80],"was":[83,110,138,152,162],"induced":[84],"at":[85],"low":[86],"concentrations":[87],"extracellular":[89],"Mn2+":[90,147,174,230],"(<":[91],"microM)":[93],"by":[95,112,116,126,130,140],"addition":[97,170],"=":[101],"20":[102],"Zn2+.":[104],"Sca":[105,192,220],"permease-mediated":[106],"inhibited":[111],"Zn2+":[113,137],"but":[114],"not":[115],"Ca2+,":[117],"Mg2+,":[118],"Fe2+,":[119],"Cu2+.":[121],"Reduced":[122],"sca":[127,167,200],"mutants":[128,201],"presence":[135],"abrogated":[139],"uncoupler":[142],"carbonylcyanide":[143],"m-chlorophenylhydrazone,":[144],"suggesting":[145],"that":[146,219],"under":[149,238],"these":[150],"conditions":[151],"proton":[153],"motive":[154],"force":[155],"dependent.":[156],"The":[157,169,216],"frequency":[158],"DNA-mediated":[160],"transformation":[161,177,196],"reduced":[163],"20-fold":[165],"mutants.":[168],"0.1":[172],"mM":[173],"to":[175,214],"medium":[178],"restored":[179],"only":[180],"partly":[181],"transformability":[183],"implying":[187],"alternate":[189],"role":[190],"for":[191,226,234],"proteins":[193],"process.":[197],"Cells":[198],"were":[202,210],"unaffected":[203,211],"other":[205],"binding":[206],"properties":[207],"tested":[208],"sensitivity":[213],"oxidants.":[215],"results":[217],"show":[218],"permease":[221],"high-affinity":[224],"mechanism":[225],"acquisition":[228],"essential":[233],"streptococci":[237],"Mn2+-limiting":[239],"conditions.":[240]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":13},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}