{"id":"https://openalex.org/W2140874356","doi":null,"title":"ASTROCYTIC COMMUNICATION AND CELL DEATH DURING METABOLIC DEPRESSION AND OXIDATIVE STRESS","display_name":"ASTROCYTIC COMMUNICATION AND CELL DEATH DURING METABOLIC DEPRESSION AND OXIDATIVE STRESS","publication_year":2008,"publication_date":"2008-03-19","ids":{"openalex":"https://openalex.org/W2140874356","mag":"2140874356"},"language":"en","primary_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/9868","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/9868","pdf_url":"http://hdl.handle.net/2077/9868","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2077/9868","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057799197","display_name":"Christina Nodin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christina Nodin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057799197"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.7050999999046326,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.20100000500679016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/metabolic-depression","display_name":"metabolic depression","score":0.6299999952316284},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9860000014305115},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.7110000252723694},{"id":"https://openalex.org/keywords/gap-junctional-intercellular-communication","display_name":"gap junctional intercellular communication","score":0.7279999852180481},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.828000009059906},{"id":"https://openalex.org/keywords/iodoacetic-acid","display_name":"iodoacetate","score":0.8410000205039978},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9649999737739563},{"id":"https://openalex.org/keywords/apoptosis-inducing-factor","display_name":"apoptosis-inducing factor","score":0.890999972820282},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.7799999713897705},{"id":"https://openalex.org/keywords/sulforaphane","display_name":"sulforaphane","score":0.9919999837875366},{"id":"https://openalex.org/keywords/n-acetylcysteine","display_name":"N-acetylcysteine","score":0.7239999771118164},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.375},{"id":"https://openalex.org/keywords/peroxynitrite","display_name":"peroxynitrite","score":0.8450000286102295},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6050000190734863},{"id":"https://openalex.org/keywords/atp-depletion","display_name":"ATP depletion","score":0.546999990940094},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.37599998712539673},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.7188382744789124},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6595186591148376},{"id":"https://openalex.org/C122356138","wikidata":"https://www.wikidata.org/wiki/Q461576","display_name":"Cortical spreading depression","level":3,"score":0.6486354470252991},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.5712336301803589},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5518506169319153},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5496633052825928},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5341702103614807},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5223547220230103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5015521049499512},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4581313729286194},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.4433841109275818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32368525862693787},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.26172786951065063},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24990373849868774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22573214769363403},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21849852800369263},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21110743284225464},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.19972896575927734},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:gupea.ub.gu.se:2077/9868","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/9868","pdf_url":"http://hdl.handle.net/2077/9868","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},{"id":"mag:2140874356","doi":null,"is_oa":false,"landing_page_url":"https://gupea.ub.gu.se/bitstream/2077/9868/1/080305%20Avhandling.