{"id":"https://openalex.org/W2140678380","doi":null,"title":"Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.","display_name":"Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2140678380","mag":"2140678380","pmid":"https://pubmed.ncbi.nlm.nih.gov/25599729"},"language":"en","primary_location":{"id":"pmh:oai:ijkd.org:article/1982","doi":null,"is_oa":true,"landing_page_url":"https://ijkd.org/index.php/ijkd/article/view/1982","pdf_url":"https://ijkd.org/index.php/ijkd/article/download/1982/735","source":{"id":"https://openalex.org/S2479614751","display_name":"Iranian Journal of Kidney Diseases","issn_l":"1735-8582","issn":["1735-8582","1735-8604"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1735-8582","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://ijkd.org/index.php/ijkd/article/download/1982/735","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053956561","display_name":"Namrata Krishnan","orcid":"https://orcid.org/0000-0001-9419-9193","observed_orcids":["https://orcid.org/0000-0001-9419-9193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Namrata Krishnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043430229","display_name":"Mark Anthony Perazella","orcid":"https://orcid.org/0000-0002-6994-2659","observed_orcids":["https://orcid.org/0000-0002-6994-2659"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark A Perazella","raw_affiliation_strings":["Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA. mark.perazella@yale.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Nephrology, Yale University School of Medicine, New Haven, Connecticut, USA. mark.perazella@yale.edu","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.3902,"has_fulltext":true,"cited_by_count":86,"citation_normalized_percentile":{"value":0.94203669,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"3","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.6366999745368958,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12962","display_name":"Nephrotoxicity and Medicinal Plants","score":0.18539999425411224,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.11670000106096268,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-acute-interstitial-nephritis","display_name":"drug-induced acute interstitial nephritis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.9290000200271606},{"id":"https://openalex.org/keywords/kidney-biopsy-pathology","display_name":"kidney biopsy pathology","score":0.6669999957084656},{"id":"https://openalex.org/keywords/haptenization","display_name":"haptenization","score":0.7749999761581421},{"id":"https://openalex.org/keywords/antigen-mimicry","display_name":"antigen mimicry","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tubular-atrophy","display_name":"tubular atrophy","score":0.9160000085830688},{"id":"https://openalex.org/keywords/corticosteroid-therapy","display_name":"corticosteroid therapy","score":0.9380000233650208},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.8579999804496765}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8813897371292114},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.6095148324966431},{"id":"https://openalex.org/C2780888721","wikidata":"https://www.wikidata.org/wiki/Q1424106","display_name":"Interstitial nephritis","level":3,"score":0.5859637260437012},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.4677714705467224},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.46090424060821533},{"id":"https://openalex.org/C2781087799","wikidata":"https://www.wikidata.org/wiki/Q7312483","display_name":"Renal biopsy","level":3,"score":0.45983263850212097},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.45456722378730774},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.44971051812171936},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.42748332023620605},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.4197908043861389},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39237549901008606},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.37923020124435425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3528668284416199},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2835918664932251}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006435","descriptor_name":"Renal Dialysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009395","descriptor_name":"Nephritis, Interstitial","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:ijkd.org:article/1982","doi":null,"is_oa":true,"landing_page_url":"https://ijkd.org/index.php/ijkd/article/view/1982","pdf_url":"https://ijkd.org/index.php/ijkd/article/download/1982/735","source":{"id":"https://openalex.org/S2479614751","display_name":"Iranian Journal of Kidney Diseases","issn_l":"1735-8582","issn":["1735-8582","1735-8604"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1735-8582","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:25599729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25599729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Iranian journal of kidney diseases","raw_type":"Journal Article"},{"id":"mag:2140678380","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25599729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ijkd.org:article/1982","doi":null,"is_oa":true,"landing_page_url":"https://ijkd.org/index.php/ijkd/article/view/1982","pdf_url":"https://ijkd.org/index.php/ijkd/article/download/1982/735","source":{"id":"https://openalex.org/S2479614751","display_name":"Iranian Journal of Kidney Diseases","issn_l":"1735-8582","issn":["1735-8582","1735-8604"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"1735-8582","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140678380.pdf","grobid_xml":"https://content.openalex.org/works/W2140678380.