{"id":"https://openalex.org/W2140678674","doi":"https://doi.org/10.1242/jcs.88.2.161","title":"Migration of neutrophils across monolayers of cultured microvascular endothelial cells An in vitro model of leucocyte extravasation","display_name":"Migration of neutrophils across monolayers of cultured microvascular endothelial cells An in vitro model of leucocyte extravasation","publication_year":1987,"publication_date":"1987-09-01","ids":{"openalex":"https://openalex.org/W2140678674","doi":"https://doi.org/10.1242/jcs.88.2.161","mag":"2140678674","pmid":"https://pubmed.ncbi.nlm.nih.gov/2961775"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.88.2.161","doi":"https://doi.org/10.1242/jcs.88.2.161","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.88.2.161","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111886652","display_name":"Martha B. Furie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martha B. Furie","raw_affiliation_strings":["Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010510777","display_name":"Beth L. Naprstek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth L. Naprstek","raw_affiliation_strings":["Rover Research Laboratory, Department of Physiology\u2019 and Cellular Biophysics, College of Physicians and Singeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rover Research Laboratory, Department of Physiology\u2019 and Cellular Biophysics, College of Physicians and Singeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113836046","display_name":"Samuel C. Silverstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel C. Silverstein","raw_affiliation_strings":["Rover Research Laboratory, Department of Physiology\u2019 and Cellular Biophysics, College of Physicians and Singeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rover Research Laboratory, Department of Physiology\u2019 and Cellular Biophysics, College of Physicians and Singeons of Columbia University, 630 West 168th Street, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":2.3254,"has_fulltext":false,"cited_by_count":120,"citation_normalized_percentile":{"value":0.90947242,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"88","issue":"2","first_page":"161","last_page":"175"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neutrophil-transendothelial-migration","display_name":"neutrophil transendothelial migration","score":0.9169999957084656},{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/fmlp-chemotaxis","display_name":"fMLP chemotaxis","score":0.9160000085830688},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.8880000114440918},{"id":"https://openalex.org/keywords/basement-membrane-penetration","display_name":"basement membrane penetration","score":0.875},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pepstatin","display_name":"pepstatin","score":0.8019999861717224},{"id":"https://openalex.org/keywords/chymostatin","display_name":"chymostatin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.5799999833106995},{"id":"https://openalex.org/keywords/neutrophil-endothelial-interaction","display_name":"neutrophil-endothelial interaction","score":0.5400000214576721}],"concepts":[{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.7340797185897827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6876562237739563},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6756463050842285},{"id":"https://openalex.org/C2776193487","wikidata":"https://www.wikidata.org/wiki/Q32846","display_name":"Basement membrane","level":2,"score":0.6400744915008545},{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.6277014017105103},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5791235566139221},{"id":"https://openalex.org/C2780646683","wikidata":"https://www.wikidata.org/wiki/Q473749","display_name":"Amnion","level":4,"score":0.5618354082107544},{"id":"https://openalex.org/C2780656570","wikidata":"https://www.wikidata.org/wiki/Q5090627","display_name":"N-Formylmethionine