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:gupea.ub.gu.se:2077/9868","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2077/9868","pdf_url":"http://hdl.handle.net/2077/9868","source":{"id":"https://openalex.org/S4306401168","display_name":"Gothenburg University Publications Electronic Archive (Gothenburg University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I881427289","host_organization_name":"University of Gothenburg","host_organization_lineage":["https://openalex.org/I881427289"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310530","display_name":"Rune och Ulla Aml\u00f6vs Stiftelse f\u00f6r Neurologisk och Reumatologisk Forskning","ror":"https://ror.org/02bctrh07"},{"id":"https://openalex.org/F4320322833","display_name":"Stiftelsen Lars Hiertas Minne","ror":"https://ror.org/03cpsrf24"},{"id":"https://openalex.org/F4320323741","display_name":"Magnus Bergvalls Stiftelse","ror":"https://ror.org/040ya8k73"},{"id":"https://openalex.org/F4320324618","display_name":"Svenska L\u00e4kares\u00e4llskapet","ror":"https://ror.org/016ks4x90"},{"id":"https://openalex.org/F4320335047","display_name":"Sahlgrenska Akademin","ror":"https://ror.org/01tm6cn81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140874356.pdf","grobid_xml":"https://content.openalex.org/works/W2140874356.grobid-xml"},"referenced_works_count":330,"referenced_works":["https://openalex.org/W29706529","https://openalex.org/W48848062","https://openalex.org/W77047966","https://openalex.org/W125106425","https://openalex.org/W126490209","https://openalex.org/W1484355820","https://openalex.org/W1499711091","https://openalex.org/W1500211708","https://openalex.org/W1509216925","https://openalex.org/W1526030258","https://openalex.org/W1548631381","https://openalex.org/W1553473547","https://openalex.org/W1558003391","https://openalex.org/W1559909669","https://openalex.org/W1560171707","https://openalex.org/W1561096292","https://openalex.org/W1562050716","https://openalex.org/W1583048096","https://openalex.org/W1587957817","https://openalex.org/W1588823477","https://openalex.org/W1591646293","https://openalex.org/W1593655973","https://openalex.org/W1607531254","https://openalex.org/W1607777232","https://openalex.org/W1642980781","https://openalex.org/W1645749844","https://openalex.org/W1745634660","https://openalex.org/W1772857860","https://openalex.org/W1791420399","https://openalex.org/W1820347542","https://openalex.org/W1831526350","https://openalex.org/W1901072277","https://openalex.org/W1901485302","https://openalex.org/W1904882776","https://openalex.org/W1940692702","https://openalex.org/W1942154378","https://openalex.org/W1942797206","https://openalex.org/W1963909386","https://openalex.org/W1964844927","https://openalex.org/W1966928113","https://openalex.org/W1968505830","https://openalex.org/W1969161489","https://openalex.org/W1969305530","https://openalex.org/W1969619562","https://openalex.org/W1970156382","https://openalex.org/W1970188265","https://openalex.org/W1970256894","https://openalex.org/W1970297715","https://openalex.org/W1970549117","https://openalex.org/W1970918690","https://openalex.org/W1971034264","https://openalex.org/W1971403814","https://openalex.org/W1971597564","https://openalex.org/W1972317764","https://openalex.org/W1972532680","https://openalex.org/W1972636570","https://openalex.org/W1972737184","https://openalex.org/W1974087258","https://openalex.org/W1975444362","https://openalex.org/W1977015296","https://openalex.org/W1980144224","https://openalex.org/W1980829692","https://openalex.org/W1980900081","https://