{"id":"https://openalex.org/W2140705491","doi":null,"title":"Ghrelin does not modulate angiogenesis in matrigel plug in normal and diet-induced obese mice.","display_name":"Ghrelin does not modulate angiogenesis in matrigel plug in normal and diet-induced obese mice.","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W2140705491","mag":"2140705491","pmid":"https://pubmed.ncbi.nlm.nih.gov/24520231","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906783"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2904002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906783","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009259832","display_name":"Zoya Tahergorabi","orcid":"https://orcid.org/0000-0002-9915-256X","observed_orcids":["https://orcid.org/0000-0002-9915-256X","https://orcid.org/0000-0002-7072-7454"]},"institutions":[{"id":"https://openalex.org/I95990688","display_name":"Birjand University of Medical Sciences","ror":"https://ror.org/01h2hg078","country_code":"IR","type":"education","lineage":["https://openalex.org/I95990688"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Zoya Tahergorabi","raw_affiliation_strings":["Department of Physiology, Birjand University of Medical Sciences, Birjand, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Birjand University of Medical Sciences, Birjand, Iran","institution_ids":["https://openalex.org/I95990688"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024440066","display_name":"Bahman Rashidi","orcid":"https://orcid.org/0000-0003-1133-9571","observed_orcids":["https://orcid.org/0000-0003-1133-9571"]},"institutions":[{"id":"https://openalex.org/I114982161","display_name":"Isfahan University of Medical Sciences","ror":"https://ror.org/04waqzz56","country_code":"IR","type":"education","lineage":["https://openalex.org/I114982161"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Bahman Rashidi","raw_affiliation_strings":["Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Isfahan University of Medical Sciences, Isfahan, Iran","institution_ids":["https://openalex.org/I114982161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002434919","display_name":"Majid Khazaei","orcid":"https://orcid.org/0000-0002-7979-5699","observed_orcids":["https://orcid.org/0000-0002-7979-5699","https://orcid.org/0000-0002-3150-5883"]},"institutions":[{"id":"https://openalex.org/I95990688","display_name":"Birjand University of Medical Sciences","ror":"https://ror.org/01h2hg078","country_code":"IR","type":"education","lineage":["https://openalex.org/I95990688"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Majid Khazaei","raw_affiliation_strings":["Department of Physiology, Birjand University of Medical Sciences, Birjand, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Birjand University of Medical Sciences, Birjand, Iran","institution_ids":["https://openalex.org/I95990688"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1341,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.44938414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"18","issue":"11","first_page":"939","last_page":"42"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.5317000150680542,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.40939998626708984,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ghrelin","display_name":"ghrelin","score":1.0},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9470000267028809},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.9190000295639038},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.9520000219345093},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.6470000147819519},{"id":"https://openalex.org/keywords/basic-fibroblast-growth-factor","display_name":"basic fibroblast growth factor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cd31","display_name":"CD31","score":0.7940000295639038},{"id":"https://openalex.org/keywords/matrigel-plug-assay","display_name":"Matrigel plug assay","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.9365236759185791},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.9205654859542847},{"id":"https://openalex.org/C2779357093","wikidata":"https://www.wikidata.org/wiki/Q422269","display_name":"Ghrelin","level":3,"score":0.884874701499939},{"id":"https://openalex.org/C2778939058","wikidata":"https://www.wikidata.org/wiki/Q4046167","display_name":"CD31","level":3,"score":0.7777256965637207},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7035045027732849},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7027809023857117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6960036754608154},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.6927508115768433},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.5844990611076355},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.46179720759391785},{"id":"https://openalex.org/C2777587049","wikidata":"https://www.wikidata.org/wiki/Q20969945","display_name":"Basic fibroblast growth