{"id":"https://openalex.org/W2140674595","doi":"https://doi.org/10.1039/c3ob42332h","title":"Design, synthesis and binding properties of a fluorescent \u03b1 9 \u03b2 1 /\u03b1 4 \u03b2 1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells","display_name":"Design, synthesis and binding properties of a fluorescent \u03b1 9 \u03b2 1 /\u03b1 4 \u03b2 1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells","publication_year":2013,"publication_date":"2013-12-13","ids":{"openalex":"https://openalex.org/W2140674595","doi":"https://doi.org/10.1039/c3ob42332h","mag":"2140674595","pmid":"https://pubmed.ncbi.nlm.nih.gov/24363056"},"language":"en","primary_location":{"id":"doi:10.1039/c3ob42332h","doi":"https://doi.org/10.1039/c3ob42332h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c3ob42332h","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2014/ob/c3ob42332h","source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.rsc.org/en/content/articlepdf/2014/ob/c3ob42332h","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045981125","display_name":"Benjamin Cao","orcid":"https://orcid.org/0000-0002-3024-3893","observed_orcids":["https://orcid.org/0000-0002-3024-3893"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Benjamin Cao","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC, VIC 3169, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC, VIC 3169, Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080295626","display_name":"Oliver E. Hutt","orcid":"https://orcid.org/0000-0002-0475-0605","observed_orcids":["https://orcid.org/0000-0002-0475-0605"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Oliver E. Hutt","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390130","display_name":"Zhen Zhang","orcid":"https://orcid.org/0000-0001-6286-8049","observed_orcids":["https://orcid.org/0000-0001-6286-8049"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Zhen Zhang","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007605785","display_name":"Songhui Li","orcid":"https://orcid.org/0000-0003-4033-4366","observed_orcids":["https://orcid.org/0000-0003-4033-4366"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Songhui Li","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072858968","display_name":"Shen Y. Heazlewood","orcid":"https://orcid.org/0000-0003-1541-0224","observed_orcids":["https://orcid.org/0000-0003-1541-0224"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shen Y. Heazlewood","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brenda Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Brenda Williams","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034043242","display_name":"Jessica A. Smith","orcid":"https://orcid.org/0000-0003-4248-6566","observed_orcids":["https://orcid.org/0000-0003-4248-6566"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jessica A. Smith","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057615707","display_name":"David N. Haylock","orcid":"https://orcid.org/0000-0002-4483-1063","observed_orcids":["https://orcid.org/0000-0002-4483-1063"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]},{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David N. Haylock","raw_affiliation_strings":[", Australia","Australian Regenerative Medicine Institute","CSIRO Materials Science and Engineering","Clayton, Australia","Monash University","Australian Regenerative Medicine Institute, Monash University, Wellington Rd,Clayton,Australia","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"Australian Regenerative Medicine Institute","institution_ids":["https://openalex.org/I2801239119"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"Clayton, Australia","institution_ids":[]},{"raw_affiliation_string":"Monash University","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Regenerative Medicine Institute, Monash University, Wellington Rd,Clayton,Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055175625","display_name":"G. Paul Savage","orcid":"https://orcid.org/0000-0001-7805-8630","observed_orcids":["https://orcid.org/0000-0001-7805-8630"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"G. Paul Savage","raw_affiliation_strings":[", Australia","CSIRO Materials Science and Engineering","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080139485","display_name":"Susan K. Nilsson","orcid":"https://orcid.org/0000-0002-7926-7335","observed_orcids":["https://orcid.org/0000-0002-7926-7335"]},"institutions":[{"id":"https://openalex.org/I1292875679","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07","country_code":"AU","type":"government","lineage":["https://openalex.org/I1292875679","https://openalex.org/I2801453606","https://openalex.org/I4387156119"]},{"id":"https://openalex.org/I2801239119","display_name":"Australian Regenerative Medicine Institute","ror":"https://ror.org/02qa5kg76","country_code":"AU","type":"facility","lineage":["https://openalex.org/I2801037857","https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Susan