{"id":"https://openalex.org/W2140674394","doi":"https://doi.org/10.1002/jnr.23077","title":"Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells","display_name":"Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells","publication_year":2012,"publication_date":"2012-06-20","ids":{"openalex":"https://openalex.org/W2140674394","doi":"https://doi.org/10.1002/jnr.23077","mag":"2140674394","pmid":"https://pubmed.ncbi.nlm.nih.gov/22714992","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418436"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.23077","doi":"https://doi.org/10.1002/jnr.23077","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.23077","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418436","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053036095","display_name":"Zhourui Wu","orcid":"https://orcid.org/0000-0001-5670-1752","observed_orcids":["https://orcid.org/0000-0001-5670-1752"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhourui Wu","raw_affiliation_strings":["Department of Spinal Surgery, Translational Stem Cell Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China","Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spinal Surgery, Translational Stem Cell Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101786905","display_name":"Kevin Y. Huang","orcid":"https://orcid.org/0000-0002-2288-3620","observed_orcids":["https://orcid.org/0000-0002-2288-3620","https://orcid.org/0000-0002-6510-9432"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Huang","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102816962","display_name":"Juehua Yu","orcid":"https://orcid.org/0000-0002-1661-0503","observed_orcids":["https://orcid.org/0000-0002-1661-0503"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juehua Yu","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085895751","display_name":"Thuc T. Le","orcid":"https://orcid.org/0000-0002-9719-4344","observed_orcids":["https://orcid.org/0000-0002-9719-4344"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thuc Le","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010151288","display_name":"Masakazu Namihira","orcid":"https://orcid.org/0000-0003-2108-5712","observed_orcids":["https://orcid.org/0000-0003-2108-5712"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masakasu Namihira","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059276926","display_name":"Yupeng Liu","orcid":"https://orcid.org/0000-0002-8652-1987","observed_orcids":["https://orcid.org/0000-0002-8652-1987"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yupeng Liu","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100433196","display_name":"Jun Zhang","orcid":"https://orcid.org/0000-0002-7630-8162","observed_orcids":["https://orcid.org/0000-0002-7630-8162"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Zhang","raw_affiliation_strings":["Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071147113","display_name":"Zhigang Xue","orcid":"https://orcid.org/0000-0001-7715-1403","observed_orcids":["https://orcid.org/0000-0001-7715-1403"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Xue","raw_affiliation_strings":["Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China","Department of Spinal Surgery, Translational Stem Cell Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Department of Spinal Surgery, Translational Stem Cell Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768271","display_name":"Liming Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liming Cheng","raw_affiliation_strings":["Department of Spinal Surgery, Translational Stem Cell Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Spinal Surgery, Translational Stem Cell Center, Tongji Hospital, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079469718","display_name":"Guoping Fan","orcid":"https://orcid.org/0000-0001-5235-6410","observed_orcids":["https://orcid.org/0000-0001-5235-6410"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Guoping Fan","raw_affiliation_strings":["Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, David Geffen School of Medicine, UCLA, Los Angeles, California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Regenerative Medicine, Stem Cell Research Center, Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079469718","https://openalex.org/A5100768271"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I161318765"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":2.2548,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.87204343,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"90","issue":"10","first_page":"1883","last_page":"1891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.8339999914169312,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.8339999914169312,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.09390000253915787,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dnmt3a","display_name":"DNMT3A","score":1.0},{"id":"https://openalex.org/keywords/de-novo-dna-methyltransferases","display_name":"de novo DNA methyltransferases","score":0.9819999933242798},{"id":"https://openalex.org/keywords/neural-stem-cells","display_name":"neural stem cells","score":0.8500000238418579},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.890999972820282},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6600000262260437},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/glial-differentiation","display_name":"glial differentiation","score":0.925000011920929},{"id":"https://openalex.org/keywords/astrocyte-differentiation","display_name":"astrocyte differentiation","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":1.0},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.7279999852180481},{"id":"https://openalex.org/keywords/global-dna-hypomethylation","display_name":"global DNA