leucyl-phenylalanine","level":4,"score":0.5571941137313843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.495519757270813},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4856094419956207},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.467914879322052},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.43817585706710815},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4236035645008087},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.26367902755737305},{"id":"https://openalex.org/C198677920","wikidata":"https://www.wikidata.org/wiki/Q3299937","display_name":"Neutrophile","level":3,"score":0.23789289593696594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18834829330444336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16585326194763184},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09996625781059265},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0849291980266571},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08247938752174377},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009240","descriptor_name":"N-Formylmethionine Leucyl-Phenylalanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/jcs.88.2.161","doi":"https://doi.org/10.1242/jcs.88.2.161","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.88.2.161","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:2961775","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2961775","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2168243056","display_name":null,"funder_award_id":"HL32210","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2370894471","display_name":null,"funder_award_id":"AI 22480","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6080357707","display_name":null,"funder_award_id":"CA06732","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W80815332","https://openalex.org/W129456264","https://openalex.org/W171459490","https://openalex.org/W232135190","https://openalex.org/W580732923","https://openalex.org/W912390272","https://openalex.org/W1234218055","https://openalex.org/W1490843989","https://openalex.org/W1523180222","https://openalex.org/W1540669721","https://openalex.org/W1541671026","https://openalex.org/W1588203473","https://openalex.org/W1593349322","https://openalex.org/W1784724717","https://openalex.org/W1917053440","https://openalex.org/W1972276146","https://openalex.org/W1976155227","https://openalex.org/W1985102595","https://openalex.org/W1993376574","https://openalex.org/W2003866166","https://openalex.org/W2004712420","https://openalex.org/W2009224474","https://openalex.org/W2011699424","https://openalex.org/W2012839797","https://openalex.org/W2018646338","https://openalex.org/W2020502307","https://openalex.org/W2022558273","https://openalex.org/W2035985781","https://openalex.org/W2037082246","https://openalex.org/W2042786025","https://openalex.org/W2049072541","https://openalex.org/W2056274413","https://openalex.org/W2061698776","https://openalex.org/W2062903573","https://openalex.org/W2068180652","https://openalex.org/W2068758906","https://openalex.org/W2076000996","https://openalex.org/W2077299636","https://openalex.org/W2081255141","https://openalex.org/W2086847208","https://openalex.org/W2092222240","https://openalex.org/W2094151171","https://openalex.org/W2095688796","https://openalex.org/W2109272101","https://openalex.org/W2127675150","https://openalex.org/W2131547680","https://openalex.org/W2133320565","https://openalex.org/W2135826556","https://openalex.org/W2138488715","https://openalex.org/W2150802228","https://openalex.org/W2183353764","https://openalex.org/W2203030996","https://openalex.org/W2212388653","https://openalex.org/W2287255503","https://openalex.org/W2303770204","https://openalex.org/W2435681853","https://openalex.org/W6679597362","https://openalex.org/W6992479402"],"related_works":["https://openalex.org/W1981505979","https://openalex.org/W207542719","https://openalex.org/W2023138187","https://openalex.org/W4242053919","https://openalex.org/W2050705754","https://openalex.org/W2182231205","https://openalex.org/W1520600447","https://openalex.org/W2004633180","https://openalex.org/W2119311154","https://openalex.org/W1640454082"],"abstract_inverted_index":{"Monolayers":[0],"of":[1,23,54,58,62,73,80,