openalex.org/W1981289985","https://openalex.org/W1981705400","https://openalex.org/W1982073360","https://openalex.org/W1982236694","https://openalex.org/W1982544871","https://openalex.org/W1983836947","https://openalex.org/W1984089779","https://openalex.org/W1984346050","https://openalex.org/W1986070505","https://openalex.org/W1986099314","https://openalex.org/W1988200868","https://openalex.org/W1988316236","https://openalex.org/W1988860478","https://openalex.org/W1989102363","https://openalex.org/W1991179192","https://openalex.org/W1991381764","https://openalex.org/W1991631628","https://openalex.org/W1992565982","https://openalex.org/W1993614010","https://openalex.org/W1995463051","https://openalex.org/W1996455354","https://openalex.org/W1997899631","https://openalex.org/W1999495459","https://openalex.org/W1999543531","https://openalex.org/W2000083423","https://openalex.org/W2000605323","https://openalex.org/W2000989128","https://openalex.org/W2002301670","https://openalex.org/W2003086985","https://openalex.org/W2003634190","https://openalex.org/W2003640569","https://openalex.org/W2004718355","https://openalex.org/W2005154363","https://openalex.org/W2005416260","https://openalex.org/W2005512795","https://openalex.org/W2006376420","https://openalex.org/W2006806309","https://openalex.org/W2008029685","https://openalex.org/W2008585165","https://openalex.org/W2009462641","https://openalex.org/W2009849990","https://openalex.org/W2013886277","https://openalex.org/W2014348091","https://openalex.org/W2014947131","https://openalex.org/W2015173171","https://openalex.org/W2015243552","https://openalex.org/W2015425771","https://openalex.org/W2015938553","https://openalex.org/W2017523469","https://openalex.org/W2017726148","https://openalex.org/W2018076136","https://openalex.org/W2019163121","https://openalex.org/W2019177876","https://openalex.org/W2021726628","https://openalex.org/W2022377100","https://openalex.org/W2022995782","https://openalex.org/W2025478209","https://openalex.org/W2025695096","https://openalex.org/W2026154459","https://openalex.org/W2026364404","https://openalex.org/W2026627501","https://openalex.org/W2027780701","https://openalex.org/W2028072707","https://openalex.org/W2028243150","https://openalex.org/W2028594138","https://openalex.org/W2028925334","https://openalex.org/W2028958046","https://openalex.org/W2030691968","https://openalex.org/W2032413974","https://openalex.org/W2032423144","https://openalex.org/W2032444047","https://openalex.org/W2033108407","https://openalex.org/W2033270976","https://openalex.org/W2033794046","https://openalex.org/W2034881930","https://openalex.org/W2034915619","https://openalex.org/W2035117212","https://openalex.org/W2036726644","https://openalex.org/W2036829402","https://openalex.org/W2040710878","https://openalex.org/W2043472746","https://openalex.org/W2044315213","https://openalex.org/W2044459826","https://openalex.org/W2044730840","https://openalex.org/W2044930326","https://openalex.org/W2046472521","https://openalex.org/W2046637240","https://openalex.org/W2047499088","https://openalex.org/W2047796217","https://openalex.org/W2048305330","https://openalex.org/W2048333479","https://openalex.org/W2048762049","https://openalex.org/W2050139814","https://openalex.org/W2051035876","https://openalex.org/W2051171548","https://openalex.org/W2051339763","https://openalex.org/W2051439699","https://openalex.org/W2051638758","https://openalex.org/W2051856314","https://openalex.org/W2052853635","https://openalex.org/W2053223951","https://openalex.org/W2053682958","https://openalex.org/W2054079425","https://openalex.org/W2055149916","https://openalex.org/W2055168645","https://openalex.org/W2055448213","https://openalex.org/W2055528775","https://openalex.org/W2055852420","https://openalex.org/W2056558115","https://openalex.org/W2057157121","https://openalex.org/W2058226902","https://openalex.org/W2058449890","https://openalex.org/W2060064603","https://openalex.org/W2060241324","https://openalex.org/W2060344266","https://openalex.org/W2060560962","https://openalex.org/W2062341643","https://openalex.org/W2063063986","https://openalex.org/W2063430288","https://openalex.org/W2063495408","https://openalex.org/W2064197300","https://openalex.org/W2064428225","https://openalex.org/W2064598952","https://openalex.org/W2064708316","https://openalex.org/W2065372694","https://openalex.org/W2065482201","https://openalex.org/W2066036370","https://openalex.org/W2067574216","https://openalex.org/W2068546618","https://openalex.org/W2068859526","https://openalex.org/W2069035576","https://openalex.org/W2069589122","https://openalex.org/W2069913959","https://openalex.org/W2070357113","https://openalex.org/W2070997299","https://openalex.org/W2071155318","https://openalex.org/W2072232906","https://openalex.org/W2072278357","https://openalex.org/W2072586423","https://openalex.org/W2072847038","https://openalex.org/W2074194694","https://openalex.org/W2074545913","https://openalex.org/W2074573663","https://openalex.org/W2076093658","https://openalex.org/W2077274654","https://openalex.org/W2077413632","https://openalex.org/W2078532409","https://openalex.org/W2078532650","https://openalex.org/W2078576469","https://openalex.org/W2078810845","https://openalex.org/W2079606432","https://openalex.org/W2079781432","https://openalex.org/W2080408380","https://openalex.org/W2081895884","https://openalex.org/W2083346530","https://openalex.org/W2083689040","https://openalex.org/W2084644507","https://openalex.org/W2085123274","https://openalex.org/W2086144679","https://openalex.org/W2087666006","https://openalex.org/W2088299086","https://openalex.org/W2088523363","https://openalex.org/W2089450477","https://openalex.org/W2089976500","https://openalex.org/W2090971379","https://openalex.org/W2091014895","https://openalex.org/W2091778411","https://openalex.org/W2092182643","https://openalex.org/W2092635505","https://openalex.org/W2092969356","https://openalex.org/W2093421851","https://openalex.org/W2093914791","https://openalex.org/W2094633691","https://openalex.org/W2095427825","https://openalex.org/W2095931805","https://openalex.org/W2096978860","https://openalex.org/W2101657617","https://openalex.org/W2104841128","https://openalex.org/W2104968232","https://openalex.org/W2105077078","https://openalex.org/W2105733113","https://openalex.org/W2107172684","https://openalex.org/W2108131089","https://openalex.org/W2109584356","https://openalex.org/W2109770177","https://openalex.org/W2111757703","https://openalex.org/W2112140076","https://openalex.org/W2112414149","https://openalex.org/W2113546972","https://openalex.org/W2114484265","https://openalex.org/W2115338196","https://openalex.org/W2116176075","https://openalex.org/W2116447221","https://openalex.org/W2118444721","https://openalex.org/W2118788831","https://openalex.org/W2119856586","https://openalex.org/W2120139857","https://openalex.org/W2120480388","https://openalex.org/W2122285447","https://openalex.org/W2122930160","https://openalex.org/W2123152434","https://openalex.org/W2123671636","https://openalex.org/W2124017577","https://openalex.org/W2125536365","https://openalex.org/W2126473492","https://openalex.org/W2127338217","https://openalex.org/W2129567809","https://openalex.org/W2130407823","https://openalex.org/W2132889264","https://openalex.org/W2134046709","https://openalex.org/W2134733089","https://openalex.org/W2135325091","https://openalex.org/W2135343497","https://openalex.org/W2135376726","https://openalex.org/W2135662322","https://openalex.org/W2136280619","https://openalex.org/W2138036162","https://openalex.org/W2138281508","https://openalex.org/W2138700374","https://openalex.org/W2138881211","https://openalex.org/W2138975833","https://openalex.org/W2139155172","https://openalex.org/W2139884360","https://openalex.org/W2141260882","https://openalex.org/W2141827300","https://openalex.org/W2141892357","https://openalex.org