hypomethylation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.6859999895095825}],"concepts":[{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.8048697710037231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7344475984573364},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6252204775810242},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.6183978915214539},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.5407476425170898},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5330174565315247},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.48080793023109436},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.46099427342414856},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.45465707778930664},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.44656872749328613},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.440494179725647},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4113270044326782},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.40337657928466797},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.3996816873550415},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.369019478559494},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34080374240875244},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.3356969952583313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18573033809661865},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1471455991268158},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.14505985379219055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11682930588722229},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11414709687232971},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.04468265175819397},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.043532997369766235}],"mesh":[{"descriptor_ui":"D000090205","descriptor_name":"DNA Methyltransferase 3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004248","descriptor_name":"DNA (Cytosine-5-)-Methyltransferases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1002/jnr.23077","doi":"https://doi.org/10.1002/jnr.23077","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.23077","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:22714992","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22714992","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2774434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3418436","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418436","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Neurosci Res","raw_type":"Text"},{"id":"pmh:oai:hub.hku.hk:10722/365704","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10722/365704","pdf_url":null,"source":{"id":"https://openalex.org/S4377196271","display_name":"The HKU Scholars Hub (University of Hong Kong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I889458895","host_organization_name":"University of Hong Kong","host_organization_lineage":["https://openalex.org/I889458895"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2774434","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3418436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1285063184","display_name":"Functional analysis of DNA methylation in post-mitotic neurons","funder_award_id":"23650215","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G1742065043","display_name":"Control of Multineage Human ESC Differentiation","funder_award_id":"P01GM081621","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2695228278","display_name":null,"funder_award_id":"NSO72924","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G7348005590","display_name":"Mapping DNA methylation in hippocampal neurons through bisulfite sequencing","funder_award_id":"R21NS072924","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1967064280","https://openalex.org/W1968717432","https://openalex.org/W1985102214","https://openalex.org/W1988875977","https://openalex.org/W2026489696","https://openalex.org/W2046241907","https://openalex.org/W2060446375","https://openalex.org/W2062118486","https://openalex.org/W2064943181","https://openalex.org/W2067004457","https://openalex.org/W2068407791","https://openalex.org/W2078972833","https://openalex.org/W2088621765","https://openalex.org/W2091414779","https://openalex.org/W2107024719","https://openalex.org/W2107038650","https://openalex.org/W2107498593","https://openalex.org/W2114599216","https://openalex.org/W2115818350","https://openalex.org/W2131072337","https://openalex.org/W2133959309","https://openalex.org/W2137296349","https://openalex.org/W2140929811","https://openalex.org/W2141554152","https://openalex.org/W2143008483","https://openalex.org/W2149790281","https://openalex.org/W2158217645"],"related_works":["https://openalex.org/W1967022955","https://openalex.org/W2042668454","https://openalex.org/W4307776260","https://openalex.org/W2792349974","https://openalex.org/W4299161980","https://openalex.org/W7036827329","https://openalex.org/W2896039271","https://openalex.org/W2061275516","https://openalex.org/W2019125403","https://openalex.org/W2038442934"],"abstract_inverted_index":{"DNA":[0,22],"methylation":[1],"is":[2],"known":[3],"to":[4,35,65],"regulate":[5],"cell":[6,39,147,151],"differentiation":[7,28,57,83,148],"and":[8,37,81,149],"neuronal":[9,36],"function":[10],"in":[11,26,54,84,92,108,140,153],"vivo.":[12],"Here":[13],"we":[14],"examined":[15],"whether":[16],"deficiency":[17],"of":[18,29,78,106,145,156],"a":[19,51,75,135],"de":[20],"novo":[21],"methyltransferase,":[23],"Dnmt3a,":[24],"affects":[25],"vitro":[27],"mouse":[30],"embryonic":[31],"stem":[32,43],"cells":[33,44],"(mESCs)":[34],"glial":[38,56],"lineages.":[40],"Early-passage":[41],"neural":[42,146],"(NSCs)":[45],"derived":[46],"from":[47,128],"Dnmt3a-deficient":[48],"ESCs":[49],"exhibited":[50],"moderate":[52],"phenotype":[53,77],"precocious":[55,79],"compared":[58,125],"with":[59,88,126],"wild-type":[60,70],"counterparts.":[61],"However,":[62],"successive":[63],"passaging":[64],"passage":[66],"6":[67],"(P6),":[68],"when":[69],"NSCs":[71,110],"become":[72],"gliogenic,":[73],"revealed":[74,102,134],"robust":[76],"astrocyte":[80],"oligodendrocyte":[82],"Dnmt3a(-/-)":[85,109,118],"NSCs,":[86],"consistent":[87],"our":[89,132],"previous":[90],"findings":[91],"the":[93,117,143,150,154],"more":[94],"severely":[95],"hypomethylated":[96],"Dnmt1(-/-)":[97],"NSCs.":[98],"Mass":[99],"spectrometric":[100],"analysis":[101],"that":[103],"total":[104],"levels":[105],"methylcytosine":[107],"at":[111],"P6":[112,129],"were":[113],"globally":[114],"hypomethylated.":[115],"Moreover,":[116],"NSC":[119],"proliferation":[120,152],"rate":[121],"was":[122],"significantly":[123],"increased":[124],"control":[127],"onward.":[130],"Thus,":[131],"work":[133],"novel":[136],"role":[137],"for":[138],"Dnmt3a":[139],"regulating":[141],"both":[142],"timing":[144],"paradigm":[155],"mESC-derived-NSCs.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
