{"id":"https://openalex.org/W2140658695","doi":"https://doi.org/10.1098/rsif.2012.0428","title":"The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation","display_name":"The effect of remodelling and contractility of the actin cytoskeleton on the shear resistance of single cells: a computational and experimental investigation","publication_year":2012,"publication_date":"2012-07-18","ids":{"openalex":"https://openalex.org/W2140658695","doi":"https://doi.org/10.1098/rsif.2012.0428","mag":"2140658695","pmid":"https://pubmed.ncbi.nlm.nih.gov/22809850"},"language":"en","primary_location":{"id":"doi:10.1098/rsif.2012.0428","doi":"https://doi.org/10.1098/rsif.2012.0428","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2012.0428","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2012.0428","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2012.0428","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070071228","display_name":"Enda P. Dowling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181231927","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120","country_code":"IE","type":"education","lineage":["https://openalex.org/I181231927"]},{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Enda P. Dowling","raw_affiliation_strings":["Mechanical and Biomedical Engineering, National University of Ireland, University Road, Galway, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical and Biomedical Engineering, National University of Ireland, University Road, Galway, Republic of Ireland","institution_ids":["https://openalex.org/I181231927","https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087952432","display_name":"William Ronan","orcid":"https://orcid.org/0000-0002-9533-4550","observed_orcids":["https://orcid.org/0000-0002-9533-4550"]},"institutions":[{"id":"https://openalex.org/I181231927","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120","country_code":"IE","type":"education","lineage":["https://openalex.org/I181231927"]},{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"William Ronan","raw_affiliation_strings":["Mechanical and Biomedical Engineering, National University of Ireland, University Road, Galway, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical and Biomedical Engineering, National University of Ireland, University Road, Galway, Republic of Ireland","institution_ids":["https://openalex.org/I181231927","https://openalex.org/I188760350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040940478","display_name":"Gidon Ofek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gidon Ofek","raw_affiliation_strings":["Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064055337","display_name":"V.S. Deshpande","orcid":"https://orcid.org/0000-0003-3899-3573","observed_orcids":["https://orcid.org/0000-0003-3899-3573"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vikram S. Deshpande","raw_affiliation_strings":["Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Engineering, University of Cambridge, Trumpington Street, Cambridge CB2 1PZ, UK","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066019368","display_name":"Robert M. McMeeking","orcid":"https://orcid.org/0000-0001-6369-7528","observed_orcids":["https://orcid.org/0000-0001-6369-7528"]},"institutions":[{"id":"https://openalex.org/I154570441","display_name":"University of California, Santa Barbara","ror":"https://ror.org/02t274463","country_code":"US","type":"education","lineage":["https://openalex.org/I154570441"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. McMeeking","raw_affiliation_strings":["Department of Materials, University of California, Santa Barbara, CA 93106, USA","Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials, University of California, Santa Barbara, CA 93106, USA","institution_ids":["https://openalex.org/I154570441"]},{"raw_affiliation_string":"Department of Mechanical Engineering, University of California, Santa Barbara, CA 93106, USA","institution_ids":["https://openalex.org/I154570441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001646095","display_name":"Kyriacos A. Athanasiou","orcid":"https://orcid.org/0000-0001-5387-8405","observed_orcids":["https://orcid.org/0000-0001-5387-8405"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyriacos A. Athanasiou","raw_affiliation_strings":["Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044131663","display_name":"Patrick McGarry","orcid":"https://orcid.org/0000-0001-8616-4011","observed_orcids":["https://orcid.org/0000-0001-8616-4011"]},"institutions":[{"id":"https://openalex.org/I181231927","display_name":"National University of Ireland","ror":"https://ror.org/00shsf120","country_code":"IE","type":"education","lineage":["https://openalex.org/I181231927"]},{"id":"https://openalex.org/I188760350","display_name":"Ollscoil na Gaillimhe \u2013 University of Galway","ror":"https://ror.org/03bea9k73","country_code":"IE","type":"education","lineage":["https://openalex.org/I188760350"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"J. Patrick McGarry","raw_affiliation_strings":["Mechanical and Biomedical Engineering, National University of Ireland, University Road, Galway, Republic of Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanical and Biomedical Engineering, National University