{"id":"https://openalex.org/W2140808846","doi":"https://doi.org/10.2337/db10-0443","title":"Response to Comment on: Jowett et al. (2010) Genetic Variation at the FTO Locus Influences RBL2 Gene Expression. Diabetes;59:726\u2013732","display_name":"Response to Comment on: Jowett et al. (2010) Genetic Variation at the FTO Locus Influences RBL2 Gene Expression. Diabetes;59:726\u2013732","publication_year":2010,"publication_date":"2010-06-29","ids":{"openalex":"https://openalex.org/W2140808846","doi":"https://doi.org/10.2337/db10-0443","mag":"2140808846"},"language":"en","primary_location":{"id":"doi:10.2337/db10-0443","doi":"https://doi.org/10.2337/db10-0443","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-0443","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/59/7/e10/399468/zdb00710000e10.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://diabetesjournals.org/diabetes/article-pdf/59/7/e10/399468/zdb00710000e10.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110264168","display_name":"Jeremy B. M. Jowett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142471025","display_name":"Baker Heart and Diabetes Institute","ror":"https://ror.org/03rke0285","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I142471025"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jeremy B.M. Jowett","raw_affiliation_strings":["Department of Genomics and Systems Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genomics and Systems Biology, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia;","institution_ids":["https://openalex.org/I142471025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004538115","display_name":"John Blangero","orcid":"https://orcid.org/0000-0001-6250-5723","observed_orcids":["https://orcid.org/0000-0001-6250-5723"]},"institutions":[{"id":"https://openalex.org/I1289525096","display_name":"Texas Biomedical Research Institute","ror":"https://ror.org/00wbskb04","country_code":"US","type":"facility","lineage":["https://openalex.org/I1289525096"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Blangero","raw_affiliation_strings":["Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas","institution_ids":["https://openalex.org/I1289525096"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110264168"],"corresponding_institution_ids":["https://openalex.org/I142471025"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.15653903,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"59","issue":"7","first_page":"e10","last_page":"e10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7451000213623047,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.13619999587535858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.9660000205039978},{"id":"https://openalex.org/keywords/rs8050136","display_name":"rs8050136","score":0.9459999799728394},{"id":"https://openalex.org/keywords/allelic-expression","display_name":"allelic expression","score":0.5479999780654907},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.7739999890327454},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.7850000262260437},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.5649999976158142},{"id":"https://openalex.org/keywords/obesity-genetics","display_name":"obesity genetics","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.750464916229248},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6510396599769592},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.5922588109970093},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5916112661361694},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5830132365226746},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5591610074043274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.539050281047821},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.48017826676368713},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.4698663651943207},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3666081428527832},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.24427887797355652}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.2337/db10-0443","doi":"https://doi.org/10.2337/db10-0443","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-0443","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/59/7/e10/399468/zdb00710000e10.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.588.9008","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.588.9008","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/59/7/e10.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.2337/db10-0443","doi":"https://doi.org/10.2337/db10-0443","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db10-0443","pdf_url":"https://diabetesjournals.org/diabetes/article-pdf/59/7/e10/399468/zdb00710000e10.pdf","source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140808846.pdf","grobid_xml":"https://content.openalex.org/works/W2140808846.grobid-xml"},"referenced_works_count":2,"referenced_works":["https://openalex.org/W2122890867","https://openalex.org/W2150572398"],"related_works":["https://openalex.org/W7101163598","https://openalex.org/W2150572398","https://openalex.org/W1965158257","https://openalex.org/W6991158717","https://openalex.org/W2355310119","https://openalex.org/W2890669541","https://openalex.org/W4386565688","https://openalex.org/W1197291680","https://openalex.org/W2237761180","https://openalex.org/W1990537591"],"abstract_inverted_index":{"The":[0,51,128],"comment":[1],"submitted":[2],"by":[3,54],"Berulava":[4,55],"andHorsthemke":[5],"(1)":[6],"on":[7,14,37],"our":[8,38,138],"recent":[9],"work":[10],"regardingthe":[11],"biological":[12],"effects":[13],"gene":[15,79],"expression":[16,46,122],"of":[17,30,77,80,91,97,119],"theFTO":[18],"single":[19],"nucleotide":[20],"polymorphism":[21],"(SNP)":[22],"rs8050136":[23],"(2)":[24],"is":[25,58],"welcomed":[26],"and":[27,56,110,115],"achieves":[28],"one":[29],"the":[31,75,78,87,95,134],"study\u2019s":[32],"goals\u2014to":[33],"inspire":[34],"follow-up":[35],"studies":[36],"observation":[39,135],"that":[40,66,117],"these":[41],"SNPs":[42],"may":[43],"affect":[44],"RBL2":[45,101,120],"but":[47,125],"not":[48,126],"FTO":[49,104],"itself.":[50],"approach":[52],"taken":[53],"Horsthemke":[57],"to":[59,132],"quantify":[60],"allelic-specific":[61],"transcript":[62],"levels":[63],"in":[64,74,86,102,137],"cells":[65],"are":[67,142],"heterozygous":[68],"for":[69,100],"a":[70],"given":[71],"indicator":[72],"variant":[73],"mRNA":[76],"interest":[81],"(in":[82],"this":[83],"case,":[84],"rs3929":[85],"3":[88],"untrans-lated":[89],"region":[90],"RBL2).":[92],"They":[93],"measure":[94],"ratio":[96],"allele-specific":[98],"transcripts":[99],"three":[103],"SNP":[105],"(rs8050136)":[106],"heterozygotous":[107],"individuals":[108,113],"(AC)":[109],"two":[111],"homozygous":[112],"(AA)":[114],"report":[116],"skewing":[118],"allelic":[121],"was":[123],"detected":[124],"significant.":[127],"presented":[129],"data":[130],"fail":[131],"replicate":[133],"published":[136],"original":[139],"study.":[140],"There":[141],"many":[143],"possible":[144]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