/W2142660334","https://openalex.org/W2144361706","https://openalex.org/W2144918294","https://openalex.org/W2145955296","https://openalex.org/W2147049445","https://openalex.org/W2147278993","https://openalex.org/W2148320340","https://openalex.org/W2149670635","https://openalex.org/W2150050842","https://openalex.org/W2151818004","https://openalex.org/W2152460583","https://openalex.org/W2155323977","https://openalex.org/W2155569675","https://openalex.org/W2156945415","https://openalex.org/W2156966478","https://openalex.org/W2158213789","https://openalex.org/W2159650080","https://openalex.org/W2159875238","https://openalex.org/W2160787016","https://openalex.org/W2160935383","https://openalex.org/W2161117320","https://openalex.org/W2161480852","https://openalex.org/W2161774676","https://openalex.org/W2162073916","https://openalex.org/W2164554425","https://openalex.org/W2165824005","https://openalex.org/W2166851454","https://openalex.org/W2168115703","https://openalex.org/W2168599730","https://openalex.org/W2169079203","https://openalex.org/W2169335244","https://openalex.org/W2169714384","https://openalex.org/W2170418680","https://openalex.org/W2229772813","https://openalex.org/W2283713899","https://openalex.org/W2306748886","https://openalex.org/W2311237560","https://openalex.org/W2405139461","https://openalex.org/W2412226697","https://openalex.org/W2418917221","https://openalex.org/W2527711180"],"related_works":["https://openalex.org/W2010660896","https://openalex.org/W1999462228","https://openalex.org/W2079662634","https://openalex.org/W4321495830","https://openalex.org/W2005365429","https://openalex.org/W1515334051","https://openalex.org/W4387538826","https://openalex.org/W2019163121","https://openalex.org/W1571970387","https://openalex.org/W2013366851"],"abstract_inverted_index":{"Stroke":[0],"is":[1,17,83,357],"a":[2,23,182,192,297,305,470],"major":[3],"cause":[4],"of":[5,22,30,36,90,136,155,198,230,270,282,299,312,347,349,374,515,521,547,561,574,588],"death":[6,42,214,244,272,279,506,536,563],"and":[7,38,70,115,153,157,184,224,314,336,426,503,524,541],"adult":[8],"disability":[9],"in":[10,60,175,195,217,247,273,296,326,353,378,390],"the":[11,20,27,31,46,56,61,64,71,134,143,170,196,268,287,290,350,360,375,384,397,404,415,419,436,451,462,465,490,493,545,559,586],"western":[12],"world.":[13],"Most":[14],"often,":[15],"stroke":[16],"caused":[18],"by":[19,127,359,382,479,538,572],"occlusion":[21,47],"brain":[24],"artery.":[25],"Within":[26],"perfusion":[28],"territory":[29],"occluded":[32],"vessel,":[33],"various":[34,118],"degrees":[35],"necrotic":[37],"delayed":[39],"programmed":[40,212,242,277],"cell":[41,213,222,243,255,271,278,339,429,505,526,535,562],"will":[43],"occur":[44],"if":[45],"persists,":[48],"leading":[49],"to":[50,67,73,98,161,226,267,289,308,319,329,406,421,467,498],"expanding":[51],"tissue":[52],"damage.":[53],"Astrocytes":[54,123],"are":[55,95,106,124],"most":[57],"numerous":[58],"cells":[59,76,249],"brain,":[62],"but":[63,250],"astrocytic":[65,148,163,534],"response":[66],"ischemic":[68,81,99,589],"conditions":[69,114],"extent":[72],"which":[74,188,317,579],"these":[75,407,530],"can":[77],"recover":[78,468,499],"after":[79],"an":[80,582],"insult":[82],"not":[84,324,496],"well":[85],"understood.":[86],"An":[87],"increasing":[88],"amount":[89],"evidence":[91],"indicates":[92],"that":[93,132,205,261,533],"astrocytes":[94,219,327,379,405,420,466,494,568],"more":[96],"sensitive":[97],"injury":[100,473,590],"than":[101],"previously":[102],"thought.":[103],"Astrocytic":[104],"functions":[105,149],"vitally":[107],"important":[108,147,557],"for":[109,145,464,558,585],"neuronal":[110],"activity":[111,197],"during":[112,117,165,239,489,564],"physiological":[113],"probably":[116],"pathological":[119],"situations,":[120],"including":[121,150],"stroke.":[122],"highly":[125],"coupled":[126],"intercellular":[128],"gap":[129,234,262,553],"junction":[130,235,263,554],"channels":[131],"enable":[133],"formation":[135],"large":[137,228,254],"cellular":[138,355],"networks.":[139],"These":[140],"networks":[141],"provide":[142],"basis":[144],"several":[146,337],"intracellular":[151],"signalling":[152],"transport":[154],"molecules":[156],"metabolites.":[158],"\\nIn":[159,528],"order":[160],"investigate":[162],"reactions":[164],"metabolic":[166,206,240,330,475,484,539,565],"depression":[167,207,331,476,485,540],"we":[168,460],"used":[169,399],"glycolytic":[171],"blocker":[172],"iodoacetate":[173],"(IA)":[174],"primary":[176],"astrocyte":[177],"cultures.":[178],"This":[179,203,259],"treatment":[180],"induced":[181,208],"reproducible":[183],"concentration-dependent":[185],"ATP":[186,424,491,501,522],"decrease":[187],"was":[189,215,237,245,257,323,380,477,486,556],"associated":[190],"with":[191,510],"profound":[193],"increase":[194],"reactive":[199],"oxygen":[200],"species":[201],"(ROS).":[202],"suggests":[204,260],"oxidative":[209,300,333,416,542],"stress.":[210,334],"Moreover,":[211],"initiated":[216,246],"individual":[218,248],"or":[220,332,392,396,412,450,513],"small":[221],"clusters":[223,229,256],"spread":[225],"include":[227],"astrocytes.":[231,274],"However,":[232,508],"when":[233,435],"communication":[236,555],"inhibited":[238],"depression,":[241],"no":[251],"expansion":[252],"into":[253],"observed.":[258],"permeable":[264],"substances":[265,408],"contribute":[266],"spreading":[269,560],"The":[275,345,370],"observed":[276,295,325,434],"involved":[280,352],"translocation":[281,546],"apoptosis":[283,548],"inducing":[284,549],"factor":[285,362,364,367],"from":[286],"mitochondria":[288],"nucleus.":[291],"Similar":[292,431],"results":[293,432,531],"were":[294,433,457,495,569],"model":[298],"stress":[301,543],"using":[302,383],"3-morpholinosyndomine":[303],"(SIN-1),":[304],"compound":[306],"known":[307],"produce":[309],"equimolar":[310],"amounts":[311],"superoxide":[313,447],"nitric":[315],"oxide":[316],"react":[318],"form":[320],"peroxynitrite.":[321],"Caspase-activation":[322],"exposed":[328],"\\nAstrocytes":[335],"other":[338],"types":[340],"express":[341],"endogenous":[342,576],"antioxidant":[343,577],"systems.":[344],"expression":[346],"many":[348],"enzymes":[351],"this":[354],"defense":[356],"regulated":[358],"transcription":[361],"nuclear":[363],"erythroid":[365],"2-related":[366],"2":[368],"(Nrf2).":[369],"potential":[371],"protective":[372],"effect":[373],"Nrf2":[376,511],"system":[377],"investigated":[381,461],"Nrf2-activating":[385],"phytochemicals":[386],"sulforaphane":[387],"(naturally":[388],"occurring":[389],"broccoli)":[391],"curcumin":[393],"(from":[394],"turmeric),":[395],"commonly":[398],"food":[400],"additive":[401],"tert-butylhydroquinone.":[402],"Exposing":[403],"before":[409],"adding":[410],"IA":[411],"SIN-1,":[413],"prevented":[414,428,525],"stress,":[417],"enabled":[418,519],"maintain":[422],"their":[423,500],"levels":[425,502,523],"efficiently":[427,570],"death.":[430,527],"exogenous":[437,516],"ROS":[438,517],"scavengers":[439,518],"trolox":[440],"(a":[441,446],"vitamin":[442],"E":[443],"analogue),":[444],"tempol":[445],"dismutase":[448],"analogue)":[449],"free":[452],"radical":[453],"scavenger":[454],"cocktail":[455],"B27":[456],"used.":[458],"\\nFinally,":[459],"possibility":[463],"following":[469],"simulated":[471],"reperfusion":[472],"where":[474],"reversed":[478],"washing":[480],"out":[481],"IA.":[482],"Although":[483],"interrupted":[487],"early":[488],"decrease,":[492],"able":[497],"widespread":[504],"occurred.":[507],"pre-treatment":[509],"activators":[512],"addition":[514],"recovery":[520],"summary,":[529],"show":[532],"mediated":[537],"involves":[544],"factor.":[550],"In":[551],"addition,":[552],"depression.":[566],"Finally,":[567],"protected":[571],"activation":[573],"Nrf2-regulated":[575],"systems,":[578],"may":[580],"represent":[581],"interesting":[583],"target":[584],"limitation":[587]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