K. Nilsson","raw_affiliation_strings":[", Australia","Australian Regenerative Medicine Institute","CSIRO Materials Science and Engineering","Clayton, Australia","Monash University","Australian Regenerative Medicine Institute, Monash University, Wellington Rd,Clayton,Australia","CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":", Australia","institution_ids":[]},{"raw_affiliation_string":"Australian Regenerative Medicine Institute","institution_ids":["https://openalex.org/I2801239119"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering","institution_ids":["https://openalex.org/I1292875679"]},{"raw_affiliation_string":"Clayton, Australia","institution_ids":[]},{"raw_affiliation_string":"Monash University","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Australian Regenerative Medicine Institute, Monash University, Wellington Rd,Clayton,Australia","institution_ids":["https://openalex.org/I2801239119","https://openalex.org/I56590836"]},{"raw_affiliation_string":"CSIRO Materials Science and Engineering, Bag 10, Clayton Sth MDC,,Australia","institution_ids":["https://openalex.org/I1292875679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055175625"],"corresponding_institution_ids":["https://openalex.org/I1292875679"],"apc_list":null,"apc_paid":null,"fwci":0.8103,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75407218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"6","first_page":"965","last_page":"978"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11440","display_name":"Click Chemistry and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/integrin-alpha9beta1","display_name":"integrin \u03b19\u03b21","score":0.9909999966621399},{"id":"https://openalex.org/keywords/integrin-alpha4beta1","display_name":"alpha4beta1 integrin","score":1.0},{"id":"https://openalex.org/keywords/integrin-antagonists","display_name":"integrin antagonists","score":0.7649999856948853},{"id":"https://openalex.org/keywords/fluorescent-probes","display_name":"fluorescent probes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.6899999976158142},{"id":"https://openalex.org/keywords/copper-catalyzed-azide-alkyne-cycloaddition","display_name":"copper-catalyzed azide-alkyne cycloaddition","score":0.5989999771118164},{"id":"https://openalex.org/keywords/binding-kinetics","display_name":"binding kinetics","score":0.847000002861023},{"id":"https://openalex.org/keywords/in-vivo-cell-imaging","display_name":"in vivo cell imaging","score":0.5339999794960022},{"id":"https://openalex.org/keywords/stem-cell-trafficking","display_name":"stem cell trafficking","score":0.5979999899864197}],"concepts":[{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.8710004091262817},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.70257169008255},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5784277319908142},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4755021035671234},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.47214439511299133},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.46148911118507385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44772061705589294},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4178146719932556},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.40125492215156555},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3191033601760864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3126125931739807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19902750849723816},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004151","descriptor_name":"Dipeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011392","descriptor_name":"Proline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012235","descriptor_name":"Rhodamines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D012235","descriptor_name":"Rhodamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012235","descriptor_name":"Rhodamines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D039041","descriptor_name":"Integrin alpha4beta1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1039/c3ob42332h","doi":"https://doi.org/10.1039/c3ob42332h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c3ob42332h","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2014/ob/c3ob42332h","source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},{"id":"pmid:24363056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24363056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Organic & biomolecular chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/c3ob42332h","doi":"https://doi.org/10.1039/c3ob42332h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/c3ob42332h","pdf_url":"https://pubs.rsc.org/en/content/articlepdf/2014/ob/c3ob42332h","source":{"id":"https://openalex.org/S179810352","display_name":"Organic & Biomolecular Chemistry","issn_l":"1477-0520","issn":["1477-0520","1477-0539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Org. Biomol. Chem.","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320006","display_name":"Royal Society","ror":"https://ror.org/03wnrjx87"},{"id":"https://openalex.org/F4320320251","display_name":"Royal Society of Chemistry","ror":"https://ror.org/025sbr097"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2140674595.pdf","grobid_xml":"https://content.openalex.org/works/W2140674595.