86,89,100,120,144,178,235,252,255,277,286,319,350,363,370],"bovine":[2],"microvascular":[3],"endothelial":[4,155,195,240],"cells":[5],"(BMECs)":[6],"grown":[7],"on":[8,283],"connective":[9,229],"tissue":[10,299],"derived":[11],"from":[12,352],"human":[13,24],"amniotic":[14,228,298],"membrane":[15,222],"were":[16,205],"used":[17,356],"to":[18,36,103,116,128,247,293,313,315,333,366,375],"examine":[19],"the":[20,47,59,66,78,84,94,101,117,121,142,148,154,161,175,189,192,201,209,217,220,226,233,250,284,291,297,345,353,358],"transendothelial":[21],"migration":[22,76,199,244,310,330],"neutrophils":[25,63,145,166,190,203,218,287],"in":[26,34,77,83,180,238,249,311,331,357],"vitro.":[27],"Neutrophils":[28,113],"placed":[29],"above":[30,91],"these":[31,50,278,324],"cultures":[32,95,150],"migrated":[33,64,152,289],"response":[35,102,312,332],"a":[37,104,110,253,280],"chemotactic":[38],"gradient":[39],"generated":[40],"by":[41,171,344],"placing":[42],"10(-7)":[43,105],"M-formyl-methionyl-leucyl-phenyl-alanine":[44],"(fMLP)":[45],"below":[46,93],"cultures.":[48],"Under":[49],"conditions,":[51],"an":[52,129],"average":[53],"29":[55],"+/-":[56],"12%":[57],"total":[60],"population":[61],"beneath":[65,153],"endothelium":[67,122,168,210],"after":[68],"1":[69],"or":[70,82,290,372],"2":[71,124],"h":[72],"incubation.":[74],"Neutrophil":[75],"absence":[79],"fMLP":[81,90,130,314],"presence":[85,251],"equal":[87],"concentrations":[88],"and":[92,167,211,223,241,271,307,317,361],"was":[96,109,133,169,186,245,339],"less":[97],"than":[98],"8%":[99],"M-fMLP":[106],"gradient.":[107],"Migration":[108,338],"rapid":[111],"event.":[112],"began":[114],"adhering":[115],"apical":[118],"surface":[119],"within":[123],"min":[125],"following":[126,346],"exposure":[127],"gradient;":[131],"Ca2+":[132],"required":[134],"for":[135],"this":[136],"initial":[137,162],"adhesion.":[138],"Within":[139],"10":[140],"min,":[141],"majority":[143],"associated":[146],"with":[147,302],"BMEC-amnion":[149],"had":[151,279],"monolayer.":[156],"Ultrastructural":[157],"studies":[158],"revealed":[159],"that":[160,288],"adhesion":[163],"between":[164,174,194,208],"migrating":[165],"characterized":[170],"close":[172,184],"contact":[173],"two":[176,325],"types":[177],"cell":[179],"focal":[181],"areas.":[182],"This":[183],"association":[185],"maintained":[187],"as":[188,300],"traversed":[191],"clefts":[193],"cells.":[196],"Following":[197],"their":[198],"across":[200],"endothelium,":[202],"often":[204],"observed":[206],"lying":[207],"its":[212],"basement":[213,221],"membrane.":[214],"With":[215],"time,":[216],"penetrated":[219,296],"moved":[224],"into":[225],"underlying":[227],"tissue.":[230],"To":[231],"test":[232],"role":[234],"neutrophil":[236],"proteinases":[237],"breaching":[239],"subendothelial":[242],"barriers,":[243],"allowed":[246],"proceed":[248],"variety":[254],"proteinase":[256],"inhibitors,":[257],"including":[258],"p-nitrophenyl":[259],"p'-guanidinobenzoate,":[260],"soybean":[261],"trypsin":[262],"inhibitor,":[263,268],"6-aminocaproic":[264],"acid,":[265],"alpha":[266],"1-proteinase":[267],"leupeptin,":[269],"antipain":[270],"methoxysuccinyl":[272],"alanine-alanine-proline-valine":[273],"chloromethyl":[274],"ketone.":[275],"None":[276],"significant":[281],"effect":[282],"number":[285],"depth":[292],"which":[294],"they":[295],"compared":[301],"controls.":[303],"In":[304],"contrast,":[305],"pepstatin":[306],"chymostatin":[308],"reduced":[309],"7%":[316],"52%":[318],"control":[320],"values,":[321],"respectively.":[322],"However,":[323],"inhibitors":[326],"did":[327],"not":[328],"affect":[329],"another":[334],"chemoattractant,":[335],"leukotriene":[336],"B4.":[337],"neither":[340],"enhanced":[341],"nor":[342],"inhibited":[343],"treatments:":[347],"(1)":[348],"removal":[349],"plasminogen":[351,376],"calf":[354],"serum":[355],"assay":[359],"medium":[360],"addition":[362,369],"polyclonal":[364,373],"antibody":[365,374],"plasminogen;":[367],"(2)":[368],"monoclonal":[371],"activator.(ABSTRACT":[377],"TRUNCATED":[378],"AT":[379],"400":[380],"WORDS)":[381]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}