of Ireland, University Road, Galway, Republic of Ireland","institution_ids":["https://openalex.org/I181231927","https://openalex.org/I188760350"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5044131663"],"corresponding_institution_ids":["https://openalex.org/I181231927","https://openalex.org/I188760350"],"apc_list":null,"apc_paid":null,"fwci":3.0862,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.91450915,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"77","first_page":"3469","last_page":"3479"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9520000219345093},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9599999785423279},{"id":"https://openalex.org/keywords/stress-fibers","display_name":"stress fibers","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cytoskeletal-remodeling","display_name":"cytoskeletal remodeling","score":0.828000009059906},{"id":"https://openalex.org/keywords/cytoskeletal-contractility","display_name":"cytoskeletal contractility","score":0.8500000238418579},{"id":"https://openalex.org/keywords/shear-deformation","display_name":"shear deformation","score":0.6430000066757202},{"id":"https://openalex.org/keywords/hyperelastic-model","display_name":"hyperelastic material models","score":0.5609999895095825},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cell-mechanics","display_name":"cell mechanics","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7501486539840698},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7016876935958862},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.5564092397689819},{"id":"https://openalex.org/C2993400109","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Actin cytoskeleton","level":4,"score":0.5228338837623596},{"id":"https://openalex.org/C96035792","wikidata":"https://www.wikidata.org/wiki/Q43606218","display_name":"Shear (geology)","level":2,"score":0.509891152381897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49389559030532837},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4526020884513855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35520899295806885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3517732620239258},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3007897138595581},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2604978382587433},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.11591124534606934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10698914527893066},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.09852960705757141}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008841","descriptor_name":"Actin Cytoskeleton","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D022502","descriptor_name":"Stress Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1098/rsif.2012.0428","doi":"https://doi.org/10.1098/rsif.2012.0428","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2012.0428","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2012.0428","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},{"id":"pmid:22809850","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22809850","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Royal Society, Interface","raw_type":"Journal Article"},{"id":"pmh:http://www.rian.ie/129961/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10379/5939","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115570527","host_organization_name":"Dublin Institute of Technology","host_organization_lineage":["https://openalex.org/I115570527"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:aran.library.nuigalway.ie/:10379/5939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/5939","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:https://researchrepository.universityofgalway.ie:10379/5939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/5939","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:europepmc.org:2838741","doi":null,"is_oa":false,"landing_page_url":"http://europepmc.org/articles/PMC3481572","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3481572","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3481572","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J R Soc Interface","raw_type":"Text"},{"id":"pmh:http://www.rian.ie/159078/","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10379/11245","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115570527","host_organization_name":"Dublin Institute of Technology","host_organization_lineage":["https://openalex.org/I115570527"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"},{"id":"pmh:oai:aran.library.nuigalway.ie/:10379/11245","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/11245","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:generic.eprints.org:454140","doi":null,"is_oa":false,"landing_page_url":"http://publications.eng.cam.ac.uk/454140/","pdf_url":null,"source":{"id":"https://openalex.org/S4406922847","display_name":"Cambridge University Engineering Department Publications Database","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:researchrepository.universityofgalway.ie:10379/5939","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10379/5939","pdf_url":null,"source":{"id":"https://openalex.org/S4377196322","display_name":"ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe \u2013 University of Galway)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I188760350","host_organization_name":"Ollscoil na Gaillimhe \u2013 University of Galway","host_organization_lineage":["https://openalex.org/I188760350"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1098/rsif.2012.0428","doi":"https://doi.org/10.1098/rsif.2012.0428","is_oa":true,"landing_page_url":"https://doi.org/10.1098/rsif.2012.0428","pdf_url":"https://royalsocietypublishing.org/doi/pdf/10.1098/rsif.2012.0428","source":{"id":"https://openalex.org/S129150467","display_name":"Journal of The Royal Society Interface","issn_l":"1742-5662","issn":["1742-5662","1742-5689"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319787","host_organization_name":"Royal Society","host_organization_lineage":["https://openalex.org/P4310319787"],"host_organization_lineage_names":["Royal Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of The Royal Society Interface","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2140658695.pdf"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W247719737","https://openalex.org/W1782148244","https://openalex.org/W1967657670","https://openalex.org/W1975781184","https://openalex.org/W1977982146","https://openalex.org/W1981750545","https://openalex.org/W1990901578","https://openalex.org/W1997844555","https://openalex.org/W2011161671","https://openalex.org/W2011369256","https://openalex.org/W2019273250","https://openalex.org/W2025515198","https://openalex.org/W2026548884","https://openalex.org/W2032496122","https://openalex.org/W2037321044","https://openalex.org/W2039152606","https://openalex.org/W2052710417","https://openalex.org/W2055771113","https://openalex.org/W2057564766","https://openalex.org/W2058396041","https://openalex.org/W2061403457","https://openalex.org/W2063133375","https://openalex.org/W2071720513","https://openalex.org/W2076904329","https://openalex.org/W2079163282","https://openalex.org/W2082067280","https://openalex.org/W2084610846","https://openalex.org/W2086061329","https://openalex.org/W2094929666","https://openalex.org/W2095117140","https://openalex.org/W2095186645","https://openalex.org/W2104325257","https://openalex.org/W2105072296","https://openalex.org/W2111811045","https://openalex.org/W2113220609","https://openalex.org/W2123389161","https://openalex.org/W2143876847","https://openalex.org/W2149871521","https://openalex.org/W2166079563","https://openalex.org/W2167067851","https://openalex.org/W2167956058","https://openalex.org/W2171577674","https://openalex.org/W2258046233","https://openalex.org/W2427556916","https://openalex.org/W4244270736"],"related_works":["https://openalex.org/W2901611760","https://openalex.org/W2904912999","https://openalex.org/W1908941310","https://openalex.org/W197432475","https://openalex.org/W4303449254","https://openalex.org/W2056665186","https://openalex.org/W4311957677","https://openalex.org/W2594707584","https://openalex.org/W2099875681","https://openalex.org/W1989836623"],"abstract_inverted_index":{"The":[0],"biomechanisms":[1],"that":[2,120,178],"govern":[3],"the":[4,54,78,93,114,121,144,147,160,163,184,199,202,208,212],"response":[5,213],"of":[6,19,133,138,143,152,162,201,207,214],"chondrocytes":[7,28,128,215],"to":[8,31,91,112,141,155,177,216],"mechanical":[9,217],"stimuli":[10],"are":[11,23,29,44],"poorly":[12],"understood.":[13],"In":[14,89,165],"this":[15,96],"study,":[16],"a":[17,35,63,85,98,131,167,172,195],"series":[18],"in":[20,25,52,66,76,115,182,211],"vitro":[21,116],"tests":[22],"performed,":[24],"which":[26,53,77,183],"single":[27],"subjected":[30],"shear":[32],"deformation":[33],"by":[34,72],"horizontally":[36],"moving":[37],"probe.":[38],"Dramatically":[39],"different":[40],"probe":[41,69,148],"force-indentation":[42,87,123,174],"curves":[43],"obtained":[45],"for":[46,50,126,180],"untreated":[47,127],"cells":[48,51,61,181],"and":[49,108,149,205],"actin":[55,80,185,209],"cytoskeleton":[56,81,186,210],"has":[57,187],"been":[58,188],"disrupted.":[59,189],"Untreated":[60],"exhibit":[62,84],"rapid":[64],"increase":[65],"force":[67],"upon":[68],"contact":[70],"followed":[71],"yielding":[73,137],"behaviour.":[74],"Cells":[75],"contractile":[79],"was":[82],"removed":[83],"linear":[86,173],"response.":[88],"order":[90],"investigate":[92],"mechanisms":[94],"underlying":[95],"behaviour,":[97],"three-dimensional":[99],"active":[100,203],"modelling":[101],"framework":[102],"incorporating":[103],"stress":[104],"fibre":[105],"(SF)":[106],"remodelling":[107,206],"contractility":[109,204],"is":[110],"used":[111],"simulate":[113],"tests.":[117],"Simulations":[118],"reveal":[119],"characteristic":[122],"curve":[124,175],"observed":[125,179],"occurs":[129],"as":[130],"result":[132],"two":[134],"factors:":[135],"(i)":[136],"SFs":[139,153],"due":[140,154],"stretching":[142],"cytoplasm":[145,157],"near":[146],"(ii)":[150],"dissociation":[151],"reduced":[156],"tension":[158],"at":[159],"front":[161],"cell.":[164],"contrast,":[166],"passive":[168],"hyperelastic":[169],"model":[170],"predicts":[171],"similar":[176],"This":[190],"combined":[191],"modelling-experimental":[192],"study":[193],"offers":[194],"novel":[196],"insight":[197],"into":[198],"role":[200],"loading.":[218]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}