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1241436880","https://openalex.org/W1839610592","https://openalex.org/W1966022051","https://openalex.org/W1968652549","https://openalex.org/W1970483666","https://openalex.org/W1978598034","https://openalex.org/W1981267628","https://openalex.org/W1991471758","https://openalex.org/W1997316241","https://openalex.org/W1997695395","https://openalex.org/W2000466466","https://openalex.org/W2009239392","https://openalex.org/W2013326206","https://openalex.org/W2020199777","https://openalex.org/W2029231027","https://openalex.org/W2036976495","https://openalex.org/W2040024224","https://openalex.org/W2040998241","https://openalex.org/W2041795914","https://openalex.org/W2048493629","https://openalex.org/W2050117419","https://openalex.org/W2050472349","https://openalex.org/W2052396649","https://openalex.org/W2052914627","https://openalex.org/W2054516994","https://openalex.org/W2057963438","https://openalex.org/W2058014425","https://openalex.org/W2058576933","https://openalex.org/W2066367871","https://openalex.org/W2082990692","https://openalex.org/W2085232212","https://openalex.org/W2099258935","https://openalex.org/W2099410333","https://openalex.org/W2101244168","https://openalex.org/W2103386895","https://openalex.org/W2120287343","https://openalex.org/W2131183827","https://openalex.org/W2145519423","https://openalex.org/W2145662716","https://openalex.org/W2167664390","https://openalex.org/W2170155327","https://openalex.org/W2549610885","https://openalex.org/W4237716389"],"related_works":["https://openalex.org/W2225392352","https://openalex.org/W4412454740","https://openalex.org/W1989753828","https://openalex.org/W2323179506","https://openalex.org/W2460594684","https://openalex.org/W4409325979","https://openalex.org/W1555207396","https://openalex.org/W2095535774","https://openalex.org/W7112067839","https://openalex.org/W2094352910"],"abstract_inverted_index":{"The":[0],"\u03b19\u03b21":[1,42,93,133,157,221,231],"and":[2,14,22,65,67,84,107,146,158,194,222,232,236,241],"\u03b14\u03b21":[3,28,139,159,166,223,233],"integrin":[4,29,43,94,134,140,167,208,234,239],"subtypes":[5],"are":[6,51],"expressed":[7],"on":[8,100,243],"bone":[9,190],"marrow":[10,191],"haemopoietic":[11,192],"stem":[12,19,193],"cells":[13,196],"have":[15,30],"important":[16],"roles":[17,26],"in":[18,58,152,247],"cell":[20,86,245],"regulation":[21],"trafficking.":[23],"Although":[24],"the":[25,39,70,81,110,153,176,227],"of":[27,41,72,89,103,185,189,220,230],"been":[31],"thoroughly":[32],"investigated":[33],"with":[34,135],"respect":[35],"to":[36,60,68,132,165,169,175,199],"HSC":[37],"function,":[38],"role":[40],"remains":[44],"poorly":[45],"characterised.":[46],"Small":[47],"molecule":[48,74,218],"fluorescent":[49,92,207],"probes":[50],"useful":[52,205],"tools":[53],"for":[54,214],"monitoring":[55],"biological":[56],"processes":[57],"vivo,":[59],"determine":[61],"cell-associated":[62],"protein":[63,76],"localisation":[64],"activation,":[66],"elucidate":[69],"mechanism":[71],"small":[73,217],"mediated":[75],"interactions.":[77],"Herein,":[78],"we":[79,123,179],"report":[80],"design,":[82],"synthesis":[83],"integrin-dependent":[85],"binding":[87,130,154,164,174,186,235],"properties":[88,229],"a":[90,101,204],"new":[91],"antagonist":[95],"(R-BC154),":[96],"which":[97,161],"was":[98,183],"based":[99],"series":[102],"N-phenylsulfonyl":[104],"proline":[105],"dipeptides":[106],"assembled":[108],"using":[109],"Cu(I)-catalyzed":[111],"azide":[112],"alkyne":[113],"cycloaddition":[114],"(CuAAC)":[115],"reaction.":[116],"Using":[117],"transfected":[118],"human":[119],"glioblastoma":[120],"LN18":[121],"cells,":[122],"show":[124,180],"that":[125,181,210],"R-BC154":[126,182,202],"exhibits":[127],"high":[128],"nanomolar":[129],"affinities":[131],"potent":[136],"cross-reactivity":[137],"against":[138],"under":[141],"physiological":[142],"mimicking":[143],"conditions.":[144],"On-rate":[145],"off-rate":[147],"measurements":[148],"revealed":[149],"distinct":[150],"differences":[151],"kinetics":[155],"between":[156],"integrins,":[160],"showed":[162],"faster":[163],"relative":[168],"\u03b19\u03b21,":[170],"but":[171],"more":[172],"prolonged":[173],"latter.":[177],"Finally,":[178],"capable":[184],"rare":[187],"populations":[188],"progenitor":[195],"when":[197],"administered":[198],"mice.":[200],"Thus,":[201],"represents":[203],"multi-purpose":[206],"probe":[209],"can":[211],"be":[212],"used":[213],"(1)":[215],"screening":[216],"inhibitors":[219],"integrins;":[224],"(2)":[225],"investigating":[226,238],"biochemical":[228],"(3)":[237],"expression":[240],"activation":[242],"defined":[244],"phenotypes":[246],"vivo.":[248]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}