factor","level":4,"score":0.4358382225036621},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.34265637397766113},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2364024519920349},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.147096186876297},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:2904002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24520231","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24520231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3906783","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3906783/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Res Med Sci","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:c246912d2f3a472c8549e3567bd202fb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c246912d2f3a472c8549e3567bd202fb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Research in Medical Sciences, Vol 18, Iss 11, Pp 939-942 (2013)","raw_type":"article"},{"id":"mag:2140705491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24520231","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2904002","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3906783","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W172579969","https://openalex.org/W568938955","https://openalex.org/W1591852023","https://openalex.org/W1901716085","https://openalex.org/W1963930004","https://openalex.org/W1968859891","https://openalex.org/W2014159666","https://openalex.org/W2027442301","https://openalex.org/W2040593344","https://openalex.org/W2043591830","https://openalex.org/W2045040707","https://openalex.org/W2054899525","https://openalex.org/W2056853742","https://openalex.org/W2058103173","https://openalex.org/W2059992589","https://openalex.org/W2080402651","https://openalex.org/W2085957571","https://openalex.org/W2099398050","https://openalex.org/W2106597264","https://openalex.org/W2111281590","https://openalex.org/W2128018781","https://openalex.org/W2129505260","https://openalex.org/W2136125772","https://openalex.org/W2150343033","https://openalex.org/W2403779027"],"related_works":["https://openalex.org/W2599657215","https://openalex.org/W1976084606","https://openalex.org/W180507913","https://openalex.org/W2372667227","https://openalex.org/W2323182365","https://openalex.org/W1994227279","https://openalex.org/W2320015478","https://openalex.org/W2888156347","https://openalex.org/W2135405968","https://openalex.org/W2027339934"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,22],"reciprocal":[2],"interaction":[3],"between":[4,213],"adipocytes":[5],"and":[6,17,45,54,91,99,150,157,204,219,244],"angiogenesis":[7,40,169,197,237,243],"is":[8],"considered":[9],"as":[10,173,175,228],"an":[11,229],"essential":[12],"component":[13],"in":[14,38,52,135,170,198,201,238],"the":[15,30,136,176,214],"development":[16],"expansion":[18],"of":[19,24,32,42,140,178,216,242],"adipose":[20],"tissue.":[21],"aim":[23],"this":[25],"study":[26,63],"was":[27,132,160,208],"to":[28],"evaluate":[29],"effect":[31],"ghrelin":[33,94,129,245],"on":[34,67],"angiogenic":[35,158,230],"response":[36,159],"using":[37],"vivo":[39],"assay":[41],"matrigel":[43,114,151,171,199,239],"plug":[44,115,172,200,240],"its":[46],"correlation":[47,212,235],"with":[48,126,236],"serum":[49,220],"leptin":[50,221],"levels":[51],"normal":[53],"diet-induced":[55],"obese":[56,90,203],"mice.":[57,142],"MATERIALS":[58],"AND":[59],"METHODS:":[60],"This":[61],"experimental":[62],"has":[64,232],"been":[65],"done":[66],"24":[68],"male":[69],"C57BL/6":[70],"mice":[71],"which":[72],"were":[73,148,153],"randomly":[74],"divided":[75],"into":[76],"four":[77],"groups:":[78],"Normal":[79],"diet":[80,106,183],"(ND)":[81],"or":[82,89,104,127],"control,":[83],"ND":[84],"+":[85,93],"ghrelin,":[86],"high-fat-diet":[87],"(HFD)":[88],"HFD":[92,103,166],"(n":[95],"=":[96,224],"6/group).":[97],"Obese":[98],"control":[100,205],"groups":[101],"received":[102],"standard":[105,182],"for":[107],"14":[108],"weeks.":[109],"Then,":[110],"growth":[111,122],"factor":[112,231],"reduced":[113],"(500":[116],"\u03bcl)":[117],"containing":[118],"bFGF":[119],"(basic":[120],"fibroblast":[121],"factor;":[123],"100":[124],"ng)":[125],"without":[128],"(100":[130],"\u03bcg/kg)":[131],"injected":[133],"subcutaneously":[134],"mid-ventral":[137],"abdominal":[138],"region":[139],"each":[141],"After":[143],"10":[144],"days,":[145],"blood":[146],"samples":[147],"taken":[149],"plugs":[152],"removed":[154],"under":[155],"anesthesia":[156],"assessed":[161],"by":[162],"immunohisochemical":[163],"staining.":[164],"RESULTS:":[165],"significantly":[167],"increased":[168],"expressed":[174],"number":[177,215],"CD31-positive":[179,217],"cells":[180,218],"than":[181],"(43":[184],"\u00b1":[185,189],"5":[186],"vs.":[187],"13":[188],"2.5":[190],"CD31(+)":[191],"cells/field).":[192],"Ghrelin":[193],"did":[194],"not":[195,247],"alter":[196,248],"both":[202],"groups.":[206],"There":[207],"a":[209,233],"strong":[210],"positive":[211,234],"concentration":[222],"(r":[223],"0.91).":[225],"CONCLUSION:":[226],"Leptin":[227],"model":[241],"could":[246],"angiogenesis.":[249]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
