{"id":"https://openalex.org/W2140875832","doi":null,"title":"Charge-dependent targeting: results in six tumor cell lines.","display_name":"Charge-dependent targeting: results in six tumor cell lines.","publication_year":2004,"publication_date":"2004-05-01","ids":{"openalex":"https://openalex.org/W2140875832","mag":"2140875832","pmid":"https://pubmed.ncbi.nlm.nih.gov/15274294"},"language":"en","primary_location":{"id":"pmid:15274294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080284464","display_name":"Marcela M\u00e1rquez","orcid":"https://orcid.org/0000-0003-2213-1063","observed_orcids":["https://orcid.org/0000-0003-2213-1063"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Marcela M\u00e1rquez","raw_affiliation_strings":["Karolinska Institute, Cancer Center Karolinska, S-17176 Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Karolinska Institute, Cancer Center Karolinska, S-17176 Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112235154","display_name":"Sten F. Nilsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sten Nilsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020805997","display_name":"Lena Lennartsson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lena Lennartsson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030526678","display_name":"Zhaoxu Liu","orcid":"https://orcid.org/0000-0001-7539-9720","observed_orcids":["https://orcid.org/0000-0001-7539-9720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaoxu Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011425417","display_name":"Teuvo L.J. Tammela","orcid":"https://orcid.org/0000-0002-3529-4649","observed_orcids":["https://orcid.org/0000-0002-3529-4649","https://orcid.org/0009-0005-0435-9613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Teuvo Tammela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042022974","display_name":"Mika Raitanen","orcid":"https://orcid.org/0009-0006-9988-6690","observed_orcids":["https://orcid.org/0009-0006-9988-6690"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mika Raitanen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110080856","display_name":"A. Holmberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anders R Holmberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4872,"has_fulltext":false,"cited_by_count":48,"citation_normalized_percentile":{"value":0.53178461,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"24","issue":"3a","first_page":"1347","last_page":"51"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.6157000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.6157000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sialic-acid","display_name":"sialic acid","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sialylation","display_name":"sialylation","score":0.6669999957084656},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.5680000185966492},{"id":"https://openalex.org/keywords/cell-growth-inhibition","display_name":"cell growth inhibition","score":0.5709999799728394},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8040000200271606},{"id":"https://openalex.org/keywords/cell-membrane-damage","display_name":"cell membrane damage","score":0.5899999737739563},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.7179999947547913},{"id":"https://openalex.org/keywords/periodate-oxidation","display_name":"periodate oxidation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/reductive-amination","display_name":"reductive amination","score":0.921999990940094},{"id":"https://openalex.org/keywords/sialic-acid-binding-lectins","display_name":"sialic acid-binding lectins","score":0.8759999871253967}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.6163731217384338},{"id":"https://openalex.org/C2780115458","wikidata":"https://www.wikidata.org/wiki/Q419311","display_name":"Sialic acid","level":2,"score":0.5785526037216187},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5229357481002808},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4891531765460968},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45618951320648193},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4464320242404938},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3885958194732666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3807794451713562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37165719270706177},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3408127427101135},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.33871233463287354},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1952008306980133