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W135129750","https://openalex.org/W1510157117","https://openalex.org/W1858217743","https://openalex.org/W1929771581","https://openalex.org/W1964628510","https://openalex.org/W1966525272","https://openalex.org/W1967136565","https://openalex.org/W1967828164","https://openalex.org/W1972359804","https://openalex.org/W1978523131","https://openalex.org/W1980009351","https://openalex.org/W1981665521","https://openalex.org/W1982976290","https://openalex.org/W1987561772","https://openalex.org/W1992910121","https://openalex.org/W1998970549","https://openalex.org/W2001363746","https://openalex.org/W2009889306","https://openalex.org/W2035725566","https://openalex.org/W2035756907","https://openalex.org/W2038262102","https://openalex.org/W2044904090","https://openalex.org/W2050068296","https://openalex.org/W2061608024","https://openalex.org/W2067027564","https://openalex.org/W2067430125","https://openalex.org/W2074983969","https://openalex.org/W2078457674","https://openalex.org/W2079676318","https://openalex.org/W2083272188","https://openalex.org/W2087094124","https://openalex.org/W2091698612","https://openalex.org/W2094257688","https://openalex.org/W2095337395","https://openalex.org/W2096760252","https://openalex.org/W2100429415","https://openalex.org/W2101118341","https://openalex.org/W2103855235","https://openalex.org/W2119745892","https://openalex.org/W2128802116","https://openalex.org/W2130473166","https://openalex.org/W2134100103","https://openalex.org/W2137183307","https://openalex.org/W2137345140","https://openalex.org/W2138453517","https://openalex.org/W2142477762","https://openalex.org/W2144551134","https://openalex.org/W2147015966","https://openalex.org/W2147551032","https://openalex.org/W2148184356","https://openalex.org/W2157142589","https://openalex.org/W2158458517","https://openalex.org/W2166188055","https://openalex.org/W2260524358","https://openalex.org/W2332571552"],"related_works":["https://openalex.org/W2755237314","https://openalex.org/W4205369718","https://openalex.org/W2091234866","https://openalex.org/W2973003790","https://openalex.org/W2594114396","https://openalex.org/W4285394439","https://openalex.org/W4285105319","https://openalex.org/W2794196136","https://openalex.org/W2090540717","https://openalex.org/W2388448331"],"abstract_inverted_index":{"Drug-induced":[0],"acute":[1,10],"interstitial":[2,42,44,100,137],"nephritis":[3],"(DAIN)":[4],"is":[5,26,64,148,157],"a":[6,32,49,65,68,127],"common":[7],"cause":[8],"of":[9,39,51,61,67,144,146,150,161,169,175,179,186,205,242],"kidney":[11,206,214],"injury":[12,79,170],"and":[13,46,55,96,103,134,139,164,190,216],"often":[14],"presents":[15],"as":[16,92,136],"an":[17,109],"unexplained":[18],"rise":[19],"in":[20,112,159,229],"serum":[21],"creatinine":[22],"level.":[23],"Kidney":[24],"biopsy":[25],"therefore":[27],"frequently":[28],"required":[29],"to":[30,80,124,126,172,226,237],"make":[31],"definitive":[33],"diagnosis.":[34,173],"The":[35,84,142],"hallmark":[36],"pathologic":[37],"features":[38],"DAIN":[40,119,147,180],"are":[41],"edema,":[43],"inflammation,":[45],"tubulitis":[47],"with":[48,58,211],"predominance":[50],"CD4+":[52],"T":[53],"lymphocytes":[54],"mononuclear":[56],"cells,":[57,102],"variable":[59],"numbers":[60],"eosinophils.":[62],"This":[63],"result":[66],"type":[69],"B":[70],"idiosyncratic":[71],"non-immunoglobulin-E-mediated":[72],"immune":[73,78],"reaction":[74],"marked":[75],"by":[76,131],"cell-mediated":[77],"the":[81,151,162,167,197,243],"renal":[82,104,155],"tubulointerstitium.":[83],"drug":[85],"becomes":[86],"immunogenic":[87],"via":[88],"various":[89],"mechanisms":[90],"such":[91],"haptenization,":[93],"antigen":[94],"mimicry,":[95],"neo-antigen":[97],"formation.":[98],"Renal":[99],"dendritic":[101],"tubular":[105,140],"epithelial":[106],"cells":[107],"play":[108],"important":[110],"role":[111],"further":[113],"propagating":[114],"this":[115],"immunologic":[116],"injury.":[117],"Acute":[118],"can":[120],"progress":[121],"within":[122],"days":[123,239],"weeks":[125],"chronic":[128,213,220],"form":[129],"triggered":[130],"fibroblast":[132],"activation":[133],"manifested":[135],"fibrosis":[138],"atrophy.":[141],"mainstay":[143],"treatment":[145,178],"discontinuation":[149,241],"offending":[152,244],"drug.":[153],"Incomplete":[154],"recovery":[156,204,210],"seen":[158],"one-third":[160],"patients":[163,230],"depends":[165],"on":[166],"duration":[168],"prior":[171],"Use":[174],"steroids":[176],"for":[177,219],"makes":[181,196],"biological":[182],"sense,":[183],"but":[184],"lack":[185],"randomized":[187],"controlled":[188],"trials":[189],"conflicting":[191],"data":[192],"from":[193],"retrospective":[194],"studies":[195],"approach":[198],"unclear.":[199],"Positive":[200],"effects":[201],"include":[202],"faster":[203],"function,":[207],"more":[208],"complete":[209],"less":[212],"disease,":[215],"reduced":[217],"need":[218],"dialysis.":[221],"Therefore,":[222],"it":[223],"seems":[224],"reasonable":[225],"employ":[227],"corticosteroids":[228],"that":[231],"do":[232],"not":[233],"rapidly":[234],"improve":[235],"3":[236],"5":[238],"following":[240],"agent.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}