{"id":"https://openalex.org/W2140700892","doi":"https://doi.org/10.1016/j.jaci.2010.07.027","title":"Immune mechanisms of sublingual immunotherapy: Are oral Langerhans cells the masters of tolerance?","display_name":"Immune mechanisms of sublingual immunotherapy: Are oral Langerhans cells the masters of tolerance?","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W2140700892","doi":"https://doi.org/10.1016/j.jaci.2010.07.027","mag":"2140700892","pmid":"https://pubmed.ncbi.nlm.nih.gov/20816196"},"language":"en","primary_location":{"id":"doi:10.1016/j.jaci.2010.07.027","doi":"https://doi.org/10.1016/j.jaci.2010.07.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2010.07.027","pdf_url":"http://www.jacionline.org/article/S0091674910011413/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jacionline.org/article/S0091674910011413/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077280281","display_name":"Mark Larch\u00e9","orcid":"https://orcid.org/0000-0002-1439-7593","observed_orcids":["https://orcid.org/0000-0002-1439-7593"]},"institutions":[{"id":"https://openalex.org/I59293822","display_name":"St. Joseph\u2019s Healthcare Hamilton","ror":"https://ror.org/009z39p97","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I59293822"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Mark Larch\u00e9","raw_affiliation_strings":["Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University and Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Immunology and Allergy, Department of Medicine, Faculty of Health Sciences, McMaster University and Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I59293822","https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5077280281"],"corresponding_institution_ids":["https://openalex.org/I59293822","https://openalex.org/I98251732"],"apc_list":{"value":4900,"currency":"USD","value_usd":4900},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"126","issue":"3","first_page":"646","last_page":"647"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.7842000126838684,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.17440000176429749,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":0.012400000356137753,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sublingual-immunotherapy","display_name":"sublingual immunotherapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.7459999918937683},{"id":"https://openalex.org/keywords/antigen-presenting-cells","display_name":"antigen-presenting cells","score":0.949999988079071},{"id":"https://openalex.org/keywords/oral-mucosa","display_name":"oral mucosa","score":0.6169999837875366},{"id":"https://openalex.org/keywords/immune-privilege","display_name":"immune privilege","score":0.6209999918937683},{"id":"https://openalex.org/keywords/vaccine-route-of-administration","display_name":"vaccine route of administration","score":0.6740000247955322},{"id":"https://openalex.org/keywords/adjuvants","display_name":"adjuvants","score":0.7459999918937683},{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2777037608","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Sublingual immunotherapy","level":4,"score":0.8848332166671753},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6149182915687561},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5669789910316467},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5636392831802368},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5342819690704346},{"id":"https://openalex.org/C3018710434","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Oral immunotherapy","level":4,"score":0.5094662308692932},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.48765575885772705}],"mesh":[{"descriptor_ui":"D000286","descriptor_name":"Administration, Sublingual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jaci.2010.07.027","doi":"https://doi.org/10.1016/j.jaci.2010.07.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2010.07.027","pdf_url":"http://www.jacionline.org/article/S0091674910011413/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},{"id":"pmid:20816196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20816196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of allergy and clinical immunology","raw_type":"Comment"}],"best_oa_location":{"id":"doi:10.1016/j.jaci.2010.07.027","doi":"https://doi.org/10.1016/j.jaci.2010.07.027","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jaci.2010.07.027","pdf_url":"http://www.jacionline.org/article/S0091674910011413/pdf","source":{"id":"https://openalex.org/S108525051","display_name":"Journal of Allergy and Clinical Immunology","issn_l":"0091-6749","issn":["0091-6749","1085-8725","1097-6825"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Allergy and Clinical Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140700892.pdf","grobid_xml":"https://content.openalex.org/works/W2140700892.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1600231838","https://openalex.org/W1960538598","https://openalex.org/W1963617959","https://openalex.org/W1977149533","https://openalex.org/W2022357294","https://openalex.org/W2040637363","https://openalex.org/W2055922854","https://openalex.org/W2138961639","https://openalex.org/W2159762698","https://openalex.org/W2161938158","https://openalex.org/W2163379341","https://openalex.org/W2172027284","https://openalex.org/W4313377040"],"related_works":["https://openalex.org/W2053968592","https://openalex.org/W2920283604","https://openalex.org/W7099629483","https://openalex.org/W1749257195","https://openalex.org/W1584140819","https://openalex.org/W2127698353","https://openalex.org/W1967287194","https://openalex.org/W4403027826","https://openalex.org/W2102869202","https://openalex.org/W2767148736"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}