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002412","descriptor_name":"Cations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019158","descriptor_name":"N-Acetylneuraminic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:15274294","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2140875832","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15274294","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W39108978","https://openalex.org/W53062406","https://openalex.org/W168708622","https://openalex.org/W1670233966","https://openalex.org/W1949917588","https://openalex.org/W1986216396","https://openalex.org/W2008545486","https://openalex.org/W2040481452","https://openalex.org/W2047940470","https://openalex.org/W2071944485","https://openalex.org/W2087116463","https://openalex.org/W2138348226","https://openalex.org/W2150380845","https://openalex.org/W2158023865","https://openalex.org/W2162275198","https://openalex.org/W2418272901"],"related_works":["https://openalex.org/W1984889103","https://openalex.org/W2098305953","https://openalex.org/W2070424834","https://openalex.org/W2184441904","https://openalex.org/W2049065649","https://openalex.org/W2133532548","https://openalex.org/W4243740998","https://openalex.org/W2021322235","https://openalex.org/W2905821037","https://openalex.org/W17178584"],"abstract_inverted_index":{"BACKGROUND:":[0],"Many":[1],"previous":[2],"studies":[3,284],"show":[4],"that":[5,243],"cell":[6,39,53,84,90,142,211,216,223,232,238,258],"surface":[7,28],"sialylation":[8],"of":[9,21,30,69,136,165,275,281],"malignant":[10],"cells":[11,128],"is":[12,41,47,242],"enhanced":[13],"compared":[14],"to":[15,187,246,265,285],"normal":[16],"tissue.":[17],"The":[18,134,218,268],"carboxyl":[19],"group":[20],"the":[22,31,83,123,126,140,163,171,175,179,192,200,203,215,247,257,261],"sialic":[23,137,150,249],"acid":[24,138,151,250],"yields,":[25],"a":[26,44,148,157,272],"negative":[27],"charge":[29],"tumor":[32,38,52,89,127,204,237],"cells.":[33],"This":[34],"study":[35],"investigates":[36],"how":[37],"growth":[40,159,180,193],"affected":[42],"when":[43],"cationic":[45,70,166,229],"polymer":[46],"incubated":[48,113],"with":[49,125,228],"six":[50,236],"different":[51,88,109,141],"lines.":[54,217,239],"MATERIALS":[55],"AND":[56],"METHODS:":[57],"Cationic":[58],"dextran":[59,230],"(CatDex)":[60],"was":[61,80,106,119,129,144,177,183],"prepared":[62],"by":[63,72,146],"periodate":[64],"oxidation":[65],"and":[66,112,122,170,185,202,252],"subsequent":[67],"coupling":[68],"sidegroups":[71],"reductive":[73],"amination.":[74],"A":[75],"fluorimetric":[76],"cytotoxicity":[77],"assay":[78],"(FMCA)":[79],"used":[81],"for":[82,114,278],"survival":[85],"assay.":[86],"Six":[87],"lines":[91,143],"(lung,":[92],"breast,":[93],"ovarian,":[94],"prostate,":[95],"colon,":[96],"urinary":[97],"bladder)":[98],"were":[99],"seeded":[100],"into":[101],"96-well":[102],"microtiter":[103],"plates.":[104],"CatDex":[105,118,155,244],"added":[107],"at":[108],"microM":[110],"concentrations":[111],"72":[115],"h.":[116],"Additionally,":[117],"fluorescence-labeled":[120],"(FITC)":[121],"interaction":[124],"studied":[130],"using":[131,147],"fluorescence":[132],"microscopy.":[133],"presence":[135],"in":[139,209,213,234,256],"confirmed":[145],"FITC-labeled":[149],"binding":[152],"lectin.":[153],"RESULTS:":[154],"showed":[156,221],"concentration-dependent":[158],"inhibitory":[160,181],"effect":[161,182],"(i.e.":[162],"number":[164],"side":[167],"groups/dextran":[168],"molecule":[169],"molarity":[172,201],"used).":[173],"If":[174],"substitution":[176,207],"<20%,":[178],"small":[184],"difficult":[186],"reproduce.":[188],"With":[189],"20-22%":[190],"substitution,":[191],"inhibition":[194],"varied":[195],"between":[196],"20-95%":[197],"depending":[198],"on":[199],"type.":[205],"Higher":[206],"resulted":[208],"complete":[210],"death":[212,233],"all":[214,235],"fluorescent":[219],"images":[220],"intensive":[222],"membrane":[224],"interaction.":[225],"CONCLUSION:":[226],"Incubation":[227],"caused":[231],"Our":[240],"hypothesis":[241],"binds":[245],"anionic":[248],"residues":[251],"causes":[253],"fatal":[254],"disturbances":[255],"membrane.":[259],"However":[260],"exact":[262],"mechanism":[263],"remains":[264],"be":[266],"elucidated.":[267],"results":[269],"may":[270],"indicate":[271],"new":[273],"method":[274],"general":[276],"interest":[277],"intra/local/regiolocal":[279],"treatment":[280],"cancer.":[282],"Clinical":[283],"explore":[286],"this":[287],"concept":[288],"are":[289],"pending.":[290]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
